New hope for kids on dialysis: drug may stop deadly infections
NCT ID NCT06714864
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests a drug called DefenCath, a liquid placed inside dialysis catheters, to see if it prevents bloodstream infections better than standard care. It involves 36 children from birth to under 18 years old with kidney failure who need hemodialysis. The goal is to keep catheters infection-free longer and improve safety.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- taurolidine and heparin catheter lock solution (DefenCath)
- What this could lead to
- If it works, this could provide a safer way to prevent serious bloodstream infections in children on dialysis, reducing hospital stays and complications.
- What could go wrong
- This is a small, early-phase study with only 36 participants, so results may not apply to all children. The drug may cause side effects or not work better than standard care.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Children's of Alabama/University of Alabama
RECRUITINGBirmingham, Alabama, 35233, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Cook Children's Health Care System
RECRUITINGFort Worth, Texas, 76104, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Hackensack University Medical Center
RECRUITINGHackensack, New Jersey, 07601, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Nemours Children's Hospital - DE
RECRUITINGWilmington, Delaware, 19803, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Phoenix Children's Hospital
RECRUITINGPhoenix, Arizona, 85016, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Stanford
RECRUITINGPalo Alto, California, 94304, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
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