Johns Hopkins University

This study is testing the RSV vaccine Arexvy in people with weakened immune systems, such as organ transplant recipients. Researchers want to see if getting one or two doses provides a better immune response. Participants will receive vaccines over a year and report any side effe…

This study is testing a new support program called 'Heart-to-Heart' that uses community health workers to help low-income patients access and complete cardiac rehabilitation after a heart event. Participants will receive 4-8 coaching sessions over 3 months for education, social s…

This study is testing a web-based app designed to help people waiting for a kidney or liver transplant. The app helps patients create and share their story on social media to find a living donor. The goal is to see if using social media makes it easier for patients to identify po…

This study is testing whether a drug called omalizumab, given as injections for 12 months, can reduce the frequency of serious symptom flare-ups in people with COPD who are also allergic to common indoor allergens like pet dander or dust mites. It will involve about 334 adults ov…

This study is testing whether children aged 1-17 who have their atopic dermatitis (eczema) well-controlled with the drug dupilumab can safely reduce their dose or stop taking it altogether. Participants will be randomly assigned to either continue their standard dose, take a lowe…

This study is testing if a drug called Isturisa (osilodrostat) can help people with a condition where a small adrenal tumor causes mildly high cortisol levels long-term. Researchers want to see if taking the drug for two years improves related health issues like blood sugar, weig…

This study follows babies with severe congenital diaphragmatic hernia (a life-threatening condition where organs push into the chest) who receive a special fetal surgery called FETO. The surgery temporarily blocks the baby's windpipe before birth to help lung growth. Researchers …

This study is testing which daily dose of aspirin (81mg, 162mg, or 325mg) best reduces blood cell inflammation linked to worse COPD symptoms. Researchers will enroll 48 adults with COPD who are former smokers. The goal is to find the most effective dose to inform a larger future …

This study is testing a comprehensive support program to help people better manage multiple chronic conditions like high blood pressure, diabetes, and kidney disease. It involves giving participants home blood pressure monitors and connecting them with a team including community …

This large study is testing if a smartwatch can safely guide when people with atrial fibrillation (AFib) need to take blood thinners. Instead of taking the medication every day, participants in the test group will only take it for one month after the watch detects an AFib episode…

This early-stage study is testing whether a single dose of psilocybin, the active compound in 'magic mushrooms,' is safe for people who had a stroke over a year ago. Researchers believe psilocybin might temporarily reopen a critical learning period in the brain, potentially makin…

This early-stage study is testing whether a modified virus (IMLYGIC), already approved for some skin cancers, can be safely injected into the numerous, often painful or itchy, skin tumors caused by neurofibromatosis type 1 (NF1). Researchers will inject the virus directly into th…

This study tests a peer-led group program designed to help people with HIV stay on their medication and in care after they are released from prison in South Africa. It will compare the new program to standard care for 400 participants. The main goal is to see if the program helps…

This study is testing whether giving two psychedelic substances, MDMA and psilocybin, together is safe and might help reduce PTSD symptoms in military Veterans. Researchers at Johns Hopkins will give the combined treatment during two therapy sessions to 40 Veterans with long-term…

This early study is testing the safety and initial effectiveness of a new brain implant system for people with paralysis in all four limbs (tetraplegia). The system records brain signals to control a device, like a robotic arm, and can also send artificial touch sensations back t…

This study aims to help adolescents and young adults with HIV achieve and maintain viral suppression, which is key to their health and preventing transmission. It focuses on personalized counseling about treatment options, including long-acting injectable medication, and helping …

This study tests whether nurses at local primary care clinics can provide treatment for drug-resistant tuberculosis that is just as effective and safe as treatment led by doctors at district hospitals. The trial involves nearly 3,000 adults in South Africa and aims to make care m…

This study tests two brief counseling approaches to help people with HIV who have alcohol use disorders maintain abstinence or low-risk drinking after periods of heavier use. Researchers will compare a computer-delivered program, a counselor-delivered program, and standard clinic…

This study is testing whether having surgeons directly refer osteoporosis patients to bone specialists before hip or knee replacement surgery leads to fewer complications. Researchers will compare this new referral pathway to the current standard of care where patients are told t…

This study is testing if a cannabis compound called CBD, taken as a pill, can help people quit smoking tobacco. Researchers at Johns Hopkins will give CBD or a placebo to 50 adult smokers who want to quit, and measure if it helps them stay smoke-free during short practice quit at…

This study is testing a tablet-based educational app designed to help people diagnosed with Hepatitis C in the emergency room understand their condition and the importance of follow-up care. Researchers want to see if the personalized app, which explains liver health and treatmen…

