Could antibodies be behind POTS? new study investigates
NCT ID NCT02673996
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study is looking at whether people with postural tachycardia syndrome (POTS) have certain antibodies that might be causing their symptoms. Researchers will compare 125 adults with and without POTS, using small doses of two drugs to see how their bodies respond. The goal is to better understand what causes POTS, not to test a new treatment.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Phenylephrine and Isoproterenol
- What this could lead to
- If successful, this could help explain what causes POTS and point toward new treatment targets.
- What could go wrong
- This is an early, small study focused on understanding the disease, not testing a treatment. It may not lead to any direct benefit for patients.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for POSTURAL TACHYCARDIA SYNDROME are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
University of Calgary
RECRUITINGCalgary, Alberta, T2N 4Z6, Canada
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Could ear nerve stimulation calm racing hearts in POTS?
- Can CO2 calm POTS? small study investigates
- Could POTS be an autoimmune disease? new study tests nerve stimulation as a treatment
- Could a blood pressure pill calm racing hearts in POTS?
- POTS patients may get relief from blood pressure drug, early study hints
- Could a nerve drug tame POTS? new trial tests pyridostigmine