Johns Hopkins University

This study looks at how well the RSV vaccine Arexvy works in 170 adults with weakened immune systems. Participants will receive up to 3 vaccine doses over a year and be monitored for side effects and immune response. The goal is to find the best dosing schedule to protect this hi…

This study tests two ways to encourage COVID-19 vaccination among Latino adults and their friends in Maryland. One group learns motivational interviewing skills to talk about vaccines, while the other just gets vaccine information. Researchers will compare how many friends get va…

This phase 2 trial tests whether NLY01, a drug similar to those used for diabetes, can slow brain and retinal shrinkage in people with multiple sclerosis. About 120 adults with stable MS will receive either NLY01 or a placebo for 96 weeks. The main goal is to see if the drug redu…

This study tests whether giving people access to healthy foods, personalized dietitian coaching, and a home blood pressure monitor can help Black and Hispanic adults with high blood pressure (and often diabetes) get their numbers down. About 100 participants will be randomly assi…

This study tests whether psilocybin, a psychedelic substance, can help people stop smoking. Sixty-six daily smokers who have tried and failed to quit before will receive either psilocybin or niacin (a vitamin) in two sessions one week apart. Researchers will check if participants…

This early-stage trial tests whether giving two medicines—erythropoietin and melatonin—together is safe for very premature babies who have bleeding in the brain. About 60 infants will receive either the drug combination or a placebo, along with standard care, to see if the treatm…

This study follows 200 people with HIV who need a kidney transplant. Half will receive a kidney from a donor with HIV, half from a donor without HIV. Researchers track how many patients experience organ rejection or death over time to see if donor HIV status affects outcomes.

This study tests whether omalizumab injections, given every two weeks for 24 weeks, can help people aged 1 to 55 with high IgE levels tolerate more of their trigger foods. Participants who respond may then try adding the food to their diet with extra injections. The goal is to se…

This study tests whether injecting a person's own skin cells from the palm or sole into their amputation stump can thicken the skin and reduce breakdown. Researchers will enroll 50 adults with below-knee amputations who use a prosthetic. The goal is to see if this treatment is sa…

This study tests two smoking cessation methods—varenicline pills and nicotine patches with gum—in 660 people with HIV in South Africa. Participants will receive one of these treatments for 12 weeks, along with counseling. The goal is to see which approach works best to help them …

This study tests if adding health coaching to regular home visiting services helps pregnant and new moms lose weight gained during pregnancy. The goal is to reduce long-term risks for heart disease and diabetes. Researchers will enroll 360 women who are overweight before pregnanc…

This study tests whether giving a newborn a nasal microbiome transplant from their parent can increase the diversity of bacteria in the baby's nose. The goal is to see if this can help prevent infections like those caused by Staphylococcus aureus. The study involves 175 premature…

This study tests whether injecting steroids into the narrowed part of the windpipe after a dilation procedure can help people with idiopathic subglottic stenosis go longer between surgeries. About 226 adults with this rare condition will receive either steroid injections or a pla…

This study tests whether a combined computer- and counselor-delivered alcohol treatment program can help people who receive an early liver transplant for severe alcoholic hepatitis stay alcohol-free. Researchers will compare this program to standard care in 200 participants, trac…

This study tests whether a 2-month combination of four drugs can cure drug-susceptible tuberculosis in children under 10 as safely and effectively as the standard 4- to 6-month regimen. Researchers will enroll 860 children, including those with HIV, to compare the shorter treatme…

This study tests a program called Full-SPARCS, where trained peers lead group sessions to help people with HIV stay in care after they leave prison in South Africa. The program includes one-on-one check-ins and group meetings in community centers. Researchers will compare viral s…

This study tests whether a custom 3D-printed external skull cap can prevent Sunken Flap Syndrome, a condition where the brain sinks after part of the skull is removed. 72 patients who had decompressive craniectomy will either wear the cap or not, and researchers will compare brai…

This Phase 2 trial at Johns Hopkins University will transplant donated hands onto 30 people who have lost one or both hands or arms. The key innovation is a bone marrow cell therapy designed to allow the body to accept the new hand with just one low-dose anti-rejection drug, inst…

This early study tests whether a drug called IMLYGIC, made from a modified herpes virus, can be safely injected into painful or disfiguring skin tumors in adults with NF1. Ten participants will receive up to 8 injections over 4 months. The goal is to see if the treatment is toler…

This study tests whether a modified Atkins diet (low carb, high fat) can control seizures in children aged 3-12 with newly diagnosed absence epilepsy, without using standard medications. Forty children will be enrolled and compared to a group whose parents chose medication instea…

This study tests whether offering small financial rewards and using video calls to watch people take their medicine can help more people complete treatment for latent tuberculosis. About 399 adults in Baltimore will be randomly assigned to usual care, video check-ins alone, or vi…

This study tests a 5-session program for Black women living with HIV who have experienced intimate partner violence in the past two years. The program teaches skills to find inner strength, build a safety net, improve communication, and overcome barriers to HIV care. Researchers …

This study looks at a fetal surgery called FETO for babies with a severe diaphragmatic hernia, where organs move into the chest. The surgery places a balloon in the baby's windpipe to help the lungs grow, then removes it before birth. Researchers will compare 40 babies who get FE…

This study tests a digital toolkit called the Corrie Virtual Atrial Fibrillation Management Program, designed to help people with atrial fibrillation learn about treatment options, stick to therapies, and manage episodes. Researchers will enroll 248 adults with AFib and a BMI of …

This study looks at whether children aged 1 to 17 with well-controlled atopic dermatitis (eczema) can safely reduce their dose or stop taking dupilumab (Dupixent) without their skin condition getting worse. About 30 children who have been on dupilumab for at least a year and have…

This study tests whether text message reminders and a smart pillbox can help teenagers and young adults take their daily anti-rejection medicine on time after a kidney or liver transplant. About 65 participants aged 13-25 will use an electronic pillbox that tracks when they take …

This study tests a drug called mirdametinib in adults with neurofibromatosis type 1 (NF1) who have skin tumors called cutaneous neurofibromas. The goal is to find a safe dose and see if the drug can shrink these tumors. About 24 people will take the drug daily or on a three-week-…

