Johns Hopkins University

This phase 3 trial tests whether an oral antioxidant called N-acetylcysteine (NAC) can slow the loss of vision in people with retinitis pigmentosa, an inherited eye disease that causes gradual blindness. About 485 adults aged 18 to 65 are taking NAC or a placebo for several years…

This study tests whether a minimally invasive procedure called Transoral Incisionless Fundoplication (TIF) can reduce acid reflux and prevent Barrett's esophagus from coming back after successful ablation. Barrett's esophagus is a precancerous condition where the lining of the es…

This study tests a program where people with slightly high blood pressure use a home monitor and get support from a community health worker. The goal is to see if this helps keep blood pressure from rising to dangerous levels. About 600 adults from 20 health centers are taking pa…

This study tests a 4-session behavioral program to reduce alcohol use in 450 people with TB and HIV in India. Unhealthy drinking can worsen TB and HIV outcomes. The program is added to usual care, and researchers will check if it lowers alcohol use and improves health. The goal i…

This study tests whether a stepped-care program using digital tools like smart scales, activity trackers, and text messages, plus in-person counseling if needed, can help adults with obesity maintain at least 5% weight loss for a year. About 258 participants first lose weight thr…

This study looks at whether the drug ofatumumab can slow down thinning of the retina (the light-sensitive layer at the back of the eye) in people with relapsing-remitting multiple sclerosis (MS). Researchers will follow 75 adults with MS who are either starting or already taking …

This study is for adult women living with HIV who have experienced intimate partner violence. It tests a program that combines trauma-informed counseling with a safety planning app to improve mental health, HIV management, and safety. The goal is to see if this approach can reduc…

This study tests whether a daily pill called dapagliflozin can help adults with Fontan circulation, a heart condition from birth. Researchers want to see if it lowers pressure in the veins and improves exercise ability. About 29 adults will take the drug for 4 weeks and have chec…

This study follows 629 older adults for 3 years to see if using hearing aids and getting hearing rehab can slow down memory loss and lower the risk of dementia. Participants were already in an earlier trial and now continue with hearing care or a delayed treatment. The goal is to…

This study tests a program called PICU Up! that helps critically ill children in the intensive care unit start moving earlier than usual. The program combines sleep support, delirium prevention, and less sedation to encourage safe mobility. Researchers will see if this approach r…

This study tests a community-based program to help Black and Latino adults with diabetes, prediabetes, high blood pressure, or obesity. Participants receive lifestyle coaching, help connecting to health and social services, and digital skills training. The goal is to see if this …

This study tests whether a brain shunt—a device that drains extra fluid—can improve walking and thinking in older adults with idiopathic normal pressure hydrocephalus (iNPH). One hundred participants will either receive an active shunt or a placebo procedure. The main goal is to …

This study tests a minimally invasive fetoscopic surgery to repair spina bifida in unborn babies. The goal is to close the spinal defect and reverse brain herniation while reducing risks like uterine rupture and preterm birth that come with open fetal surgery. Thirty pregnant wom…

This study tests an experimental drug called MW189 in 120 adults who have had a brain bleed (intracerebral hemorrhage). The goal is to see if the drug is safe and can reduce brain swelling. Participants receive the drug within 24 hours of their stroke and are monitored for side e…

This study looks at whether having a nurse case manager helps people with multidrug-resistant tuberculosis (MDR-TB) and HIV complete their long treatment. About 3,600 patients in South Africa are involved. Half of the clinics have a nurse case manager to guide care, while the oth…

This study tests whether psilocybin, the active ingredient in magic mushrooms, can help people with both major depression and alcohol use disorder. Researchers at Johns Hopkins will give 90 adults either psilocybin or a placebo and track changes in mood and drinking habits. The g…

This study is testing a new device called a multichannel vestibular implant for people who have lost most or all of their balance function due to inner ear damage. The implant electrically stimulates the balance nerve to help improve stability and vision during movement. Up to 30…

This study aimed to see if adding a single high dose of psilocybin (30 mg) to standard buprenorphine treatment could help people with opioid use disorder stay off illicit opioids and improve their quality of life. It planned to enroll adults aged 21–70 who were not already on opi…

