Johns Hopkins University
Clinical trials sponsored by Johns Hopkins University, explained in plain language.
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Grocery delivery and coaching tested to fight high blood pressure
Disease control CompletedThis study tested whether a digital program could help adults with high blood pressure eat healthier. 67 participants with limited access to quality food received a grocery delivery membership, personalized shopping lists, and health coaching for 4 months. Researchers wanted to s…
Phase: NA • Sponsor: Johns Hopkins University • Aim: Disease control
Last updated Apr 01, 2026 14:42 UTC
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New hope for heart attack recovery: drug trial targets cholesterol and inflammation
Disease control CompletedThis study tested if adding the cholesterol-lowering drug evolocumab to standard treatment could help people who recently had a heart attack. Researchers wanted to see if the drug could better control cholesterol, reduce harmful inflammation in the heart and blood vessels, and im…
Phase: PHASE2 • Sponsor: Johns Hopkins University • Aim: Disease control
Last updated Apr 01, 2026 14:42 UTC
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Computer heart model aims to zap dangerous rhythms faster
Disease control CompletedThis study tested a new computer simulation, called a 'virtual heart,' to help doctors find the best spots to treat dangerous, fast heartbeats (ventricular tachycardia) in people with scarred hearts. The goal was to see if using this model could make the treatment procedure more …
Phase: NA • Sponsor: Johns Hopkins University • Aim: Disease control
Last updated Apr 01, 2026 14:42 UTC
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Incentives boost HIV care for High-Risk groups in india
Disease control CompletedThis study tested whether adding financial incentives for treatment improved HIV care for people who inject drugs and men who have sex with men in India. Researchers compared standard care centers to centers that also offered incentives, tracking whether people started medication…
Phase: NA • Sponsor: Johns Hopkins University • Aim: Disease control
Last updated Apr 01, 2026 14:41 UTC
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Hopeful drug trial aims to ease dangerous throat scarring
Disease control CompletedThis small, early study tested if the drug everolimus could help people with a rare condition where dangerous scar tissue narrows the windpipe (called idiopathic subglottic stenosis). The goal was to see if the drug could help patients go longer between surgeries to reopen their …
Phase: EARLY_PHASE1 • Sponsor: Johns Hopkins University • Aim: Disease control
Last updated Mar 31, 2026 12:12 UTC
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New hope for millions: drug trial targets common sinus misery
Disease control CompletedThis study tested whether the drug dupilumab could help adults with chronic sinusitis who do not have nasal polyps. Thirty-three participants were randomly assigned to receive either dupilumab or a placebo for six months to see if it improved their sinus symptoms and quality of l…
Phase: PHASE2 • Sponsor: Johns Hopkins University • Aim: Disease control
Last updated Mar 31, 2026 12:12 UTC
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Mobile care van brings HIV & addiction help to the streets
Disease control CompletedThis study tested if bringing healthcare directly to people who inject drugs via a mobile van could improve their health. The van, linked to a needle exchange program, offered HIV testing and treatment, addiction medication, and other services. Researchers wanted to see if this a…
Phase: NA • Sponsor: Johns Hopkins University • Aim: Disease control
Last updated Mar 31, 2026 12:11 UTC
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Baltimore tests new approach to help public housing residents kick smoking habit
Disease control CompletedThis study tested a community-based program designed to help residents of Baltimore public housing quit or reduce smoking. The program provided free quit-smoking medications and counseling support delivered remotely to participants' homes. Researchers worked with community leader…
Phase: NA • Sponsor: Johns Hopkins University • Aim: Disease control
Last updated Mar 30, 2026 14:35 UTC
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Zambia's first stroke unit aims to save lives and reduce disability
Disease control CompletedThis study tested whether creating a specialized stroke care unit at a major hospital in Zambia could improve patient outcomes. Researchers compared 300 stroke patients treated in the new unit to similar patients treated before it existed. They tracked whether patients received r…
Phase: NA • Sponsor: Johns Hopkins University • Aim: Disease control
Last updated Mar 30, 2026 14:34 UTC
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Head-to-Head COPD drug showdown: which keeps patients out of hospital?
Disease control CompletedThis large, 6-year study directly compared two existing medications—roflumilast and azithromycin—to see which is better at preventing severe COPD flare-ups that lead to hospitalization or death. It enrolled over 1,000 adults with severe COPD who had recently been hospitalized. Th…
Phase: PHASE4 • Sponsor: Johns Hopkins University • Aim: Disease control
Last updated Mar 30, 2026 14:33 UTC
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Could Fine-Tuning blood pressure in surgery protect the brain?