This study is testing if providing free healthy groceries and coaching helps adults with type 2 diabetes and high blood pressure better manage their health. It focuses on people living in Baltimore neighborhoods with limited access to fresh food. Participants are randomly assigne…

This study is testing whether giving patients IV fluids at home after major bladder cancer surgery helps them recover better and avoid being readmitted to the hospital. About 130 patients at Johns Hopkins will be randomly assigned to either receive the home IV fluid program along…

This study is testing if a shorter, 2-month treatment plan can cure drug-susceptible tuberculosis (TB) in children as well as the current standard 4-6 month plan. It will enroll 860 children under 10 years old to compare the safety and effectiveness of the two regimens. The goal …

This study is testing whether sildenafil (the active ingredient in Viagra) can help people with scleroderma who have mildly elevated blood pressure in their lungs. Researchers want to see if the drug improves how far patients can walk in 6 minutes and helps their heart function b…

This study is testing if adding Botox (Dysport) injections to standard back bracing works better than bracing alone for teens with a curved spine (scoliosis). Researchers want to see if relaxing specific back muscles with Botox makes the spine more flexible, helping the brace con…

This study is testing whether transferring healthy bacteria from a parent's nose to their child's nose can restore the child's natural nasal microbiome after antibiotic treatment for staph bacteria. Researchers want to see if this 'nasal microbiota transplant' helps prevent futur…

This study is testing whether adding a home-based breathing and exercise program to standard tuberculosis (TB) treatment can help prevent long-term lung damage. Researchers will compare two program lengths (8 weeks and 24 weeks) against usual care in 690 adults starting TB treatm…

This study is testing a new program designed to help people in Africa better manage high blood pressure. It will enroll 800 adults with high blood pressure to see if a bundle of support tools for patients, doctors, and clinics can improve blood pressure control. The goal is to cr…

This early-stage study is testing whether psilocybin, the active compound in psychedelic mushrooms, can help control symptoms of obsessive-compulsive disorder (OCD). Researchers at Johns Hopkins University will give 30 adults with treatment-resistant OCD two doses of psilocybin a…

This study is testing a digital health program called Corrie Lipids, which uses a smartphone app and doctor coaching to help people with high cholesterol get it under control. It aims to see if this approach helps more people reach their cholesterol goals and stick with their tre…

This study is testing a surgically implanted device, similar to a cochlear implant but for balance, in adults who have lost inner ear function in both ears. The goal is to see if the device can improve stability, walking, and reduce dizziness by electrically stimulating the balan…

This large hospital study is testing whether patients with serious Gram-negative bloodstream infections can safely switch from intravenous (IV) antibiotics to oral pills earlier in their treatment. Researchers want to see if taking pills works as well as staying on IV antibiotics…

This study is testing a long-term, surgically implanted device that sends electrical signals to the inner ear's balance nerve. It aims to help adults with severe, untreatable balance loss walk more steadily, reduce dizziness, and improve their vision when moving. The research wil…

This study aims to understand how different hormone treatments affect bone health in young women with cystic fibrosis (CF). Researchers will observe some participants and test estrogen skin patches in others to see if they improve bone density and quality of life. The study invol…

This study is testing a surgically implanted device, similar to a cochlear implant but for balance, in older adults (ages 65-90) who have severe, chronic dizziness and unsteadiness from inner ear damage. The implant sends electrical signals to the balance nerve to try to improve …

This large study is testing a new care program called 'PICU Up!' for children who are very sick and on breathing machines in intensive care. The program combines early movement, managing medications, preventing confusion, and involving families to see if it helps kids get off the…

This study is testing whether providing easier access to healthy foods helps people with obesity and food insecurity lose weight. 300 adults will receive weight loss counseling and be randomly assigned to also get either free home-delivered groceries, grocery store vouchers, or n…

This study is testing if using a special blue light during bladder cancer surgery helps doctors see and remove more of the cancer compared to the standard white light. Researchers want to see if this leads to less cancer left behind and a lower chance of the cancer coming back. A…

This study is testing whether adding a daily antidepressant pill (escitalopram) to standard speech therapy helps people recover language skills better after a recent stroke. Researchers will compare the pill to a placebo in 88 adults who have had a stroke in the last three months…

This study is testing whether a special balance therapy can help prevent falls in people with mild-to-moderate Alzheimer's disease. Researchers will work with 100 participants who have both Alzheimer's and inner-ear balance problems. The therapy involves weekly sessions and daily…

