FAMILIAL ADENOMATOUS POLYPOSIS
Clinical trials for FAMILIAL ADENOMATOUS POLYPOSIS explained in plain language.
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New drug aims to cut polyp burden in inherited colon cancer condition
Disease control Recruiting nowThis study tests a drug called TPST-1495 in 38 people with familial adenomatous polyposis (FAP), an inherited condition that causes many polyps in the colon and small bowel and raises colon cancer risk. The drug works by blocking certain signals that help polyps grow. The main go…
Matched conditions: FAMILIAL ADENOMATOUS POLYPOSIS
Phase: PHASE2 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated May 17, 2026 00:59 UTC
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New drug aims to shrink polyps in inherited colon condition
Disease control Recruiting nowThis study tests an experimental drug called REC-4881 in 67 adults with familial adenomatous polyposis (FAP), a genetic condition that causes many polyps in the colon and small intestine. The goal is to see if the drug can safely reduce the number and size of polyps. The trial ha…
Matched conditions: FAMILIAL ADENOMATOUS POLYPOSIS
Phase: PHASE1, PHASE2 • Sponsor: Recursion Pharmaceuticals Inc. • Aim: Disease control
Last updated May 17, 2026 00:48 UTC
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Tailored surveillance aims to prevent cancer in FAP patients
Disease control Recruiting nowThis study tests a personalized plan to monitor and treat polyps in the stomach and duodenum of people with familial adenomatous polyposis (FAP), a condition that raises the risk of colorectal and upper GI cancers. Researchers will enroll 1,000 adults with FAP and follow them ove…
Matched conditions: FAMILIAL ADENOMATOUS POLYPOSIS
Sponsor: Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) • Aim: Disease control
Last updated May 12, 2026 13:40 UTC
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New personalized plan aims to catch polyps early in FAP patients after surgery
Disease control Recruiting nowThis study tests a personalized monitoring and treatment plan for 1000 people with familial adenomatous polyposis (FAP) who have had their colon removed. The goal is to see if tailored check-ups can keep the rate of advanced polyps or cancer below 5% over 5 years. Participants wi…
Matched conditions: FAMILIAL ADENOMATOUS POLYPOSIS
Sponsor: Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) • Aim: Disease control
Last updated May 01, 2026 15:58 UTC
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Could a Cancer-Killing pill stop colon cancer before it starts?
Prevention Recruiting nowThis early-phase study tests the safety of a drug called ONC201 (dordaviprone) in 36 people at high risk for colorectal cancer due to familial adenomatous polyposis (FAP) or a history of many polyps. The drug aims to kill precancerous cells without harming normal ones. Researcher…
Matched conditions: FAMILIAL ADENOMATOUS POLYPOSIS
Phase: PHASE1 • Sponsor: National Cancer Institute (NCI) • Aim: Prevention
Last updated May 17, 2026 01:00 UTC
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Can a home treadmill keep polyps away? new study tests exercise as prevention
Prevention Recruiting nowThis study looks at whether different amounts of exercise can help prevent colorectal polyps from coming back in people with Familial Adenomatous Polyposis (FAP). About 32 participants will follow a personalized treadmill program at home for 26 weeks. Researchers will take small …
Matched conditions: FAMILIAL ADENOMATOUS POLYPOSIS
Phase: NA • Sponsor: University of Michigan Rogel Cancer Center • Aim: Prevention
Last updated May 17, 2026 00:48 UTC
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Supplement could cut cancer risk for rare genetic condition
Prevention Recruiting nowThis study tests whether taking a beta-hydroxybutyrate (BHB) supplement can slow or stop the growth of intestinal polyps in people with familial adenomatous polyposis (FAP), a genetic condition that greatly raises colon cancer risk. Twenty participants will take BHB daily to see …
Matched conditions: FAMILIAL ADENOMATOUS POLYPOSIS
Phase: NA • Sponsor: Abramson Cancer Center at Penn Medicine • Aim: Prevention
Last updated May 06, 2026 16:01 UTC
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Hunt for hidden cancer genes: 1,500 families join landmark study
Knowledge-focused Recruiting nowThis research study aims to discover new genes that may cause cancer to run in families. Researchers will collect blood samples and health information from 1,500 people in families where multiple members have had childhood cancers. Participants will not receive direct treatment o…
Matched conditions: FAMILIAL ADENOMATOUS POLYPOSIS
Sponsor: St. Jude Children's Research Hospital • Aim: Knowledge-focused
Last updated May 17, 2026 00:59 UTC
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New risk model could save lives of FAP patients from duodenal cancer
Knowledge-focused Recruiting nowThis study aims to create a more accurate way to predict duodenal cancer risk in people with familial adenomatous polyposis (FAP), a genetic condition that causes many polyps. Researchers will analyze endoscopy images from 300 participants to develop and test new risk models. The…
Matched conditions: FAMILIAL ADENOMATOUS POLYPOSIS
Sponsor: Fondazione IRCCS Istituto Nazionale dei Tumori, Milano • Aim: Knowledge-focused
Last updated May 14, 2026 12:02 UTC
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Massive cancer registry aims to unlock secrets of the disease
Knowledge-focused Recruiting nowThis study is creating a large database of medical information and biological samples from adults with or at risk for many types of cancer, as well as healthy volunteers. The goal is to help researchers better understand what causes cancer, how it progresses, and how to improve p…
Matched conditions: FAMILIAL ADENOMATOUS POLYPOSIS
Sponsor: University of Nebraska • Aim: Knowledge-focused
Last updated Apr 29, 2026 15:02 UTC