This study aimed to test a closed-loop spinal cord stimulation device to reduce spasticity and pain in people who had a stroke or brain injury. It was designed for adults with chronic neuropathic pain and spasticity lasting more than three months. However, the trial was withdrawn…

This study tests a smartphone app and a tablet dashboard for community health workers to support people with both tuberculosis (TB) and HIV in South Africa. The app helps patients stay on track with their medications, while the dashboard alerts health workers if someone needs ext…

This study looks at how ketogenic diets impact heart health in adults with epilepsy. Researchers will measure cholesterol, blood pressure, weight, and artery thickness over 12 months. Participants are adults 18 or older who are already on a keto diet or starting the modified Atki…

This study looks at whether having a trained peer (someone with similar experiences) as a case manager can help people with HIV who also have mental health or substance use problems get the care they need. About 405 adults from an HIV clinic will be randomly assigned to either us…

This study was designed to test a new metal implant called the Artemis Proximal Femoral Nail for fixing a common type of hip fracture. The plan was to compare results from patients who received this implant to similar patients from the past who received other implants. However, t…

This early study tests whether transferring a parent's healthy nasal bacteria to their newborn can help prevent staph infections. Researchers will give the baby a nasal spray containing the parent's bacteria or a placebo, then monitor the baby's nose bacteria and safety. The stud…

This expanded access program tested HBOC-201 (Hemopure), a liquid oxygen carrier made from cow hemoglobin, in adults with life-threatening anemia who cannot receive blood transfusions. The goal was to improve oxygen delivery to tissues. Participants had very low hemoglobin levels…

This trial compares two treatment strategies for people with relapsing-remitting multiple sclerosis: starting with high-efficacy drugs early versus starting with standard first-line therapies and switching if needed. The study involves 900 participants across multiple sites and t…

This study looks at whether a statin drug (atorvastatin) and swapping some saturated fats for healthier ones can safely lower cholesterol in adults with epilepsy who have been on a modified Atkins diet for at least a year. The diet helps control seizures but can raise cholesterol…

This study is testing the long-term safety of a high-dose antioxidant called N-Acetylcysteine (NAC) in 30 adults with retinitis pigmentosa, an inherited eye disease that causes gradual vision loss and blindness. Participants take 1800 mg of NAC twice daily for two years, with reg…

This study tests a procedure called FETO, where a tiny balloon is placed in the windpipe of a fetus with severe left congenital diaphragmatic hernia (CDH). The balloon blocks fluid from leaving the lungs, causing them to grow larger before birth. The goal is to improve survival f…

This study looks at whether being overweight makes children with asthma more sensitive to air pollution. About 200 children from Baltimore, half overweight and half normal weight, will get either real or fake air purifiers in their homes. Researchers will track asthma symptoms to…

This study will screen 200 adults in urban Cameroon for undiagnosed cardiometabolic disease risk factors like high blood pressure, diabetes, and obesity. Participants will receive a simple health check to find hidden conditions. The goal is to improve early detection and connect …

This study tests advanced ultrasound signal processing to make breast images clearer. Researchers will compare new beamforming methods to standard ultrasound in 252 women with breast findings like cysts or microcalcifications. The goal is to better see important features and tell…

This trial tests a wearable insole system that monitors foot pressure, temperature, and movement, giving real-time alerts to help users shift weight and avoid injury. The study includes people with type 1 or 2 diabetes who have nerve damage and a recent history of healed foot ulc…

This study tests a program called ACTFAST that trains doctors and nurses at three children's trauma centers to talk with families about safe firearm storage. The goal is to help prevent gun injuries in kids. Researchers will survey parents, teens, and clinicians to see if the tra…

This study tests a program called ACTFAST in three trauma centers. The program screens injured patients for firearm access, offers brief counseling on safe storage, and connects them to community resources. Researchers will track whether the program increases safe storage practic…

This study tests whether collecting sexual health information electronically during routine gynecologic visits can increase the use of PrEP, a medication that prevents HIV. About 1,170 women aged 15-65 who are not living with HIV will participate. The goal is to see if this appro…