This study is testing a 6-month support program designed to prevent heart failure in adults with type 2 diabetes and obesity who have limited income and resources. The program combines exercise training at a local YMCA with problem-solving coaching and regular check-ins from a co…

This study is testing whether a drug called tesamorelin can help nerves heal better after a serious cut injury in the hand or wrist. It will involve 36 adults who have had surgery to repair a specific nerve. Half will receive the drug, and half will not, to compare recovery in st…

This study is testing if a low-dose sleep medication called trazodone can improve sleep quality and, in turn, help preserve memory in people with early signs of Alzheimer's disease. About 100 participants with mild memory problems and sleep complaints will take either trazodone o…

This study compares two surgical approaches for bladder cancer removal in men. Researchers want to see if leaving more prostate tissue intact during surgery helps preserve sexual function without compromising cancer treatment. The study will follow 70 men for two years, tracking …

This study is testing whether treating insomnia first helps breast cancer survivors lose weight more effectively. Researchers will compare two approaches: one group receives insomnia treatment before weight loss coaching, while the other gets basic sleep education first. The stud…

This small pilot study is exploring whether psilocybin, the active compound in 'magic mushrooms,' combined with therapy, can help people reduce or stop problematic cannabis use. Twelve adults with cannabis use disorder will receive two guided psilocybin sessions along with counse…

This study is testing if a simpler, two-drug HIV treatment works as well as the standard three-drug treatment for people who are also taking medicine for tuberculosis (TB). It will enroll 150 adults with both HIV and TB who are starting HIV treatment for the first time. The goal …

This study is testing whether home-delivered meals rich in omega-3 fats (like fish) can help people with COPD breathe better and reduce flare-ups. Researchers want to see if this diet can also protect the lungs from the harmful effects of indoor air pollution. The trial focuses o…

This study is testing whether combining two existing home-based care programs can help homebound older adults who feel lonely or isolated. The program, called CAPABLE, involves visits from an occupational therapist, a nurse, and a handyman over four months to help people perform …

This study is testing whether a safe, mild form of brain stimulation (tDCS) can boost the benefits of computer-based brain training for people who have trouble with memory and thinking after a minor stroke. About 60 participants will be randomly assigned to receive either the rea…

This small pilot study is testing a new program to help people quit smoking. It combines a virtual coach delivered by a computer avatar with support from a real community health worker. The program also helps connect eligible participants to lung cancer screening. Researchers wil…

This study is testing if the medication tirzepatide can help adults with obesity and binge-eating disorder. Researchers will compare it against a placebo (inactive shot) and another active medication, lisdexamfetamine. All participants will also receive a guided self-help therapy…

This study is testing if adding a patient's own concentrated bone marrow cells to a standard hip surgery works better than the surgery alone. The goal is to stop the progression of early-stage bone death in the hip joint, potentially delaying or avoiding the need for a total hip …

This study aims to find out if performing reconstructive skin flap surgery within 72 hours of a severe open leg fracture or dislocation leads to fewer infections and better outcomes than the current standard timing. It will involve 356 adults with these injuries who need a flap. …

This study is testing whether adding alcohol reduction counseling to regular TB and HIV medical care can help patients drink less and improve their health. Researchers will work with 450 adults in India who have tuberculosis, HIV, or both, and who report unhealthy drinking. Parti…

This study is testing whether metformin, a common diabetes medication, can help control asthma in overweight or obese adults whose asthma isn't well-managed with standard inhalers. 100 participants will take either metformin or a placebo pill daily for six months while researcher…

This study is testing a home-based support program for people waiting for a kidney transplant who are currently 'inactive' on the official waitlist. A team of a nurse, an occupational therapist, and a handyman will visit participants at home over four months to help them tackle p…

This study aims to find the best way to help teens reduce their alcohol use during routine doctor's visits. Researchers are comparing two approaches: a brief counseling session with a doctor, and that same counseling session plus a free mindfulness training app. They will follow …

This early-stage study is testing the safety of an experimental drug called MW189 in people who have had a brain bleed (intracerebral hemorrhage). The drug aims to reduce harmful brain inflammation and swelling that can worsen damage after a stroke. Researchers will enroll 120 pa…

This study is testing a new robotic device called ProBot to see if it is safe and practical for performing prostate biopsies. The device is designed to be more precise and potentially cause less discomfort during the procedure, which is used to diagnose prostate cancer. Researche…

This study is testing whether a special camera with artificial intelligence (AI) software can help more young people with diabetes get screened for eye damage. Researchers want to see if using this quick, in-office camera increases screening rates, especially for underserved yout…