Disease control CompletedThis small pilot study tested whether carefully managing a patient's blood pressure during surgery could help protect the brain and reduce serious complications. It involved 27 adults aged 60 and older having hip, knee, or lung surgery. Researchers compared a specific blood press…
Phase: NA • Sponsor: Johns Hopkins University • Aim: Disease control
Last updated Mar 30, 2026 14:32 UTC
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Phone-Based heart rehab tested against traditional care
Disease control CompletedThis study tested whether a virtual cardiac rehabilitation program delivered via a mobile app could improve patients' health more than standard in-person rehab. It involved 259 adults who recently had a heart attack, stent placement, or heart surgery. Researchers compared how far…
Phase: NA • Sponsor: Johns Hopkins University • Aim: Disease control
Last updated Mar 30, 2026 14:32 UTC
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Heart rhythm breakthrough? computer model guides better AFib treatment
Disease control CompletedThis study tested whether adding a personalized, computer-guided ablation technique to the standard procedure could better control a persistent heart rhythm disorder called atrial fibrillation (AFib). Researchers used a special heart scan and computer modeling to find and target …
Phase: NA • Sponsor: Johns Hopkins University • Aim: Disease control
Last updated Mar 30, 2026 14:30 UTC
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New digital coach helps HIV patients kick smoking habit
Disease control CompletedThis small pilot study tested whether a computer-based program, combined with support from a community health worker, could help hospitalized people with HIV quit smoking. The main goals were to see if the program was practical and acceptable to patients, and if it increased thei…
Phase: NA • Sponsor: Johns Hopkins University • Aim: Disease control
Last updated Mar 30, 2026 14:28 UTC
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Pharmacist-Led program aims to cut risky medication load for dementia patients
Disease control CompletedThis study tested a program to help reduce unnecessary or risky medications for people with dementia. A pharmacist met with patients and their caregivers via video call to review all medications based on the patient's personal health goals. The goal was to see if this approach sa…
Phase: NA • Sponsor: Johns Hopkins University • Aim: Disease control
Last updated Mar 30, 2026 14:28 UTC
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New hope for hidden heart risk? drug trial targets silent blood flow problem
Disease control CompletedThis study tested whether a drug called vericiguat could improve the function of tiny blood vessels in the heart for people with metabolic syndrome, a cluster of conditions like high blood pressure and high blood sugar. Forty-five participants were randomly assigned to receive ei…
Phase: PHASE2 • Sponsor: Johns Hopkins University • Aim: Disease control
Last updated Mar 27, 2026 12:41 UTC
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Brain-Zapping device tested as opioid withdrawal aid
Disease control CompletedThis study tested whether a medical device called the Bridge could help people with opioid addiction get through withdrawal. Researchers at Johns Hopkins enrolled 46 people with active addiction to stay in a research unit. They compared the real device against a fake device and a…
Phase: PHASE2, PHASE3 • Sponsor: Johns Hopkins University • Aim: Disease control
Last updated Mar 27, 2026 12:40 UTC
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Friend-Turned-Advocate program aims to speed up liver transplants
Disease control CompletedThis study tested a short training program for liver transplant patients and a chosen friend or family member, called a 'Champion.' The goal was to teach the Champion how to help the patient find a living liver donor. Researchers wanted to see if this support program made it easi…
Phase: NA • Sponsor: Johns Hopkins University • Aim: Disease control
Last updated Mar 27, 2026 12:40 UTC
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Groundbreaking trial tests HIV+ to HIV+ kidney transplants
Disease control CompletedThis study explored whether people living with HIV could safely donate a kidney to other HIV-positive patients who needed a transplant. It followed three carefully screened donors to monitor their health after donation, including kidney function, blood pressure, and HIV control. …
Sponsor: Johns Hopkins University • Aim: Disease control
Last updated Mar 27, 2026 12:39 UTC
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Personal guide helps patients master diabetes tech
Disease control CompletedThis study tested whether having a 'Diabetes Navigator'—a support person who helps patients overcome challenges—was better than standard care at helping people with type 1 diabetes start using or improve their use of advanced technology like continuous glucose monitors and insuli…
Phase: NA • Sponsor: Johns Hopkins University • Aim: Disease control
Last updated Mar 27, 2026 12:39 UTC
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Virtual avatar helps smokers quit in hopkins pilot
Disease control CompletedThis study tested a new computer program called 'C-Raven' designed to help people quit smoking. The program uses an interactive avatar named Edna Poe to guide users through sessions, followed by optional nicotine patches and support from a community health worker. Researchers wan…
Phase: NA • Sponsor: Johns Hopkins University • Aim: Disease control
Last updated Mar 27, 2026 12:38 UTC
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Food as medicine: can a 'Produce Prescription' help control weight?
