Tailored scope schedule aims to cut cancer risk in FAP patients

NCT ID NCT04678011

Recruiting now Disease control Sponsor: Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests a personalized surveillance plan for people with familial adenomatous polyposis (FAP) who have had their colon removed. Instead of a fixed schedule, the timing of follow-up endoscopies (every 6 months to 2 years) is based on each person's polyp burden and past treatments. The goal is to see if this tailored approach keeps the rate of advanced polyps or cancer below 5% over 5 years. Up to 1,000 adults will take part.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: personalized endoscopic surveillance protocol
What this could lead to: If successful, this could provide a tailored, safer follow-up schedule for FAP patients after surgery, lowering the chance of developing advanced polyps or cancer.
What could go wrong: This is an observational-style study without a control group, so it cannot prove the protocol is better than standard care. The 5-year follow-up may be too short to fully assess cancer prevention.

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Conditions

The condition(s) this trial relates to.

Adenomatous Polyposis Coli classic familial adenomatous polyposis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

FAMILIAL ADENOMATOUS POLYPOSIS

Contacts and locations

Locations

Academic Medical Centre
RECRUITING

Amsterdam, North Holland, 1105AZ, Netherlands
MD Anderson
RECRUITING

Houston, Texas, 77030, United States

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