Tailored scope schedule may cut cancer risk in FAP patients

NCT ID NCT04677998

Recruiting now Disease control Sponsor: Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests a personalized surveillance plan for people with familial adenomatous polyposis (FAP), a condition that raises the risk of polyps and cancer in the stomach and duodenum. Participants will have endoscopic exams at intervals tailored to their polyp severity, ranging from every 3 months to every 5 years. The goal is to see if this approach reduces the chance of advanced polyps or cancer.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: personalized surveillance and intervention protocol
What this could lead to: If successful, this could provide a tailored monitoring schedule that reduces the risk of advanced polyps and cancer in people with FAP.
What could go wrong: This is an observational-style study without a control group, so it may not prove the protocol is better than standard care. Results depend on long-term follow-up.

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Conditions

The condition(s) this trial relates to.

Adenomatous Polyposis Coli classic familial adenomatous polyposis carcinoma of duodenum prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

FAMILIAL ADENOMATOUS POLYPOSIS

Contacts and locations

Locations

Academic Medical Centre
RECRUITING

Amsterdam, North Holland, 1105AZ, Netherlands
MD Anderson
RECRUITING

Houston, Texas, 77030, United States

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