Can a freezing balloon zap away precancerous gut growths?
NCT ID NCT03847636
First seen Aug 04, 2026 · Last updated Aug 06, 2026 · Updated 2 times
Summary
This trial tests whether a freezing balloon, called cryoballoon ablation, can safely and effectively remove non-cancerous but potentially precancerous growths (adenomas) in the duodenum, the first part of the small intestine. The study includes people with sporadic adenomas or those with a genetic condition called familial adenomatous polyposis (FAP) who are not good candidates for surgery or standard removal. The procedure uses a catheter to freeze and destroy the abnormal tissue, and the trial will measure how completely the growths are eradicated and whether any complications occur.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Cryoballoon ablation (a freezing catheter that destroys abnormal tissue in the duodenum)
- What this could lead to
- If effective, this freezing technique could offer a less invasive way to treat duodenal adenomas, potentially avoiding surgery or repeated endoscopic procedures.
- What could go wrong
- This is a small, early-stage trial. The procedure may cause side effects like pain, bleeding, or incomplete removal, and results may not apply to all patients.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Geisinger Medical Center
Danville, Pennsylvania, 17822, United States
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Johns Hopkins Hospital
Baltimore, Maryland, 21287, United States
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Methodist Dallas Medical Center
Dallas, Texas, 75203, United States
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Northwell Health
Manhasset, New York, 11030, United States
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