This study tests whether a program combining daily text reminders, nurse home visits, and field-based treatment can help young women (ages 13-25) avoid repeat sexually transmitted infections after being treated for pelvic inflammatory disease (PID). The 150 participants in Baltim…

This study tests whether an injection of hyaluronidase can reduce muscle stiffness and spasticity in the arm after a stroke. 56 adults with moderate-to-severe stiffness will receive either the study drug or a placebo, and later switch to the other option. The goal is to improve r…

This study tests whether drinking a ketone supplement (Ketone-IQ) before bed can improve sleep quality and reduce sleep apnea severity in 30 adults who already use a CPAP machine. Participants will try two different doses and compare effects to a placebo. The goal is to find a si…

This early-stage study tests whether psilocybin (the active ingredient in magic mushrooms) can safely help adults with long-term PTSD who are already taking antidepressants. Twenty participants will receive psilocybin, and some will also get trauma-focused talk therapy. The goal …

This study tests whether a safe, painless brain stimulation technique called tDCS can improve verbal learning in people with Alzheimer's disease. Researchers will compare active stimulation to a sham (fake) version in 90 participants with typical or language-based Alzheimer's. Th…

This study tests whether combining music-based movement cues (patterned sensory enhancement) with mild brain stimulation can improve arm and hand function in people with corticobasal syndrome, a rare brain disorder. Twenty participants will be split into two groups: one receiving…

This phase 2 trial tests whether a single low-dose ketamine infusion can reduce fatigue in people with multiple sclerosis. About 110 adults with MS-related fatigue will receive either ketamine or a mild sedative (midazolam) as a placebo. The study measures changes in fatigue scor…

This study tests a nurse-led program called COORDINATE for older adults (50+) with two or more chronic conditions who are leaving intermediate care units. The program includes discharge planning, symptom tracking, and follow-up calls over 3 months. Researchers will compare it to …

This early-phase study at Johns Hopkins University is testing whether psilocybin, the active compound in magic mushrooms, can safely help people with obsessive-compulsive disorder (OCD). Thirty-five adults with moderate to severe OCD who have already tried other treatments will r…

This study tests a hearing care program for older Korean Americans (age 60+) who have hearing loss but do not use hearing aids. The program includes a low-cost sound amplifier and communication training, delivered in the community. Researchers will compare participants who get th…

This study tests whether a non-invasive brain stimulation technique called tDCS can improve depression and other non-motor symptoms in people with Parkinson's disease. About 80 participants will receive either real or fake (sham) stimulation for 30 minutes over 10 sessions. The g…

This study tests whether the Gracie Diet can reduce symptoms of gastroesophageal reflux disease (GERD) in adults who want to stop taking standard acid-reducing drugs. About 30 participants will stop their medication and follow the diet for 8 weeks. Researchers will track symptom …

This study looks at whether prescribing fewer opioid painkillers after laparoscopic hysterectomy still keeps patients comfortable. About 120 adults having the surgery for non-cancer reasons will be randomly assigned to get a smaller or standard opioid prescription. The goal is to…

This study tests a standardized, high-intensity swallowing therapy program for adults who have trouble swallowing after an ischemic stroke. Researchers will enroll 60 participants in an acute rehab facility to see if the therapy improves swallowing safety and oral intake. The goa…

This study aimed to compare two treatments for chronic low back pain caused by worn-out discs: injections of a person's own stem cells (from bone marrow) versus steroid injections. It planned to enroll adults with pain lasting over 6 months who had not improved with other treatme…

This pilot study is testing a tele-wellness app for family child care providers and parents in Baltimore City. The app offers self-care tips, parenting support, and learning games for children. Researchers want to see if it reduces stress and improves support for those caring for…

This study aims to find early DNA changes in blood and esophageal tissue that could signal a higher risk of developing esophageal cancer. Researchers are studying 600 people with gastroesophageal reflux, Barrett's esophagus, or esophageal cancer who are already scheduled for an u…