This study tests a brain implant that records and stimulates brain areas to help adults with severe paralysis (from spinal cord injury, ALS, or stroke) control assistive devices like computers or wheelchairs. The main goal is to check safety, and researchers will also see if part…

This study tests if people with atrial fibrillation (an irregular heartbeat) can use a smartwatch to decide when to take blood thinners, instead of taking them every day. About 5,350 adults with a low-to-moderate stroke risk will be randomly assigned to either standard daily bloo…

This study tests whether an 8-week or 24-week pulmonary rehabilitation program (exercise and breathing training) helps people recover lung function after completing tuberculosis (TB) treatment. About 690 adults with confirmed TB will be randomly assigned to one of two rehab progr…

This study tests whether a 6-month program of problem-solving training, community health worker support, and exercise coaching at a YMCA can improve fitness and heart health in 210 adults with type 2 diabetes, obesity, and low income. Participants are compared to those who receiv…

This study looks at whether providing healthy food and lifestyle coaching can help adults with high blood pressure and type 2 diabetes who live in areas with limited access to fresh groceries. About 80 participants from Baltimore will be randomly assigned to receive either standa…

This study tests a program called PICU Up! that helps critically ill children start moving earlier while in the pediatric intensive care unit. The program includes daily activity plans, better sedation management, and family involvement. Researchers want to see if this approach r…

This study tests a digital health program called Corrie Lipids in about 1,000 adults with high LDL cholesterol and heart disease risk. The program includes a smartphone app for tracking cholesterol, medication reminders, and education, plus training for doctors to improve cholest…

This pilot study at Johns Hopkins University is testing whether psilocybin, the active ingredient in magic mushrooms, can help people with cannabis use disorder. Twelve adults will receive two doses of psilocybin along with counseling over 12 weeks. Researchers will track cannabi…

This study tests whether giving adults with obesity and food insecurity free healthy groceries or grocery vouchers, plus behavioral weight loss counseling, helps them lose more weight than counseling alone. Researchers will enroll 300 adults and track weight loss at 24 and 52 wee…

This study tests whether eating more omega-3s (found in fish and certain oils) can improve breathing and daily life for people with COPD. Researchers will provide food to 200 adults with moderate-to-severe COPD and track their symptoms and flare-ups over time. The goal is to see …

This study compares two ways to treat Gram-negative bloodstream infections: staying on IV antibiotics versus switching to oral pills early. Researchers want to see if the oral option works just as well but causes fewer side effects. About 1,030 hospitalized adults will take part,…

This study follows 15 adults (ages 22–90) with severe, long-term balance disorders caused by inner ear damage. Participants have already received a vestibular implant, a device that electrically stimulates the balance nerve to help restore steadiness and clear vision during movem…

This study tests whether the drug Isturisa can improve blood sugar, cholesterol, blood pressure, weight, and bone strength in people with mild autonomous cortisol secretion (MACS), a condition where the body makes too much cortisol. Ten adults with MACS will take Isturisa for two…

This study looks at the best time to give hepatitis C medication to people without HCV who receive a kidney from an HCV-positive donor. One group starts the drug just before transplant and takes it for only 2 weeks; the other starts after transplant and takes it for 12 weeks. The…

This study tests a short, computer-based program to help people with HIV and alcohol use disorder avoid returning to heavy drinking. About 150 adults from a Johns Hopkins HIV clinic will take part. The goal is to see if the program helps them stay alcohol-free longer and drink le…

This study tests if omalizumab (Xolair), an allergy drug, can reduce serious flare-ups in people with COPD who also have allergies. About 334 participants will receive injections of the drug or a placebo for 12 months. The goal is to see if the drug lowers the number of COPD exac…

This pilot study tests a new way to help adults aged 50 and older quit smoking. Participants interact with a virtual counselor on a computer, receive nicotine patches and gum or lozenges, and get support from a community health worker who also helps them schedule lung cancer scre…

This study tests a program called SAVVY that helps young people with HIV choose their preferred antiretroviral therapy (ART) and overcome barriers to getting it. The program includes counseling and a decision-support tool. Researchers will enroll 288 participants to see if this a…

This study tests a program to help 800 adults in Africa get their high blood pressure under control. It combines patient education, provider training, and health system improvements. The goal is to lower blood pressure and reduce the risk of heart disease, stroke, and kidney prob…

This study tests whether metformin, a common diabetes medication, can improve asthma control in overweight or obese adults whose asthma is not well-managed by their current inhalers. About 100 participants will take either metformin or a placebo for 24 weeks while tracking their …

This study tests a vestibular implant in 15 older adults (ages 65-90) with chronic balance issues due to bilateral vestibular hypofunction. The implant electrically stimulates the inner ear to improve balance and vision. Researchers will measure changes in gait and eye reflexes o…

This study tests a vestibular implant, a device surgically placed in the inner ear to electrically stimulate balance nerves. It aims to improve balance, posture, and vision in up to 8 adults with bilateral vestibular hypofunction, a condition causing chronic dizziness and instabi…

This study tests whether using special gait analysis software and custom shoe inserts (orthotics) can help people with a history of diabetic foot ulcers avoid new ulcers and amputations. Researchers will analyze how participants walk and fit them with corrective orthotics. The go…

This study tests whether injecting Dysport (a muscle relaxant similar to Botox) into back muscles, combined with wearing a brace, can improve spine curvature in teens aged 10-16 with mild to moderate scoliosis. About 90 participants will receive either Dysport or a placebo, plus …

This study tests whether adding a patient's own concentrated bone marrow cells to a standard hip surgery (core decompression) can prevent the hip ball from collapsing and delay or avoid the need for a hip replacement. It includes 192 adults with early-stage osteonecrosis (before …

This study looks at whether giving patients IV fluids at home for four weeks after bladder cancer surgery can lower the chance of needing to go back to the hospital. About 130 adults having this surgery will be randomly assigned to either get the usual care or the usual care plus…

This study tests whether using blue light during bladder tumor removal surgery helps surgeons see and remove more cancer than standard white light. About 200 adults with high-risk non-muscle invasive bladder cancer will be randomly assigned to one of the two methods. The goal is …

This phase 2 trial tests whether tesamorelin, a daily self-injected drug, can speed nerve regrowth and reduce muscle loss after surgical repair of injured nerves in the arm. 36 adults with a cut ulnar nerve at the wrist will be randomly assigned to receive tesamorelin or no addit…