Disease control CompletedThis small, completed study tested two practical ways to help adults with overweight or obesity who find it hard to afford healthy food. For 8 weeks, 48 participants either received vouchers to buy fresh produce or had boxes of their preferred fruits and vegetables delivered to t…
Phase: NA • Sponsor: Johns Hopkins University • Aim: Disease control
Last updated Mar 27, 2026 12:38 UTC
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Home team program cuts disability risk for seniors after hospital
Disease control CompletedThis study tested a program called CAPABLE, which sends a team of an occupational therapist, a nurse, and a handyman to help older adults at home after they leave the hospital. The goal was to see if this support could improve their ability to perform daily tasks like walking, ba…
Phase: NA • Sponsor: Johns Hopkins University • Aim: Disease control
Last updated Mar 25, 2026 14:08 UTC
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Can video calls replace hearing aid checkups? study tests telehealth option
Disease control CompletedThis study tested whether getting hearing aid care through video calls (telehealth) works as well as going to a clinic for older adults who already use hearing aids. Researchers compared the two methods to see if telehealth helps people use their hearing aids more often and impro…
Phase: NA • Sponsor: Johns Hopkins University • Aim: Disease control
Last updated Mar 25, 2026 14:08 UTC
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Two drugs better than one for Kids' lung pressure?
Disease control CompletedThis study tested whether starting children with pulmonary arterial hypertension on two oral medications (sildenafil and bosentan) together works better than starting with just one (sildenafil alone). It involved 28 children and teenagers with moderate symptoms, aiming to see whi…
Phase: PHASE3 • Sponsor: Johns Hopkins University • Aim: Disease control
Last updated Mar 25, 2026 14:08 UTC
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Phone app and video coaching aim to stop asthma attacks in young adults
Disease control CompletedThis study tested whether adding video coaching sessions to a smartphone-based medication tracker could help young people with poorly controlled asthma. Researchers wanted to see if this combination helped participants take their daily controller medication more consistently and …
Phase: NA • Sponsor: Johns Hopkins University • Aim: Disease control
Last updated Mar 25, 2026 14:07 UTC
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Video game prescribed to fight dementia risk after brain injury
Disease control CompletedThis study tested if playing an immersive computer game that combines physical and mental challenges could help adults with a past traumatic brain injury (TBI). Researchers wanted to see if the game could improve memory, thinking skills, and mood, and possibly reduce the long-ter…
Phase: NA • Sponsor: Johns Hopkins University • Aim: Disease control
Last updated Mar 24, 2026 12:02 UTC
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Sleep pill shows promise in fighting dual drug addiction
Disease control CompletedThis study tested whether a prescription sleep medication called suvorexant could help people who are addicted to both opioids and stimulants like cocaine. Twenty participants who were already receiving standard treatment for opioid addiction were randomly given either the sleep …
Phase: PHASE2 • Sponsor: Johns Hopkins University • Aim: Disease control
Last updated Mar 23, 2026 15:19 UTC
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Doctors use new computer alert to tackle hidden causes of poor health
Disease control CompletedThis study tested a new computer tool for doctors. The tool automatically flags patients with chronic diseases who may also be struggling with needs like stable housing, food, or transportation. Doctors could then refer these patients to community organizations for help, aiming t…
Phase: NA • Sponsor: Johns Hopkins University • Aim: Disease control
Last updated Mar 23, 2026 15:18 UTC
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New heart attack treatment aims to calm dangerous inflammation
Disease control CompletedThis study tested if adding a cholesterol-lowering drug called evolocumab to standard care could help patients who recently had a specific type of heart attack (NSTEMI). Researchers wanted to see if the drug could further reduce 'bad' cholesterol and, importantly, lower inflammat…
Phase: PHASE2 • Sponsor: Johns Hopkins University • Aim: Disease control
Last updated Mar 19, 2026 14:56 UTC
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New program tackles weight and heart risks in vulnerable youth
Disease control CompletedThis study tested a year-long health coaching program designed to help overweight or obese youth who are also receiving mental health treatment. The program involved a health coach who worked with both the young person and their parent to promote healthy eating and physical activ…
Phase: NA • Sponsor: Johns Hopkins University • Aim: Disease control
Last updated Mar 17, 2026 12:55 UTC
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Virtual coach teams up with local health workers to fight smoking in public housing
Disease control CompletedThis small pilot study tested whether a program using a virtual counselor on a tablet, combined with support from a community health worker, is a practical and acceptable way to help people quit smoking. It involved 15 adults from public housing in Baltimore who wanted to quit. T…
