Johns Hopkins University

This pilot trial tests whether tirzepatide, a weekly injection used for diabetes and weight loss, can treat active central centrifugal cicatricial alopecia (CCCA), a permanent scarring hair loss condition. Twenty adults with active CCCA will inject tirzepatide for 12 months and u…

This study tests a 6-month program where patients work with a pharmacist and their primary care doctor to make shared decisions about medications and lifestyle. The goal is to see if this team-based approach improves heart and kidney health scores and medication adherence. The st…

This trial investigates whether guanfacine or cromolyn sodium—two drugs already approved for other conditions—can improve physical functioning and reduce symptoms like fatigue, brain fog, and gastrointestinal issues in adults with postural orthostatic tachycardia syndrome (POTS).…

This pilot study will test whether deep brain stimulation (DBS) can help people with schizophrenia who still hear voices and have delusions despite trying multiple medications. Fifteen adults will have electrodes placed in a brain region linked to schizophrenia symptoms. The goal…

This study tests whether the drug emetine can help people hospitalized with dengue fever. About 600 adults aged 18 to 65 will take either a low or high dose of emetine or a placebo pill for 7 days. Researchers will track if the drug reduces deaths or stops the disease from becomi…

This study will test whether a low-sodium salt substitute, which contains potassium chloride, is safe for adults with high blood pressure who are on medication. About 607 participants in Bangladesh will replace regular salt with the substitute for a period. Researchers will monit…

This Phase 2 trial at Johns Hopkins will test whether combining semaglutide (a GLP-1 drug used for diabetes) with naltrexone (a medication for alcohol dependence) is safe and helps reduce alcohol use. About 45 adults with alcohol use disorder will take the combination or a placeb…

This study tests whether a nurse-led, community-based program can help lower blood pressure in adults aged 25 and older with uncontrolled hypertension in Monrovia, Liberia. Trained community health nurses provide medication and lifestyle counseling at mobile clinics in high-traff…

This study tests whether peer support specialists—people who have been through liver transplant for alcohol-related disease themselves—can help others in the same situation stay sober and attend medical appointments. About 95 participants will meet regularly with a peer supporter…

This study looks at whether people with HIV who need a liver transplant can safely receive a liver from a donor who also had HIV. Researchers will compare infections and cancer rates between those who get an HIV-positive donor liver and those who get an HIV-negative donor liver. …

This early-stage trial tests whether lithium orotate, a form of the mineral lithium, is safe and reaches the brain in people with early Alzheimer's. Forty adults with confirmed Alzheimer's will take either the supplement or a placebo for 9 weeks. Researchers will measure lithium …

This phase 2 trial tests whether an oral supplement called N-acetylglucosamine (GlcNAc) can safely help control Crohn's disease in the ileum or ileocolon. Forty adults with stable Crohn's will receive either GlcNAc or a placebo for 6 weeks, then switch after a washout period. The…

This study tests whether daridorexant, a drug used for insomnia, can reduce alcohol cravings and drinking while improving sleep in people with alcohol use disorder and sleep problems. About 150 adults will receive either daridorexant or a placebo for several weeks. The goal is to…

This study explores whether regular voice recordings can help predict disease severity in people with laryngotracheal stenosis, a condition that narrows the airway. Researchers will use artificial intelligence to analyze voice changes and see if they can forecast when a dilation …

This study tests whether an AI-powered digital stethoscope can help health workers more accurately diagnose pneumonia in children aged 2 months to 5 years. 350 children with cough or breathing difficulty will be randomly assigned to standard care or care plus the AI stethoscope. …

This study looks at whether a new finger-stick test for hepatitis C, which gives results in about an hour, is acceptable to patients in the emergency department. Researchers will enroll 200 adults who have tested positive for hepatitis C antibodies but don't know if they have an …

This study tests whether a program led by community health workers can improve lung health for 800 people in Bhaktapur, Nepal, who are at risk for chronic respiratory diseases. The program includes tobacco cessation counseling, mask use during high pollution, handwashing, and flu…

This pilot study tests whether a single, personalized conversation with a healthcare team member or a brief message through a patient portal can encourage adults with prediabetes to take action—like joining a diabetes prevention program or starting medication. Researchers will co…

This pilot study tests whether N-acetylcysteine (NAC), an antioxidant supplement, can reduce repetitive and self-injurious behaviors in people with Cornelia de Lange syndrome (CdLS). Ten participants aged 13–35 will receive both NAC and a placebo in random order over 18 weeks. Th…

This study tests a device called Scrambler Therapy to relieve nerve pain in children with cancer that has spread to the bone. The treatment is non-invasive and aims to lower pain levels and reduce the need for pain medications. About 70 children who can describe their pain will t…

This study tests whether a safe, noninvasive brain stimulation technique called tDCS, combined with thinking exercises, can improve attention, memory, and problem-solving in people who had a traumatic brain injury at least two years ago. About 20 adults will receive personalized …

This study tests a personalized, non-invasive brain stimulation device for 10 people with mild cognitive impairment (MCI). The device uses AI to tailor electrical stimulation to each person's brain patterns while they do memory exercises. The goal is to see if this approach can i…

