KIDNEY FAILURE

This study looks at how well the shingles vaccine (Shingrix) works and how safe it is in adults with kidney failure who are waiting for a kidney transplant. Some participants will get an extra dose of the vaccine after their transplant to see if it improves their immune protectio…

This study tests whether empagliflozin (Jardiance), a drug currently used for diabetes, can safely raise low sodium levels in patients with conditions like SIADH, liver failure, or kidney failure. About 172 adults with chronic low sodium will receive either the drug or a placebo …

This study tests a new device called the InnAVasc graft, which is placed under the skin to connect an artery and vein for dialysis. It includes 133 adults with end-stage kidney disease who need a graft for hemodialysis. The main goals are to see if the graft stays open and workin…

This early-phase study tests a treatment called Sip-Tego in 12 adults with kidney failure who are getting a living-donor kidney transplant. The goal is to help the body accept the new kidney so patients can take fewer or even no anti-rejection drugs over time. The study checks sa…

This study tests a new preservation solution (Custodiol-N) against the standard one for keeping donated kidneys, livers, and pancreases healthy before transplant. About 362 adults receiving these organs will take part, and researchers will check organ function for 90 days after s…

This study tests whether starting haemodialysis gradually (incremental dialysis) can help maintain quality of life for people with kidney failure. About 372 adults starting dialysis will be randomly assigned to either incremental or standard dialysis. The goal is to see if a slow…

This study tests a new approach using a patient's own modified immune cells (CAR T cells) to lower the risk of rejecting a donated kidney. It is for people with kidney failure who have been on the transplant waiting list for at least a year and have a very high chance of rejectin…

This study looks at whether starting peritoneal dialysis (a type of home dialysis) at a low dose and gradually increasing it is better than the standard full-dose approach. The goal is to see if this gentler start improves quality of life and reduces side effects. The trial invol…

This study tests whether a special egg white pudding can help improve nutrition and frailty in people with kidney failure who are on dialysis. About 54 adults will receive either the egg white pudding or a standard supplement after dialysis three times a week for 12 weeks. The go…

This study looks at whether a home-based exercise program is safe and practical for adults aged 60 and older who are waiting for a kidney transplant. Participants will wear an activity tracker and may be assigned to online exercise classes or usual care. The goal is to see if the…

This study looks at medical records of 10 adults who had a transplant and later got a CMV infection that was hard to treat, along with severe kidney disease or kidney failure (including those on dialysis). The goal is to see if the drug maribavir caused any side effects. No new t…

This study looks at how a gene called APOL1 affects kidney transplant success. People of African ancestry are more likely to have certain versions of this gene that can cause kidney disease. Researchers will test DNA from 5,000 kidney donors and recipients to learn how these gene…

This study aims to understand how blood flow to the kidneys and liver changes in adults seriously injured in accidents. Researchers will use bedside ultrasound scans on 350 patients in intensive care to see if certain blood flow patterns can predict who develops kidney problems o…