Ventricular tachycardia

This trial tests whether a non-invasive mapping system called VIVO can help doctors locate the source of a dangerous heart rhythm called ventricular tachycardia (VT) before an invasive procedure. Patients with structural heart disease who need catheter ablation will be randomly a…

This study tests a new device that uses extreme cold to destroy small areas of heart tissue causing a dangerous fast heartbeat called ventricular tachycardia. The trial will include 100 adults with this condition who have not responded to medication. Researchers will check if the…

This trial investigates whether a new dual energy catheter system can safely and effectively treat ventricular arrhythmias—abnormal heart rhythms that can be life-threatening. The system uses both radiofrequency and pulsed field energy to ablate the heart tissue causing the probl…

This early-stage trial tests a single dose of SGT-501, a gene therapy given by IV, in 18 people with a rare inherited heart condition called CPVT that can cause dangerous fast heartbeats during exercise or stress. The main goal is to check safety and find the right dose in adults…

This trial compares two ways to guide ablation for ventricular tachycardia, a dangerous fast heart rhythm. One method uses standard voltage mapping to burn away all low-voltage scar tissue. The other uses a newer technique called ILAM that targets specific zones where the electri…

This study tests whether adding a vein-injected alcohol treatment to the usual heart ablation procedure can better control dangerous heart rhythms in people with prior heart attacks. About 156 adults with an implanted defibrillator and recent episodes of rapid heartbeat will be r…

This study tests whether etripamil nasal spray can safely and quickly stop episodes of paroxysmal supraventricular tachycardia (PSVT) in children aged 6 to 17. PSVT causes sudden rapid heartbeats that can be frightening and require medical attention. The spray is designed to be u…

This study tests whether destroying small areas of heart muscle that cause dangerous rhythms (ventricular tachycardia ablation) during LVAD implant surgery can reduce the number of these rhythms after surgery. About 100 adults with advanced heart failure who are getting an LVAD w…

This study tests an experimental drug called CRD-4730 in 12 adults with a rare inherited heart condition (CPVT) that can cause dangerous heart rhythms during exercise or stress. Participants will receive two different doses of the drug and a placebo in random order to see if it s…

This study is testing a new device called the Sphere-9 catheter, used with the Affera mapping system, to treat ventricular tachycardia (VT) — a fast, dangerous heart rhythm. The procedure uses heat to destroy small areas of scarred heart tissue that cause the abnormal rhythm. The…

This study looks at two ways to treat a fast, dangerous heart rhythm called ventricular tachycardia in people with coronary artery disease and relatively good heart function. One treatment uses a catheter to burn the tiny area causing the problem (radiofrequency ablation), and th…

This study tests a new device called MAGiC that uses magnets to help doctors treat abnormal heart rhythms. About 150 adults who need a standard heart ablation procedure will take part. The goal is to see if the device is safe and works well, both right after the procedure and ove…

This study follows 50 patients with ventricular tachycardia that hasn't responded to standard treatments. They receive a single, high-dose radiation treatment (STAR) aimed at the heart tissue causing the abnormal rhythm. Researchers will track how well the treatment controls the …

This study tests a new device (TS-RF system) that uses radiofrequency energy to help doctors safely reach the left side of the heart during procedures for abnormal heart rhythms or mitral stenosis. About 70 adults will be randomly assigned to receive either the new device or a st…

This study tests a new approach for people with a life-threatening fast heart rhythm called ventricular tachycardia (VT) that keeps coming back after standard treatment. It compares a single, targeted radiation dose (cardiac radioablation) to a repeat catheter ablation, which is …

This study tests a new method called decrement evoked potential (DeEP) mapping to guide catheter ablation for ventricular tachycardia (VT) in people with structural heart disease. VT is a fast, dangerous heart rhythm that can cause sudden cardiac arrest. The standard ablation pro…

This study compares two methods—DEEP mapping and activation mapping—used during catheter ablation to treat ventricular tachycardia (VT), a fast, dangerous heart rhythm. About 222 adults with an implanted defibrillator and VT will be randomly assigned to one technique. The goal is…

