Johns Hopkins University

This trial tests whether repeatedly adding sterile fluid into the womb can help fetuses with severe kidney failure grow enough lungs to survive after birth. Pregnant women with early pregnancy kidney failure can choose to receive the infusions or just be monitored. Babies who sur…

This study tested whether video-based medication coaching helps adolescents and young adults with uncontrolled asthma take their inhaled steroids more regularly. 375 participants received either standard care or telehealth sessions to improve medication use. The goal was to see i…

This study tested a new strategy: giving TB prevention medicine at the same time as TB testing to people with HIV starting or restarting antiretroviral therapy. The goal was to see if this approach gets more people on TB prevention quickly without missing active TB cases. The tri…

This study tested whether telehealth can replace in-person clinic visits for older adults who already use hearing aids. 339 participants were randomly assigned to receive hearing care either through telehealth or traditional clinic visits. The goal was to see if telehealth could …

This study tested a device called the Bridge, which uses mild electrical pulses to ease opioid withdrawal symptoms. 36 adults with opioid addiction were randomly assigned to get the active device, withdrawal medication (lofexidine), or a placebo. The goal was to see if the device…

This study tested whether starting HIV treatment on the same day and providing care in community centers for people who inject drugs improves viral suppression. 800 participants were randomly assigned to same-day or standard treatment start, and to community or government-based c…

This study looked at whether it is safe to transplant livers from deceased HIV-positive donors into HIV-positive recipients. Researchers followed 80 participants to track complications like graft failure, infections, and HIV breakthrough. The goal was to see if using HIV-positive…

This study looked at whether a DASH-style diet (modified for diabetes) combined with lower salt intake can lower blood pressure in adults with type 2 diabetes and high blood pressure. 105 participants ate specially prepared meals for 5-week periods. The goal was to find a practic…

This study tested a new injectable material called acellular adipose tissue (AAT) to repair modest soft tissue defects on the trunk, such as those from injury or surgery. Fifteen adults received one or more injections of AAT, which is made from donated fat cells stripped of their…

This study tested whether evolocumab (Repatha), a drug that lowers LDL cholesterol, can reduce inflammation and improve heart function in people who recently had a mild heart attack (NSTEMI). Sixty participants received either evolocumab or a placebo within 24 hours of admission.…

This study tested a virtual health program for African immigrants aged 25-75 who had at least two risk factors like diabetes, high blood pressure, or obesity. Participants used Bluetooth scales and blood pressure monitors to track their health over 6 months. The program was deliv…

This study tested whether offering rapid hepatitis C treatment with help from a peer mentor (someone who has been cured) works better than the usual referral to an outside clinic. 198 people who use drugs and were in an opioid treatment program took part. The goal was to see if m…

This early-phase trial tested whether the immunosuppressant drug everolimus could help people with idiopathic subglottic stenosis, a rare condition where scarring narrows the airway. Eight participants took everolimus for 42 days after a dilation surgery to open the airway. The g…

This completed phase 3 trial tested whether giving children with pulmonary hypertension two drugs (sildenafil and bosentan) from the start works better than just one drug (sildenafil alone). The study enrolled 28 children who had not yet received long-term treatment. Researchers …

This study tested whether a mobile care van linked to a needle exchange program could improve HIV prevention and treatment for people who inject drugs. 720 participants received services like HIV testing, treatment, and risk reduction through the van. The goal was to see if this …

This study tested a new computer simulation, called a 'virtual heart,' to help doctors find the best spots to burn heart tissue (ablation) in patients with ventricular tachycardia (VT) caused by prior heart attacks. Ten adults with VT and scarred heart muscle were enrolled. The a…

This study tested whether the drug vericiguat can improve the function of small blood vessels in the heart for people with metabolic syndrome (a cluster of conditions like high blood pressure and belly fat). 45 adults took either vericiguat or a placebo for 6 weeks. Researchers u…

This completed study looked at whether people with HIV can safely donate a kidney to others with HIV. Only 3 participants were enrolled, and the main goal was to track any side effects from the donor surgery. The study also monitored donors for long-term kidney problems and chang…

This study tested a smoking cessation program for adults living in Baltimore City public housing. The program combined remote support from specialists, access to quit-smoking medications, and on-site community leaders to help residents reduce or quit smoking. The goal was to see …

