Can CO2 calm POTS? small study investigates
NCT ID NCT04271878
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study looks at whether raising carbon dioxide levels in the blood can lower heart rate and reduce symptoms in people with Postural Orthostatic Tachycardia Syndrome (POTS) when they stand up. Researchers will test different CO2 levels in 26 adults with POTS during a tilt-table test. The goal is to find the best CO2 concentration for symptom relief.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Carbon dioxide (CO2) via RespirAct™ system
- What this could lead to
- If it works, this could point toward a simple breathing-based strategy to help manage POTS symptoms.
- What could go wrong
- This is a very small, early study (26 people) testing a temporary effect, not a treatment. It may not translate into real-world benefit or work for everyone.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
University of Calgary
RECRUITINGCalgary, Alberta, T2N 4Z6, Canada
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Other studies related to the condition(s) this trial covers.
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