University Of Calgary

This study tests whether giving children with a severe E. coli infection extra fluids through an IV can prevent kidney failure. About 1,040 children aged 9 months to 21 years will take part. The goal is to see if this simple approach reduces the need for dialysis or long-term kid…

This study tests whether a virtual home hospital program with remote monitoring can help people recover from acute kidney injury without needing to stay in the hospital. Researchers will enroll 354 adults who are at high risk of readmission. Participants will receive digital tool…

This study tests whether CBD oil (a non-psychoactive cannabis compound) can prevent chronic migraines. About 72 adults with frequent migraines will receive either a low dose of CBD, a higher dose, or a placebo for several months. Researchers will track changes in headache days to…

This study tests a stem cell transplant for children with sickle cell disease who have a matched family donor whose blood type is incompatible. The goal is to see if a gentle conditioning regimen using alemtuzumab, low-dose radiation, and sirolimus can safely allow the transplant…

This study tests whether taking a prebiotic fibre supplement for 6 months can help people with type 1 diabetes have fewer dangerous low blood sugar episodes. Researchers will also see if it improves overall blood sugar control and gut health. The study involves 144 people aged 7 …

This phase 3 trial is testing two different doses of the clot-busting drug tenecteplase in 4,000 people who have had an acute ischemic stroke. The goal is to find out which dose works best and is safest, especially for patients who have taken blood thinners or are undergoing a pr…

This study is testing whether a small, handheld biosensor can accurately measure a brain injury protein (GFAP) in the blood of people with mild concussions. Researchers will compare the sensor's results to standard lab tests and track symptoms over 12 weeks. If it works, this dev…

This study tests whether giving a short course of intravenous Ringer's lactate fluid around the time of an ERCP procedure can prevent pancreatitis, a common and serious side effect. Researchers will enroll 505 adults aged 18-75 who are having their first ERCP. Participants will r…

This study tests whether regular aerobic exercise can prevent or slow memory decline in older adults (ages 50-80) who have memory complaints but no dementia. Participants will be randomly assigned to either an aerobic exercise program or a stretching and toning group for six mont…

This study tests whether using a genetic test to guide antidepressant dosing helps teens aged 12-17 with anxiety or depression. About 452 teens will be randomly assigned to either gene-guided dosing or standard dosing. The goal is to see if the genetic approach leads to more remi…

This trial tests whether a surgeon-given nerve block (TAP block) can improve pain control after a cesarean section. The block uses a long-acting numbing medicine injected into the abdominal wall. Researchers want to see if it reduces the need for narcotics, helps women move soone…

This study tests whether a non-invasive brain stimulation technique called theta burst rTMS can reduce ADHD symptoms in children aged 9 to 15. Thirty participants with an ADHD diagnosis will receive the treatment, and researchers will measure attention and symptom severity. The g…

This study tests whether injecting Botox into leg muscles can reduce pain during exercise in people with chronic exertional compartment syndrome (CECS). Fifty adults with confirmed CECS will receive either Botox or a placebo injection. Researchers will track pain levels and leg f…

This study looks at whether eating more salt can help people with POTS, a condition that causes a fast heart rate and dizziness when standing. Researchers will compare a high-salt diet to a normal-salt diet over 3 months in 50 adults. The goal is to see if extra salt lowers heart…

This study looks at whether wearing compression garments (like tight waist-high stockings or abdominal shapewear) can help adults with POTS feel better and lower their heart rate during normal daily activities. About 30 participants will wear the garments at home and have their h…

This study looks at whether a large IV bag of saline (salt water) can improve thinking problems like brain fog in people with Long COVID or a condition called POTS. About 100 adults will receive either a full or tiny dose of saline to compare effects on reaction time and memory. …

This study looks at whether a simple device that makes you breathe in a little extra carbon dioxide (CO2) can help raise blood pressure in people with a condition called neurogenic orthostatic hypotension (nOH). People with nOH get dizzy or even faint when they stand up because t…

This study looks at whether breathing air with a little extra carbon dioxide can help people with neurogenic orthostatic hypotension (NOH) — a condition where blood pressure drops sharply upon standing, causing dizziness and fainting. Researchers will test this in 80 adults (pati…

This study looks at whether a custom mouthpiece that gently moves the lower jaw forward during sleep can improve sleep quality, heart rate patterns, and blood oxygen levels. About 24 healthy adults aged 40-65 will wear both the active device and a placebo device to compare effect…