Phase: PHASE4 • Sponsor: Johns Hopkins University • Aim: Disease control
Last updated Mar 13, 2026 15:06 UTC
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Study tests faster hepatitis c care for people in addiction treatment
Disease control CompletedThis study compared two strategies to help people with hepatitis C who use drugs get treatment. One group received rapid on-site treatment with support from a peer mentor who had been cured. The other group received the standard referral to an off-site clinic. The goal was to see…
Phase: NA • Sponsor: Johns Hopkins University • Aim: Disease control
Last updated Mar 12, 2026 13:51 UTC
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Fresh food & coaching tested to fight high blood pressure in black communities
Disease control CompletedThis pilot study tested a personalized program to help Black adults with high blood pressure eat healthier. 80 participants from areas with limited access to fresh food were randomly assigned to receive either standard produce bags or an enhanced program with produce prescription…
Phase: NA • Sponsor: Johns Hopkins University • Aim: Disease control
Last updated Mar 11, 2026 14:53 UTC
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New biopsy tool aims for better lung diagnosis
Diagnosis CompletedThis study tested whether a newer, smaller freezing probe (cryoprobe) is better than standard forceps for taking lung tissue samples during a biopsy. Researchers compared the two tools in 500 patients to see which one provided better quality tissue for diagnosis and had fewer com…
Phase: NA • Sponsor: Johns Hopkins University • Aim: Diagnosis
Last updated Apr 01, 2026 23:26 UTC
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Faster HIV tests aim to stop spread in baltimore
Diagnosis CompletedThis study tested new, faster HIV tests that give results during a clinic visit. The goal was to see if these quick tests help connect people to treatment if they have HIV, or to prevention medication if they don't, much sooner than standard lab tests. Researchers enrolled 419 ad…
Phase: NA • Sponsor: Johns Hopkins University • Aim: Diagnosis
Last updated Apr 01, 2026 14:42 UTC
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Hopkins tests 'Infection Spotlight' scan
Diagnosis CompletedThis study tested a new imaging tracer called 18F-FDS to see if it could help doctors better pinpoint serious bacterial and fungal infections using PET scans. Researchers enrolled 16 patients who had confirmed infections, inflammatory diseases, or cancer to see where the tracer a…
Sponsor: Johns Hopkins University • Aim: Diagnosis
Last updated Apr 01, 2026 14:42 UTC
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Hopkins team tests new method to spot deadly pancreatic cysts before they turn cancerous
Diagnosis CompletedThis study aimed to create and test a better way to diagnose pancreatic cysts and predict which ones might become cancerous. Researchers followed 477 adults with pancreatic cysts, using imaging scans and fluid tests to track changes over three years. The goal was to combine patie…
Sponsor: Johns Hopkins University • Aim: Diagnosis
Last updated Mar 31, 2026 12:11 UTC
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Hopkins tests 'Glowing' tracer to spot hidden infections
Diagnosis CompletedThis small, early-stage study tested a new radioactive tracer called 11C-PABA for PET scans. The goal was to see if this tracer could help doctors better locate infections in the body and tell them apart from other problems like inflammation or cancer. Researchers scanned 13 adul…
Sponsor: Johns Hopkins University • Aim: Diagnosis
Last updated Mar 30, 2026 14:34 UTC
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Eye test could spot stroke in dizzy patients
Diagnosis CompletedThis study tested whether a portable eye-tracking device could help emergency room doctors quickly and accurately diagnose the cause of dizziness or vertigo. Researchers compared the device-guided approach to standard emergency care in 130 patients to see if it could better disti…
Phase: PHASE2 • Sponsor: Johns Hopkins University • Aim: Diagnosis
Last updated Mar 30, 2026 14:28 UTC
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New test could spot dangerous pancreatic cysts earlier
Diagnosis CompletedThis study aims to develop better tools to tell harmless pancreatic cysts apart from those that could turn into cancer. Researchers will collect information from 3,000 adults with pancreatic cysts, using imaging scans and fluid analysis to look for patterns. The goal is to create…
Sponsor: Johns Hopkins University • Aim: Diagnosis
Last updated Mar 18, 2026 18:25 UTC
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Healing generations: new program aims to break cycle of trauma in native families
Prevention CompletedThis study tested a program called 'Wakȟáŋyeža' (Little Holy One) designed to support Native American families. It aimed to help caregivers manage stress and trauma, improve their parenting skills, and promote healthy emotional development in their young children (ages 2-5). The …
Phase: NA • Sponsor: Johns Hopkins University • Aim: Prevention
Last updated Apr 01, 2026 23:26 UTC
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Can couples counseling stop the spread of STIs in young adults?
