Johns Hopkins University

This large, late-stage trial is testing whether a common antioxidant pill called N-acetylcysteine (NAC) can slow the progression of retinitis pigmentosa, an inherited eye disease that causes gradual vision loss. About 485 adults with the condition will take either NAC or a placeb…

This study aimed to test a spinal cord stimulator (an implanted device) to reduce chronic muscle stiffness (spasticity) and pain in people who have had a stroke. The device was designed to send electrical signals to the spinal cord to calm overactive nerves and muscles. The goal …

This study is testing a fetal surgery procedure called FETO to improve survival for babies with severe congenital diaphragmatic hernia (CDH). Doctors temporarily place a tiny balloon in the baby's windpipe before birth to help the lungs grow. The goal is to see if this procedure …

This study is testing whether a smartphone app can help community health workers better support people in South Africa who have both tuberculosis (TB) and HIV. The app helps coordinate care, allows for video check-ins for medication doses, and provides extra support if someone st…

This study aims to understand the connection between how consistently people with sarcoidosis take their prescribed oral medications and their health outcomes. Researchers will follow 150 patients with lung sarcoidosis for one year to see if better medication adherence is linked …

This study is testing whether having a trained peer supporter helps people with HIV get better care for mental health or substance use problems. About 405 participants at a Johns Hopkins clinic were randomly assigned to either receive this peer support or continue with their usua…

This trial tests an experimental therapy for a severe fetal condition where the baby's kidneys don't work, leaving no protective fluid in the womb. Without treatment, this condition is fatal after birth because the lungs can't develop. The therapy involves carefully placing fluid…

This study is testing whether assigning a dedicated nurse case manager to patients improves treatment success for people with hard-to-treat, drug-resistant tuberculosis (MDR-TB), many of whom also have HIV. In South African hospitals, half will use these nurses to coordinate care…

This study is testing different ways to help community mental health centers successfully offer a proven heart health program to their clients with serious mental illness. Researchers are working with centers in Michigan and Maryland to see which support methods work best for sta…

This study is checking the long-term safety and side effects of a high-dose antioxidant supplement called N-Acetylcysteine (NAC) in 30 adults with retinitis pigmentosa, a disease that damages vision. The goal is to see if people can safely take this medication twice daily for an …

This study is testing if a medication called buspirone can help people with opioid addiction get through withdrawal more comfortably. One hundred adults will stay in a residential unit for 10-12 days to detox and will receive either buspirone, a different withdrawal medication (l…

This study tests whether combining a youth rabbit-farming program with a couples counseling course improves mental health for teenagers in conflict-affected areas of the Democratic Republic of Congo. It involves 3,024 people—teenagers and their parents—across 30 villages. Researc…

This study aims to find safe ways to lower high cholesterol in adults with epilepsy who are on a special high-fat, low-carb diet that controls their seizures. Researchers will test if making small changes to the diet or adding a common cholesterol-lowering pill (a statin) can imp…

This study provided emergency treatment for critically ill patients with dangerously low red blood cell counts who couldn't receive standard blood transfusions. It tested HBOC-201, an oxygen-carrying liquid made from purified cow hemoglobin, as a temporary substitute for blood. T…

This study aimed to test a new type of metal rod (the Artemis PFN) used to fix broken hips. The goal was to see if it was safer, worked better, and was easier for surgeons to use than older implants. The study planned to compare results from patients getting the new implant to pa…

This study aims to find the best position for preterm babies during the first minute after birth when the umbilical cord is still attached. Researchers are testing whether placing babies on their stomachs (prone) or backs (supine) during this time helps them breathe better and re…

This study aims to understand if performing liver transplants earlier for patients with sudden, severe liver failure from heavy alcohol use is safe and effective. Researchers will track 300 patients to see how well they survive and if they return to drinking after transplant. The…

This study aims to determine if liver transplants from deceased donors who have HIV are safe for recipients who also have HIV. It will compare survival and complication rates between patients receiving HIV-positive donor livers and those receiving standard HIV-negative donor live…