This study follows 250 obese adults who are having a weight-loss procedure—either surgery or an endoscopic stomach reduction. The goal is to see how often acid reflux (GERD) develops afterward, including silent reflux with no symptoms. By tracking symptoms and using tests, resear…

This Johns Hopkins study looks at whether a leaky blood-brain barrier and immune changes contribute to cognitive problems in people with ME/CFS (chronic fatigue syndrome), both those who got sick before the pandemic and those who developed it after COVID-19. Researchers will use …

This study follows 350 people who survived a brain bleed (intracerebral hemorrhage) and were part of earlier trials. Researchers will test memory, thinking, and movement skills over time, and collect blood samples to look for signs of ongoing inflammation. The goal is to see if s…

This study looks at how to best help people with serious mental illness take part in a program that lowers heart disease risk. Researchers will test different support strategies at community mental health clinics in Michigan and Maryland. The goal is to find the most effective wa…

This study looks at whether images of the optic nerve head taken at two different eye pressures can predict how glaucoma will change over time. Researchers will compare these strain measurements to actual vision loss in 130 glaucoma patients. The goal is to develop a new biomarke…

This study looks at the bacteria living on the skin and in the gut of people with moderate to severe rosacea compared to healthy volunteers. Researchers want to find unique bacterial patterns in rosacea patients and see how these change after four weeks of antibiotic treatment. T…

This study tests whether a diagnostic stewardship program—a set of guidelines to help doctors decide when to order respiratory cultures—can safely reduce antibiotic use in critically ill children on ventilators. Researchers will track changes in how often cultures are taken and h…

This pilot study tests a digital tool that doctors use during visits to help patients with prediabetes become more active in managing their health. The tool asks patients a few questions and then gives the doctor tips on how to talk about lifestyle changes and resources like heal…

This study looks at whether certain genetic changes (mutations) in endometriosis tissue are linked to resistance to progesterone therapy. Researchers will compare tissue samples from 135 women with and without endometriosis. The goal is to better understand why some cases don't r…

This study uses advanced CT scans to look for fat and scar tissue inside the heart. Researchers want to see if these findings can help predict who is at risk for dangerous heart rhythms. About 110 adults with heart disease who already have a defibrillator or need one will get a C…

This study compares three ways of delivering genetic counseling to adults with inherited heart conditions. Some participants get counseling before testing, others get it after, with or without a required phone call. The goal is to see which approach is most efficient and empoweri…

This study tests a digital literacy program for adults aged 65 and older to help them better communicate with their healthcare team, manage health information, and feel more socially connected. Twenty participants will learn to use digital tools in their own homes. The goal is to…

This study is testing two new types of pulse oximeters—simple devices that measure oxygen levels—for babies and toddlers with pneumonia in Cape Town, South Africa. Researchers want to see if these devices help healthcare workers correctly identify children with low oxygen and ref…

This study analyzes de-identified lipid test results from over 5 million patients to better understand cholesterol and related blood fats. Researchers aim to identify rare lipid disorders and improve how doctors personalize treatment for abnormal blood lipids. The data comes from…

This study tests whether giving young teens rabbits to raise (an economic program) and teaching their parents healthy relationship skills can improve adolescent mental health. Over 3,000 families in rural, conflict-affected areas of the Democratic Republic of Congo are taking par…

This study looks at how psilocybin, the active ingredient in magic mushrooms, changes brain function and thinking in 15 healthy adults. Participants receive psilocybin in a controlled setting while their brain activity is measured with EEG and non-invasive brain stimulation (TMS)…

This study looks at how data from wearable devices (like activity trackers and heart monitors) relates to heart and muscle function in people with a type of heart failure called HFpEF. Researchers will compare 60 adults with and without HFpEF using tests like MRI, exercise testin…

This pilot study at Johns Hopkins will enroll 24 older adults having hip fracture surgery with bone cement. It compares general anesthesia to epidural (neuraxial) anesthesia to see which one lowers the risk of bone cement implantation syndrome—a serious complication that can caus…

This study aims to find the genes and other factors that explain why some people with cystic fibrosis develop diabetes while others do not. Researchers will analyze DNA from 1,500 people with cystic fibrosis and their parents. The goal is to better understand the causes of cystic…

