Academisch Medisch Centrum - Universiteit Van Amsterdam (amc-uva)

This study tests a shorter, more intense radiation schedule combined with chemotherapy for people with locally advanced esophageal cancer. The goal is to see if this approach is safe and feasible, and to reduce side effects like low white blood cell counts. About 60 adults will r…

This study tests whether using lung ultrasound to personalize ventilator settings can reduce deaths in people with acute respiratory distress syndrome (ARDS). About 538 adults on breathing machines will be assigned to either standard care or a personalized plan based on their lun…

This study tests whether using heat (radiofrequency ablation) to destroy cancer tissue inside the bile duct before placing a metal stent can keep the duct open longer than placing a stent alone. It involves 122 adults with inoperable bile duct cancer. The main goal is to see how …

This study tests whether taking a probiotic called Desulfovibrio piger for 4 weeks can lower inflammation and help preserve the body's own insulin production in people who have had type 1 diabetes for more than 5 years. Twenty adults with remaining beta cell function will receive…

This clinical trial is looking at the best timing for local treatments like surgery or radiation in people with esophageal or stomach cancer that has spread to only a few spots. All participants first get 4 months of standard drug therapy. Then, depending on their response, they …

This study tests whether using less of the drug noradrenaline, by aiming for a lower blood pressure target (55 mmHg instead of 65 mmHg), can improve survival and reduce severe kidney failure in people with cardiogenic shock after a heart attack. About 776 adults will be randomly …

This study tests a personalized surveillance plan for people with familial adenomatous polyposis (FAP) who have had their colon removed. Instead of a fixed schedule, the timing of follow-up endoscopies (every 6 months to 2 years) is based on each person's polyp burden and past tr…

This study tests a personalized surveillance plan for people with familial adenomatous polyposis (FAP), a condition that raises the risk of polyps and cancer in the stomach and duodenum. Participants will have endoscopic exams at intervals tailored to their polyp severity, rangin…

This study tests a single, high-dose radiation treatment aimed at the area of the heart causing dangerous rapid rhythms (ventricular tachycardia). It includes 12 adults with an implanted defibrillator who have not been helped by medications or standard procedures. The goal is to …

This study is testing a procedure called duodenal mucosal resurfacing (DMR) to see if it can safely improve blood sugar control in people with type 2 diabetes who are not on insulin. About 18 adults will be randomly assigned to receive DMR or a sham (fake) procedure. The study wi…

This study tests whether a drug-coated balloon can reduce fatty deposits in heart arteries better than standard medications alone. Researchers will enroll 400 adults who recently had a heart-related event (acute coronary syndrome). Participants will get either the balloon treatme…

Some people with long COVID have harmful antibodies that may be attacking their own bodies, causing severe fatigue and other symptoms. This study tests a treatment called immunoadsorption, which filters the blood to remove those antibodies. About 70 participants will receive eith…

This trial tests whether giving three treatments together—two medicines and a surgical patch—can lower the risk of major complications after Whipple surgery for pancreatic cancer and other tumors. The study includes 400 high-risk patients with a small pancreatic duct. If successf…

This study tests a procedure called bronchial thermoplasty (BT) for adults with severe asthma that remains uncontrolled even with biologic drugs. BT uses a thin tube to deliver heat to the airway walls, aiming to reduce muscle overreactivity. Researchers will compare asthma attac…

This study tests whether using lung ultrasound to guide removal of extra fluid helps patients on breathing machines in the ICU breathe on their own sooner. About 1,000 adults who need a ventilator for at least another day will be randomly assigned to have fluid removal guided by …

This study tests whether adults with well-controlled eczema can safely extend the time between doses of the drug Dupilumab (Dupixent). 216 participants will be randomly assigned to receive the drug every 2, 3, or 4 weeks. Researchers will compare eczema severity and quality of li…

This study tests whether starting strong cholesterol-lowering therapy early can reverse plaque buildup in the arteries of young adults (ages 18-50) with familial hypercholesterolemia, a genetic condition causing very high cholesterol. Researchers will use CT scans to measure chan…

This phase 3 trial tests whether ziltivekimab, a drug that targets inflammation, can reduce swelling in the arteries of 40 people with coronary artery disease. Participants receive either the drug or a placebo, and researchers use advanced imaging and blood tests to measure chang…