This study aims to improve how doctors identify which heart patients are at highest risk for sudden cardiac death. Researchers will use detailed MRI scans to look at the heart's structure in 400 patients with weakened heart function who are being considered for defibrillator impl…

This study aims to improve the selection process for an implanted device that treats sleep apnea. Researchers will test if a simple measurement of airflow, taken during a standard pre-surgery procedure, can predict whether the device will successfully treat a patient's sleep apne…

This study is testing a new imaging technology called full-field optical coherence tomography (FFOCT) on small tissue samples taken during lung biopsies. The goal is to see if this quick, high-resolution imaging can help doctors assess the quality of the biopsy sample in real-tim…

This study aims to develop and test a better way to tell which pancreatic cysts are harmless and which might turn into cancer. Researchers will follow 5,000 adults with pancreatic cysts to see if a new diagnostic model using clinical information, imaging, and biomarkers can more …

This study aims to find out if a newer, ultra-high-resolution CT scan is better at detecting serious blockages in heart arteries compared to the standard CT scan. Researchers will enroll 140 adults with suspected heart disease and compare the two scan types using the same machine…

This study is testing two new, low-cost pulse oximeter devices designed for children in low-resource clinics in Cape Town, South Africa. It aims to see if these devices help healthcare workers better identify babies and toddlers with dangerously low oxygen levels from pneumonia, …

This study is testing whether advanced MRI and CT scans can help doctors better predict which patients with weakened hearts are at the highest risk for sudden cardiac death. It involves 400 people who already have a plan to get a special heart device (an ICD) to prevent sudden de…

This study is testing whether a new robotic system can help doctors perform more accurate prostate biopsies. Researchers will compare the robotic system against current standard biopsy methods in 483 men who need a prostate check due to elevated PSA levels or an abnormal exam. Th…

This study is testing a simple, swallowable sponge capsule called EsophaCap to collect cell samples from the esophagus and stomach. Researchers aim to find biological markers that can identify early signs of Barrett's esophagus, esophageal cancer, and stomach cancer. The goal is …

This study is testing a new device to help diagnose a dangerous leg condition called compartment syndrome in sedated patients on life support (ECMO). Because these patients cannot report pain, doctors need better tools to detect the problem early. The study will compare the new c…

This study is testing whether transferring healthy bacteria from a parent's nose to their newborn's nose can help prevent dangerous staph infections. Researchers will enroll 175 premature babies in the NICU and their parents to compare single versus repeated transfers. The goal i…

This study aims to see if adding testing for common sexually transmitted infections (STIs) to standard HIV prevention screening helps more young women in Africa start and continue taking PrEP, a daily pill that prevents HIV. About 4,500 women in Uganda will be randomly assigned t…

This study is testing the best time to start medication to prevent Hepatitis C (HCV) in people without HCV who receive a kidney from a donor who had HCV. Participants will be randomly assigned to either start the medication before the transplant for a short 2-week course, or star…

This study aims to see if busy hospital emergency rooms can be used to find people at high risk for HIV and connect them to prevention services. Researchers will offer HIV testing and information about prevention drugs (PrEP) to all eligible patients in emergency departments in S…

This study is testing if a detailed analysis of how people walk, followed by creating custom shoe inserts or braces, can prevent painful foot ulcers from returning in people with diabetes. It aims to reduce the risk of future sores and the need for foot or leg amputations. The st…

This large Phase 3 trial aims to prevent pancreatitis, a painful and costly complication that can occur after a common gallbladder/bile duct procedure called ERCP. Researchers are testing whether adding an oral dose of the drug tacrolimus to the current standard preventive treatm…

This study is testing whether providing healthy, prepared meals and grocery support to new mothers can help them lose pregnancy weight and prevent developing type 2 diabetes. It focuses on Black women who had diabetes during pregnancy and face food insecurity. Researchers will co…

This study is testing a text message program designed to support first-time fathers from mid-pregnancy through their baby's first two months. Researchers are recruiting 180 men across the U.S. via social media to see if the texts improve fathers' confidence, engagement in care, a…

This five-year study in Uganda is testing two different strategies to find people with tuberculosis (TB) and connect them to treatment or preventive medicine. One approach works from health clinics, while the other targets specific high-risk neighborhoods. The goal is to see whic…

This study is testing whether a new digital tool in the doctor's computer system, combined with special communication training, helps pediatricians better talk to parents about safe sleep for their babies. The goal is to see if this approach leads parents to follow safer sleep pr…