Prevention CompletedThis pilot study tested whether a counseling program for young couples could help prevent sexually transmitted infections (STIs) and HIV. Researchers worked with 68 young heterosexual partners in Baltimore, providing them with individual and joint health education sessions. The g…
Phase: NA • Sponsor: Johns Hopkins University • Aim: Prevention
Last updated Apr 01, 2026 23:26 UTC
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Nurses take lead in fight to stop HIV in women
Prevention CompletedThis study tested whether having a registered nurse lead HIV prevention services could help more at-risk women start a daily medication (PrEP) that prevents HIV infection. The trial involved 440 women at risk for HIV who visited OB/GYN clinics. Researchers compared standard clini…
Phase: NA • Sponsor: Johns Hopkins University • Aim: Prevention
Last updated Apr 01, 2026 14:42 UTC
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Phone coaches help Moms-to-Be fight weight gain and future obesity
Prevention CompletedThis study tested whether phone-based health coaching could help pregnant women manage their weight gain during pregnancy and prevent obesity after giving birth. Researchers enrolled 534 women from diverse backgrounds who were overweight or obese early in pregnancy. The program p…
Phase: NA • Sponsor: Johns Hopkins University • Aim: Prevention
Last updated Mar 31, 2026 12:17 UTC
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Virtual support groups aim to break silence around postpartum depression in latina mothers
Prevention CompletedThis study tested whether virtual group sessions during pediatric visits could help Spanish-speaking mothers learn about postpartum depression and connect with support resources. Researchers worked with 26 mothers of infants to provide education about depression symptoms, reduce …
Phase: NA • Sponsor: Johns Hopkins University • Aim: Prevention
Last updated Mar 27, 2026 12:38 UTC
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Breakthrough Blood-Cleaning tech fights hidden transfusion dangers
Prevention CompletedThis study tested a new technology called Mirasol that treats donated blood to kill germs before it's given to patients. Researchers compared it to standard blood in 2,000 anemic patients in Uganda to see if it could prevent infections like malaria, hepatitis, and HIV from being …
Phase: PHASE3 • Sponsor: Johns Hopkins University • Aim: Prevention
Last updated Mar 09, 2026 14:23 UTC
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Can your phone prevent diabetes? app vs. human coach Face-Off
Prevention CompletedThis study tested whether a fully automated smartphone app could be as effective as a traditional human coach program at helping people with prediabetes lower their risk of developing type 2 diabetes. 368 adults were randomly assigned to use either the app with a smart scale or a…
Phase: NA • Sponsor: Johns Hopkins University • Aim: Prevention
Last updated Mar 05, 2026 13:59 UTC
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Cleaner air at home tested to help smokers with lung disease breathe easier
Symptom relief CompletedThis study tested whether using special air cleaners and receiving counseling to reduce indoor smoke could help people with COPD who smoke. Researchers wanted to see if this approach could improve breathing, quality of life, and reduce flare-ups. The study involved 144 adult smok…
Phase: NA • Sponsor: Johns Hopkins University • Aim: Symptom relief
Last updated Apr 01, 2026 23:26 UTC
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Shining a light on MS sleep troubles
Symptom relief CompletedThis small pilot study tested whether daily bright light therapy could safely help people with multiple sclerosis (MS) sleep better. Researchers wanted to see if this non-drug approach could reduce insomnia and fatigue by potentially resetting the body's internal clock. The study…
Phase: NA • Sponsor: Johns Hopkins University • Aim: Symptom relief
Last updated Apr 01, 2026 23:26 UTC
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Virtual coach tested to help smokers quit
Symptom relief CompletedThis small pilot study tested whether a computer program delivered by a virtual 'avatar' coach, combined with support from a community health worker, could help people quit smoking. The study involved 30 adults from Baltimore public housing who were current smokers. Researchers m…
Phase: PHASE4 • Sponsor: Johns Hopkins University • Aim: Symptom relief
Last updated Apr 01, 2026 14:43 UTC
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Can a sleep pill help break the cycle of addiction?
Symptom relief CompletedThis study tested whether a prescription sleep aid (suvorexant) could improve sleep and reduce daily stress for people in early recovery from opioid addiction. Participants were already receiving standard medication-assisted treatment (like methadone or buprenorphine) and reporte…
Phase: PHASE2 • Sponsor: Johns Hopkins University • Aim: Symptom relief
Last updated Apr 01, 2026 14:42 UTC
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Phone therapy trial aims to help ICU survivors recover from depression and physical decline
Symptom relief CompletedThis study tested whether a combined mental and physical health program, delivered mostly by phone with a few home visits, is practical and helpful for people recovering from life support in the ICU. It involved 52 adult survivors who were experiencing depressive symptoms. The go…
Phase: NA • Sponsor: Johns Hopkins University • Aim: Symptom relief
Last updated Apr 01, 2026 14:42 UTC
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Wearable cords aim to give walkers a lift
Symptom relief CompletedThis study tested a new wearable device called Gigstride to see if it helps people with leg mobility problems. 44 adults who had been recommended a cane, brace, or walker tried the device while walking and doing simple tasks. Researchers wanted to know if users found it comfortab…
Phase: NA • Sponsor: Johns Hopkins University • Aim: Symptom relief
Last updated Apr 01, 2026 14:41 UTC
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Beating the beat against brain disease: can drumming ease symptoms?
