University Of Calgary

This study tests a stem cell transplant for children with sickle cell disease who have a family donor with a different blood type. The goal is to see if a milder conditioning regimen can safely allow the transplant to work, reducing complications like severe anemia. Up to 12 chil…

This study tests whether taking a prebiotic fiber supplement for 6 months can help people with type 1 diabetes better control their blood sugar and reduce dangerous lows. The researchers will also look at how the supplement affects gut bacteria and gut health. The study involves …

This study tests whether a virtual home hospital program, using digital tools and remote monitoring, can help adults with acute kidney injury recover at home instead of staying in the hospital. The goal is to reduce hospital readmissions and improve long-term outcomes. About 354 …

This study is testing different doses of the clot-busting drug tenecteplase in 4,000 people who have had a stroke caused by a blood clot. The goal is to find the safest and most effective dose, especially for patients who are also on blood thinners or undergoing a procedure to re…

This study tests a wellness program for adults waiting for a kidney or liver transplant. The program includes exercise, nutrition, stress reduction, and sleep support before and after surgery. Researchers want to see if it improves quality of life, physical fitness, and reduces h…

This study looks at three types of iron supplements (low-dose, low-dose yeast-bound, and high-dose) in 36 female athletes aged 16–35 with low iron. Participants take their assigned supplement every other day for 12 weeks and complete fitness tests, blood draws, and gut bacteria s…

This study tests whether a small, hand-held biosensor can accurately measure a brain injury protein in the blood of adults with mild concussion. Researchers will compare the sensor's results to standard lab tests and track symptoms over 12 weeks. The goal is to see if this device…

This study looks at whether regular aerobic exercise can help prevent Alzheimer's and related dementias in older adults who are at higher risk. Researchers will enroll 264 inactive men and women aged 50-80 with memory concerns but no dementia. Participants will either do aerobic …

This study tests whether giving IV fluids for a short time around an ERCP procedure can prevent pancreatitis, a common and serious side effect. About 505 adults aged 18-75 who have not had this procedure before will be enrolled. Researchers will compare different fluid plans to f…

This study looks at whether giving patients extra fluids through an IV right before and during an ERCP procedure can lower their risk of getting pancreatitis afterward. Researchers will track 13,000 adults to find the best timing and amount of fluids. The goal is to create a simp…

This study tests whether a custom mouthpiece that gently moves the lower jaw forward during sleep can improve sleep quality, heart rate patterns, and blood oxygen levels. About 24 healthy adults aged 40-65 will wear both the active device and a placebo device to compare effects. …

This study looks at whether breathing a little extra carbon dioxide can raise blood pressure and improve blood flow to the brain in people with neurogenic orthostatic hypotension (NOH), a condition where blood pressure drops sharply upon standing, causing dizziness or fainting. R…

This study tests a simple device that lets people rebreathe some of their own exhaled CO2 to raise blood pressure. It is for adults with neurogenic orthostatic hypotension, a condition where blood pressure drops sharply upon standing, causing dizziness or fainting. Researchers wi…

This study tests whether probenecid, a safe drug already used for gout, can reduce the unpleasant symptoms of opioid withdrawal in people with chronic pain who are voluntarily lowering their opioid dose. About 40 adults will receive either probenecid or a placebo to see if it hel…

This study looks at whether wearing compression garments (like tight leggings or abdominal shapewear) during normal daily activities can help control heart rate and ease symptoms in people with POTS. Researchers will measure heart rate changes and symptom relief in 30 Canadian ad…

This study tests whether a program that lets cancer patients report symptoms from home using a phone or computer can improve their quality of life and reduce emergency room visits. About 1,055 adults with cancer will use an online questionnaire weekly or monthly and get advice fr…

This study tests whether using a genetic test to guide antidepressant selection helps teens aged 12-17 with anxiety or depression feel better faster and with fewer side effects. About 452 teens will be randomly assigned to either gene-guided prescribing or standard care for 12 we…

This study looks at whether therapeutic cuddling (like kangaroo care or comfort holding) can help reduce pain, agitation, and delirium in children in the pediatric intensive care unit (PICU). About 112 kids expected to stay more than 48 hours will be randomly assigned to receive …

This study tests whether a pain-relief gel applied to the skin works as well as ibuprofen pills for children aged 6 to 18 with recent ankle or knee injuries. About 60 kids will use either the gel or the pills three times a day for three days and report their pain levels. The main…

This study tests whether a robotic gait trainer (the Trexo) can help children and adults with walking impairments from conditions like cerebral palsy or brain injury. Researchers will see if a structured hospital-based training program is practical and helps participants achieve …

This study tests whether psilocybin (the active ingredient in magic mushrooms) combined with talk therapy can safely reduce long-lasting symptoms after a concussion. Forty adults aged 18 to 65 with symptoms lasting 3 months to 5 years will receive either a high or low dose of psi…

This study looks at whether a large dose of IV saline (999 mL) can improve thinking and memory in people with Long COVID or POTS who experience brain fog. Researchers will compare the effects of the large dose to a small placebo dose (50 mL) in 100 adults. The goal is to find a s…

This study tests whether botulinum injections can reduce leg pain during sports in people with chronic exertional compartment syndrome (CECS). About 50 adults with confirmed CECS will receive either the botulinum injection or a placebo. Researchers will track pain levels and leg …

This study tests an 8 to 12-week exercise program for people with or past cancer. The program includes supervised exercise classes, either online or in person. The goal is to help participants become more active and reduce cancer-related symptoms like fatigue. About 740 adults ac…