This study compares nurse-led treatment for drug-resistant tuberculosis (TB) in local clinics to standard doctor-led care in hospitals. About 2,944 people will take part across South Africa. The goal is to see if nurse-led care works just as well, is safe, and lowers costs for pa…

This phase 2 trial tests whether sildenafil, a drug used for pulmonary hypertension, can help people with scleroderma who have mildly elevated lung pressures. Thirty participants will receive either sildenafil or a placebo for 4 months. The main goal is to see if the drug improve…

This study compares getting flap surgery within 72 hours of a severe leg injury versus waiting longer. The goal is to see if faster surgery reduces death, amputation, infections, and hospital stays. About 356 adults with open fractures or dislocations below the knee will take par…

This study tests a program that helps people with high blood pressure, diabetes, or kidney disease manage their health at home. Participants use a blood pressure monitor that sends readings to their care team, and they get support from community health workers and pharmacists. Th…

This pilot study at Johns Hopkins University will enroll 40 Black women who recently had gestational diabetes and are overweight. Half will receive prepared low-carb, low-fat meals plus nutrition counseling, lactation support, and culturally tailored food bundles; the other half …

This study tests whether a two-drug HIV regimen (dolutegravir plus lamivudine) works as well as the standard three-drug regimen in people who also have tuberculosis and are on TB treatment. About 150 participants who have never taken HIV medication will be randomly assigned to on…

This phase 2 trial tests whether tirzepatide, a drug used for diabetes and weight loss, can reduce binge-eating episodes and help with weight loss in adults with obesity and binge-eating disorder. About 105 participants will receive tirzepatide, a placebo, or the existing drug li…

This study is testing two ways to help teenagers reduce their alcohol use. Both groups get a short counseling session with their doctor. One group also gets a smartphone app that teaches mindfulness. The study will follow 1,500 teens for a year to see which approach works better.

This early study tests a brain implant system called BiCNS in 5 people with tetraplegia (paralysis from the neck down). The implant records brain signals and may allow users to control assistive devices like a robotic arm. The main goal is safety—making sure the device stays in p…

This study tests whether an AI-powered digital stethoscope can help doctors in rural Bangladesh safely reduce antibiotic use in children with respiratory infections. About 2,500 children will be randomly assigned to standard care or care guided by the AI stethoscope. The goal is …

This study compares two types of CT scans—PET/CT and ultra-high-resolution CT—to see which one better detects early signs of coronary artery disease in people with symptoms like chest pain. Researchers will measure the amount of plaque in the arteries and check how accurately eac…

This study tests whether a new MRI contrast agent called Elucirem can detect heart scarring as effectively as the standard agent, but at a much lower dose. Researchers will compare images from 25 adults who previously had a heart MRI with the standard agent. If Elucirem works wel…

This study tests whether a new ultra-high resolution CT scanner is better than a standard CT at finding blocked arteries in the heart. About 140 adults with suspected coronary heart disease will get one scan, and the images will be compared to the usual method (catheterization). …

This study tests whether using an AI-driven retinal camera during regular diabetes checkups can increase the number of young people screened for diabetic retinopathy, a leading cause of blindness. Researchers will enroll 500 youth with type 1, type 2, or cystic fibrosis-related d…

This study tests a robotic device that helps guide the ultrasound probe during prostate biopsies. The goal is to see if it can improve cancer detection and reduce errors compared to the standard freehand method. About 483 men scheduled for their first prostate biopsy will take pa…

This study is testing a simple, less invasive way to detect early signs of Barrett's esophagus, esophageal cancer, and stomach cancer. Participants swallow a capsule attached to a string, which expands into a sponge in the stomach to collect cell samples. Researchers then look fo…

This study is testing a new imaging technique called full-field optical coherence tomography (FFOCT) to examine small lung biopsy samples taken during bronchoscopy. Researchers want to see if FFOCT can provide results that match standard lab analysis, potentially allowing faster …

This early-stage trial tests a new robot and ultrasound probe, called ProBot, designed to make prostate biopsies more precise and comfortable. The study will enroll 60 men with suspected prostate cancer to see if the device is safe and works as intended. If successful, it could l…

This Phase 3 study is testing whether markers in pancreatic fluid and blood can detect early pancreas cancer in people with high genetic risk. Participants receive a secretin injection to collect fluid during an endoscopy. The goal is to improve early detection in those with here…

This study tests if special sensor-equipped insoles can help prevent foot ulcers from coming back in people with diabetes and nerve damage. About 400 high-risk participants will use the insoles alongside standard care or just standard care alone. The goal is to see if the insoles…

This study tests whether a 4-week course of the drug bedaquiline can prevent tuberculosis (TB) as well as standard longer treatments. It involves 2,530 people living with HIV and close contacts of TB patients. The goal is to find a safer, easier-to-complete prevention option.

This study expands on a previous mobile van HIV/STI testing program for men who have sex with men (MSM) in online spaces. Researchers will add a peer health navigator to help participants get PrEP or HIV care after testing. The study will compare this navigator approach to a refe…

This study looks at how a one-time dose of two F/TAF tablets (a medicine used to prevent HIV) works in healthy adults. Researchers want to see how much of the drug gets inside cells over 14 days. 24 healthy volunteers will take the pills and have their blood tested. The goal is t…

This study tests whether adding an oral medication (tacrolimus) before an ERCP procedure can prevent pancreatitis, a painful inflammation of the pancreas that sometimes occurs afterward. About 4,800 adults undergoing ERCP will be randomly assigned to receive either the standard r…

This study aims to see if training people who inject drugs to become peer educators can help their friends get tested for HIV and use prevention tools like PrEP and treatment for opioid use. About 360 participants from syringe service programs in Maryland will be recruited, along…

This study in Uganda tests whether adding lab tests for common sexually transmitted infections (STIs) to standard HIV risk screening helps more women start and stick with PrEP, a daily pill that prevents HIV. About 4,500 HIV-negative women aged 15-39 will be randomly assigned to …

This study tests whether a silicone mouth tape worn during sleep can reduce snoring and improve sleep quality in people with mild sleep apnea or simple snoring. About 100 adults with a bed partner will use the tape for a period, and both the snorer and partner will report on snor…

