Donor immune cells take on Virus-Linked cancer after transplant

NCT ID NCT03394365

Recruiting now Disease control Sponsor: Pierre Fabre Medicament Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 31, 2026 · Updated 1 time

Summary

This phase 3 trial tests tabelecleucel, a cell therapy made from donor immune cells, in 115 organ or stem cell transplant patients who developed a rare cancer (EBV+ PTLD) after standard treatment failed. The goal is to see if it can shrink tumors and improve outcomes. Participants must have measurable disease and a suitable donor cell match.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: tabelecleucel (a cell therapy using donor immune cells to fight the virus)
What this could lead to: If successful, this could offer a new treatment option for transplant patients with a rare, life-threatening complication when standard therapy fails.
What could go wrong: This is still an experimental therapy; it may not work for everyone, and there are risks like infusion reactions or graft-versus-host disease. The trial is relatively small (115 participants).

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ALLOGENEIC HEMATOPOIETIC CELL TRANSPLANT EPSTEIN-BARR VIRUS+ ASSOCIATED POST-TRANSPLANT LYMPHOPROLIFERATIVE DISEASE (EBV+ PTLD) LYMPHOPROLIFERATIVE DISORDERS SOLID ORGAN TRANSPLANT COMPLICATIONS STEM CELL TRANSPLANT COMPLICATIONS

Contacts and locations

Locations

Alberta Children's Hospital (Adults and Pediatrics)
RECRUITING

Calgary, Alberta, T3B 6A8, Canada
Ann & Robert H. Lurie Children's Hospital of Chicago (Adults and Pediatrics)
RECRUITING

Chicago, Illinois, 60611, United States
Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (Adults and Pediatrics)
RECRUITING

Columbus, Ohio, 43210, United States
Arthur M. Blank Hospital (Pediatrics)
RECRUITING

Atlanta, Georgia, 30329, United States
Azienda Ospedaliera - Universitaria Città della Salute e della Scienza di Torino (Adults only)
COMPLETED

Torino, Torino, 10126, Italy
Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda (Adults only)
COMPLETED

Milan, Milano, 20162, Italy
Baylor Scott and White Research Institute (Adults only)
RECRUITING

Dallas, Texas, 75246, United States
Carolinas Medical Center/Levine Children's Hospital (Adults and Pediatrics)
RECRUITING

Charlotte, North Carolina, 28204, United States
Centre Hospitalier Régional Universitaire de Lille (Adults and Pediatrics)
COMPLETED

Lille, Hauts-de-France, 59037, France
Centre Hospitalier Universitaire de Bordeaux (Adults only)
COMPLETED

Pessac, Aquitaine, 33600, France
Centre Hospitalier Universitaire de Liège Site Sart Tilman (Adults and Pediatrics)
COMPLETED

Liège, Brussels Capital, 4000, Belgium
Children's Hospital Los Angeles, Div. of Research Immunology/BMT (Adults and Pediatrics)
RECRUITING

Los Angeles, California, 90027, United States
City of Hope (Adults and Pediatrics)
COMPLETED

Duarte, California, 91010, United States
Cleveland Clinic Foundation (Adults and Pediatrics)
RECRUITING

Cleveland, Ohio, 44195, United States
Columbia University Medical Center (Adults and Pediatrics)
COMPLETED

New York, New York, 10032, United States
Dana Farber Cancer Institute, Brigham and Women's Hospital (Adults and Pediatrics)
RECRUITING

Boston, Massachusetts, 02215, United States
Duke Cancer Institute (Adults and Pediatrics)
RECRUITING

Durham, North Carolina, 27710, United States
Fiona Stanley Hospital (Adults only)
RECRUITING

Murdoch, Western Australia, 6150, Australia
Fondazione IRCCS Policlinico San Matteo (Adults and Pediatrics)
COMPLETED

Pavia, Pavia, 27100, Italy
Fondazione Policlinico Universitario Agostino Gemelli (Adults only)
COMPLETED

Roma, Roma, 00168, Italy
Froedtert and Medical College of Wisconsin - Clinical Cancer Center (Adults only)
COMPLETED

Milwaukee, Wisconsin, 53226, United States
Hospital Duran i Reynals (Adults and Pediatrics)
RECRUITING

Badalona, BARCELONA, 8908, Spain
Hospital General Universitario Gregorio Marañón (Adults and Pediatrics)
RECRUITING

Madrid, Madrid, 28009, Spain
Hospital Universitari Vall d'Hebrón - Institut de Recerca (Adults and Pediatrics)
RECRUITING

Barcelona, Barcelona, 08035, Spain
Hospital Universitario La Fe (Adults and Pediatrics)
RECRUITING

Valencia, Valencia, 46009, Spain
Hospital Universitario Marqués de Valdecilla (Adults and Pediatrics)
RECRUITING

Santander, Cantabria, 39008, Spain
Hospital of the University of Pennsylvania (Adults only)
RECRUITING

Philadelphia, Pennsylvania, 19104, United States
Hôpital Necker-Enfants Malades (Pediatrics only)
COMPLETED

Paris, Île-de-France Region, 75015, France
Hôpital Saint Antoine (Adults only)
COMPLETED

Paris, Île-de-France Region, 75571, France
Hôpital Universitaire Pitié Salpêtrière (Adults only)
COMPLETED