This study is testing a program called 'PICU Up!' that aims to help critically ill children in the intensive care unit recover better. The program bundles together promoting sleep, preventing confusion, and safely reducing sedation to allow kids to start moving and sitting up ear…

This study is following older adults for six years to see if using hearing aids can slow down memory loss and thinking problems, and reduce the risk of developing dementia. It builds on a previous 3-year trial and involves about 629 participants aged 70-84 who have untreated hear…

This study investigates whether using air purifiers at home helps overweight children with asthma more than it helps lean children with asthma. Researchers from Johns Hopkins University enrolled 198 children with persistent asthma, giving half real air purifiers and half fake one…

This large trial aims to find the best treatment strategy for people newly diagnosed with relapsing-remitting multiple sclerosis (MS). It compares starting with powerful, higher-risk medications right away versus beginning with traditional, first-line therapies and only switching…

This study is testing if a drug called dapagliflozin, already used for other types of heart failure, can help adults born with a Fontan circulation. The goal is to see if the drug can reduce dangerous fluid pressure in their veins and improve their ability to exercise and feel be…

This study is testing whether a simple smartphone questionnaire can help doctors confirm when someone with multiple sclerosis (MS) is having a true disease relapse. Researchers want to see if this tool, along with better communication with the clinic, can save patients from makin…

This study is testing three ways to help people who inject drugs in India stay on their HIV medication and achieve better health outcomes. It will compare starting treatment the same day as diagnosis versus waiting, receiving care in community centers versus government clinics, a…

This small, early-stage study at Johns Hopkins University is testing whether psilocybin, the active compound in 'magic mushrooms,' is safe and can help reduce symptoms of chronic PTSD. The study involves 20 adults who are already taking standard antidepressant medication. Researc…

This study tests whether community health nurse visits combined with text message support can help young women avoid getting repeat sexually transmitted infections after being treated for pelvic inflammatory disease (PID). Researchers are working with 150 young women in Baltimore…

This study is testing whether a single dose of psilocybin, the active compound in 'magic mushrooms,' can help people who have both major depression and alcohol use disorder. Researchers at Johns Hopkins are comparing the effects of psilocybin to a placebo in 90 participants. The …

This study is testing a less invasive 'keyhole' surgery to repair spina bifida in unborn babies. It aims to provide the same benefits to the baby as traditional open fetal surgery—like potentially reducing brain complications and improving movement—while lowering serious risks fo…

This is a first-in-human study testing a new device called a vestibular implant. It's designed for people who have lost their inner ear's balance function, causing chronic dizziness and unsteady vision. The implant works like a cochlear implant but stimulates the balance nerves i…

This study tests whether training and a Facebook app can help adults with kidney failure find a living person willing to donate a kidney. It compares two new approaches against standard care to see which is better at increasing transplant rates. The goal is to help patients who a…

This study is testing a new support program for women who drink heavily and are at risk for or living with HIV. The program combines a computer-based session with help from a trained community health worker. Researchers want to see if this approach helps women drink less and bett…

This study aimed to see if a single, guided session with the psychedelic compound psilocybin (found in 'magic mushrooms') could improve outcomes for people starting standard medication treatment (buprenorphine) for opioid addiction. Participants would have received either a high …

This early, withdrawn study aimed to see if applying tartrazine, a common yellow food dye, could temporarily make human skin more transparent. The goal was to help doctors see blood vessels and other structures under the skin more clearly for better diagnosis. Healthy volunteers …

This study aims to find out if having a lab technician check tissue samples during a lung biopsy procedure helps doctors collect better quality material for advanced genetic testing. Researchers are comparing the standard biopsy method to one where a technician provides real-time…

This study aimed to test a new ultrasound device designed to help doctors place a needle into a leg artery more safely and accurately. The device was intended for use in patients undergoing a specific liver cancer treatment procedure. The goal was to see if this tool could make t…

This study is testing new ways to process ultrasound signals to create clearer pictures of the breast. Researchers want to see if these advanced techniques can help doctors better see important features like microcalcifications and tell the difference between fluid-filled cysts a…

