Disease related to solid organ transplantation

This phase 3 trial tests tabelecleucel, a cell therapy made from donor immune cells, in 115 organ or stem cell transplant patients who developed a rare cancer (EBV+ PTLD) after standard treatment failed. The goal is to see if it can shrink tumors and improve outcomes. Participant…

This study tests whether giving a long-acting version of the anti-rejection drug tacrolimus early after a lung transplant can help protect kidney function while still preventing organ rejection. About 48 adults who have recently received a lung transplant will be randomly assigne…

This early-stage trial tests whether giving a special mix of blood cells after an organ transplant can help the body accept the new organ without needing lifelong anti-rejection drugs. About 10 children and adults receiving kidney, lung, or intestinal transplants will get the cel…

This study offers a special way to prepare donor stem cells for children and teens under 22 who need a transplant but lack a perfectly matched sibling donor. The method uses the CliniMACS® system to remove certain immune cells, which may help reduce the risk of graft-versus-host …

This study tests a tablet game called Mystic Wizard, designed to help children aged 7-14 who have received a solid organ transplant learn about their daily medications. In the game, players act as a young wizard who must give 'potions' to keep a magical flame (representing their …

This study looks at 60 people getting a stem cell transplant to see if their autonomic nervous system (which controls things like heart rate and sweating) can help predict a serious complication called graft-versus-host disease (GvHD). Participants will have simple nerve tests be…