Zapping the heart: radiation therapy for stubborn arrhythmias

NCT ID NCT05439031

Recruiting now Disease control Sponsor: Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 2 times

Summary

This study tests a single, high-dose radiation treatment aimed at the area of the heart causing dangerous rapid rhythms (ventricular tachycardia). It includes 12 adults with an implanted defibrillator who have not been helped by medications or standard procedures. The goal is to see if this approach can reduce episodes by at least half over a year while keeping side effects low.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: radiation therapy (stereotactic arrhythmia radiotherapy)
What this could lead to: If successful, this could offer a new, non-invasive treatment option for patients with difficult-to-control ventricular tachycardia.
What could go wrong: This is a small, early-phase study with only 12 participants, so results may not apply broadly. Radiation also carries risks of damage to nearby healthy tissue.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Arrhythmias, Cardiac cardiac rhythm disease ventricular tachycardia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ARRYTHMIA, CARDIAC VENTRICULAR TACHYCARDIA

Contacts and locations

Locations

Amsterdam UMC location University of Amsterdam
RECRUITING

Amsterdam, North Holland, 1105AZ, Netherlands

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