Could a bone marrow transplant free kidney patients from lifelong pills?

NCT ID NCT06972069

Recruiting now Disease control Sponsor: Tatsuo Kawai, MD, PhD Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jul 23, 2026 · Updated 3 times

Summary

This early-phase trial tests a combined kidney and bone marrow transplant from the same donor to help the body accept the new kidney without needing lifelong anti-rejection drugs. Up to 12 adults with kidney failure will receive the treatment. The goal is to see if this approach can safely reduce or eliminate the need for daily immunosuppression.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Combined kidney and bone marrow transplant with siplizumab, rituximab, tegoprubart, and low-dose cyclophosphamide
What this could lead to: If successful, this could allow kidney transplant recipients to stop or greatly reduce their lifelong anti-rejection medications.
What could go wrong: This is a very early, small trial with only 12 participants. The approach carries risks like graft rejection, infection, and a rare complication called chimeric transition syndrome.

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Conditions

The condition(s) this trial relates to.

disease related to solid organ transplantation end stage renal failure kidney failure

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

IMMUNOSUPPRESION IMMUNOSUPPRESSION AFTER KIDNEY TRANSPLANTATION KIDNEY FAILURE TRANSPLANT RECIPIENT (KIDNEY) TRANSPLANT TOLERANCE

Contacts and locations

Locations

Massachusetts General Hospital
RECRUITING

Boston, Massachusetts, 02114, United States

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