This study aims to see if a patient navigator can help women get timely follow-up tests after an abnormal mammogram, especially for groups most affected by COVID-19 delays. It will enroll about 196 women and randomly assign them to receive either usual care or support from a navi…

This study is testing whether a special year-long education program in rural middle schools can help prevent violence against young women and girls in Madagascar. About 4,500 students and teachers will participate, with half the schools receiving the program and half not, to comp…

This small pilot study is testing a new program in a primary care clinic to help prevent low blood sugar (hypoglycemia) in people with diabetes who take medications that can cause it. The main goal is to see if the program is practical and acceptable to patients, doctors, and cli…

This study is testing whether having women fill out an electronic health form before a routine gynecology visit can help identify those at risk for HIV and connect them to preventive medication (PrEP). Over 1,100 women are participating. The goal is to see if this automated, clin…

This study aimed to test a food delivery program designed to help Black mothers who had high blood pressure during pregnancy. The goal was to see if providing healthy meals and groceries could help them manage their weight after giving birth and prevent long-term high blood press…

This study is testing a hospital-based program called ACTFAST that aims to prevent firearm injuries. Trauma centers will screen patients for risk factors and provide education about safe firearm storage. Researchers want to see if this approach helps change attitudes and behavior…

This small pilot study is testing whether transferring healthy nose bacteria from a parent to their newborn in the NICU is safe and feasible. The goal is to see if this 'microbiome transplant' can help the baby's nose resist colonization by Staphylococcus aureus, a bacteria that …

This study tests a program to help prevent serious high blood pressure. It combines home blood pressure monitors, a smartphone app for tracking, and regular support from community health workers. The goal is to see if this extra support helps people with slightly elevated blood p…

This study aims to prevent firearm injuries by training doctors and staff at three major children's trauma centers to talk with families about gun safety. It will involve up to 1,000 parents and young patients to see if the training helps doctors provide better safety advice and …

This study is testing whether an affordable, community-based hearing care program can help older Korean Americans communicate better and improve their quality of life. The program provides low-cost hearing amplification devices along with hearing rehabilitation training. Research…

This study is testing a new, intensive swallowing exercise program for adults who have trouble swallowing after a stroke. The program involves two 30-minute therapy sessions per day, 5-6 days a week, focusing on strengthening tongue and breathing muscles. Researchers will measure…

This study aimed to see if a patient's own stem cells, taken from their bone marrow and injected into a worn spinal disc, would work better than a standard steroid injection to ease chronic low back pain. It planned to enroll adults with long-term pain from one or two degenerated…

This study is testing if a drink containing ketones (Ketone-IQ) taken before bed can improve sleep and breathing for people with obstructive sleep apnea (OSA). Researchers want to see if this supplement is a practical alternative to a strict ketogenic diet, which has shown benefi…

This small pilot study is testing whether a personalized coaching program can help older adults feel more confident using technology like tablets and the internet. Researchers from Johns Hopkins will provide devices and home visits to 20 participants to see if improving digital s…

This study is testing if a 3-month course of the antibiotic tetracycline is tolerable and can help reduce symptoms like severe fatigue in people with Post-Treatment Lyme Disease (PTLD). Researchers are comparing the drug to a placebo in 60 participants to see if it eases symptoms…

This study is testing whether low doses of ketamine, given through an IV, can reduce the severe fatigue that many people with multiple sclerosis experience. Researchers at Johns Hopkins are comparing ketamine to a placebo in 110 participants to see if it improves energy levels an…

This study is testing whether short, soap-opera style educational videos can help family caregivers of hospice patients. The videos, shown during regular telehealth visits, are designed to reduce anxiety and increase caregivers' confidence in their role. The study is comparing th…

This study is testing if two non-invasive therapies can help improve arm and hand function in people with corticobasal syndrome (CBS), a rare movement disorder. Twenty participants will receive either a music-based therapy or that therapy combined with gentle brain stimulation. R…

This study is testing a digital app designed to support Baltimore City childcare providers and the parents they serve. The app offers self-care and parenting resources, plus access to a nurse hotline for wellness counseling. It also provides educational games for children to supp…

