Can two common drugs tame the debilitating symptoms of POTS?

This trial investigates whether guanfacine or cromolyn sodium—two drugs already approved for other conditions—can improve physical functioning and reduce symptoms like fatigue, brain fog, and gastrointestinal issues in adults with postural orthostatic tachycardia syndrome (POTS). Participants will receive each drug and a placebo in random order over three 4-week periods, while continuing standard lifestyle management. The study aims to see if either drug offers meaningful relief compared to placebo and to explore how they might work.