This study tests whether a program delivered by trained older adult peers can help people aged 60 and over with hearing loss. Participants receive an over-the-counter hearing device fitted to their needs along with communication training. The goal is to see if this affordable, co…

This trial tests whether a smartphone app can help patients follow pre- and post-surgery instructions better than the usual paper handouts. Adults scheduled for shoulder arthroscopy at Johns Hopkins are randomly assigned to receive instructions via app or on paper. The app tailor…

This early-phase study tests whether a shortened LSD experience, combined with the drug risperidone, can safely ease symptoms of major depression. Ten adults with moderate to severe depression will receive LSD followed by risperidone 45 minutes later. Researchers will monitor saf…

This study looks at whether racism-related stress affects how well a digital cognitive behavioral therapy program (Sleepio) works for insomnia in Black adults. One hundred participants will use the app for 6-10 weeks while researchers track their sleep and stress levels. The goal…

This pilot study tests whether a pre-visit questionnaire helps Black parents of preterm infants with chronic lung disease set and achieve health goals during primary care visits. Thirty parents will complete the questionnaire before a well-child visit and then report back on goal…

This study tests whether cannabidiol (CBD), a compound from cannabis, can reduce alcohol withdrawal symptoms and cravings in people with moderate-to-severe alcohol use disorder. 105 adults will stay in a hospital for 5 days, receive either CBD or a placebo alongside standard care…

This study explores whether a mild electrical stimulation on the face (trigeminal nerve) can reduce the feeling of breathlessness. It first tests the technique in healthy volunteers to understand how it affects breathing control, then checks if it is feasible and helpful for peop…

This study tests whether a handheld robot that guides meditation with touch and voice can improve sleep quality in older adults with mild memory concerns. 100 participants will either use the robot or a standard meditation app for daily sessions. The goal is to see if the robot h…

This pilot study tests whether simple bedroom changes and sleep tips can improve sleep for older adults (65+) who live alone, have memory concerns, and struggle with insomnia. Over 8 weeks, researchers will visit participants' homes to adjust the bedroom environment and provide s…

This study tests a personalized brain stimulation device for people with primary progressive aphasia (PPA), a condition that slowly destroys language abilities. Ten participants will receive daily 30-minute sessions over three weeks, where an AI analyzes their brain activity and …

This early study tests whether applying nitroglycerin ointment (a medicine that widens blood vessels) to surgical wounds during high-risk leg surgeries can improve blood flow and reduce complications like infection or wound separation. Fifteen adults undergoing specific ankle, he…

This study tests whether a biofeedback breathing system called Freespira can reduce anxiety and panic symptoms in young people aged 9 to 17. Over 8 weeks, one group uses the device while a control group waits. The goal is to see if the device helps lower anxiety scores on a stand…

This study tests whether drinking a ketone supplement (Ketone-IQ) before sleep can improve sleep quality and reduce breathing pauses in people with moderate-to-severe obstructive sleep apnea. Thirty adults who already use CPAP will try the ketone drink for two nights and a placeb…

This study looks at how different doses of THC (the active ingredient in cannabis) affect eye movements and attention. Researchers will test 40 adults—some who use cannabis often and some who use it rarely—to see if eye-tracking can reliably detect impairment. The goal is to deve…

This study will compare custom 3D printed splints made at the hospital with those made by outside companies for jaw surgery. The splints help surgeons align the teeth and jaws correctly during the operation. Researchers want to see if the in-house splints are faster to get, cheap…

This study will test 70 healthy adults aged 21-55 to see how cannabis products labeled as indica, sativa, or generic affect thinking, driving, and feelings. Participants will complete memory tasks, driving simulations, and questionnaires after using cannabis. The goal is to under…

This early-stage study will give 32 healthy adults who use cannabis vaporized THC, beta-myrcene, or a placebo to see how these substances affect their feelings of being high and sleepy. Researchers want to learn how beta-myrcene, a compound found in cannabis and other plants, cha…

This study looks at whether a 50-minute education session can help pregnant and new mothers taking medication for opioid use disorder, along with a friend or family member, learn more about their treatment and newborn withdrawal. Researchers will measure how many women are intere…

This study investigates whether a digital tool embedded in hospital electronic records can help doctors make better decisions about heart tests and consultations before urgent inpatient surgeries. Researchers will compare care patterns and outcomes for about 3,000 adults admitted…

This study will test whether combining continuous glucose monitor (CGM) data with information from a smartwatch and a phone app (like meals and activity) can better predict blood sugar levels in people with type 2 diabetes. Thirty-six adults will wear a CGM and smartwatch and log…

This pilot study tests a new software platform called SOAR that uses AI to analyze videos of surgeries and give feedback to surgical trainees. About 100 participants, including residents and attending surgeons at Johns Hopkins, will use the app to review their own operations and …

This early-phase study tests a special dye called [11C]CPPC used in PET scans to see if it can safely detect brain inflammation in people with ALS. Researchers will compare scans from 20 ALS patients and healthy volunteers to check if the dye highlights areas of inflammation and …