This study tested two strategies to improve HIV care among people who inject drugs and men who have sex with men in India. One group received care at integrated centers that offer harm reduction, testing, and treatment all in one place. The other group got the same care plus fina…

This study tested a 12-month healthy lifestyle program for 112 youth aged 8-18 with serious emotional disturbance who were overweight or obese. Participants worked with a health coach to improve diet and physical activity, with parents involved. The goal was to see if this approa…

This study tested a virtual cardiac rehabilitation program using a smartphone app, a fitness wristband, and a blood pressure monitor for people who recently had a heart attack, heart surgery, or a stent. The goal was to see if this home-based program could improve walking ability…

This study tested a computer program called C-Raven that uses an interactive avatar to help people quit smoking. Participants used an iPad for two 20-minute sessions and could get nicotine replacement therapy and support from a community health worker. The study was small (18 peo…

This pilot study tested a program called THRIVE in 80 Black adults with high blood pressure. Participants received personalized dietitian coaching, culturally tailored messages, free produce from a mobile market, and help connecting to social services. The goal was to see if this…

This study tested whether adding evolocumab, a drug that lowers bad cholesterol, to standard care helps people who recently had a heart attack. The goal was to see if it reduces cholesterol and inflammation in the heart and blood vessels. 100 adults aged 25 to 90 who had a specif…

This study tested whether adding a personalized, computer-model-guided ablation (OPTIMA) to the standard pulmonary vein isolation (PVI) procedure improves outcomes for people with persistent atrial fibrillation. 67 participants were randomly assigned to receive either PVI alone o…

This study tested a special light-based treatment for donated blood to see if it could prevent infections like malaria, HIV, and hepatitis from spreading through transfusions. About 2000 people who needed a blood transfusion took part. The treated blood was compared to standard b…

This study tested whether using HEPA air cleaners at home along with phone-based motivational interviewing could improve breathing and quality of life in smokers with COPD. 144 current smokers with COPD were randomly assigned to receive either active air cleaners and counseling o…

This pilot study tested whether a virtual counselor program, combined with support from a community health worker, could help people in public housing quit smoking and get screened for lung cancer. Five participants were offered nicotine replacement therapy and two counseling ses…

This study tested whether a specially designed stroke unit at the University Teaching Hospital in Lusaka, Zambia, improves care and survival for adults with stroke. The unit uses local protocols and trained staff to standardize treatment. Researchers compared outcomes for 300 pat…

This study compares a new ultra-high-resolution CT scanner (UHR-CT) to the standard invasive coronary angiography for detecting significant blockages in the heart's arteries. It focuses on patients with severe calcium buildup or stents, where regular CT scans often fall short. Th…

This study tested three rapid, point-of-care HIV tests to see how well they work compared to standard lab tests. Researchers enrolled 224 adults at high risk for HIV in Baltimore. The goal was to see if faster results help more people start treatment or prevention the same day.

This study looked at 477 adults with pancreatic cysts to find better ways to tell which cysts are harmless and which might become cancer. Researchers combined medical images, patient history, and fluid from the cysts to create a more accurate prediction model. The goal is to help…

This study tested whether a special eye-tracking device (video-oculography) helps emergency room doctors more accurately diagnose the cause of vertigo or dizziness. About 130 adults with dizziness were randomly assigned to get either the eye-tracking test plus standard care, or s…

This early study tested a new radioactive tracer called 18F-FDS in 16 people with suspected bacterial or fungal infections. The tracer is designed to light up infection sites on PET/CT scans, helping doctors see exactly where an infection is. The goal was to check how the tracer …

This early study tested whether a special PET scan using a radioactive form of vitamin B9 (11C-PABA) can help doctors see infections deep inside the body. Researchers scanned 13 healthy people and patients with known or suspected infections. The goal was to see if this method can…

This study tested two medications, roflumilast and azithromycin, in over 1,000 people with severe COPD and chronic bronchitis. The goal was to see which drug better prevents hospitalizations or death. Participants were current or former smokers aged 40 or older who had been hospi…

This study tested a phone-based health coaching program for pregnant women with a higher body mass index. The goal was to help them gain a healthy amount of weight during pregnancy and prevent problems like gestational diabetes and later obesity in both mothers and children. Over…