This pilot study tests whether probenecid, a drug currently used for gout, can reduce withdrawal symptoms in people with chronic pain who are voluntarily lowering their opioid dose. Researchers will enroll 40 adults and randomly assign them to take probenecid or a placebo for 12 …

This study looks at whether therapeutic cuddling (like kangaroo care or comfort holding) can help reduce pain, agitation, and delirium in children in the pediatric intensive care unit (PICU). About 112 children expected to stay in the PICU for more than 48 hours will be randomly …

This study tests a safe, non-invasive treatment called transauricular vagus nerve stimulation (taVNS) for people with chronic whiplash. It uses mild electrical pulses through the ear to calm the nervous system and may reduce pain, disability, and stress. The trial will enroll 40 …

This study tests a program where cancer patients report symptoms from home using a digital questionnaire. A nurse monitors the results and provides advice between clinic visits. The goal is to see if this improves quality of life and reduces emergency room visits and hospital sta…

This study tests a 12-week wellness program for people waiting for or recovering from a kidney or liver transplant. The program includes exercise, nutrition advice, stress reduction, and sleep support. Researchers want to see if it improves quality of life, fitness, and mood, and…

This pilot study tests whether a topical diclofenac gel (Voltaren) works as well as oral ibuprofen for reducing pain in children aged 6-18 with ankle or knee sprains. Sixty participants will use either the gel or oral medicine three times a day for three days, then report their p…

This study looks at how much walking practice on a special treadmill (split-belt) with virtual reality stroke survivors can handle in early recovery. About 72 people who had their first stroke within the past three months will try different amounts of training to find the safest …

This study tests a smartphone app called ICanWALK that teaches people how to properly fit and use walking aids like crutches, canes, and walkers. Researchers will compare it to a breathing app in 52 adults with lower limb injuries or conditions like stroke or multiple sclerosis. …

This study looks at whether a robotic walking trainer, called Trexo, can help people with walking problems from conditions like cerebral palsy or brain injury. About 120 participants will use the robot in a hospital setting to see if it's practical and helps them reach their pers…

This study is testing whether transcranial magnetic stimulation (TMS) can reduce anxiety and depression in children and teens aged 6 to 18. About 120 participants will receive TMS treatment, and researchers will track symptom changes using questionnaires. The goal is to see if th…

This study tests whether psilocybin (the active ingredient in magic mushrooms) combined with talk therapy can safely reduce symptoms in adults with persisting symptoms after concussion. Forty participants will receive either a high or low dose of psilocybin, plus weekly therapy s…

This study is testing a supervised exercise program for people with cancer. Participants will take part in group exercise classes twice a week for 8 to 12 weeks. The goal is to see if the program helps improve physical activity levels and manage cancer-related symptoms. The study…

This study aims to find out whether the intense subjective experience caused by psilocybin (the active ingredient in magic mushrooms) is necessary for its positive after-effects. 128 healthy adults will receive either a high or low dose of psilocybin, combined with either a place…

This observational study will follow 1,460 girls and women (age 10+) with and without ADHD across Canada. Participants complete surveys about their mental health, hormones, and life experiences. The goal is to build a detailed picture of how ADHD affects females over their lifesp…

This pilot study tests whether having patients with coronary artery disease fill out online surveys about their symptoms and quality of life, and sharing the results with their doctors, is practical and helpful. About 200 patients and their cardiologists will take part. The goal …

Many people with chronic kidney disease also have heart disease, but heart procedures like angiograms and surgery can raise the risk of kidney complications. This study tests an online decision aid called 'My Heart and CKD' that helps patients and doctors weigh the benefits and r…

This study looks at whether a child's genes can predict if they will have certain side effects from common antidepressants (SSRIs). Researchers will collect saliva samples from 120 children and young adults aged 6 to 24 with depression, anxiety, or OCD. The goal is to find geneti…

This study looks at whether raising carbon dioxide levels in the blood can lower heart rate and reduce symptoms in people with Postural Orthostatic Tachycardia Syndrome (POTS) when they stand up. Researchers will test different CO2 levels in 26 adults with POTS during a tilt-tabl…