This pilot study tests a self-management program based on cognitive behavioral therapy to help people who survived acute respiratory failure and now struggle with anxiety. Sixty ICU survivors will either receive the program or usual care. The goal is to see if the program is prac…

This study tests whether adding neck massage, stretches, and pain education to standard voice exercises can improve voice, swallowing, and scar quality after total thyroidectomy. Adults scheduled for total thyroid removal are invited to participate. They will attend sessions with…

This study tests a type of talk therapy called Emotional Awareness and Expression Therapy (EAET) for people who have ongoing pain after a serious orthopedic injury. Researchers want to see if it's possible to run a larger study by checking how many people sign up, attend sessions…

This study tests whether trazodone, a sleep medication, can improve sleep and memory in people with early Alzheimer's and sleep problems. About 100 participants will receive either trazodone or a placebo for 4 weeks. Researchers will measure changes in sleep quality and memory pe…

This study tests whether a telehealth physical therapy program, tailored to each person's risk level, can reduce pain and disability from chronic low back pain better than standard education. About 434 adults in rural communities who have had back pain for at least 6 months will …

This study tests whether solriamfetol (Sunosi), a drug used for sleepiness, can reduce fatigue in people with multiple sclerosis who also have excessive daytime sleepiness. About 46 participants will receive either the drug or a placebo for four weeks, then switch after a washout…

This study compares two pain management plans after laparoscopic tubal sterilization: one with opioids and one without. About 38 women will report their pain levels and satisfaction. The goal is to see if non-opioid drugs like Tylenol and ibuprofen work just as well.

This study tests a program called SPARK for adults aged 50 and older who have pain, depressive symptoms, and trouble moving around. Participants receive 8 nurse visits at home to help them cope with pain and improve their mood. The goal is to see if this approach reduces pain int…

This study tests whether a program called CAPABLE, when added to regular home-based primary care, can help older adults who feel socially isolated or lonely. Researchers will work with 450 homebound seniors to see if the program improves their daily function, reduces pain and dep…

This study tests a program called CAPABLE Transplant, where an occupational therapist, nurse, and handy worker visit people at home over 4 months. The goal is to help kidney transplant candidates who are currently inactive on the waitlist become active again, and to improve their…

This study tests two behavioral treatments—cognitive behavioral therapy (CBT) and mindfulness—to help people with traumatic brain injury (TBI) sleep better and feel less stressed. 360 veterans and service members with mild to moderate TBI, insomnia, and PTSD symptoms will receive…

This study tests a standardized anesthesia plan for children aged 14 and older undergoing LeFort jaw surgery. Researchers will compare pain levels, hospital stay length, and need for intensive care between a group receiving the new protocol and a group from past records. The goal…

This study at Johns Hopkins tests whether using personalized mobile health assessments can improve cognitive-behavioral therapy (CBT) for children aged 8-17 with obsessive-compulsive disorder (OCD). 30 participants will receive either standard CBT or CBT guided by their own sympt…

This study tests whether a mindfulness-based program can help adults with Tourette syndrome or persistent tic disorders reduce their tics. Participants will either learn mindfulness techniques to manage urges or receive standard relaxation and coping support. The goal is to see w…

This study compares two ways to treat chronic low back pain: physical therapy done through video calls (telerehabilitation) versus in-person clinic visits. Researchers will enroll 1000 adults with ongoing back pain to see which approach better reduces disability and pain after 8 …

This study tests whether rhythmic auditory stimulation (RAS) — listening to a metronome beat — can improve walking in people with Parkinson's disease who have a deep brain stimulator (DBS). Ten participants will walk to the beat for four minutes with their DBS turned on and off. …

This study tests if blocking the middle meningeal arteries in the brain is safe and feasible for people with hard-to-treat chronic migraines. About 13 participants will undergo the procedure and be followed for 6 months. The goal is to reduce migraine-causing substances in the br…

This study tests whether personalized virtual music therapy can boost memory and mood in people with mild cognitive impairment or early Alzheimer's disease. Sixty participants will receive two 30-minute online music therapy sessions each week for 8 weeks, led by a certified thera…

This pilot study tests whether switching from ocrelizumab to ublituximab can reduce or delay the return of MS symptoms that some patients experience before their next scheduled infusion. Researchers will enroll 50 adults with relapsing MS who have been on ocrelizumab for at least…

This study tests a digital program called BSHAPE designed to help immigrant women who have experienced violence and suffer from PTSD or depression. The program includes education, skill-building, and mindfulness exercises. Researchers will compare it to a general wellness program…

This Phase II trial tests whether a safe, non-invasive brain stimulation technique called tDCS, combined with language therapy, can improve word-finding in people with primary progressive aphasia (PPA). The study enrolls 180 adults aged 50–90 with certain types of PPA. Participan…

This study aims to find the best way to prevent suicide in young people ages 12-24 who are at high risk. Researchers will compare two short, proven crisis interventions given in emergency rooms: one focuses on creating a safety plan and follow-up calls, while the other teaches sk…

This study tests whether a natural hormone called pregnenolone can reverse the effects of cannabis intoxication. Researchers at Johns Hopkins will give 20 healthy adults who have used cannabis before either pregnenolone or a placebo, then measure changes in drug effects, thinking…

This study tests whether a device called ScentCare, used with a companion app, can improve smell and well-being in adults aged 60 and older who have lost their sense of smell. Participants will use the device or solve Sudoku puzzles twice daily for three months. Researchers will …

This study tests whether a mobile health program (mPATH) can help low-income older adults who have trouble sleeping and are not very active. Participants will use the program to increase physical activity, and researchers will measure changes in memory and sleep quality. The goal…

This study tests whether a low-dose extended-release version of levetiracetam (AGB101) can reduce overactivity in the hippocampus, a brain region often overactive in early dementia. Sixty adults aged 50–80 with normal thinking skills will take the drug or a placebo for two weeks …

This study tests whether a special belt that vibrates can help people with balance disorders walk better and feel more steady. Researchers will enroll 90 adults aged 18-80 who have balance issues from conditions like inner ear problems or ataxia. Participants will use the belt an…

This study tests whether a mild electrical current applied to the back of the brain (cerebellar tDCS) can boost language therapy for people who have trouble finding words after a stroke. Sixty adults who had a left-hemisphere stroke at least six months ago and still have aphasia …