Symptom relief CompletedThis study tested whether group drumming classes could help people with Parkinson's or Huntington's disease. Eighteen participants attended drum lessons twice a week for 12 weeks. Researchers measured changes in movement, mood, and overall well-being to see if the music therapy p…
Phase: NA • Sponsor: Johns Hopkins University • Aim: Symptom relief
Last updated Mar 31, 2026 12:12 UTC
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New endoscopic bypass may offer longer relief for Cancer-Related stomach blockages
Symptom relief CompletedThis study compared two less-invasive endoscopic procedures to relieve stomach blockages caused by inoperable cancer. Researchers tested a newer bypass technique against the standard method of placing a stent to see which was safer and more effective at keeping the blockage from …
Phase: NA • Sponsor: Johns Hopkins University • Aim: Symptom relief
Last updated Mar 30, 2026 14:34 UTC
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Patients help design their own dementia care plan
Symptom relief CompletedThis study tested a new approach to help people in the early stages of dementia. Researchers worked directly with 61 participants to co-design a personalized plan of meaningful activities, aiming to improve their well-being and sense of control. The goal was to see if this tailor…
Phase: NA • Sponsor: Johns Hopkins University • Aim: Symptom relief
Last updated Mar 30, 2026 14:34 UTC
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New device aims to retrain the brain after injury to stop dizziness
Symptom relief CompletedThis study tested a new device designed to improve dizziness and balance problems in people with mild brain injuries or inner ear disorders. It compared the new device, which provides specific eye-head coordination training, against traditional balance rehabilitation exercises. R…
Phase: NA • Sponsor: Johns Hopkins University • Aim: Symptom relief
Last updated Mar 30, 2026 14:32 UTC
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Can smell training help patients regain taste after brain surgery?
Symptom relief CompletedThis study looked at whether smell and taste problems after skull base tumor surgery can be improved. Researchers tested if a special 'olfactory training' program could help patients recover their sense of smell faster. They followed 41 patients who had surgery for benign skull b…
Phase: NA • Sponsor: Johns Hopkins University • Aim: Symptom relief
Last updated Mar 27, 2026 12:41 UTC
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Heart valve patients get coaching boost to walk more
Symptom relief CompletedThis study tested whether motivational coaching and home exercise programs could help older adults become more active after a minimally invasive heart valve replacement procedure. Researchers compared these programs to standard care in 40 patients who had the TAVR procedure. The …
Phase: NA • Sponsor: Johns Hopkins University • Aim: Symptom relief
Last updated Mar 24, 2026 12:02 UTC
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New program aims to lighten the load for heart failure caregivers
Symptom relief CompletedThis study tested a program designed to support the family and friends who care for people with advanced heart failure. The program, delivered by a nurse in the caregiver's home, helped participants set personal health goals, manage stress, and reduce feelings of burden. Research…
Phase: NA • Sponsor: Johns Hopkins University • Aim: Symptom relief
Last updated Mar 24, 2026 12:02 UTC
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Speech therapists step in to help ease dementia distress through hearing care
Symptom relief CompletedThis study tested a new way to provide hearing care to people living with dementia at home. A speech-language pathologist delivered affordable hearing help instead of an audiologist. Researchers wanted to see if this improved patients' behavioral symptoms and overall quality of l…
Phase: NA • Sponsor: Johns Hopkins University • Aim: Symptom relief
Last updated Mar 19, 2026 14:56 UTC
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Nurses visit homes to fight pain and depression in aging women
Symptom relief CompletedThis small pilot study tested whether eight home visits from a nurse could help older African American women manage chronic pain and depressive symptoms. The program, called DAPPER, combined counseling and practical support to help participants set personal goals for improving th…
Phase: NA • Sponsor: Johns Hopkins University • Aim: Symptom relief
Last updated Mar 16, 2026 15:26 UTC
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Virtual buddies ease Dementia's loneliness and burden
Symptom relief CompletedThis study tested a virtual companion program called MEMORI Corps. It matched trained senior volunteers with people living with dementia at home to provide regular companionship and personalized activities. The goal was to reduce social isolation for the person with dementia, eas…
Phase: NA • Sponsor: Johns Hopkins University • Aim: Symptom relief
Last updated Mar 11, 2026 14:53 UTC
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Doctors test new blade for safer IV insertion
Knowledge-focused CompletedThis study tested a new type of surgical knife used to make the initial cut when placing a central venous catheter (a large IV line). Researchers wanted to see if doctors liked using the new knife and if it led to fewer problems during the insertion process. They observed 24 clin…
Sponsor: Johns Hopkins University • Aim: Knowledge-focused
Last updated Apr 01, 2026 23:26 UTC
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Doctors test if chest pressure predicts recovery from collapsed lung