This study is testing whether a combination of non-opioid pain medications (like ibuprofen and acetaminophen) can control pain just as well as opioid pills after a common outpatient hysterectomy surgery. Researchers want to see if this approach reduces the number of opioid pills …

This study is testing whether a gentle, non-invasive brain stimulation technique can help ease depression and other non-motor symptoms in people with Parkinson's disease. Participants receive either real or sham stimulation for 30 minutes over 10 sessions. The main goal is to see…

This study is testing whether following the Gracie Diet for 8 weeks can improve symptoms of acid reflux disease (GERD). Researchers want to see if this specific way of combining foods can help people feel better and potentially reduce or stop their usual heartburn medications. Th…

This study aims to discover the genetic and environmental factors that cause inflammatory bowel diseases (IBD) like Crohn's disease and ulcerative colitis. Researchers are collecting blood samples from people with IBD, their family members, and healthy volunteers to analyze DNA a…

This study aims to discover new antibodies in the blood that might cause autoimmune gastrointestinal motility disorders, where the immune system mistakenly attacks nerves controlling digestion. Researchers will analyze blood samples from 300 patients who have unexplained, long-te…

This study aims to understand how the brain learns connections between sights, sounds, and sensations, and how this might change with age. Researchers used a mild, non-invasive brain stimulation technique on healthy young adults while they performed simple learning tasks. The goa…

This study is testing a new hospital program designed to help doctors decide when to order lung fluid tests for children on breathing machines in intensive care. The goal is to reduce unnecessary testing, which often leads to overuse of antibiotics. Researchers will compare data …

This study aims to find patterns in the blood and immune system that can predict if liver cancer will come back after surgery. Researchers will collect blood and tissue samples from 360 patients in Vietnam who have had surgery to remove early-stage liver cancer. The goal is to id…

This small, early-stage study is exploring whether a cream containing sulforaphane, a compound found in broccoli, can change how skin ages and reacts to sunlight. Researchers are measuring specific proteins in the skin of 12 healthy adults before and after applying the cream for …

This study is creating a large registry to collect information on patients who undergo a specialized scope procedure for bile duct or pancreas issues, like stones or blockages. It will track how well the procedure works, how often patients can have their drainage tubes removed, a…

This study created a huge database of cholesterol and lipid measurements from over 5 million people to better understand how different types of cholesterol relate to heart disease risk. Researchers analyzed existing lab test results from patients across the United States who had …

This study aims to understand how common hidden risk factors for heart disease and diabetes are among adults in urban Cameroon. Researchers from Johns Hopkins University will screen 200 invited participants to measure things like blood pressure and blood sugar. The goal is to gat…

This study aims to understand how common and severe acid reflux disease (GERD) is in obese patients after they undergo weight-loss procedures. Researchers are following 250 patients who have either surgical or endoscopic weight-loss treatments to track their reflux symptoms and c…

This study aims to see if MRI scans can be done safely for all patients with pacemakers or defibrillators, without needing lengthy and restrictive pre-screening checks. It will include 1,700 participants who have one of these devices and a medical need for an MRI. The goal is to …

This study aims to understand what causes inflammatory bowel diseases (IBD) like Crohn's and ulcerative colitis. Researchers are collecting tissue samples from over 1,100 people during routine endoscopies or surgeries to analyze genes, proteins, and gut bacteria. The goal is to d…

This study collects blood or small skin samples from adults with inherited heart rhythm conditions and healthy family members. Researchers use these samples to create special stem cells that can be turned into heart muscle cells in the lab. The goal is to study these 'disease-in-…

This study aims to find better ways to predict which benign nerve tumors in people with Neurofibromatosis type 1 (NF1) might turn into a dangerous, hard-to-treat cancer called MPNST. Researchers will follow 80 participants considered at high risk, using annual whole-body MRI scan…

This study aims to understand why and when lung fluid stops returning in some cancer patients who have drainage tubes. Researchers will measure a protein called TGF-B in the fluid to see if it can predict which patients' bodies will naturally seal the space. The goal is to help d…