This pilot study is testing whether psilocybin, the active ingredient in magic mushrooms, can safely help depression in people with mild cognitive impairment or early Alzheimer's disease. Twenty participants will receive one or two doses under supportive conditions. Researchers w…

This study tests whether the antidepressant vortioxetine can improve mood symptoms and thinking abilities in people with early-stage behavioral variant frontotemporal dementia (bvFTD). Participants will take the medication for 12 weeks and undergo brain scans and memory tests bef…

This study tests whether listening to Mozart or other age-appropriate songs can reduce seizure activity in children with epilepsy. Ten children aged 4 to 17 staying in an epilepsy monitoring unit will listen to short music clips through earbuds. Researchers will measure changes i…

This study tests whether a relaxation technique called progressive muscle relaxation (PMR) — done with or without virtual reality (VR) — can ease chronic symptoms like pain, itch, anxiety, and sleep problems in adult burn survivors. About 34 participants will try both VR-enhanced…

This study tests whether injecting hyaluronidase into the shoulder muscles can relieve pain and stiffness in stroke survivors. About 68 participants will receive either the drug or a placebo injection. Researchers will use MRI and ultrasound to measure changes in muscle health an…

This study tests if treating insomnia first helps breast cancer survivors lose more weight. 250 women with early-stage breast cancer who are overweight and have insomnia will either get a sleep therapy (CBT-I) or sleep education before starting a weight loss program. Researchers …

This study tests whether psilocybin, a psychedelic substance, is safe for people who had a stroke at least a year ago. Researchers will monitor blood pressure and other vital signs in 20 participants. The goal is to see if psilocybin can help with lingering symptoms like weakness…

This pilot study tests a wellness program for adults with cystic fibrosis (CF) to see if it helps with fatigue, sleep, and physical activity. The program includes 8 coaching sessions on topics like balancing activity and rest, improving sleep, and managing stress. Researchers wil…

This study tests whether an 8-10 week program can improve well-being for caregivers with disabilities. Participants will get help finding resources, making self-care plans, preparing for emergencies, and connecting with peers. The goal is to reduce stress, burden, and depression …

This study tests a device called Scrambler Therapy to see if it can reduce pain after a stroke by at least 50%. Researchers will enroll 100 adults who have had a stroke and have ongoing pain. Participants will receive either 5 or 10 treatments, and the results will be compared to…

This study looks at whether adding a structured yoga program to usual care can reduce back pain and improve quality of life for teens with scoliosis. About 500 participants aged 10-20 who are not having surgery will be randomly assigned to standard care or standard care plus yoga…

This study tests whether psilocybin (the active ingredient in magic mushrooms) can help ease depression and improve quality of life in people with ALS. Researchers will enroll 24 adults with ALS and depressed mood to see if the therapy is feasible and reduces symptoms. The goal i…

This study tests whether vestibular therapy—a set of head-movement exercises done with a physical therapist—can reduce falls in people with Alzheimer's disease who also have inner-ear balance problems. About 100 participants aged 60 and older will receive either the therapy or st…

This study tests whether giving a single dose of methadone during laparoscopic or robotic hysterectomy can reduce the need for opioid painkillers after surgery. About 100 women with non-cancerous fibroids will be randomly assigned to receive either methadone or standard short-act…

This pilot study tests whether scrambler therapy, a device that uses mild electrical signals on the skin, can reduce nerve pain in people with corticobasal syndrome (CBS). Twenty-five adults with CBS and moderate-to-severe pain will be randomly assigned to receive either scramble…

This study tests whether a daily oral dose of cannabidiol (CBD) can help people stop smoking tobacco. Fifty adults who smoke more than 10 cigarettes a day and want to quit will take CBD during several practice quit attempts. The goal is to see if CBD increases short-term abstinen…

This study compares two ways of draining fluid from around the lungs in people with advanced cancer: one using suction (vacuum) and one using gravity. The goal is to see which method causes less chest pain during drainage. About 200 participants will be randomly assigned to one o…

This study is testing a new mental health program for preschool children from low-income families. About 160 parents and their children, ages 2-5, enrolled in Head Start in Maryland will participate. The program offers virtual sessions to help parents manage their child's behavio…

This study tests whether a special thulium laser can safely improve the look and feel of keratosis pilaris (KP), the common 'chicken skin' bumps on arms. Researchers will treat one arm of 25 adults with the laser and compare it to the untreated arm. They will check for changes in…

This study tests whether a personal sound amplifier, along with hearing training, can reduce troubling symptoms like agitation and distress in older adults with Alzheimer's or related dementias who also have hearing loss. Researchers will enroll 300 people aged 60-100 and their c…

This study compares two surgical approaches for removing the bladder in men with bladder cancer: prostate capsule-sparing and nerve-sparing. The goal is to see which technique better preserves erectile function and urinary control. Seventy men will be randomly assigned to one of …

This study tests if entering an MRI machine more slowly can reduce the dizziness and vertigo some people feel near strong magnets. Researchers will have 100 participants enter the MRI at different speeds (20 seconds to 3 minutes) and report their symptoms. The goal is to find a s…

This study tests whether cannabidiol (CBD) pills can reduce anxiety, mood problems, sleep issues, and agitation in adults with autism spectrum disorder (ASD). 40 adults with ASD will receive CBD for 6 weeks and a placebo for 6 weeks, with a 2-week break in between. Researchers wi…

This study tests a device called SWAN that guides people through head movements to reduce motion sickness and improve balance. It is for adults with inner ear disorders, motion sickness, or those recovering from vestibular schwannoma surgery. Participants use the device at home f…

This study looks at how psilocybin (the active ingredient in magic mushrooms) affects mood and pain in people with both chronic low back pain and depression. About 40 adults will receive either a single high dose of psilocybin or a control drug. Researchers will track changes in …

This study tests whether AGB101, a low-dose seizure medication, can reduce hallucinations and delusions in people with Parkinson's disease. About 30 adults aged 40-85 will take the drug and a placebo at different times, with brain scans and questionnaires to track changes. The go…

This study looks at whether extra education and support can help women with bladder cancer feel better emotionally and sexually. Researchers will compare a group that gets standard care with a group that also receives handouts, counseling, a support group, and educational session…