This study looks at people with an implanted defibrillator who had a successful first procedure to fix a dangerous fast heart rhythm (ventricular tachycardia). A few days later, they get a non-invasive heart stimulation test. If the test triggers the rhythm again, patients are ra…

This study tests a noninvasive radiation treatment (SBRT) for people with ventricular tachycardia, a dangerous heart rhythm that can cause sudden death. The 12 participants have structural heart disease and have not been helped by standard treatments like drugs or catheter ablati…

This study tests a new way to treat persistent atrial fibrillation (AFib) by targeting specific high-frequency areas in the heart that may be driving the condition. Researchers will compare this new ablation method to standard treatment in 78 adults with long-lasting AFib or recu…

This study compares a single dose of targeted radiation (SBRT) to the standard catheter ablation procedure for reducing dangerous heart rhythms in people with advanced heart disease. Sixty participants will be randomly assigned to one of the two treatments. The main goal is to se…

This study looks at whether low-dose beta-blockers can reduce dangerous heart rhythms in people who have survived a cardiac arrest with no clear cause. About 218 participants will receive one of several beta-blockers and be followed for up to 3 years. The goal is to see if this t…

This study tests whether a single, lower dose of radiation can safely reduce episodes of ventricular tachycardia (a dangerous fast heart rhythm) in people who haven't been helped by standard treatments. About 40 adults with structural heart disease and recurrent VT will receive e…

This study tests a single, high-dose radiation treatment aimed at the area of the heart causing dangerous rapid rhythms (ventricular tachycardia). It includes 12 adults with an implanted defibrillator who have not been helped by medications or standard procedures. The goal is to …

This study tests a new catheter (Vision-MR 2.0) to treat ventricular tachycardia, a fast, dangerous heart rhythm, in people with ischemic heart disease. About 64 adults will undergo a procedure to burn small areas of heart tissue causing the abnormal rhythm. The goal is to stop t…

This study tests a new oral drug called AGP100 in people with a rare inherited heart condition (CPVT) that can cause dangerously fast heartbeats during stress or exercise. Ten adults aged 18-75 will take three different doses of AGP100 over six weeks while continuing their usual …

This study compares a low cumulative dose of epinephrine (adrenaline) to the standard dose during resuscitation for out-of-hospital cardiac arrest. About 3,790 adults with a shockable heart rhythm will be enrolled. The goal is to see if using less epinephrine improves survival to…

This trial tests two ways to treat ventricular tachycardia (a fast, dangerous heart rhythm) in people who have had a heart attack and have an implanted defibrillator. One method uses standard ablation inside the heart; the other also ablates outside the heart. The study will trac…

This study tests a new, non-invasive radiation treatment against the standard catheter procedure for ventricular tachycardia, a dangerous fast heartbeat. About 244 adults with heart failure and an implanted defibrillator will be randomly assigned to one of the two treatments. The…

This study tests whether using an AI tool (Ablation Index) during heart ablation can shorten the procedure for patients with ventricular tachycardia caused by prior heart attacks. About 100 adults with ischemic cardiomyopathy and scar-related VT will be randomly assigned to stand…

This study aims to develop a new clinical test to diagnose Calcium Release Deficiency Syndrome (CRDS), a rare inherited heart condition that increases the risk of sudden cardiac arrest. Researchers will use a pacing procedure to measure heart wave changes in 400 participants, inc…

This study compares two types of portable heart monitors in people who have symptoms of an irregular heartbeat (arrhythmia) but whose standard heart test was normal. About 588 participants will wear either a continuous ECG patch or use a handheld ECG device for one month. The goa…

This study evaluates a new multichannel ECG system designed to detect early signs of cardiovascular disease (CVD) in people who may have no symptoms yet. The system uses advanced algorithms to analyze electrical signals from the heart, looking for subtle abnormalities that could …

This study explores whether a quick, painless cheek swab can spot protein changes linked to inherited heart conditions that cause sudden cardiac death in young people. Researchers will collect samples from 26 patients with arrhythmic disorders or family members at risk. If the te…