This study aims to improve HIV prevention for men who have sex with men (MSM) in Baltimore. It tests whether connecting people to a peer health navigator is better than just giving referrals for getting HIV prevention medication (PrEP) or HIV care after a mobile van test. The stu…

This study is testing a community program designed to prevent violence against women and girls in Somalia. It will involve 3,500 adults and adolescents (age 10+) in specific districts. Researchers will compare areas that run the program to similar areas that do not, measuring cha…

This study is testing how a double dose of a common HIV prevention pill (Descovy) moves through the body of healthy volunteers over 14 days. The goal is to understand if taking the pill less often could still provide protection against HIV. This early-phase research involves 24 p…

This study is testing whether a 12-session parenting program can help improve children's social skills and readiness for kindergarten. It will involve 840 families with 4-5 year olds in low-income Maryland school districts. Schools will be randomly assigned to either offer the pa…

This study aims to find the best way to encourage more Latino adults in Maryland to get vaccinated against COVID-19. Researchers will compare two methods: training vaccinated people to have supportive conversations with their friends and family versus simply providing vaccine inf…

This study aims to see if training people who inject drugs to become peer educators for their social networks can help increase HIV testing and the use of prevention services. The research will involve 360 participants from syringe service programs in Maryland. It will compare a …

This study is testing two different telehealth programs to help veterans with mild to moderate traumatic brain injury sleep better. Researchers will compare a structured sleep coaching program (CBT-I) with a mindfulness-based approach (MBTI), both delivered in six video sessions.…

This study is testing whether listening to music helps children and teenagers with glaucoma pay better attention during important eye exams called visual field tests. Researchers at Johns Hopkins University are enrolling 40 young patients, ages 8 to 17, to see if music makes the …

This study is testing if a medication called vortioxetine can help improve mood symptoms like depression and anxiety, as well as thinking skills, in people with early-stage behavioral variant frontotemporal dementia (bvFTD). Researchers will give participants the drug for 12 week…

This study aims to find out if draining fluid from around the lungs using a gravity bag causes less chest pain than using a vacuum bottle. Researchers will enroll 200 cancer patients who need a permanent chest catheter to manage fluid buildup. The goal is to improve comfort and q…

This study is testing whether a gentle, non-invasive electrical stimulation to the brain can boost the benefits of speech therapy for people who have lost language skills after a stroke. Researchers will compare real stimulation to a placebo (sham) treatment in 60 stroke survivor…

This study is testing if a specific laser can safely improve the rough, bumpy skin caused by keratosis pilaris (KP). Researchers at Johns Hopkins will use the laser on the upper arms of 25 adult participants to see if it reduces redness and skin roughness. The goal is to find a b…

This study is testing a new digital toolkit—a mobile app and online program—designed to help people with atrial fibrillation (AFib) better manage their condition. Researchers want to see if using this tool improves patients' quality of life by helping them understand treatment op…

This study is testing whether a safe, non-invasive brain stimulation technique, combined with speech therapy, can help people with primary progressive aphasia (PPA) improve their ability to name objects and spell words. PPA is a disorder that gradually impairs language skills. Re…

This early-stage study from Johns Hopkins University is testing whether a single dose of psilocybin, the active compound in 'magic mushrooms,' can help people who suffer from both chronic lower back pain and depression. Forty participants will receive either psilocybin or a stimu…

This study aims to reduce the dizziness and vertigo many people feel when entering powerful MRI machines. Researchers will test if slowing down how quickly people move into the scanner from 20 seconds to 1-3 minutes makes these symptoms less severe. They are recruiting 100 people…

This study is testing whether a new type of talk therapy can help people who still have pain months after a serious bone or muscle injury. About 30 participants will attend 8 weekly therapy sessions focused on emotional awareness and expression. The main goal is to see if this ap…

This study is testing whether physical therapy delivered through video calls can help people with long-term low back pain who live in rural areas. Researchers want to see if this convenient approach can reduce pain, improve function, and lower the need for opioid painkillers. The…

This study is testing whether providing hearing aids and communication support to older adults with both Alzheimer's disease and hearing loss can reduce distressing symptoms like agitation and improve their relationship with their caregiver. Researchers will enroll 300 participan…

This study is testing whether a special belt that provides gentle vibrations can help improve walking and balance for people with conditions like vestibular hypofunction or ataxia. Researchers will enroll 90 adults with balance disorders to see if using the 'BalanceBelt' during w…