Knowledge-focused CompletedThis study aimed to understand if measuring the pressure inside the chest of patients with a collapsed lung (pneumothorax) could help predict their recovery. Researchers measured this pressure in 37 adults as they received standard treatment with a chest tube. They then tracked w…
Sponsor: Johns Hopkins University • Aim: Knowledge-focused
Last updated Apr 01, 2026 23:26 UTC
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Scientists probe why scleroderma Patients' hearts fail
Knowledge-focused CompletedThis research study aims to understand why people with scleroderma and pulmonary hypertension develop heart muscle weakness. Researchers will compare heart function and collect tissue samples from 43 participants during their standard medical procedures. The goal is to identify d…
Sponsor: Johns Hopkins University • Aim: Knowledge-focused
Last updated Apr 01, 2026 23:26 UTC
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Scientists probe why UTI prevention fails half the time
Knowledge-focused CompletedThis study aims to understand why vaginal estrogen therapy prevents recurrent urinary tract infections (UTIs) in only about half of the postmenopausal women who use it. Researchers will examine how the treatment changes the bacteria and immune responses in the vagina and bladder …
Phase: PHASE4 • Sponsor: Johns Hopkins University • Aim: Knowledge-focused
Last updated Apr 01, 2026 14:43 UTC
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Clinic tracks young hearts at risk
Knowledge-focused CompletedThis study created a registry to track the long-term heart health of children and young adults who are overweight or obese and have high blood pressure. Researchers collected health information from about 200 participants over time through their regular clinic visits. The goal wa…
Sponsor: Johns Hopkins University • Aim: Knowledge-focused
Last updated Apr 01, 2026 14:42 UTC
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Scientists test 'Legal' vs 'Illegal' THC: What's the real difference?
Knowledge-focused CompletedThis study aimed to understand how Delta-8 THC, a compound sold in many stores, compares to the more common Delta-9 THC found in regular cannabis. Researchers at Johns Hopkins measured how both substances, when inhaled or swallowed, affected people's feelings, thinking, and body …
Phase: PHASE1 • Sponsor: Johns Hopkins University • Aim: Knowledge-focused
Last updated Mar 30, 2026 14:34 UTC
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Can bad sleep make pain pills less effective and more addictive?
Knowledge-focused CompletedThis study aimed to understand how common sleep problems affect the brain's response to pain medication. Researchers tested healthy adults after disrupting their sleep to see if poor sleep changed how well a pain drug worked and whether it increased the risk of misuse. The goal w…
Phase: PHASE2 • Sponsor: Johns Hopkins University • Aim: Knowledge-focused
Last updated Mar 30, 2026 14:28 UTC
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Scientists test how high and drunk mix for road safety
Knowledge-focused CompletedThis study aimed to understand how taking cannabis by mouth and drinking alcohol, both separately and together, affects a person's ability to drive, think clearly, and pass standard sobriety tests. Researchers at Johns Hopkins University gave 60 healthy adults different combinati…
Phase: PHASE1 • Sponsor: Johns Hopkins University • Aim: Knowledge-focused
Last updated Mar 27, 2026 12:40 UTC
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Late-Night eating may disrupt your Body's clock, study finds
Knowledge-focused CompletedThis study aimed to understand how the timing of your last meal affects your metabolism. Researchers at Johns Hopkins University had 41 healthy young adults eat dinner either early or late relative to their personal body clock, and measured their blood sugar and fat burning overn…
Phase: NA • Sponsor: Johns Hopkins University • Aim: Knowledge-focused
Last updated Mar 27, 2026 12:38 UTC
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Can you drive high? scientists test two cannabis compounds in simulator
Knowledge-focused CompletedThis study measured how two similar cannabis compounds—Delta-8-THC and the more common Delta-9-THC—affect a person's ability to drive. Researchers at Johns Hopkins had 30 adults with past cannabis use try both substances and then perform simulated driving tests and cognitive task…
Phase: PHASE1 • Sponsor: Johns Hopkins University • Aim: Knowledge-focused
Last updated Mar 25, 2026 14:08 UTC
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Scientists hunt for clues to predict postpartum depression
Knowledge-focused CompletedThis study aimed to understand what causes mood episodes like depression after childbirth. Researchers followed 300 pregnant women, some with and some without a history of mood disorders, to track their mental health. They collected information on genes, hormones, stress, and sle…
Sponsor: Johns Hopkins University • Aim: Knowledge-focused
Last updated Mar 25, 2026 14:07 UTC
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New program aims to bridge gap between mental and physical health care
Knowledge-focused CompletedThis pilot study tested a new quality improvement program to help mental health providers better manage heart disease risk factors in their patients. Researchers worked with 85 participants from community mental health organizations to see if the program improved care for conditi…
Phase: NA • Sponsor: Johns Hopkins University • Aim: Knowledge-focused
Last updated Mar 25, 2026 14:07 UTC
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Can better training help mental health patients quit smoking?