This study tested a program called Wakȟáŋyeža (Little Holy One) with 124 Native American caregivers and their 2-to-5-year-old children on a Northern Plains reservation. The goal was to reduce trauma and stress in parents, improve parenting skills, and boost children's emotional a…

This study tested whether a fully automated digital program could help people with prediabetes lose weight and lower their blood sugar as effectively as a program led by a human coach. About 368 adults with prediabetes and overweight took part. The goal was to see which approach …

This pilot study tested whether a couples-based counseling program could help young people (ages 16-25) and their partners prevent STIs and HIV. The program added joint health education sessions to existing individual prevention counseling. Researchers enrolled 68 participants fr…

This study tested whether a registered nurse could help women at risk for HIV learn about and start PrEP (a daily pill that prevents HIV) during OB/GYN visits. 440 women were randomly assigned to either standard care or a nurse-led program that included counseling and lab tests. …

This study tests whether watching short telenovela-style videos can reduce anxiety and boost confidence in African-American and Hispanic family caregivers of hospice patients. 62 caregivers will either watch the videos during telehealth visits or receive usual hospice care. The g…

This study tested whether group drumming classes could improve quality of life and motor skills in people with Parkinson's or Huntington's disease. Eighteen participants took drum lessons twice a week for 12 weeks. Researchers measured changes in anxiety, depression, hand functio…

This study tested a program where a pharmacist worked with people living with dementia, their care partners, and their doctors to review and reduce unnecessary medications. The goal was to simplify medication routines and lower treatment burden. The study included 138 participant…

This study tested whether watching telenovela-style educational videos can help family caregivers of hospice patients feel more confident and less anxious. 59 caregivers participated over 8 weeks. The approach used weekly video lessons during regular hospice visits.

This study tested whether taking tetracycline for 3 months is tolerable for people with Post-Treatment Lyme Disease (PTLD) — those who still have symptoms like fatigue after standard antibiotic treatment. 60 adults received either tetracycline or a placebo, then switched treatmen…

This study tested a program called PRIME for older women with chronic pain and depression who also have physical disabilities. Nine women took part in nurse-led goal-setting visits and group therapy sessions focused on acceptance and commitment. The goal was to see if this combin…

This study looked at whether playing music helps children with glaucoma stay focused during a visual field exam (a test that checks side vision). 38 children took part, and researchers measured how often they made mistakes or lost focus. The goal was to see if music could make th…

This study looked at whether a short sleep therapy program (BBTI) can improve sleep and help people stay in treatment for substance use disorders. About 83 adults living in a residential recovery program took part. They wore sleep trackers, completed surveys, and did sleep diarie…

This study tested a step-by-step treatment plan for people with knee osteoarthritis pain. Participants first received duloxetine (Cymbalta), a drug that helps with pain, and then, if needed, an injection of hyaluronic acid mixed with a steroid into the knee joint. The goal was to…

This study tested whether using a video game called MindPod Dolphin is safe and practical for arm rehabilitation in people who recently had a stroke. 58 participants played the game, controlling a dolphin with their affected arm. The goal was to see if patients would stick with i…

This study looked at 112 adults with stomach blockage caused by advanced cancer. It compared two less invasive procedures: one using an ultrasound-guided bypass and the other using a stent to open the blockage. The goal was to see which method better prevents the blockage from co…

This study tested a hearing care program for older adults with both hearing loss and dementia. Speech-language pathologists delivered the program at home. The goal was to see if better hearing could reduce troubling symptoms like agitation and improve quality of life. 77 people t…

This study looked at whether motivational coaching and a home exercise program can help older adults become more active after a minimally invasive heart valve replacement called TAVR. Forty people who had the procedure took part. The goal was to see if these programs are practica…

This study looked at whether smell training with scented oils can help people regain their sense of smell after endoscopic skull base surgery. 41 adults with benign skull base tumors participated. Half used scented sticks and half used unscented sticks for training. Researchers m…

This study tested whether bright light therapy could help people with multiple sclerosis who have trouble sleeping. 27 participants used a light box at home. The goal was to see if it was safe and if it improved sleep and daily function.