This study is testing whether a common relaxation technique is more helpful for burn survivors when it's delivered through virtual reality (VR). Adult burn survivors with ongoing symptoms like pain, itch, or anxiety will try both a standard relaxation program and a VR-enhanced ve…

This study compares two approaches to managing pain after laparoscopic tubal sterilization surgery. Researchers want to see if a combination of non-opioid medications and thorough patient counseling works just as well for pain relief as a standard regimen that includes opioid pil…

This study is testing whether a simple piece of silicone tape placed over the lips at night can reduce snoring and improve sleep. It will involve 100 adults who snore or have mild sleep apnea, along with their bed partners. Researchers aim to see if this low-cost, non-invasive me…

This study is testing if a single dose of methadone given during a hysterectomy surgery can provide longer-lasting pain relief. The goal is to see if this reduces the total number of opioid pain pills patients need to take afterward. Researchers hope this approach can help tackle…

This study is testing a new 8-10 week support program designed for people with disabilities who are also caring for a loved one. The program offers personalized help with resources, self-care planning, and peer support. Researchers want to see if this approach is practical and he…

This study is testing whether a safe, non-invasive brain stimulation technique, combined with word-list training, can help improve memory and language skills in people with Alzheimer's disease. Researchers at Johns Hopkins University are enrolling 90 participants with typical mem…

This study is testing whether a brief sleep improvement program can help people with substance use disorders stay longer in their recovery treatment. Researchers will work with 150 adults living in a residential recovery program who also have insomnia. The goal is to see if impro…

This study is testing a new wellness program designed to help adults with cystic fibrosis who struggle with severe fatigue and poor sleep. The program combines virtual coaching sessions with strategies to improve sleep and increase physical activity. Researchers will enroll 80 pa…

This study is testing whether Scrambler Therapy, a non-invasive device that delivers gentle electrical signals through the skin, can help reduce severe abdominal pain in adults with chronic pancreatitis. About 40 participants who still have pain despite standard treatments will r…

This study is testing whether providing extra educational support can help women with bladder cancer feel less demoralized and improve their sexual function. Researchers will enroll 80 women and randomly assign them to receive either standard care or standard care plus a special …

This small, early-stage study from Johns Hopkins University is testing whether the psychedelic compound psilocybin, given in a controlled setting with support, can safely reduce depression in people with mild cognitive impairment or early Alzheimer's disease. Up to 20 participant…

This study is testing whether cannabidiol (CBD), a compound from the cannabis plant, can help reduce anxiety, mood problems, and challenging behaviors in adults with autism. Over 14 weeks, 40 participants will try both CBD pills and inactive placebo pills to see which one works b…

This study is testing whether a gentle, non-invasive electrical brain stimulation can boost the benefits of language therapy for people with logopenic variant primary progressive aphasia (lvPPA), a rare form of early-onset dementia that steals a person's ability to speak and comm…

This study is testing whether a medication called AGB101 can help reduce hallucinations and delusions in people with Parkinson's disease. Researchers at Johns Hopkins University will enroll 30 participants who experience these symptoms at least weekly. Participants will take both…

This study is testing whether injections of an enzyme called hyaluronidase can reduce shoulder pain and stiffness in people who have had a stroke. Researchers will enroll 68 stroke survivors to compare the injection treatment against a placebo. The goal is to see if the treatment…

This study is testing if adding a structured 20-minute yoga routine to standard care helps reduce back pain and improve quality of life for teens with scoliosis who aren't ready for surgery. Researchers at Johns Hopkins will compare 500 participants split into two groups: one rec…

This early-stage study is exploring whether psilocybin, the active compound in 'magic mushrooms,' can help treat depression in people with ALS (Lou Gehrig's disease). Researchers at Johns Hopkins will give up to 24 participants with ALS and depression two guided psilocybin sessio…

This study is testing a digital program designed to help immigrant women who have experienced violence and are dealing with PTSD or depression. The program aims to teach coping skills, reduce stress, and improve safety and mental health. It will involve about 676 participants and…

This study is testing a new parenting support program designed to help improve the emotional and behavioral wellbeing of young children (ages 2-5) from low-income families. The program works with parents through Head Start programs in Maryland, offering virtual sessions with nurs…

This study is testing whether listening to recorded music, including a specific Mozart piece, can reduce the number of seizures and abnormal brain activity in children with epilepsy. Researchers at Johns Hopkins will have children aged 4 to 17 listen to music during their hospita…

This study is testing whether a non-invasive electrical therapy called 'scrambler therapy' can reduce severe nerve pain in people with corticobasal syndrome, a rare and debilitating movement disorder. Researchers will compare scrambler therapy to a standard electrical nerve stimu…

