Magic mushroom therapy could ease persistent concussion symptoms
NCT ID NCT06615908
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether psilocybin (the active ingredient in magic mushrooms) combined with talk therapy can safely reduce symptoms in adults with persisting symptoms after concussion. Forty participants will receive either a high or low dose of psilocybin, plus weekly therapy sessions. The main goals are to check safety, feasibility, and whether symptoms improve over six months.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
psilocybin (the active ingredient in magic mushrooms)
What this could lead to
If it works, this could point toward a new treatment option for people with long-lasting concussion symptoms.
What could go wrong
This is a very early phase 1 trial with only 40 participants, so results may not apply widely. Psilocybin can cause temporary psychological distress, and the low-dose control group may also show effects.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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University of Calgary
RECRUITINGCalgary, Alberta, T2N 2T9, Canada
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••