This early-stage study at Johns Hopkins is testing whether giving both psilocybin and MDMA together is safe and can help reduce PTSD symptoms in military veterans. Forty veterans with PTSD will receive the drugs in a controlled setting. The study tracks side effects, suicidal tho…

This study tests a new behavioral therapy called PICTURE IT, delivered via telemedicine, to help people with aphasia after a stroke. The therapy uses pictures and spoken words to stimulate the right side of the brain, aiming to improve language skills. Researchers will compare it…

This study tests whether escitalopram (Lexapro), a common antidepressant, combined with computer-based naming therapy can improve language recovery in people with aphasia after a stroke. About 88 participants who had a left-hemisphere stroke within the past 5 days will receive ei…

This pilot study tests Scrambler Therapy, a non-invasive device that sends electrical signals through the skin to retrain the brain's pain response. Forty adults with chronic pancreatitis and persistent abdominal pain will receive 5-10 daily sessions. Researchers will measure pai…

This study tests whether a gentle electrical current applied to the scalp (tDCS) combined with computer-based cognitive training can improve memory, attention, and thinking in people who had a mild stroke. About 60 participants will receive either real tDCS or a sham (fake) versi…

This study tests whether a gentle electrical current applied to specific brain areas can boost the effects of language therapy in people with logopenic variant primary progressive aphasia (lvPPA), a form of Alzheimer's that mainly affects language. Sixty participants will receive…

This early-stage study at Johns Hopkins is testing whether cannabidiol (CBD) can reduce stress and nicotine withdrawal symptoms in people who smoke. Ninety healthy smokers will receive CBD and then be exposed to stress while researchers measure their mood, heart rate, and stress …

This study looks at how natural hormones and hormone therapy (like birth control or gender-affirming hormones) affect the way the HIV prevention drug cabotegravir works in the body. Researchers will measure drug levels in blood, tissues, and fluids in 32 HIV-negative adults. The …

This study tests whether giving clinics a dedicated coach helps them offer alcohol treatment to people with HIV who drink too much. The coach provides tools and guidance to support a stepped care model, which starts with brief advice and progresses to therapy or medication if nee…

This study is developing a way to measure resilience in people with opioid use disorder. Researchers will have 125 adults complete tasks that test thinking, emotions, and sense of control, both with and without stress. The goal is to see if these tasks match how resilient people …

This early-stage study at Johns Hopkins University is testing how blocking a specific brain receptor (5-HT1a) alters the effects of psilocybin, the active ingredient in magic mushrooms. Eighteen healthy volunteers will receive psilocybin with either pindolol (a receptor blocker) …

This study uses a special eye scan (OCT angiography) to take detailed pictures of blood vessels in the back of the eye. Researchers will follow about 1,050 people with retinal diseases like diabetic retinopathy and healthy volunteers to see how these images can help detect early …

This study tests a program that uses a patient portal to help older adults with mild cognitive impairment or dementia, along with their care partners, reduce medications that may be harmful. Participants receive educational materials and can meet with a pharmacist to review their…

This study looks at how well leg muscles produce energy in older adults (60+) with and without HIV. Researchers will use MRI scans and walking tests to measure muscle metabolism and fatigue. The goal is to understand if metabolic problems in the calf muscle are linked to reduced …

This study explores whether injecting special skin cells (fibroblasts) can change normal skin into the thicker skin found on palms and soles. Researchers will take a small skin sample, grow the cells in a lab, and inject them back into the skin. They will measure changes in cell …

This study tests a web-based app designed to help teenage boys and their doctors discuss sexual and reproductive health more easily. About 2,752 males aged 13-21 who have had sex will use the app before a clinic visit. Researchers will measure if the app improves condom use and r…

This study uses a brain imaging technique called MEG to look at how the brain recovers after a minor stroke. Researchers will scan 40 stroke survivors and 15 healthy older adults at 1, 6, and 12 months after the stroke while they perform a naming task. The goal is to understand w…

This study compares two strategies for finding undiagnosed tuberculosis (TB) in peri-urban Uganda. One strategy sets up screening at a large health clinic, while the other sends mobile screening teams into local hotspots where TB is thought to be most common. Researchers will tra…

This study tests whether alerts in electronic health records help doctors follow best-practice guidelines for bronchiolitis, a common lung infection in young children. About 8,000 children under 2 years old will take part. Doctors will receive either no alert, a gentle reminder, …

This study looks at how a natural citrus compound called d-limonene affects the body's response to THC, the main psychoactive ingredient in cannabis. Researchers will give healthy adults oral doses of THC, d-limonene, or both, and measure their feelings of drug effect and liking.…

This study aims to find new markers in the blood that appear during non-allergic drug infusion reactions. Healthy adults will receive the antibiotic vancomycin and have blood samples taken to measure drug levels and other substances. The goal is to better understand and predict t…

This study at Johns Hopkins Hospital is looking at how COVID-19 infection and mRNA vaccines (Pfizer or Moderna) affect pregnant women and their newborns. Researchers will collect blood, placenta, and breast milk samples from 300 participants to study immune responses and pregnanc…

This study enrolls people who have already had a hand or arm transplant to collect information over time. Researchers will measure hand function, pain, quality of life, and mental well-being using questionnaires and tests. The goal is to better understand the long-term safety and…

This study looks at how the cerebellum, a part of the brain, influences alcohol cravings and reward in people with alcohol use disorder (AUD). Researchers will compare brain activity in people with AUD and healthy volunteers using MRI scans and a mild electrical stimulation techn…

This study looks at how a person's natural sleep pattern (chronotype) affects their body's ability to handle sugar. Researchers will compare blood sugar and insulin responses in 70 overweight young adults (ages 18-23) who are either night owls or early birds. Participants will ta…

This study looks at why some children become overweight or obese by examining their eating habits, brain activity, and family history. Researchers will measure how kids' brains respond to food and how well they control their eating. The goal is to find early clues that could lead…

This study looks at whether group visits for new mothers and their babies, instead of individual check-ups, can improve health for both. About 1,125 women and their infants in Malawi will take part. Researchers will measure things like mom's mood, baby's vaccines, and how connect…

This study from Johns Hopkins aims to find epigenetic markers in blood that could help identify premenstrual dysphoric disorder (PMDD). Researchers will collect blood samples and track mood changes across the menstrual cycle in 500 women — some with PMDD and some without. The goa…