This study is testing a self-guided rehabilitation device designed to help people with inner ear disorders or severe motion sickness. Participants use the device at home to practice specific head movements, aiming to reduce feelings of nausea and improve balance and stability. Re…

This study is testing whether an enzyme injection called hyaluronidase can reduce muscle stiffness and improve arm movement in people who have had a stroke. Researchers will compare the injection to a placebo (saltwater) in 56 participants with moderate to severe arm stiffness. T…

This study is testing two different online speech therapy programs for people who have trouble speaking after a stroke (aphasia). Researchers want to see if a new therapy designed to activate a different part of the brain is better at improving conversation skills than a standard…

This study is testing whether a non-drug treatment called Scrambler Therapy works better than standard pain medications for people with pain after a stroke. Researchers will enroll 100 stroke survivors who have had pain for at least one month. Participants will choose either the …

This study aims to understand how heart failure affects brain structure. Researchers will use MRI scans to measure brain volume changes in 100 people with heart failure compared to those with normal heart function. The goal is to learn more about the connection between heart heal…

This large study aims to find better ways to detect pancreatic cancer early in people at high genetic risk. Researchers will collect and analyze pancreatic fluid from 9,000 participants during scheduled endoscopies, looking for biological markers that signal developing cancer. Th…

This study aims to understand how well the immune systems of adults over age 75 respond to the annual flu shot. Researchers want to see if a common, lifelong virus called CMV affects how well the vaccine works in this age group. The study involves giving participants a free flu s…

This study aims to understand how the uterus absorbs fluid during early pregnancy by comparing tissue samples from women with and without endometriosis. Researchers will analyze specific proteins in uterine tissue collected from 140 participants across their menstrual cycles. The…

This study aims to understand how using cannabis and alcohol together affects a person's ability to drive, think clearly, and perform tasks. Healthy adult volunteers who have used both substances before will attend several lab sessions where they receive different combinations of…

This study aims to learn what healthy lungs look like in young adults aged 25-35. Researchers will observe 1000 participants, taking detailed measurements of their lung structure and function. The goal is to identify early signs of future lung problems and understand how lifestyl…

This study aims to understand how adults recovering from serious lung failure (acute respiratory failure) and their family caregivers think about the first 6 months of recovery. Researchers want to see if expectations about the recovery process are linked to anxiety, depression, …

This study is testing a special wearable collar device that continuously measures radiation around the neck. The goal is to see if it can provide more detailed information than current methods about how patients with thyroid cancer or Graves' disease absorb radioactive iodine tre…

This study aims to understand what 'healthy lungs' look like in young adults and identify early warning signs for future lung disease. It will follow 4,000 healthy people aged 25-35 for several years, tracking their lifestyle, environment, and lung function. The goal is to learn …

This study aims to understand how small vessel disease in the brain develops and progresses, which can lead to memory problems and dementia. Researchers will follow 50 people who have had a stroke and have risk factors like high blood pressure or diabetes. Participants will have …

This study aims to understand how mood changes in people with early-stage bladder cancer who are receiving a standard treatment called BCG. Researchers will follow 42 patients, asking them to complete daily mood diaries and questionnaires while collecting blood and urine samples.…

This study aims to learn why some people with weakened hearts are at higher risk of sudden cardiac death. Researchers will follow 1,500 patients who already have an implanted defibrillator, collecting health data over many years. The goal is to find better markers—like blood test…

This study aims to create a better tool for measuring opioid craving, which is a key factor in relapse for people with opioid use disorder. Researchers are recruiting 81 adults currently in treatment to understand their thoughts and feelings when shown opioid-related images and o…

This study aims to find biological markers in the blood that could help identify Premenstrual Dysphoric Disorder (PMDD), a severe form of premenstrual syndrome. Researchers will track 500 women with and without PMDD symptoms across their menstrual cycles using at-home blood colle…

This study aims to understand how the heart's energy production changes in people with heart failure and other heart conditions. Researchers will use a special type of MRI scan to measure energy-related chemicals in the heart muscle of 500 healthy volunteers and patients. The goa…

This study aims to understand how commercial kratom extract products affect people who use them regularly. Researchers at Johns Hopkins University will measure how these products make users feel, think, and how their bodies process them. The study involves 16 adults who already u…

This study aims to discover early warning signs of cancer by tracking 10,000 healthy adults for 20 years. Researchers will collect lifestyle information and blood samples from participants who are already scheduled for routine endoscopy procedures. By comparing data from people w…