Knowledge-focused CompletedThis pilot study tested a training program for staff at community mental health clinics. The goal was to see if the training improved how staff helped their patients quit smoking. Researchers measured changes in staff knowledge, confidence, and how often they provided proven quit…
Phase: NA • Sponsor: Johns Hopkins University • Aim: Knowledge-focused
Last updated Mar 24, 2026 12:02 UTC
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Scientists test how your daily pills might change your mind
Knowledge-focused CompletedThis research study aimed to understand how everyday over-the-counter and prescription medications might influence a person's mood and their preference for taking certain drugs. Healthy adult volunteers took capsules containing substances like caffeine or nicotine (or a placebo) …
Phase: PHASE1 • Sponsor: Johns Hopkins University • Aim: Knowledge-focused
Last updated Mar 24, 2026 12:01 UTC
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Scientists probe why HIV drug might work differently as we age
Knowledge-focused CompletedThis study aimed to understand how aging affects specific enzymes in the body that are needed to activate a common HIV prevention and treatment medication. Researchers collected blood and colon tissue samples from 21 adults of different ages, including people with HIV, people tak…
Sponsor: Johns Hopkins University • Aim: Knowledge-focused
Last updated Mar 23, 2026 15:18 UTC
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Scientists test if new nicotine pouches can satisfy Smokers' cravings
Knowledge-focused CompletedThis study aimed to understand how tobacco-free nicotine pouches work in the body and affect cravings compared to regular cigarettes. Researchers tested different flavors and nicotine strengths of these pouches on adult smokers. They measured nicotine levels in the blood and aske…
Phase: PHASE1 • Sponsor: Johns Hopkins University • Aim: Knowledge-focused
Last updated Mar 23, 2026 15:16 UTC
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What makes you trust your doctor? a big study has answers
Knowledge-focused CompletedThis study aimed to understand what factors influence a patient's trust in their primary care doctor. Researchers asked over 1,100 adults to read short stories about a doctor's visit that varied details like appointment length and the doctor's attentiveness. Participants then rat…
Phase: NA • Sponsor: Johns Hopkins University • Aim: Knowledge-focused
Last updated Mar 18, 2026 14:41 UTC
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Scientists use scans to watch TB drug travel through patients
Knowledge-focused CompletedThis small study aimed to understand how a tuberculosis drug, pretomanid, moves through and concentrates in the bodies of patients. Researchers used a special PET scan to track a tiny, safe amount of a radioactive version of the drug in 10 people with TB. The goal was to see if t…
Sponsor: Johns Hopkins University • Aim: Knowledge-focused
Last updated Mar 16, 2026 15:24 UTC
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Friends & family trained to find kidney donors in new program
Knowledge-focused CompletedThis study tested a new education program for patients waiting for a kidney transplant. The program teaches patients and their chosen friends or family members (called 'Live Donor Champions') about living kidney donation. The goal was to see if this program could be successfully …
Phase: NA • Sponsor: Johns Hopkins University • Aim: Knowledge-focused
Last updated Mar 11, 2026 14:54 UTC
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Can a website help jails care for pregnant women with opioid addiction?
Knowledge-focused CompletedThis study tested a new web-based toolkit designed to help jail staff provide better care for pregnant women with opioid addiction. Jail staff at four locations used the toolkit and shared their experiences through surveys and interviews over a year. The goal was to understand wh…
Phase: NA • Sponsor: Johns Hopkins University • Aim: Knowledge-focused
Last updated Mar 11, 2026 14:53 UTC
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Scientists test common Antibiotic's power against stubborn lung infection
Knowledge-focused CompletedThis small, completed study aimed to measure how effectively the antibiotic azithromycin kills the bacteria that cause Mycobacterium Avium Complex (MAC) lung disease in the first two weeks of treatment. It involved 10 adults with MAC lung disease who were about to start standard …
Phase: PHASE2 • Sponsor: Johns Hopkins University • Aim: Knowledge-focused
Last updated Mar 09, 2026 14:25 UTC