Johns Hopkins University

This study is testing a new computer tool that uses artificial intelligence to help emergency room doctors spot and manage sudden kidney injury (AKI) earlier. It will be used at three hospitals with up to 200,000 adult patients who get a blood test in the ER. The goal is to see i…

This study is testing whether a medication currently used for diabetes can slow down brain and eye nerve damage in people with multiple sclerosis (MS). Researchers will give 120 participants either the study drug or a placebo for about two years and use brain scans to measure cha…

This study is testing whether a low-dose, repurposed drug called emetine can stop dengue fever from becoming severe or fatal. It will involve 600 hospitalized adults in Nepal who will take the drug or a placebo pill for 7 days. Researchers will monitor if the treatment reduces de…

This study is testing an online program called e-ALIGN. It aims to help older adults with mild memory problems or dementia, and their caregivers, work with doctors to safely stop or reduce medications that might be harmful or unnecessary. The program sends educational videos and …

This study is testing if a natural sugar supplement called N-acetylglucosamine (GlcNAc) can help control symptoms of Crohn's disease. It will enroll 40 adults with Crohn's affecting the small intestine. Participants will take either the supplement or a placebo powder for several …

This study is testing if applying a nitropaste during surgery can improve blood flow to the surgical wound in patients with serious lower leg fractures. Better blood flow may help prevent dangerous wound infections and healing problems. The researchers will use a special imaging …

This study tests whether a combination of a digital food marketplace, personalized dietitian coaching, and home blood pressure monitoring can help lower blood pressure. It will involve 100 Black and Hispanic adults with high blood pressure who live in areas with limited access to…

This early-stage study is checking if a form of lithium called lithium orotate is safe and can get into the brain in people with early Alzheimer's disease. Over 9 weeks, 40 participants will take either the lithium pill or a placebo to see if it's well-tolerated and reaches the s…

This study aims to find out if using a low-sodium salt substitute is safe for adults with high blood pressure who are taking medication. Researchers will check if the salt swap causes dangerously high potassium levels or helps correct low potassium. About 600 participants in Bang…

This study is testing whether custom 3D printed guides made in the hospital are as good as ones ordered from outside companies for jaw surgery. The guides help surgeons correctly align a patient's upper and lower teeth during the operation. Researchers will compare the cost, prod…

This study aims to see if combining two medications, semaglutide (a drug also used for weight loss) and naltrexone (an existing treatment for alcohol use disorder), is safe and more effective than naltrexone alone. It will involve 45 adults already enrolled in a 4-week inpatient …

This study is testing if a ketone supplement drink taken before bed can help control obstructive sleep apnea. Researchers will compare the supplement to a placebo in 30 adults with moderate-to-severe sleep apnea who already use a CPAP machine. The goal is to see if the supplement…

This study is testing a 50-minute education session for pregnant and postpartum women receiving medication for opioid dependency and a support person they choose. The goal is to see if the session is practical and well-received, and to provide accurate information about treatment…

This study tests whether connecting liver transplant recipients who had alcohol-related liver disease with trained peer support specialists improves their recovery. The peer specialists have personal experience with similar challenges and will provide regular support between medi…

This study is testing a new program where hair stylists in beauty salons are trained to check blood pressure and help connect their clients to health resources. It aims to see if this community-based approach helps Black and Hispanic women better manage their high blood pressure.…

This small pilot study explores whether switching from the MS medication ocrelizumab to a similar drug called ublituximab can help patients who experience a 'wearing off' effect, where their MS symptoms return or worsen in the weeks before their next scheduled infusion. The study…

This study is testing whether a 12-week home exercise program can help protect vision in people with glaucoma. Researchers will enroll 150 people, half with glaucoma and half without eye disease, to see if supervised resistance and cycling workouts can improve eye blood flow and …

This study aims to see if injecting steroids directly into a narrowed part of the throat after a surgical procedure can help patients go longer before needing another surgery. It will involve 226 adults with a condition that causes unexplained throat narrowing, making it hard to …

This small, early-stage study is testing the safety of a procedure that blocks arteries in the head to see if it can help people with severe, untreatable chronic migraines. Researchers will perform the procedure on 13 adults whose migraines have not improved with standard medicat…

This study will test a new group healthcare model for mothers and their babies during the first year after birth. It compares group sessions, where 8-10 mothers with similarly aged infants receive care together, to standard individual care. The goal is to see if this approach imp…

This study is testing a new, faster way to diagnose active Hepatitis C infection in the emergency room. Researchers want to see if patients prefer a new 1-hour finger-prick test over the standard blood draw that takes 1-2 days for results. They will also check if getting results …

This study is testing whether a new type of PET scan can detect lung scarring (fibrosis) in people with tuberculosis. Researchers will give 30 adult TB patients a special imaging tracer and perform a full-body scan to see if it highlights areas of lung damage. The goal is to deve…

This study tests if an AI-powered digital stethoscope can help doctors safely give fewer antibiotics to children with pneumonia in rural Bangladesh. The AI analyzes lung sounds to decide if a child needs antibiotics or a placebo. Researchers will compare health outcomes in 2,500 …