This study tested whether a digital program could help adults with high blood pressure who have limited access to healthy food. 67 participants received a grocery delivery membership, personalized meal lists, dietary tracking, text message feedback, and health coaching over 4 mon…

This study tested a program called MEMORI Corps, where trained volunteers aged 55+ provide companionship and personalized activities to people with dementia living at home. The program was delivered virtually over 12 weeks. Researchers measured changes in mood, quality of life, a…

This study involved 61 people with early-stage dementia and their caregivers. Researchers worked with participants to create a personalized plan of meaningful activities, designed to adapt as the disease progresses. The goal was to see if this approach could improve thinking skil…

This study tested whether suvorexant, a sleep medication, can reduce drug use and cravings while improving sleep and stress in people being treated for both opioid and stimulant use disorders. Twenty adults stable on methadone or buprenorphine took either suvorexant or a placebo …

This pilot study tested a program for hospitalized people with HIV who smoke. Participants received two computer counseling sessions, nicotine replacement therapy, and follow-up support from a community health worker for up to 8 weeks. The goal was to see if this approach is feas…

This study tested a program for caregivers of people with advanced heart failure. The program helps caregivers build on their strengths, find purpose, and set goals for a healthier lifestyle. Researchers wanted to see if it could improve caregivers' quality of life, reduce their …

This study looked at whether a sleep medication called suvorexant can improve sleep and reduce stress in people recovering from opioid addiction. About 138 participants on medications like methadone or buprenorphine were given either suvorexant or a placebo for 8 weeks. The goal …

This pilot study tested a program called DAPPER for African American women aged 50 and older who have pain, depressive symptoms, and trouble moving around. Participants received 8 nurse visits at home to help manage their pain and mood. The study aimed to see if the program could…

This study tested a new device called Incremental Velocity Error (IVE) that uses a headband to help retrain the brain's balance system. It compared the device to standard eye and head exercises in 24 adults with dizziness from mild traumatic brain injury or inner-ear nerve damage…

This study tested a device called Gigstride in 44 adults who have trouble walking due to leg problems like arthritis, multiple sclerosis, or after joint replacement. The goal was to see if people liked using it and if it helped with walking speed, stairs, and balance. Results wil…

This Phase 2 study tested dupilumab (Dupixent) in 33 adults with chronic sinusitis but no nasal polyps. Participants received injections every two weeks for six months. The main goal was to see if the drug improves sinus symptoms and quality of life compared to a placebo.

This study tested a program called CAPABLE for older adults who had trouble with daily tasks after being in the hospital. Participants received help with medications, strength and balance exercises, pain management, and home modifications. The goal was to see if these services co…

This study tested whether playing an immersive video game called Bandit the Dolphin could improve thinking and movement in adults who had a traumatic brain injury years ago. The game involves moving your arms to control a dolphin in an ocean environment, combining physical and me…

This pilot study tested whether a therapy that combines behavioral activation for depression with physical rehabilitation is feasible for survivors of acute respiratory failure. Fifty-two adults who had been on life support in the ICU received home visits and phone calls from the…

This pilot study looked at how well the antibiotic azithromycin kills Mycobacterium avium complex (MAC) bacteria in the lungs during the first 14 days of treatment. Ten adults with MAC lung disease took azithromycin daily, and researchers measured bacterial levels in their sputum…

This early study tested if gentle wounding (using a laser or mild scraping) can trigger new hair growth in people with a type of scarring hair loss called CCCA. Researchers mapped bald spots on the scalp, applied different wounding methods with or without FDA-approved creams, and…

This completed study used advanced MRI and CT scans to look for lasting damage in the brain, heart, lungs, and liver of 206 people who had COVID-19. Researchers compared those who were hospitalized with those who were not, to understand how the virus affects organs over time. The…

This study tested a special bassinet designed to keep mother and baby together safely after birth. 160 new mothers used either the new Couplet Care bassinet or a standard one. Researchers surveyed mothers about sleep, breastfeeding, and satisfaction, and reviewed medical charts. …

This study tested whether smartphone communication and a special questionnaire could help confirm MS relapses without requiring an in-person visit. Researchers worked with 150 people with relapsing-remitting MS to see if this approach improves patient satisfaction and care. The g…

