KIDNEY FAILURE

This study looks at how well the shingles vaccine (Shingrix) works in adults with kidney failure who are waiting for a kidney transplant. Researchers want to see if giving an extra dose after the transplant boosts the immune response. About 132 participants will be followed for u…

This study tests the shingles vaccine (SHINGRIX) in 160 people: transplant recipients on different immunosuppressant drugs and their healthy housemates. Researchers will measure immune responses at five time points over a year to see if the vaccine works well in these groups. The…

This early-phase trial tests a combined kidney and bone marrow transplant from the same donor to help the body accept the new kidney without needing lifelong anti-rejection drugs. Up to 12 adults with kidney failure will receive the treatment. The goal is to see if this approach …

This study tests whether a new type of immunotherapy called CAR T cells can safely lower the immune system's reactivity in people waiting for a kidney transplant. Participants have a very high chance of rejecting most donor kidneys (cPRA of 99.5% or higher). The treatment involve…

This study tests a drug called DefenCath, a liquid placed inside dialysis catheters, to see if it prevents bloodstream infections better than standard care. It involves 36 children from birth to under 18 years old with kidney failure who need hemodialysis. The goal is to keep cat…

This study tests whether starting haemodialysis gradually (incremental dialysis) can help preserve quality of life and remaining kidney function in adults with kidney failure. About 372 people who are just beginning dialysis will take part. The goal is to see if this approach is …

This study tests whether a special egg white protein pudding can help people with kidney failure who are on dialysis. Participants will eat one pudding after each dialysis session, three times a week for 12 weeks. The researchers want to see if this is practical and if it improve…

This study tests whether a daily ergothioneine supplement can replenish low levels of this nutrient in people with kidney failure who are on dialysis. Dialysis removes waste but also strips away beneficial chemicals like ergothioneine. Researchers will give 28 participants either…

This study tests whether canagliflozin, a diabetes drug, can improve fluid removal and reduce scarring in people on peritoneal dialysis for kidney failure. Thirty adults will receive either the drug or a placebo for 26 weeks, then switch. The goal is to see if the drug helps the …

This study tests a new device called the InnAVasc graft, which is surgically placed in the arm to provide a reliable access point for hemodialysis in people with end-stage kidney disease. About 133 participants will receive the graft and be followed for two years to see how well …

This study tests whether the diabetes drug empagliflozin (Jardiance) can safely raise low sodium levels in people with certain conditions like SIADH, liver failure, or kidney failure. About 172 adults with chronic low sodium will receive either the drug or a placebo for up to 30 …

This phase 3 trial tests a new solution called Custodiol-N for preserving donated kidneys, livers, and pancreases before transplant. About 362 recipients will be randomly assigned to receive organs stored in either Custodiol-N or the standard Custodiol solution. The goal is to se…

This study tests whether starting peritoneal dialysis (a home-based treatment for kidney failure) at a low dose and gradually increasing it can improve patients' quality of life compared to the standard full-dose approach. About 224 adults new to dialysis will take part. The goal…

This pilot study tests a 13-week Dialectical Behavioural Therapy (DBT) skills training program for Canadians who have recently started or will soon start facility-based hemodialysis. The goal is to see if the program is feasible and helpful for improving mental health and reducin…

This study tests whether a 12-week home-based exercise program is safe and practical for adults aged 60 and older who are waiting for a kidney transplant. Participants will either receive usual care plus a physical activity tracker, or usual care plus the tracker and online exerc…

This study compares two common dialysis methods—high-flux hemodialysis and hemodiafiltration—to see which one causes less fatigue and helps people aged 85 and older recover energy faster after treatment. Each participant will try both methods for three months, acting as their own…

This study follows 350 adults with major injuries admitted to intensive care. Doctors will use a non-invasive bedside ultrasound to check blood flow in the kidneys and liver at several time points. The goal is to see if certain ultrasound patterns are linked to acute kidney injur…

This study is testing whether a special CT scan of the heart (CTCA) can better predict heart attacks and other heart problems in people waiting for a kidney transplant. About 332 patients on the transplant list will get a single CTCA scan before their surgery. Researchers will th…

This study reviews medical records of 10 adult transplant patients who have a hard-to-treat CMV infection along with severe kidney disease or kidney failure. Researchers want to see how safe the drug maribavir is for these patients. No new treatments or procedures are given; the …

This study explores whether a special type of MRI, called manganese-enhanced MRI, can help identify people with kidney disease who are at risk for heart problems. Researchers will scan the heart and kidneys of 120 adults with various kidney conditions, including acute kidney inju…

This study is testing a new device called PatenSee that can check the health of dialysis access points without touching the patient. About 90 adults with kidney failure who need regular dialysis will take part. The device uses light and sound to see and hear the access point, and…

This study tests whether a digital website called Careverse can help caregivers of people with serious illnesses engage more in advance care planning. About 200 caregivers will be randomly assigned to use the website or receive usual care. Researchers will measure how involved ca…