Heart disease detective: 1,000-Person study hunts for hidden genetic triggers of sudden cardiac death

NCT ID NCT03049254

Recruiting now Knowledge-focused Sponsor: Mayo Clinic Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study is looking for new genes and blood markers linked to arrhythmogenic cardiomyopathy (AVC), a genetic heart condition that can lead to heart failure and sudden cardiac arrest. Researchers will enroll 1,000 people, including patients with AVC or unexplained cardiac arrest, and their blood relatives. By collecting medical data, images, and samples, they hope to better understand how the disease starts and progresses, which could improve diagnosis and screening for at-risk families.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If successful, this could lead to better genetic tests and early detection methods for arrhythmogenic cardiomyopathy, potentially preventing sudden cardiac death in at-risk families.
What could go wrong: This is an observational study, not a treatment trial. It may not directly benefit participants, and findings may take years to translate into clinical practice.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Arrhythmias, Cardiac arrhythmogenic right ventricular cardiomyopathy cardiac sarcoidosis cardiomyopathy Cardiovascular Abnormalities cardiovascular disorder congenital anomaly of cardiovascular system Death, Sudden, Cardiac familial dilated cardiomyopathy familial isolated arrhythmogenic ventricular dysplasia, left dominant form heart disorder hypertrophic cardiomyopathy myocarditis sarcoidosis sudden arrhythmia death syndrome sudden cardiac arrest ventricular arrhythmias due to cardiac ryanodine receptor calcium release deficiency syndrome ventricular tachycardia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ARRHYTHMOGENIC RIGHT VENTRICULAR CARDIOMYOPATHY ARRHYTHMOGENIC RIGHT VENTRICULAR DYSPLASIA ARRHYTHMOGENIC VENTRICULAR CARDIOMYOPATHY CARDIAC ARRHYTHMIA CARDIAC SARCOIDOSIS CARDIOMYOPATHIES CARDIOVASCULAR ABNORMALITIES CARDIOVASCULAR DISEASES FAMILIAL DILATED CARDIOMYOPATHY HEART DISEASES INFLAMMATORY CARDIOMYOPATHY MYOCARDITIS RIGHT VENTRICULAR OUTFLOW TRACT VENTRICULAR TACHYCARDIA SARCOIDOSIS SUDDEN CARDIAC ARREST SUDDEN CARDIAC DEATH VENTRICULAR TACHYCARDIA

Contacts and locations

Locations

Mayo Clinic
RECRUITING

Rochester, Minnesota, 55905, United States
Royal Papworth Hospital NHS Foundation Trust
RECRUITING

Papworth Everard, Cambridge, CB23 3RE, United Kingdom

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