This study tested a program called SHARE that helps older adults with memory problems and their families talk about healthcare wishes with their primary care doctor. About 273 people took part. The program provided tools and guidance to improve communication and advance care plan…

Infantile spasms are a type of seizure that can harm development if not treated quickly, but they are often mistaken for normal movements. This study tested a computer program that learns from parent-recorded videos to tell the difference between these seizures and harmless movem…

This study tested whether a special PET scan tracer is safe for people with Long COVID. Six adults with a history of COVID-19 (some with ongoing symptoms, some without) received the tracer and MRI scans. The goal was to see if the tracer can highlight brain inflammation differenc…

This completed study tested a program that uses trained community health workers to help primary care clinics better screen and support Latinx teenagers at risk for suicide. The program included phone sessions with parents focusing on safety planning and education. Researchers me…

This pilot study tested a new program to help prevent low blood sugar (hypoglycemia) in people with diabetes who take medications that can cause it. The program included a patient survey and a toolkit for doctors. The study involved 35 patients and their primary care providers at…

This completed Phase 1 trial from Johns Hopkins University enrolled 13 transgender women to see how the HIV prevention drug Truvada interacts with feminizing hormones like estrogen. Participants took Truvada alone and then with added hormones or a testosterone blocker. The goal w…

This study looked at whether hearing and vision loss are linked to delirium (sudden confusion) in older hospital patients. Over 1,500 participants answered screening questions and had their hearing and vision tested. In a smaller trial, researchers tested if posting communication…

This completed study from Johns Hopkins University compared two methods for taking lung tissue samples during a bronchoscopy: a 1.1mm cryoprobe (which freezes tissue) versus standard 2.0mm forceps (which grab tissue). The trial enrolled 500 adults scheduled for a lung biopsy and …

This study tested a simple way to get more HIV patients in South Africa the medicine that prevents tuberculosis (TB). Instead of doctors having to choose to prescribe it, the new approach made TB prevention the standard option, requiring doctors to actively opt out if they didn't…

This study tested a new type of knife used to make a small cut when inserting a central venous catheter (a large IV line). Doctors rated how easy and safe the knife was to use, and the team tracked problems like needing to re-cut or restart the procedure. 86 patients and their do…

This study looked at 27 postmenopausal women with frequent urinary tract infections (UTIs) to understand why vaginal estrogen therapy prevents UTIs in only about half of them. Researchers examined changes in bacteria in the vagina and bladder, as well as immune responses, before …

This study looked at 3,000 adults with pancreatic cysts to find better ways to tell harmless cysts from those that might become cancer. Researchers used imaging scans, cyst fluid analysis, and genetic markers to improve accuracy. The goal is to help doctors make better decisions …

This study looked at how Delta-8 THC, a compound similar to the main psychoactive ingredient in cannabis, affects people compared to Delta-9 THC and a placebo. 28 healthy adults took the substances by mouth or by inhalation. Researchers measured their mood, thinking skills, and c…

This study tested a web-based toolkit called MOM CARE designed to help jail staff provide better care for pregnant people with opioid use disorder. The toolkit includes medical guidance and best practices from intake to release. Researchers worked with 22 jail staff members to se…

This study looked at how common medications like methylphenidate and nicotine affect mood and drug preference in 25 healthy adults. Participants rated their liking and perceived value of the drugs. The goal was to understand the psychological effects of these medications, not to …

This study looked at how eating dinner early versus late affects metabolism in 41 healthy adults aged 18-30. Researchers timed meals based on each person's natural body clock and took blood samples to measure sugar and fat levels. The goal was to understand how meal timing impact…

This pilot study tested whether a computer avatar that delivers a smoking cessation program, combined with help from a community health worker, could help people in Baltimore public housing quit smoking and get screened for lung cancer. Ten adults aged 50 or older who smoked took…

This study created a registry of 200 overweight children and young adults with high blood pressure to track their heart health over time. Researchers collected medical information from clinic visits to understand how weight affects the heart. No treatments or interventions were g…

This study looked at 43 adults with scleroderma or unexplained pulmonary arterial hypertension (PAH) to understand why the right side of the heart weakens. Researchers collected blood and tissue samples during routine procedures and measured heart function over 6 months. The goal…