This study looks at how brain chemicals called neuroactive steroids change across the menstrual cycle in women with Premenstrual Dysphoric Disorder (PMDD) compared to healthy women. It also tests whether a low-dose antidepressant (sertraline) affects these chemical levels. The go…

This study is testing an artificial intelligence tool designed to help emergency room doctors detect and manage acute kidney injury (AKI) sooner. Researchers will roll out the AI system at three hospitals and track whether it improves care, reduces kidney damage, and fits into do…

This study looks at how heart failure may cause changes in brain structure. Researchers will measure brain volume and heart function in 100 adults with heart failure. The goal is to understand the link between heart health and brain health. No treatment is given; this is an obser…

This study is looking at whether a special CT scan can measure scarring in the heart muscle of people with atrial fibrillation (AF) before they have a procedure called catheter ablation. The goal is to see if more scarring means a higher chance of AF coming back or needing hospit…

This study from Johns Hopkins University is testing how different cannabis edibles—like chocolates, gummies, and drinks—affect thinking, coordination, and blood levels of THC. Forty healthy adults will each try several types of edibles in a controlled setting. The goal is to unde…

This study looks at whether eating dinner earlier in the evening, in sync with your body's internal clock, helps burn more fat and control blood sugar. Researchers will compare early versus late dinner in 32 adults—some healthy weight, some with obesity and prediabetes. Participa…

This study looks at how THC, the active part of cannabis, changes people's desire for e-cigarettes and their body's response. Researchers will give different doses of THC to 100 adults who use both e-cigarettes and cannabis, then measure how much they vape, their cravings, heart …

This study is creating a database of children and young adults with eczema who have used or will start systemic (whole-body) treatments. Researchers will track how well these treatments work using doctor and patient reports. The goal is to make it easier to recruit for future stu…

This study tests whether a special drink containing ketones can change how healthy people breathe, especially during sleep. Twenty volunteers will try the drink and a placebo on separate visits. The goal is to see if ketones might one day help with breathing problems like sleep a…

This study is creating a database of health information from people with achondroplasia, a common form of dwarfism. Researchers will collect growth measurements and surgery records from up to 1,500 patients across several U.S. hospitals. The goal is to answer future questions abo…

This study looks at how the immune system of adults over 75 responds to the annual flu shot. Researchers want to know if a common virus called CMV affects how well the vaccine works. Participants will receive the flu shot for free and provide blood samples over several weeks. The…

This study is testing different doses of aspirin to see which one best reduces inflammation in people with COPD. The goal is to find the right dose that could improve breathing and reduce flare-ups. The study involves 48 former smokers with COPD and will measure blood and urine m…

This study looks at how the uterus absorbs fluid during early pregnancy, which may affect fertility. Researchers will compare tissue samples from women with and without endometriosis or infertility. The goal is to understand the role of certain proteins in this process. No treatm…

This study uses magnetic resonance spectroscopy, a special MRI technique, to measure the heart's energy levels without needles or biopsies. Researchers will compare healthy volunteers, people with heart failure, and those with other heart conditions to see if low energy metabolis…

This study looks at why people with a type of heart failure (HFpEF) have trouble exercising. Researchers will measure energy use in the heart and leg muscles using special scans. They aim to link these energy problems to how well patients can walk and exercise. The study does not…

This study tests whether the Chicago Parent Program (CPP), a 12-session group-based parenting class, can improve social-behavioral skills and school readiness in 4-5-year-olds from low-income communities. Researchers will enroll 840 families from public pre-K programs in Maryland…

This observational study is looking at 1,000 healthy people aged 25 to 35 to learn more about how the lungs work and what affects their structure and function. Participants will take four different breathing tests to measure lung size, air movement, and gas exchange. The goal is …

This study at Johns Hopkins University will follow 50 people who have had a stroke and have risk factors like high blood pressure, high cholesterol, or diabetes. Researchers will use repeated MRI scans over about 15 months to track changes in the brain's white matter. The goal is…

This study follows 5,000 adults with pancreatic cysts to understand how these cysts behave over time. Researchers aim to create a better way to tell which cysts are harmless and which may turn into cancer. Participants provide medical records and samples, but no new treatment is …

This study gives healthy adults a single dose of psilocybin (the active ingredient in magic mushrooms) or a placebo, then uses brain scans and thinking tasks to measure changes in thoughts and brain activity. The goal is to understand how the drug works, not to treat any disease.…

This study tests a program called Heart-to-Heart, where community health workers help low-income patients make informed choices about cardiac rehab after a heart event. About 50 adults from Johns Hopkins Hospital will take part. The goal is to see if the program is practical and …

This study aims to find ways to detect cancer earlier by following 10,000 healthy adults for up to 20 years. Researchers will collect lifestyle data and blood samples to identify changes that happen before a cancer diagnosis. The goal is to improve early detection, when treatment…

This study at Johns Hopkins University aims to see if various psychoactive substances—like ketamine, MDMA, and THC—produce experiences similar to classic psychedelics. Fifty healthy volunteers aged 25–55 will receive up to 6 different drugs or a placebo in blinded sessions. The m…

This early-stage study at Johns Hopkins University is testing whether very small, repeated doses of psilocybin (the active ingredient in magic mushrooms) are safe for healthy people to take at home. Twenty volunteers will receive four different microdoses and a placebo on separat…

This study at Johns Hopkins University is testing nicotine pouches (like Zyn) in 120 adults—60 regular smokers and 60 people who rarely use nicotine. Participants will use the pouches in two lab sessions while researchers measure how much nicotine gets into the blood, how appeali…

This study tests a program called Communities Care, which aims to change social norms that allow violence against women and girls. Researchers will follow 3,500 adults and adolescents in Somalia over three years, comparing communities that receive the program to those that do not…

This study follows 235 adults who survived acute respiratory failure (ARF) and their family caregivers. Over 6 months, they complete surveys about their expectations, mood, and coping. The goal is to see if positive or negative expectations are linked to anxiety, depression, and …

This study will follow 4,000 adults aged 25-35 without severe lung disease over time. Researchers will measure lung function to learn what healthy lungs look like and find early warning signs of chronic lung disease. Participants do not receive any treatment—the goal is to gather…

This study will offer HIV tests to everyone visiting emergency departments in South Africa and Baltimore, regardless of risk factors. The goal is to find undiagnosed HIV cases and connect people to either treatment or preventive medication (PrEP). Researchers will track how many …