This study is testing whether a treatment called TMS (transcranial magnetic stimulation) can reduce anxiety and depression in children and teens. About 120 young people aged 6 to 18 with a doctor's diagnosis will receive TMS, which uses magnetic pulses to stimulate the brain. The…

This study looks at whether eating more salt can help people with POTS, a condition that causes a fast heartbeat and dizziness when standing. Researchers will compare a high-salt diet to a normal-salt diet over 3 months in 50 adults. Participants will have tests like tilt-table e…

This study tests whether cannabis (CBD) can reduce the number of headache days in people with chronic migraines. About 72 adults will receive either a low or high dose of CBD or a placebo. Researchers will compare headache frequency before and after treatment to see if CBD helps …

This study looks at whether a child's genes can predict if they will have behavioral side effects from common antidepressants (SSRIs). Researchers will collect saliva samples from 120 children and young adults aged 6-24 with depression, anxiety, or OCD. The goal is to find geneti…

This study tests an online decision aid for adults with both chronic kidney disease and heart disease. The tool helps patients and doctors understand the risks and benefits of heart procedures like angiograms or surgery, which can be riskier for people with kidney problems. About…

This study tests how much walking practice on a special treadmill (split-belt treadmill with virtual reality) stroke survivors can handle in early recovery. About 72 people who had their first stroke within the past week to three months will take part. The goal is to find the rig…

This study looks at how changing your heart rate changes blood flow to your brain. Researchers will temporarily speed up the hearts of 20 adults already scheduled for a heart procedure, using a temporary pacemaker. They will measure brain blood flow with ultrasound to understand …

This study aims to test a new, non-invasive way to measure how well the heart and blood vessels work in adults, both with and without heart failure. Participants will squeeze a handgrip device for two minutes while their heart activity and blood pressure are monitored. The goal i…

This study aims to find out if people with Postural Tachycardia Syndrome (POTS) have certain antibodies that might be causing their symptoms. Researchers will compare blood samples from 125 adults with and without POTS. The goal is to better understand what causes POTS, not to te…

This study looks at how sleep quality and physical activity are linked to memory in people living in assisted-living facilities. Researchers will measure sleep using monitors and questionnaires, and assess memory with thinking tasks. The goal is to find factors that can improve s…

This study looks at how well the drug guselkumab works in adults with Crohn's disease. Researchers will use intestinal ultrasound and blood tests to measure response over one year. About 90 people will take part to help find better ways to track treatment success.

This study is creating a detailed database of 6,000 adults who undergo ERCP, a procedure to diagnose and treat bile duct or pancreas problems. Researchers are tracking complications like pancreatitis, bleeding, or infections within 30 days after the procedure. The goal is to bett…

This study follows 825 pregnant women who need blood thinners for blood clots. Researchers will track how doctors manage these medications around childbirth and the weeks after. The goal is to find the safest approach to prevent bleeding while protecting mother and baby.

This study aims to see if a smartphone app can help track recovery in 800 sarcoma patients after surgery. Participants will fill out health questionnaires and let the app monitor their steps, stairs, and walking patterns for one year. The goal is to better understand how patients…

This study tests whether a smartphone app called ICanWALK can teach people to use walking aids like crutches, canes, and walkers more safely. Researchers will enroll 52 adults who use a walking aid most of the time due to a leg injury, stroke, or multiple sclerosis. Participants …

This study looks at how different heart rates and body positions change the amount of blood the heart pumps. Researchers will safely adjust the heart rates of 25 people with permanent pacemakers while they lie down or stand up. The goal is to better understand fainting (vasovagal…

This study looks at how well different choking treatments work for infants aged 2 years or younger. Researchers in Alberta, Canada will collect information from real-life choking incidents to see which methods are safest and most effective. The goal is to improve first aid guidel…

This study looks at whether a less invasive fine needle biopsy can give the same genetic information as a larger surgical sample in people with papillary thyroid cancer. About 130 adults with suspected or confirmed thyroid cancer will have both samples tested using the Thyroid Gu…

This study looks at how a robotic walking trainer (Trexo) helps people with physical disabilities like cerebral palsy. Researchers want to understand how different robot modes—like full assistance or requiring some effort—affect heart rate, steps, and brain activity. About 50 par…

This study aims to collect information about choking incidents in Alberta, Canada, to understand which first aid treatments work best and are safest for adults and children over age 2. Researchers will test if they can identify and enroll patients quickly after a choking event. T…

This study looks at how changes in blood flow to the brain affect breathing during sleep in healthy adults. Researchers will measure breathing responses to low oxygen and high carbon dioxide levels under normal and low-oxygen sleep conditions. The goal is to better understand bre…

This study tests whether brain-computer interfaces (BCI) can be used at home by children aged 5-18 with severe physical disabilities, such as cerebral palsy or brain injury. The goal is to help them achieve personal goals, like communicating or playing. Researchers will also see …

This study looks at whether donor breast milk can help restore healthy gut bacteria in full-term babies born by C-section who need extra feeding. About 90 mothers and their infants will take part, with some babies getting donor milk and others getting formula. The goal is to see …

This study explores how a child's genetic makeup influences their response to methylphenidate, a common ADHD medication. Researchers will track symptom changes and side effects in 400 participants aged 6 to 24 across Western Canada. The goal is to find genetic markers that could …

This study looks at better ways to diagnose common bile duct stones, which can be dangerous if missed. Researchers will check if changes in liver enzyme levels can help decide who truly needs a procedure called ERCP. The goal is to avoid unnecessary ERCPs, which carry risks, espe…