This study aims to understand how THC, the main active ingredient in cannabis, affects a person's desire to smoke cigarettes and their actual smoking behavior. Researchers at Johns Hopkins will give 100 adult participants who regularly use both cannabis and cigarettes different d…

This study aims to understand how nicotine pouches affect both smokers and people who rarely use nicotine. Researchers will measure cravings, side effects, and how appealing the pouches feel to use. The goal is to gather data to help regulators make informed decisions about these…

This study aims to find out if very small, non-intoxicating doses of psilocybin (a compound from 'magic mushrooms') are safe for healthy people to take at home. Researchers will give 20 healthy adults increasing doses in a controlled lab setting to check their blood pressure, hea…

This study aims to understand how the common ADHD medication methylphenidate affects the brain. Researchers will use brain scans to measure activity and chemical levels in adults with ADHD after they take the medication or a placebo. The goal is to find brain patterns that can pr…

This is a laboratory study, not a treatment trial. Researchers are collecting nasal cells from 8 adults with chronic sinusitis and nasal polyps. They will test how the drug mepolizumab affects these cells in a dish to understand how it might reduce inflammation and help the nasal…

This study aims to understand why older adults living with HIV often experience more muscle fatigue and difficulty exercising than their peers without HIV. Researchers will use leg muscle scans and blood tests to compare 200 participants aged 60+ with and without HIV. The goal is…

This study aims to understand how a part of the brain called the cerebellum helps us process sequences of information, like remembering a phone number. Researchers will use brain scans and mild magnetic stimulation on 50 healthy adults while they perform memory tasks. The goal is…

This study aims to see if skin cells taken from a person's palm or sole can be grown in a lab and injected into another area (like the buttock) to create thicker, tougher skin. Researchers will remove the injected skin later to check if it changed. The goal is to learn if this ap…

This study aims to find better ways to spot and understand right heart failure in people who have a weakened main heart pump and high blood pressure in their lungs. Researchers will test 50 patients during exercise and take tiny heart tissue samples to look for early signs of mus…

This study aims to understand why people with a specific type of heart failure (where the heart pumps normally but still fails) get tired so easily during exercise. Researchers will use special MRI scans to measure energy levels in the heart and leg muscles of 130 participants. T…

This study aims to understand if taking a ketone supplement before bed affects sleep quality and breathing in healthy adults. Researchers will give 20 volunteers two different doses of the supplement and measure their sleep patterns and ketone levels at home. The goal is to gathe…

This study is creating a registry to collect information from young people with eczema who are using or starting systemic (whole-body) treatments. The goal is to build a database that helps researchers understand which treatments work best, monitor safety, and quickly connect pat…

This study aims to learn more about how kratom affects people who use it regularly. Researchers will observe 22 healthy adults after they take their usual kratom dose and then monitor them for several days after they stop using it. The goal is to measure the immediate effects, ho…

This early-stage study aims to understand if the compound CBD (cannabidiol) can help people who smoke cigarettes better manage stress and the cravings that come with nicotine withdrawal. Researchers at Johns Hopkins will give 90 daily smokers different doses of CBD or a placebo, …

This study aims to understand how specific 'senescent' or aging cells contribute to the growth of uterine fibroids. Researchers will analyze tissue samples from 150 women with fibroids to map how these cells communicate and promote scarring. The goal is to gather knowledge that c…

This study aims to understand how symptoms change over time in people with a rare inherited nerve disorder caused by a TRPV4 gene mutation. Researchers will follow 70 patients for six years with annual visits to track muscle weakness, sensory problems, and daily function. The inf…

This study aims to improve how doctors track eye diseases by using advanced, non-invasive imaging scans. Researchers will follow 1,050 people, including healthy volunteers and those with conditions like diabetic retinopathy, to see how blood vessels in the eye change over time. T…

This study aims to understand how the body's response to stress and a person's genes might predict future memory and thinking problems in people with mild cognitive impairment, a potential early sign of Alzheimer's disease. Researchers will enroll 240 participants to undergo brie…

This study aims to understand why some stroke survivors experience memory and thinking problems afterward. Researchers will follow 150 stroke patients for 3 years to see if damage to the brain's protective barrier during the stroke predicts future cognitive decline. The study use…

This study aims to understand how a single dose of psilocybin, the compound in psychedelic mushrooms, changes how people think and how their brains work. Researchers at Johns Hopkins will give 30 healthy volunteers a moderate dose or a placebo and measure their brain activity, cr…