This study looks at whether a tilt table test, which provokes fainting in a controlled setting, can help people with vasovagal syncope (common fainting) reduce future episodes. About 238 adults will be randomly assigned to receive biofeedback training either with or without the t…

This study tests a portable EEG device called StrokePointer that ambulance crews can use to detect severe strokes caused by large vessel blockages. Currently, over half of these patients are taken to hospitals that cannot perform the needed clot-removal procedure, causing an aver…

This trial tests whether adding a quick blood test for presepsin can safely reduce unnecessary antibiotic use in very preterm infants. Currently, over 85% of these babies get antibiotics right after birth, but only 1 in 70 actually has an infection. The study will enroll 900 infa…

This trial investigates whether an online, nurse-guided version of cognitive behavioral therapy (CBT) can reduce severe fatigue in people with advanced cancer who are receiving palliative systemic treatment. Participants complete a 12-week online CBT program with support from the…

This study tests whether fluvoxamine, an antidepressant, can reduce severe fatigue and other symptoms in people with post-COVID. 160 adults aged 18-70 with long-lasting fatigue after COVID will receive either the drug or a placebo for 12 weeks. The goal is to see if it improves e…

This study looks at whether a program of exercise and dietary changes can improve or maintain quality of life for people with incurable stomach or esophageal cancer. Researchers will compare two groups of about 196 patients: one group receives standard care, and the other adds a …

This study compares two ways of delivering deep brain stimulation (DBS) to people with Parkinson's disease: adaptive DBS, which adjusts stimulation in real time based on brain signals, and continuous DBS, which delivers constant stimulation. About 130 adults who already have a DB…

This pilot study tests whether using virtual reality (VR) to expose cabin crew to their workplace can help them return to work faster after sick leave due to mental health issues. About 118 participants will either get usual care or usual care plus at least one VR session where t…

This study looks at whether keeping low- and intermediate-risk fainting patients in the hospital for 24 hours with a heart monitor is better than sending them home right away. About 640 adults will be randomly assigned to either stay or go home. The goal is to see if the longer m…

This study looks at how a specific type of heart failure (left ventricular diastolic dysfunction) affects short-term results after heart surgery, especially in women. Researchers will track 1,000 patients undergoing cardiac surgery, comparing men and women to find differences in …

This study observes 150 ICU patients who need excess fluid removed. Researchers will track how fast and when fluid is removed, and look for signs of success or side effects like low blood pressure. The goal is to find safer, more personalized fluid removal methods, but this study…

This study looks at how the liver reacts to a sugar injection during bariatric surgery in people with obesity, comparing those with and without fatty liver disease (MASLD). Forty adults will receive either a sugar solution or salt water during surgery, and small tissue samples wi…

People with type 2 diabetes are at high risk for heart disease. This study will follow 1,000 such patients who have already had a heart CT scan. Researchers will repeat the scan and track how plaque buildup in the heart's arteries changes over time. The goal is to better understa…

This study is collecting information from 3,000 people who receive a special drug-coated balloon to open blocked heart arteries. The goal is to see how effective and safe the balloon is in real-world use, including for different types of blockages and patient conditions. Research…

This study aims to understand why Crohn's disease often returns after surgery by examining specific immune cells that respond to a protein called IL-23. Researchers will collect tissue samples from 40 patients with Crohn's disease during routine colonoscopies, before and after 12…

This study looks at whether measuring a different thyroid hormone (fT3) or the ratio of two hormones (fT3/fT4) can give a clearer picture of thyroid health in people taking levothyroxine. It includes 500 adults with various types of hypothyroidism who are on a stable dose of the …

This study follows over 3,000 people with low-risk Barrett's esophagus who have stopped having routine endoscopic surveillance, as recommended by new guidelines. Researchers will track them for at least 10 years to see if stopping these scopes leads to a rise in serious esophagea…

This study compares two minimally invasive surgical techniques—laparoscopic and robot-assisted—for removing the left side of the pancreas in people with benign or pre-cancerous growths. About 256 participants will be randomly assigned to one of the two procedures. The goal is to …

This study looks at whether the spleen can be safely left in place during surgery for left-sided pancreatic cancer. Currently, the spleen is removed as a standard part of the operation to ensure any cancer in the surrounding fat is also taken out. The study will check how often c…