Magic mushroom therapy could ease persistent concussion symptoms

NCT ID NCT06615908

Recruiting now Symptom relief Sponsor: University of Calgary Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether psilocybin (the active ingredient in magic mushrooms) combined with talk therapy can safely reduce symptoms in adults with persisting symptoms after concussion. Forty participants will receive either a high or low dose of psilocybin, plus weekly therapy sessions. The main goals are to check safety, feasibility, and whether symptoms improve over six months.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: psilocybin (the active ingredient in magic mushrooms)
What this could lead to: If it works, this could point toward a new treatment option for people with long-lasting concussion symptoms.
What could go wrong: This is a very early phase 1 trial with only 40 participants, so results may not apply widely. Psilocybin can cause temporary psychological distress, and the low-dose control group may also show effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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