Academisch Medisch Centrum - Universiteit Van Amsterdam (amc-uva)

This study is testing a medical procedure called bronchial thermoplasty for adults with severe asthma that isn't controlled by standard medications, including newer biologic drugs. The procedure uses gentle heat on the airways during a bronchoscopy, aiming to reduce the frequency…

This study is testing a single, precise dose of radiation to treat a dangerous, fast heart rhythm called ventricular tachycardia in patients who haven't been helped by standard drugs or procedures. The goal is to see if this one-time treatment can safely and effectively reduce th…

This study is testing whether adults with atopic eczema (atopic dermatitis) that is already well-controlled can safely take their dupilumab medication less often. Researchers will randomly assign 216 participants to receive their standard injection every 2 weeks, or to try extend…

This study is creating a large registry to collect real-world information on patients receiving a specific drug-coated balloon to open blocked heart arteries. It aims to see how well this treatment works and how safe it is over the long term for different types of patients and bl…

This study is testing whether adding a tilt table test to standard care helps people with vasovagal syncope (fainting spells). Researchers will compare two groups: one that gets standard education and lifestyle advice, and another that gets the same advice plus a tilt table test.…

This study is testing whether treating dangerous, fat-filled plaques in heart arteries with a special drug-coated balloon is better than using standard heart medications alone. It involves 400 adults who have recently had a type of heart attack. Researchers will compare how much …

This study aims to see if using a simple lung ultrasound scan to guide personalized ventilator settings can help more patients survive Acute Respiratory Distress Syndrome (ARDS), a severe lung condition. Researchers will compare this personalized approach to standard ventilator c…

This international study compares two types of minimally invasive surgery for removing benign or pre-cancerous tumors from the left side of the pancreas. 256 patients will be randomly assigned to either laparoscopic (traditional keyhole) surgery or robot-assisted surgery, with ne…

This study is testing if using a lower blood pressure target for patients in severe shock after a heart attack is better than the current standard. Researchers want to see if using less of a strong blood pressure medication (noradrenaline) helps patients survive and protects thei…

This study is testing a personalized monitoring and treatment plan for people with Familial Adenomatous Polyposis (FAP), a condition that causes many polyps in the digestive tract. The goal is to find and remove dangerous polyps in the stomach and small intestine early, before th…

This study is testing whether an experimental drug called ziltivekimab can reduce inflammation in the arteries of people with heart disease. Researchers will give the drug or a placebo to 40 patients for 20 weeks and use advanced scans and blood tests to see if it lowers inflamma…

This study aims to see if a new blood test (for a marker called presepsin) can help doctors safely give fewer antibiotics to very premature babies right after birth. Currently, most of these babies get antibiotics because of infection risk, but very few actually have one. The tri…

This study is testing if using a simple, safe bedside lung ultrasound can help doctors better guide fluid removal in critically ill patients on ventilators. The goal is to see if this approach helps patients breathe on their own sooner, potentially reducing their time in the ICU.…

This study is testing a personalized monitoring and treatment plan for people with Familial Adenomatous Polyposis (FAP) who have had their colon removed to prevent cancer. It aims to find the best schedule for follow-up scopes to find and remove growths before they turn into adva…

This international study is testing whether a combination of three existing treatments can reduce serious complications after a complex surgery to remove pancreatic tumors. The surgery, called a pancreatoduodenectomy, has a high risk of a dangerous fluid leak. The trial will enro…

This study is testing whether an 'adaptive' deep brain stimulation system works better than the standard continuous system for people with Parkinson's disease. Researchers want to see if the adaptive system gives patients more daily hours of good movement control with fewer troub…

This study is testing whether a one-time, minimally invasive procedure can help people with type 2 diabetes better control their blood sugar. Doctors use an endoscope to gently resurface the lining of the first part of the small intestine (the duodenum). The goal is to see if thi…

This study is testing a treatment called immunoadsorption for people with long COVID who have harmful antibodies in their blood. The treatment filters the blood to remove these antibodies. About 70 participants will be randomly assigned to receive either the real blood-filtering …

This study is testing if starting powerful cholesterol-lowering treatment early can actually shrink dangerous plaque buildup in the heart arteries of young adults (under 50) who have an inherited condition causing very high cholesterol. Researchers will use special heart scans to…

This study aims to improve blood tests for people with an underactive thyroid (hypothyroidism) who take replacement hormone medication (levothyroxine). Researchers want to see if newer or different blood markers can give a more accurate picture of a patient's thyroid hormone leve…

This study is testing a portable, headset-like device that measures brain waves (EEG) to help ambulance crews quickly identify if a patient is having a severe type of stroke. The goal is to get these patients directly to the right specialized hospital for urgent treatment, avoidi…

This small pilot study is testing if a single ketone drink can improve symptoms for people with schizophrenia or bipolar disorder. Researchers will compare the ketone drink to a similar-tasting carbohydrate drink in 24 participants. The main goal is to see if the drink improves h…

This study is testing whether using virtual reality (VR) glasses to safely practice being back at work can help flight attendants on mental health leave return to their jobs faster. Researchers will compare 118 cabin crew members who receive standard care plus a VR session with t…

This study is checking if it's safe to stop routine camera scans (endoscopies) for people with a low-risk form of Barrett's esophagus, a condition in the throat. It will follow over 3,000 patients in the Netherlands for at least 10 years to see how many develop serious cancer. Th…

This study aims to understand how specific immune cells that respond to a protein called IL-23 are involved in Crohn's disease returning after surgery. Researchers will analyze tissue samples from 40 adult patients with recurring Crohn's disease before and after they receive stan…

This study aims to find out whether patients who come to the cardiac emergency room with fainting spells (syncope) and are considered low-to-medium risk should be sent home immediately or observed in the hospital for 24 hours with heart monitoring. Researchers will compare these …

This study aims to understand the best timing and methods for safely removing excess fluid from critically ill patients in intensive care. Researchers will observe 150 patients who need fluid removal as part of their standard care. They'll collect data on how doctors currently pe…

This study aims to understand how heart disease develops over time in people with type 2 diabetes. Researchers will follow 1,000 participants who have already had a detailed heart scan, repeating the scan to measure changes in plaque buildup in their arteries. By tracking these c…

This study aims to understand how the liver responds to sugar in people with obesity who are having weight-loss surgery. Researchers will compare 40 patients with and without fatty liver disease (MASLD), giving some a sugar solution and others salt water during surgery, then taki…

This study is gathering information to see if surgeons can safely leave the spleen in place when removing left-sided pancreatic cancer. Currently, the spleen is always removed during this surgery to clear nearby tissue, but this carries risks for the patient. Researchers will exa…

This study aims to understand why women with a specific type of heart failure (left ventricular diastolic dysfunction) may have worse recovery after heart surgery than men. Researchers will observe 1,000 patients undergoing heart surgery, collecting data on their health before, d…