This study tests whether a sedative called dexmedetomidine can help people in the ICU who have a life-threatening heart rhythm problem called electrical storm. About 192 adults will receive either the sedative or a placebo for 2-3 days. The goal is to see if it reduces deaths and…

This study tests a modified imaging catheter (ViewFlex X ICE) to help doctors see heart structures during procedures for irregular heartbeats. About 500 adults who are already scheduled for a heart procedure using ultrasound will be enrolled. The goal is to see if the new cathete…

This study compares a simple nasal swab to the standard Valsalva maneuver for stopping a common rapid heartbeat condition called supraventricular tachycardia (SVT). About 60 adults with SVT in the emergency room will be randomly assigned to one of the two methods. The goal is to …

This study looks at how a child's quality of life changes after a procedure called transcatheter ablation, which treats abnormal heart rhythms. Researchers will ask 200 children aged 5 to 17 and their parents to fill out questionnaires about physical, emotional, social, and schoo…

This study tests whether a non-invasive magnetic stimulation device can reduce dangerous heart rhythm episodes in people with ventricular tachycardia storm. About 60 adults who have had multiple episodes despite medication will receive either real or sham stimulation. The goal is…

This study tests whether a special mapping catheter (Optrell) can better locate and treat heart rhythm problems coming from the papillary muscles, which are small muscle bumps inside the heart. About 20 adults with frequent or bothersome premature ventricular contractions (PVCs) …

This study tests whether using a tiny ultrasound camera inside the heart during ablation can reduce or replace X-rays. Ablation uses catheters to fix abnormal heart rhythms, and X-rays are normally used to guide them. Half of the 70 participants will get the ultrasound-guided pro…

This trial is testing a medical device that has not been approved by the U.S. FDA. The purpose is to gather information about how the device works and its safety in people. Participants will be monitored closely, but the device is not yet proven to treat or cure any condition.

This study is testing a new paddle-shaped catheter designed to map the heart's electrical signals in people with various heart rhythm disorders like atrial fibrillation and ventricular tachycardia. The device has many sensors to create a detailed map of the heart's chambers. The …

This study involves 100 adults with heart rhythm problems who are already scheduled for a standard heart mapping procedure. Researchers will test new software features on the mapping system to see how well they work. The goal is to gather feedback to improve future versions of th…

This observational study will follow 1,500 adults with ventricular tachycardia (VT) to see how well different treatments work over the long term. Participants will receive either catheter ablation or non-ablation management (including drugs or an implantable defibrillator). The g…

This study will collect ECG recordings from 600 people using the HeartBeam 3-Lead ECG recorder. The goal is to build a database of heart rhythm information for future research and regulatory use. Participants will have their ECG taken as part of routine care, and their de-identif…

This observational study will follow 8,000 people with irregular heartbeats (arrhythmias) who are scheduled for a standard catheter ablation procedure using Biosense Webster devices. Researchers will track safety issues and how well the procedure works in everyday hospital practi…

This study follows up with people who survived a dangerous heart condition called electrical storm and were treated in the ICU. Researchers want to understand how the experience and treatments affect mental health and quality of life. Participants fill out questionnaires about PT…

This study uses a special catheter to record detailed electrical signals from the heart during a standard procedure for dangerous heart rhythms (ventricular tachycardia). Researchers aim to better understand why these rhythms start and how to pinpoint the exact trouble spots. Ten…

This study is a registry that will follow 4,000 people in China who are having a procedure called catheter ablation to treat atrial fibrillation or ventricular tachycardia. The goal is to see how well the procedure works over the long term and how safe it is. Participants will be…

This study looks at people who had a heart attack and also developed a dangerous heart rhythm (ventricular arrhythmia) while still in the hospital. Researchers want to learn more about how these patients are treated and how many die after leaving the hospital. The study does not …