Paris, Île-de-France Region, 75651, France
Imperial College Healthcare NHS Trust (Adults only)
RECRUITING

London, England, W12 0HS, United Kingdom
King's College Hospital NHS Foundation Trust (Adults only)
COMPLETED

London, England, SE5 9RS, United Kingdom
Loma Linda University Medical Center (Adults only)
RECRUITING

Loma Linda, California, 92354, United States
Loyola University Medical Center (Adults and Pediatrics)
RECRUITING

Maywood, Illinois, 60153, United States
MD Anderson Cancer Center (Pediatrics and Adult)
RECRUITING

Houston, Texas, 77030, United States
MedStar Georgetown University Hospital (Adults and Pediatrics)
RECRUITING

Washington D.C., District of Columbia, 20007, United States
Medical University of South Carolina (Adults and Pediatrics)
COMPLETED

Charleston, South Carolina, 29425, United States
Medizinische Universitat Wien (Adults only)
ACTIVE_NOT_RECRUITING

Vienna, Austria, 1090, Austria
Memorial Sloan Kettering Cancer Center (Adults and Pediatrics)
COMPLETED

New York, New York, 10065, United States
Montefiore Medical Center (Adults only)
COMPLETED

The Bronx, New York, 10467, United States
Montefiore Medical Center (Pediatrics only)
COMPLETED

The Bronx, New York, 10467, United States
Nationwide Children's Hospital (Pediatrics only)
COMPLETED

Columbus, Ohio, 43205, United States
Oregon Health and Science University Physicians Pavilion (Adults and Pediatrics)
RECRUITING

Portland, Oregon, 97239, United States
Ospedale Pediatrico Bambino Gesu (Pediatrics only)
COMPLETED

Roma, Roma, 165, Italy
Princess Margaret Cancer Centre (Adults only)
RECRUITING

Toronto, Ontario, M5G 2M9, Canada
Royal Adelaide Hospital (Adults only)
RECRUITING

Adelaide, South Australia, 5000, Australia
Saint Jude Children's Research Hospital (Pediatrics only)
COMPLETED

Memphis, Tennessee, 38105, United States
Sick Kids (Pediatrics only)
RECRUITING

Toronto, Ontario, M5G 1X8, Canada
The Children's Hospital at Westmead (Pediatrics only)
RECRUITING

Westmead, New South Wales, 2145, Australia
The Children's Hospital of Philadelphia Oncology Division, Blood & Marrow Transplant Section (Pediatrics)
RECRUITING

Philadelphia, Pennsylvania, 19104, United States
The Prince Charles Hospital (Adults only)
COMPLETED

Chermside, Queensland, 4032, Australia
The Royal Children's Hospital Melbourne (Pediatrics only)
RECRUITING

Melbourne, Victoria, 3052, Australia
UCLA Medical Center (Adults and Pediatrics)
COMPLETED

Los Angeles, California, 90095, United States
Universitair Ziekenhuis Leuven (Adults and Pediatrics)
ACTIVE_NOT_RECRUITING

Leuven, Flemish Brabant, 3000, Belgium
University Hospital Virgen del Rocio (Adults and Pediatrics)
RECRUITING

Seville, Spain, 41013, Spain
University Hospitals Birmingham NHS Foundation Trust (Adults only)
RECRUITING

Birmingham, England, B15 2GW, United Kingdom
University of California Davis Comprehensive Cancer Center (Adults only)
COMPLETED

Sacramento, California, 95817, United States
University of California San Diego Moores Cancer Center (Adults only)
COMPLETED

La Jolla, California, 92093, United States
University of Chicago Medical Center - Duchossois Center for Advanced Medicine (Adults only)
COMPLETED

Chicago, Illinois, 60637, United States
University of Florida (Adults and Pediatrics)
COMPLETED

Gainesville, Florida, 32610, United States
University of Maryland School of Medicine (Adults only)
COMPLETED

Baltimore, Maryland, 21201, United States
University of Miami/Jackson Memorial Hospital (Adults only)
RECRUITING

Miami, Florida, 33136, United States
University of North Carolina at Chapel Hill, Lineberger Comprehensive Cancer Center (Adults and Pediatrics)
COMPLETED

Chapel Hill, North Carolina, 27599, United States
University of Pittsburgh Medical Center (Adults only)
COMPLETED

Pittsburgh, Pennsylvania, 15232, United States
University of Texas Southwestern Medical Center - Children's Medical Center (Pediatrics only)
RECRUITING

Dallas, Texas, 75390, United States
Vanderbilt University Medical Center Henry-Joyce Cancer Clinic (Adults and Pediatrics)
RECRUITING

Nashville, Tennessee, 37232, United States
Washington University School of Medicine (Adults only)
RECRUITING

St Louis, Missouri, 63110, United States
Weill Cornell Medicine (Adults only)
COMPLETED

New York, New York, 10021, United States
Westmead Hospital (Adults only)
RECRUITING

Westmead, New South Wales, 2145, Australia
Winship Cancer Institute (Adults only)
COMPLETED

Atlanta, Georgia, 30322, United States
Yale University (Adults and Pediatrics)
COMPLETED

New Haven, Connecticut, 06519, United States

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