This study followed 300 pregnant women to understand why some develop mood disorders like depression or bipolar episodes after giving birth. Researchers collected genetic, hormonal, and environmental data to find patterns that could predict these episodes. The goal is to better i…

This study looked at how aging changes certain enzymes (proteins) in the blood and colon. Researchers collected blood and colon tissue samples from 21 healthy adults, both younger (18-50) and older (65-80). They also checked if the HIV medications tenofovir and emtricitabine affe…

This pilot study tested a program called the Liver Live Donor Champion Program for people waiting for a liver transplant. The program trains a friend or family member to be an advocate and help the patient find a living donor. Researchers enrolled 76 liver transplant candidates a…

This study tested a program called the Live Donor Champion Program, which trains a friend or family member to help a kidney patient find a live donor. The program was offered to 111 patients on the kidney transplant waitlist. Researchers wanted to see if the program could be succ…

This study used a special PET scan to track how the tuberculosis drug pretomanid moves through the body. Ten people with or without TB received a tiny radioactive version of the drug, and the scanner measured where it went. The goal was to see how much drug reaches infected areas…

This study tested whether reading short stories (vignettes) can change how much people trust their primary care doctors. Over 1,100 adults completed a survey measuring trust levels. The goal was to see if trust can be influenced, which may help understand why some people get unne…

This study tested whether a pharmacist-led program could help older adults with dementia and their caregivers reduce unnecessary medications. The program included an educational brochure, a telehealth visit with a pharmacist, and tailored recommendations for the patient's doctor.…

This study tested two ways to help adults with overweight or obesity who struggle to afford healthy food. One group got weekly vouchers to buy produce at a local market; the other got fresh produce delivered to their home along with daily text messages about healthy eating. The g…

This study tested whether a Diabetes Navigator—a personal guide—helps people with type 1 diabetes use advanced devices like continuous glucose monitors and insulin pumps more effectively. 148 participants were randomly assigned to get navigator support or standard care. The main …

This study measured the pressure inside the chest in 37 adults with a collapsed lung (pneumothorax) who needed a chest tube. Researchers wanted to see if these pressure readings could help predict who would need additional treatments like surgery or a valve. The study was observa…

This study looked at how eating cannabis (in a brownie) and drinking alcohol, alone or together, affects people's ability to think clearly, stay coordinated, and drive safely. Sixty healthy adults aged 21 to 55 took part in a controlled lab setting. Researchers measured impairmen…

This pilot study tested a quality improvement process called CUSP to help community mental health staff deliver better care for cardiovascular risk factors like high blood pressure, diabetes, and high cholesterol. The study included 85 staff and patients from psychiatric rehabili…

This study tested 30 healthy adults to see how Delta-8-THC and Delta-9-THC affect driving in a simulator. Participants took the drugs by vaping or eating, then performed driving and sobriety tests. The goal is to understand how Delta-8 impairs driving compared to Delta-9, helping…

This study looks at how disrupted sleep changes the way common drugs (like painkillers, stimulants, and sedatives) work in the body. Researchers will disturb the sleep of 148 healthy adults in a lab and then measure how their brains respond to these drugs, including pain relief a…

This study tested how tobacco-free nicotine pouches affect the body and mind compared to regular cigarettes. Seventy-one adult smokers tried different doses and flavors of pouches, as well as their own cigarettes, in a controlled setting. Researchers measured nicotine levels in t…

This study tested a clinical decision support tool that helps doctors identify social needs—like food, housing, or transportation—in African American patients with chronic diseases such as diabetes or heart failure. The tool uses a social risk score to flag patients who may need …

This study tested whether a single virtual group session could help Spanish-speaking mothers learn about postpartum depression and available resources. Twenty-six mothers of infants under 2 months old participated. The session included a video testimonial, discussion of symptoms,…

This pilot study tested whether keeping blood pressure within a range that ensures good blood flow to the brain during surgery is feasible and safe compared to usual care. Researchers enrolled 27 older adults having hip, knee, or lung surgery. They measured how often blood pressu…

This study tested whether training, coaching, and strategy meetings help community mental health clinic staff deliver better smoking cessation support. Researchers worked with 91 staff members from multiple clinics. The goal was to see if staff knowledge and confidence in helping…