This observational study looks at how signals from a left bundle branch pacing lead change during daily activities and overdrive pacing in 50 people with an ICD or CRT-D. Researchers want to see if these leads can accurately detect ventricular tachycardia or fibrillation. Partici…

This study is building a registry of 1,211 people in Brazil who have inherited heart conditions like cardiomyopathy, arrhythmias, and Marfan syndrome. Researchers will collect DNA samples and medical information to discover which genes are most commonly affected and how often the…

This observational study looks at 200 adults with early-onset atrial fibrillation and certain genetic variants. Researchers will use cardiac MRI and electrophysiologic mapping during scheduled heart procedures to find who is at high risk for ventricular tachycardia, a dangerous h…

This study is looking for new genes and blood markers linked to arrhythmogenic cardiomyopathy (AVC), a genetic heart condition that can lead to heart failure and sudden cardiac arrest. Researchers will enroll 1,000 people, including patients with AVC or unexplained cardiac arrest…

This observational study at Imperial College London will enroll 70 people undergoing heart catheterization to understand why some patients tolerate ventricular tachycardia (VT) better than others. Researchers will measure blood pressure and blood flow in the heart during simulate…

This study aims to improve how doctors predict the risk of sudden cardiac death or heart failure in people with inherited heart diseases. Researchers will use artificial intelligence to analyze data from 1,000 participants, including medical history, ECGs, imaging, genetic tests,…

This study tests whether combining detailed heart scans (MRI/CT) with electrical mapping can help doctors better target and treat scar-related ventricular tachycardia (VT), a dangerous heart rhythm. Twenty people with VT who already have an implanted defibrillator will undergo ex…

This study looks at how a heart rhythm treatment called catheter ablation affects the quality of life of people with ventricular tachycardia who have an implantable defibrillator. Researchers will ask 70 participants to fill out questionnaires about their health and well-being at…

This study looks at whether MRI scans can help predict serious heart events in people who have implanted heart devices like pacemakers or defibrillators. Researchers will scan 1,500 adults before they get their device and track their health for years. The goal is to see if MRI fi…

This study looks at whether certain medications known to affect the heart's electrical activity (QT-prolonging drugs) actually cause major heart problems in hospitalized adults. Researchers will analyze data from over 990,000 patients across Ontario hospitals, comparing those who…

This study is looking at 400 people with weak hearts who are getting an implantable defibrillator (ICD) to prevent sudden cardiac death. Researchers want to see if detailed heart MRI scans can find structural problems that better predict who will actually have a dangerous heart r…

This study compares a continuous heart-monitoring patch with standard electrocardiograms (ECGs) in 60 adults receiving cancer drugs that can cause dangerous heart rhythm changes. The goal is to see if the patch detects problems more accurately and consistently. Participants will …

This study looks at how early menopause (premature ovarian insufficiency) affects the heart's electrical signals, which can raise the risk of dangerous heart rhythms. Researchers will compare 120 women with and without this condition, and also check how hormone replacement therap…

This study looks at how a nerve block (stellate ganglion block) changes the heart's electrical activity in 20 people with ventricular tachycardia, a fast and potentially dangerous heart rhythm. Researchers will measure how the heart's refractory period changes and whether the ner…

This registry collects information from 1,000 patients who have had or will have a heart rhythm procedure at University Hospital Düsseldorf. The goal is to track safety and success of these standard procedures in everyday care. No new treatments are being tested; instead, researc…

This study will follow 90 people with mitral valve prolapse who are already scheduled for mitral valve surgery. Researchers will use heart scans and 7-day rhythm monitors before and 6 months after surgery to see if the procedure reduces dangerous heart rhythms and scarring. The g…

This study collects blood and tissue samples from 2,000 people with or without heart rhythm problems. Researchers will analyze the samples to find genetic differences linked to arrhythmias. The goal is to better understand the causes of these conditions, not to test a new treatme…

This study is testing a special heart monitor, the BIOMONITOR IV, in 300 people with heart failure who also have irregular heartbeats. The device tracks heart activity, fluid levels, and breathing patterns to see if it can predict when heart failure gets worse. Researchers hope t…