This study is testing a mobile app designed to help teenage boys and young men have better conversations with their doctors about sexual and reproductive health. The app asks questions and provides personalized information before a clinic visit, aiming to make these important tal…

This study aims to see if a 4-week course of the drug bedaquiline is as safe and effective as standard, longer drug regimens at preventing active tuberculosis (TB). It will enroll over 2500 people living with HIV and close contacts of people with TB who are at high risk of develo…

This study is testing a program where nurses visit older adults in their homes to help them better manage chronic pain and feelings of depression. Over eight weekly visits, nurses will work one-on-one with participants to set personal goals, teach pain and mood management skills,…

This study is testing whether making simple changes to a person's bedroom and giving brief sleep tips can improve sleep for older adults. It focuses on people aged 65+ who live alone, have memory concerns, and have trouble sleeping. Researchers will visit participants' homes to h…

This study is testing a new nurse-led care program called COORDINATE, designed to help older adults who have two or more chronic health conditions and are leaving a special hospital unit. The program provides personalized support, helps patients set health goals, and tracks sympt…

This study is testing whether cannabidiol (CBD), a compound from cannabis, can help people going through alcohol withdrawal. Adults with moderate-to-severe alcohol use disorder will stay in a hospital research unit for 5 days while they stop drinking. They will receive either CBD…

This study is testing if a handheld robot that provides gentle vibrations along with audio guidance can help older adults with memory concerns sleep better. It compares this robot-guided meditation to standard audio-only meditation apps. The goal is to see if the physical feedbac…

This study is testing whether a hormone called pregnenolone can help reverse the unwanted effects of being too high on cannabis. Healthy adults who have used cannabis before will take either cannabis or a placebo, then receive either pregnenolone or a placebo to see if it reduces…

This small pilot study aims to see if the supplement N-acetylcysteine (NAC) can help reduce repetitive and self-injurious behaviors in teens and adults with Cornelia de Lange Syndrome (CdLS). Ten participants will take either NAC or a placebo for 8-week periods to compare effects…

This study is testing whether a gentle, non-invasive brain stimulation technique can help improve thinking skills in people with long-term effects from a traumatic brain injury (TBI). Researchers will combine this stimulation with personalized cognitive training therapy. The goal…

This study is testing whether a portable home device called the Freespira Breathing System can help reduce anxiety and panic symptoms in children and teenagers. Researchers at Johns Hopkins University will enroll 73 young people aged 9-17 who have been diagnosed with an anxiety d…

This study is testing a device called Scrambler Therapy to see if it can safely reduce nerve pain in children and young adults with cancer that has spread to their bones. Participants will have 5 to 10 short therapy sessions over a couple of weeks. The main goal is to see if the …

This small pilot study is testing whether a simple pre-visit questionnaire helps parents of Black preterm infants with chronic lung disease set and achieve care goals for their child. Researchers want to see if the tool is practical and acceptable for families to use. They will a…

This study aims to understand how different types of cannabis, labeled as 'indica,' 'sativa,' or generic, affect people's minds and bodies. Researchers at Johns Hopkins will have 70 occasional cannabis users smoke different products in a controlled setting. They will then measure…

This study aims to see if tracking eye movements can accurately detect impairment from THC, the main active ingredient in cannabis. Researchers will give different doses of THC or a placebo to 40 frequent and infrequent cannabis users and test their eye control and attention. The…

This study aims to understand if a drink containing ketones (Ketone IQ) changes how healthy people breathe, especially their response to high carbon dioxide levels. Twenty healthy volunteers will drink either the ketone supplement or a placebo on two separate visits, and research…

This study aims to understand why people with Chronic Fatigue Syndrome (ME/CFS) and similar long COVID symptoms experience 'brain fog' and mood problems. Researchers will compare 200 patients who developed ME/CFS before the pandemic to those who developed it after a COVID-19 infe…

This study aims to understand how two common cannabis compounds, THC and myrcene, affect people when inhaled. Researchers at Johns Hopkins will have 32 healthy adults try different combinations of these substances and a placebo. The main goal is to measure how strong the drug eff…

This study aims to understand how glaucoma damages the eye by examining healthy volunteers. Researchers will take pictures of participants' optic nerves before and after they use standard glaucoma eye drops for two weeks. The results will be compared to glaucoma patients to learn…

This study aims to understand if racism-related stress makes a common sleep therapy less effective for Black adults who have insomnia and naturally sleep for short periods. Researchers will enroll 100 Black adults to complete a 6-week digital sleep therapy program. They will use …

This study is testing a new type of brain scan to see if it can detect inflammation in the brains of people with ALS. Researchers will compare scans from 20 people with ALS to scans from healthy people to see if the scan can spot differences linked to the disease. The main goal i…

This study aims to understand how people with opioid addiction cope with stress. Researchers will test 125 participants with opioid use disorder by measuring their thinking, emotions, and sense of control during both stressful and non-stressful situations. The goal is to create b…

This study is testing a new mobile app designed to help train surgeons. The app uses artificial intelligence to automatically review videos of a trainee's surgical procedures and provide feedback on their skills and decisions. Researchers want to see if this tool is easy to use a…