This study is a registry that collects information from patients who have a procedure called percutaneous cholangiopancreatoscopy (PCPS). During PCPS, doctors use a tiny camera to see inside the bile ducts and remove stones or take tissue samples. The goal is to learn how well th…

This long-running study at Johns Hopkins aims to identify the genetic and environmental factors that cause inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis. Researchers are enrolling 2,500 participants — including patients, their family members, …

This study follows 400 adults with HIV to learn how nonalcoholic fatty liver disease (NAFLD) develops and progresses in this group. Researchers will use a non-invasive scan to measure liver stiffness and fat content over one year. The goal is to fill major knowledge gaps, since p…

This study aims to better understand inflammatory bowel disease (IBD) by collecting tissue samples from 1,100 people undergoing endoscopy or bowel surgery. Researchers will analyze gene activity, proteins, and gut microbes to learn what causes the disease. The study includes both…

This study collects blood or skin samples from 100 adults with inherited heart rhythm disorders (like Long QT Syndrome or Brugada Syndrome) and healthy volunteers. Researchers will turn these samples into stem cells and then into heart cells to study how these diseases work and t…

This study aims to find genes that cause inflammatory bowel disease (IBD) specifically in African Americans. Researchers will collect health information and blood samples from 2,400 African Americans, both with and without IBD. No treatment is given—the goal is to better understa…

This study follows 80 people with Neurofibromatosis type 1 (NF1) who are at high risk for developing malignant peripheral nerve sheath tumors (MPNST). Researchers will use yearly whole-body MRI scans, blood samples, and checkups to track changes in nerve lesions over time. The go…

This study aimed to see if giving extra oxygen at night could improve blood sugar control in people living at high altitudes who have sleep-disordered breathing. It was designed for permanent residents of Puno, Peru, but was withdrawn before any participants were enrolled. No res…

This study aims to find new antibodies that may cause autoimmune gastrointestinal motility disorders, where the gut doesn't move food properly. Researchers will collect blood samples from 300 patients with chronic gut symptoms to look for these antibodies. The goal is to better u…

This study tests different ways to reach and enroll women and Black/Latino adults in heart disease research. Participants receive educational text messages about heart health and research opportunities. The goal is to see if these methods increase diversity and trust in clinical …

This study looks at whether having a patient navigator—a person who helps guide you through the healthcare system—can help women get timely follow-up care after an abnormal mammogram. The COVID-19 pandemic caused many delays in cancer diagnosis, especially for at-risk groups. Res…

This study is creating a large registry of 2,000 people with gastroesophageal reflux disease (GERD) and related conditions like Barrett's esophagus. Researchers will collect data from medical records and questionnaires over 5 years to better understand the disease and its treatme…

This study follows 300 patients with severe alcoholic hepatitis who receive early liver transplants, before the usual 6-month sobriety period. Researchers will track how many survive one year after transplant and how many return to drinking. The goal is to better understand the r…

This study looks at whether a mobile health app can help living kidney donors complete their required follow-up visits after donating a kidney. About 400 donors will be randomly assigned to use the app or receive standard care. The goal is to see if the app improves compliance wi…

This study looks at whether MRI scans are safe for people with pacemakers or implantable defibrillators, without the usual strict pre-screening. Researchers will scan up to 4,500 patients who need an MRI and check for device changes right after and weeks later. The goal is to see…

This study tracks 95 people with cancer-related fluid buildup around the lung who have a tunneled pleural catheter. Researchers measure a protein called TGF-B in the fluid to see if it can predict when the fluid stops draining on its own (pleurodesis). The goal is to understand w…

This study compares two ways of doing a lung biopsy (EBUS) for people with known or suspected non-small cell lung cancer. In one group, a cytotechnologist checks the tissue sample on-site during the procedure to give feedback. In the other group, no on-site check is done. The goa…

This study looks at how well people with sarcoidosis take their prescribed medicines and whether that affects their disease. Researchers will follow 150 adults in Maryland and D.C. for one year, tracking lung function, symptoms, and hospital visits. The goal is to find ways to he…