This study looks at how stress hormones and genes linked to Alzheimer's affect memory and thinking in older adults with mild cognitive impairment. Participants undergo a stress test and provide blood and saliva samples, then return after 2 years for follow-up. The goal is to unde…

This observational study from Johns Hopkins University is watching 22 adults who regularly use kratom. On the first day, participants take their usual dose under supervision, then stop for about 2.5 days. Researchers measure physical and mental effects, including withdrawal sympt…

This study is looking at 400 people with weak hearts who are getting an implantable defibrillator (ICD) to prevent sudden cardiac death. Researchers want to see if detailed heart MRI scans can find structural problems that better predict who will actually have a dangerous heart r…

This study follows 1500 people who already have an implantable cardioverter-defibrillator (ICD) to prevent sudden cardiac death. Researchers will track heart function, genetics, and blood markers to find better ways to predict who is at highest risk. The goal is to improve how do…

This study looks at how THC, the active part of cannabis, affects cigarette cravings and smoking habits. Researchers will give 100 adults who smoke both tobacco and cannabis different doses of THC or a placebo, then measure how many cigarette puffs they take and how they feel. Th…

This study looks at how a commercially available ketone drink (Ketone-IQ) affects sleep and breathing in 20 healthy adults aged 18-50. Participants take two different doses at home on separate nights and measure their ketone levels and sleep quality using a headband device. The g…

This study is testing whether advanced MRI and CT scans can identify people at highest risk for sudden cardiac death. Researchers will follow 400 participants who have low heart function and are scheduled to receive an implantable defibrillator. The goal is to see if these imagin…

This early lab study from Johns Hopkins University examines how mepolizumab (Nucala) affects the health and function of nasal cells from people with chronic sinusitis and nasal polyps. Researchers will measure changes in inflammation markers and cell barrier integrity. Only 8 par…

This study uses transcranial magnetic stimulation (TMS) to temporarily influence the cerebellum while healthy adults perform tasks that require sequencing or memory. By comparing brain scans with and without stimulation, researchers hope to understand how the cerebellum contribut…

This study aims to understand why the right side of the heart fails in people with heart failure and high blood pressure in the lungs. Researchers will look at heart tissue samples from 50 adults to find the best ways to diagnose and treat this condition. Participants must be bet…

This study looks at 60 people with moderate to severe sleep apnea who are being evaluated for a nerve stimulator implant (Inspire). During a routine sleep endoscopy, researchers will measure how the airway responds to direct muscle stimulation. They want to see if these measureme…

This study tests a new device that continuously measures pressure in the leg to detect a dangerous condition called compartment syndrome in patients on ECMO. ECMO patients are often sedated and cannot report symptoms, making diagnosis difficult. The device may help doctors diagno…

This study tests a smartphone app designed to teach emergency room patients about hepatitis C (HCV) and help them connect to follow-up care. Researchers will enroll 308 HCV-positive patients at an urban ER. The app provides personalized information on liver health and care option…

This study tests whether a new digital tool can help doctors talk to parents about safe sleep for babies. The tool includes a questionnaire for parents and a smart form for doctors, plus training in motivational interviewing. Researchers will enroll 350 parents and their infants …

This study at Johns Hopkins University is looking at how aging cells (senescent cells) contribute to uterine fibroids, which are non-cancerous growths in the uterus. Researchers will analyze tissue samples from 150 women with fibroids to map these cells and their signals. The goa…

This study looks at how the standard BCG treatment for non-muscle invasive bladder cancer may affect patients' mood. Researchers will collect urine and blood samples to measure immune responses, and participants will fill out mood questionnaires and daily diaries. The goal is to …

This study from Johns Hopkins University aims to understand how commercial kratom extract products affect mood, thinking, and physical signs like heart rate and pupil size in adults who use them regularly. Researchers will also study how the body processes these products. The goa…

This study looks at how estrogen and other hormones affect bone development in teenage and young adult women with cystic fibrosis (CF). It has two parts: an observational study that tracks bone health in women using different types of birth control, and a small feasibility study …

This study tests a web-based app that helps people waiting for a kidney or liver transplant share their story on social media to find a living donor. Researchers want to see if this approach brings in more potential donors and leads to more transplants. The study involves 1000 ad…

This study aims to document how TRPV4 neuropathy changes over 6 years in people with a confirmed TRPV4 gene mutation. Researchers will track symptoms, nerve function, and disability through annual visits at Johns Hopkins. The study does not test any treatment but will help unders…

This study aims to create a better tool for measuring opioid cravings in people being treated for opioid use disorder. Researchers will show participants opioid-related images and objects, then interview them about their feelings and thoughts. The goal is to improve how cravings …

This study tests a special collar worn around the neck that measures radiation exposure in people with thyroid cancer or Graves' disease receiving radioactive iodine therapy. The goal is to see if this device gives more accurate dosing information than current methods, potentiall…

This study uses brain imaging (fMRI and MRS) to see how a single dose of methylphenidate changes brain activity and glutamate levels in 30 adults with ADHD. Participants will receive both the drug and a placebo in a double-blind crossover design. The goal is to find brain-based m…

This study looks at whether having a surgeon send patients with osteoporosis to a bone specialist after hip or knee replacement leads to fewer implant problems and broken bones. About 2,000 adults over 50 with confirmed osteoporosis will be observed for two years. The goal is to …

This study looks at whether damage to the blood-brain barrier right after a stroke can help predict who will have memory or thinking problems later. Researchers will follow 150 stroke survivors for three years, checking their thinking skills by phone. The goal is to better unders…

This study tests whether sending twice-weekly text messages to first-time fathers can help them feel more confident and engaged during pregnancy and after birth. Researchers will recruit 180 dads across the U.S. via social media. The texts include tips, videos, and links to resou…

This study looks at how using vaporized cannabis and drinking alcohol together affects thinking, coordination, and driving skills. About 90 healthy adults will take part in sessions where they receive different doses of cannabis (THC) and alcohol or placebos. Researchers will mea…

This early study tests whether transferring nasal bacteria from a parent to a child can restore the child's nasal microbiome after they have been treated with antibiotics for staph bacteria. The study involves 175 children who have had staph in their nose and recently finished an…