STEM CELL TRANSPLANT COMPLICATIONS

This study tests a treatment called tabelecleucel for people who develop a rare, virus-related cancer after an organ or stem cell transplant and whose cancer did not respond to standard therapy. The treatment uses specially matched immune cells to fight the cancer. About 115 part…

This study tests a stem cell transplant for children with sickle cell disease who have a family donor with a different blood type. The goal is to see if a milder conditioning regimen can safely allow the transplant to work, reducing complications like severe anemia. Up to 12 chil…

This early-phase study tests a new stem cell transplant method for people with aggressive or returning acute myeloid leukemia (AML) or myelodysplastic syndromes (MDS). The approach uses specially processed donor cells to reduce the risk of graft-versus-host disease, with the goal…

This study tests whether adding the drug ruxolitinib to standard steroids works better than steroids alone for treating grade II acute graft-versus-host disease (GVHD), a common and serious complication after a stem cell transplant. The trial will enroll 168 people who have recen…

This study tests whether adding the drug ruxolitinib to standard steroids can better control severe graft-versus-host disease (GVHD) after a stem cell transplant. About 54 adults who develop severe GVHD within 100 days of their first transplant will receive the combination. The m…

This study tests whether an 8-week home exercise program, done before a stem cell transplant, can improve muscle strength and physical fitness in people with multiple myeloma. Thirty participants will either exercise or continue normal activities. The goal is to see if pre-transp…

This study tests whether loratadine, a common allergy medicine, can prevent or reduce bone pain caused by a drug called G-CSF used during stem cell collection. About 78 adults with lymphoma or multiple myeloma will receive either loratadine or a placebo. The goal is to see if thi…

This study tests a smartphone app called SHIFT to help stem cell transplant survivors with sexual health concerns. About 300 adults who had a transplant more than three months ago and feel distressed about their sexual health will use the app or receive standard care. The goal is…

This study is looking at how antibiotics given during a stem cell transplant affect the bacteria in your gut. Researchers will track changes in the microbiome over time in 255 adults aged 18-80 who are getting a stem cell transplant for blood cancer or bone marrow failure. The go…