This study is creating a registry to collect information from 2,000 people with chronic heartburn (GERD) and related conditions. Participants will be followed for 5 years to gather data on their symptoms, treatments, and long-term health. The goal is to better understand how thes…

This study aimed to understand if low oxygen levels at night worsen blood sugar control in people living at high altitudes. Researchers planned to test if giving supplemental oxygen during sleep could improve glucose levels. The study was withdrawn before any participants were en…

This research aims to discover the genetic and environmental factors that contribute to inflammatory bowel disease (IBD) in African Americans. The study is enrolling 2,400 African American participants, both with and without IBD, to compare their health information and blood samp…

This study aims to find early DNA changes in blood and tissue that might warn when Barrett's esophagus is turning into cancer. Researchers are analyzing samples from 600 people with acid reflux, Barrett's esophagus, or esophageal cancer to identify these warning signs. The goal i…

This study aims to understand how listening to personally meaningful music compares to standard playlists during a psilocybin session. Researchers at Johns Hopkins will give 100 healthy adults a single dose of psilocybin while monitoring their brain waves, heart rate, and emotion…

This study is testing whether a simple video camera can accurately measure vital signs like heart rate and blood oxygen levels. Researchers at Johns Hopkins are collecting data from 94 healthy adults to build a database for developing future telemedicine tools. The goal is to cre…

This study aims to understand how and why benign skin tumors grow in people with Neurofibromatosis Type 1 (NF1). Researchers at Johns Hopkins will follow 500 participants for five years, using annual 3D whole-body imaging to track changes in these tumors over time. The goal is to…

This early study aims to check if a new imaging tracer is safe for use in brain scans of people with Long COVID. Researchers will give the tracer to 6 people who had COVID-19, some with ongoing symptoms and some without, then perform PET and MRI scans. The goal is to see if this …

This study is testing a new online platform called CONNECT, designed to help more women, Black, and Latino adults join heart disease research. The program sends educational text messages about heart health and clinical trials for one year and helps connect interested people to on…

This study is testing whether a smartphone app can help people who have donated a kidney complete their required health check-ups. About 400 donors will be randomly assigned to use the app for reminders or to follow the standard process. The goal is to see if the app makes it eas…

This study was designed to understand how different drugs and drug combinations affect people's mood, pain tolerance, and mental performance. It planned to enroll healthy volunteers to take study drugs and complete tasks measuring their feelings, thinking, and pain response. The …

This research aims to learn more about cleidocranial dysplasia (CCD), a rare genetic condition affecting bone and tooth development. The study will enroll 300 people with CCD to examine their genes, document their symptoms, and understand how the condition affects their daily lif…

This study aims to understand the long-term effects of ketogenic diets on heart health in adults with epilepsy. Researchers are measuring cholesterol, blood pressure, weight, and artery wall thickness over two years. The study includes adults already on the diet and those startin…

This study aims to understand why some oral HPV infections last a long time and may lead to throat cancer. Researchers are screening 1,500 adults, then following those with signs of the virus for several years to track their health. The goal is to learn which factors put people a…

This study aims to find out if a simple observation during a standard neck pain treatment can predict how well it works. Researchers will watch for muscle twitching in 60 patients undergoing a procedure called radiofrequency ablation for chronic neck pain. They want to see if mor…

This small pilot study aims to understand if the type of anesthesia used affects a dangerous complication called Bone Cement Implantation Syndrome (BCIS) during hip fracture surgery. Researchers at Johns Hopkins will compare general anesthesia (where you are asleep) to spinal/epi…

This study is testing whether a community-based education and navigation program, led by trained community health workers, can help Korean American elders with signs of dementia get connected to medical care. It also aims to see if the program improves caregivers' knowledge, conf…

This study aims to understand how fatty liver disease develops and progresses in people living with HIV. Researchers will follow 400 participants for at least one year, using non-invasive scans to measure liver fat and stiffness. The goal is to fill critical knowledge gaps about …

This study analyzes detailed blood fat measurements from over 5 million people to better understand different types of fat disorders. Researchers are using this large database to identify patterns that could lead to more personalized treatments for abnormal blood fats. The study …