New hope for kids with sickle cell: stem cell transplant from mismatched blood type donors
NCT ID NCT03214354
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests a stem cell transplant for children with sickle cell disease who have a matched family donor whose blood type is incompatible. The goal is to see if a gentle conditioning regimen using alemtuzumab, low-dose radiation, and sirolimus can safely allow the transplant to work. Up to 12 children aged 1 to 18 will be enrolled.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
stem cell transplant with alemtuzumab, total body irradiation, and sirolimus
What this could lead to
If successful, this could offer a new transplant option for children with sickle cell disease who have a matched family donor with a different blood type.
What could go wrong
This is a small early-phase trial with only 12 participants, so results may not apply broadly. Risks include graft failure, pure red cell aplasia, and side effects from immune suppression.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Alberta Children's Hospital
RECRUITINGCalgary, Alberta, T3B 6A8, Canada
Contact
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Contact Phone: •••-•••-••••
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Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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