This study looks at how changing heart rate affects blood flow in the brain. Researchers will temporarily pace the hearts of 20 adults already scheduled for a heart procedure, then measure brain blood flow using ultrasound. The goal is to better understand the link between heart …

Researchers at the University of Calgary are testing a new, non-invasive way to assess heart function using a handgrip exercise. The study involves 100 adults, half with heart failure and half without. Participants squeeze a device with maximum force for two minutes while sensors…

This study is looking at whether people with postural tachycardia syndrome (POTS) have certain antibodies that might be causing their symptoms. Researchers will compare 125 adults with and without POTS, using small doses of two drugs to see how their bodies respond. The goal is t…

This study looks at how different heart rates and body positions change the amount of blood the heart pumps. Researchers will safely adjust the heart rates of 25 people with permanent pacemakers while they lie down or stand up. The goal is to better understand fainting spells (va…

This study tests whether brain-computer interfaces (BCIs) can be used at home by children aged 5-18 with severe physical disabilities, such as cerebral palsy or brain injury. Families receive a BCI kit and participate in 12 virtual coaching sessions over 3-6 months. The goal is t…

This study looks at how changes in brain blood flow affect breathing control during sleep in healthy adults. Researchers will expose participants to normal oxygen and low oxygen levels to see how the brain responds. The goal is to better understand sleep apnea and related conditi…

This study looks at how sleep quality and physical activity are linked to memory in people living in assisted-living facilities. Researchers will measure sleep using monitors and questionnaires, and assess physical function with walking tests. The goal is to find factors that can…

This study looks at better ways to diagnose bile duct stones, which can be dangerous if missed. Current methods often lead to unnecessary procedures. Researchers will test if changes in liver enzyme levels can improve accuracy. About 2000 adults with suspected stones will take pa…

This study is looking at whether giving patients intravenous (IV) fluids right before and during an ERCP procedure can lower their chance of developing pancreatitis afterward. ERCP is a procedure used to diagnose and treat problems in the bile ducts and pancreas, and pancreatitis…

This study is creating a detailed record of 6,000 adults who had an ERCP procedure for bile duct or pancreas problems. Researchers are collecting information before, during, and after the procedure to track complications like pancreatitis or bleeding. The goal is to better unders…

This study looks at how different types and doses of oral iron supplements affect iron levels, exercise performance, and gut health in young female athletes with low iron stores. Participants will take one of three iron supplements every other day for 12 weeks and complete fitnes…

This study looks at whether donor breast milk can help restore healthy gut bacteria in full-term babies born by C-section who need extra feeding. About 90 mothers and their infants will take part, with some babies getting donor milk and others getting formula. The goal is to see …

This study from the University of Calgary is testing a robotic gait trainer called the Trexo in 50 people who have trouble walking due to conditions like cerebral palsy. Researchers want to understand how different settings on the robot (like endurance vs. strength mode) affect h…

This pilot study aims to see if researchers can successfully identify and recruit people who have experienced choking (foreign body airway obstruction) in Alberta, Canada. The study will track adults and children over age 2 who received first aid treatments like abdominal thrusts…

This study looks at whether a fine needle biopsy (a small sample taken with a thin needle) gives the same molecular classification results as a larger surgical sample in people with papillary thyroid cancer. About 130 adults with confirmed or suspected thyroid cancer will provide…

This study looks at how to best help infants (up to 2 years old) who are choking. Researchers in Alberta, Canada will collect information from real-life choking incidents to see which first aid methods work best and are safest. The goal is to improve future guidelines and save mo…

This study explores whether a child's genetic makeup influences how well they respond to the ADHD medication methylphenidate. Researchers will track symptom changes and side effects in 400 participants aged 6-24 across Western Canada. The goal is to find genetic markers that coul…

This study follows 825 pregnant women who need blood thinners for blood clots, observing how these medications are managed around labor and delivery. Researchers aim to see how different strategies affect bleeding risks. The goal is to find safer ways to handle blood thinners dur…

This study looks at how well the drug guselkumab works in adults with Crohn's disease. Researchers will use intestinal ultrasound and blood tests to measure response over one year. The goal is to find better ways to track treatment success without invasive procedures. About 90 pa…

This study is testing whether a smartphone app can help track recovery in 800 sarcoma patients after surgery. Participants will fill out questionnaires and have their phone passively monitor steps, stairs, and other mobility data for up to a year. The goal is to see if this digit…