Can CO2 calm POTS? small study investigates
NCT ID NCT04271878
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study looks at whether raising carbon dioxide levels in the blood can lower heart rate and reduce symptoms in people with Postural Orthostatic Tachycardia Syndrome (POTS) when they stand up. Researchers will test different CO2 levels in 26 adults with POTS during a tilt-table test. The goal is to find the best CO2 concentration for symptom relief.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Carbon dioxide (CO2) via RespirAct™ system
What this could lead to
If it works, this could point toward a simple breathing-based strategy to help manage POTS symptoms.
What could go wrong
This is a very small, early study (26 people) testing a temporary effect, not a treatment. It may not translate into real-world benefit or work for everyone.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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University of Calgary
RECRUITINGCalgary, Alberta, T2N 4Z6, Canada
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••