This study uses a mild brain stimulation technique called transcranial direct current stimulation (tDCS) to temporarily disrupt a brain region involved in learning. Researchers want to see if this disruption changes how aware people are of the connection between a tone and an air…

This study tests whether an educational program and a mobile health app can help adults with kidney failure find a living donor for a transplant. About 775 participants who haven't yet identified a donor will take part. The goal is to see if these tools increase the number of liv…

This study looks at whether trained community health workers can help Korean American elders with dementia and their caregivers. About 288 pairs (elder and caregiver) will either get the program or usual care. The goal is to see if the program improves access to medical services …

This pilot study looks at whether a computer-based alcohol intervention, combined with help from a community health worker, can reduce heavy drinking and improve HIV prevention among women. About 12 women who drink heavily and are either living with HIV or at risk for it will tak…

This study tests a 22-week comprehensive sexual education program in 25 rural middle schools in Madagascar, comparing them to 25 schools without the program. Researchers will survey about 4,500 students, plus teachers and directors, to see if the program reduces bullying, dating …

This study is collecting blood and tissue samples from 360 people with early-stage liver cancer who have had surgery to remove their tumors. Researchers want to find biological markers that could predict if the cancer will come back. The goal is to better understand the immune sy…

This study aimed to see if tartrazine, a common food dye, could make skin temporarily transparent in healthy adults. Researchers planned to apply different doses to the back, stomach, and forearm and take photos every 5 minutes. However, the study was withdrawn before any partici…

This study was designed to see how various drugs, including stimulants, cannabinoids, and opioids, affect mood, pain, and thinking in healthy adults aged 18-55. Participants would have taken blinded oral medications and reported their experiences. However, the study was withdrawn…

This study aims to better understand Cleidocranial Dysplasia (CCD), a rare genetic condition affecting bones and teeth. Researchers will collect medical history, quality-of-life surveys, and genetic samples from 300 participants. The goal is to improve diagnosis and care for peop…

This study was designed to test a new ultrasound device with a needle guide for placing a needle into the femoral artery during liver cancer treatment. The goal was to see if the device made the procedure safer and more accurate. However, the trial was withdrawn before enrolling …

This study follows 500 people with neurofibromatosis type 1 (NF1) to see how their skin tumors (called cutaneous neurofibromas) grow and change over time. Researchers use 3D whole-body photography to track tumor number and size each year. The goal is to better understand these tu…

This study aimed to see if providing medically tailored meals, lactation support, and food for children could help Black women with hypertensive disorders of pregnancy control their weight after childbirth. The trial was withdrawn before any participants were enrolled, so no resu…

This study compares placing preterm newborns on their belly versus on their back during the 30–60 seconds of delayed cord clamping after birth. The goal is to see if one position reduces the need for a breathing tube. About 89 babies born between 25 and 30 weeks of pregnancy are …

This early-stage study tests whether a cream made from sulforaphane, a compound found in broccoli, can improve skin aging and protect against damage from sunlight and visible light. Researchers will measure changes in skin proteins linked to aging and fragility in 12 adults. The …

This study looks at whether muscle twitching in the neck during a standard pain treatment (radiofrequency ablation) can help predict who will get good pain relief. Researchers will grade twitching in 60 adults with chronic neck pain and then check if those with more twitching had…

This study tests whether listening to personally meaningful music during a psilocybin session changes emotions, brain activity, and well-being more than standard playlists. One hundred healthy adults will take a single 25 mg dose of psilocybin and listen to one of five music cond…

This study is screening 1,500 adults for oral HPV infection and antibodies to build a group at higher risk for HPV-related throat cancer. Researchers will follow them over time to see which infections persist and what factors (like mouth bacteria or immune response) increase canc…

This study from Johns Hopkins University is testing whether a video camera can accurately measure vital signs like blood oxygen levels. Researchers will record 94 healthy adults and compare video data with standard medical sensors. If it works, this technology could make telemedi…

This study analyzes detailed blood fat measurements from over 5 million people to better understand different types of fat disorders. Researchers are using this large database to identify patterns that could lead to more personalized treatments for abnormal blood fats. The study …