Can dialysis change how a kidney drug works? a trial investigates
NCT ID NCT07754331
First seen Aug 10, 2026 · Last updated Aug 11, 2026 · Updated 1 time
Summary
This early-stage trial is testing whether hemodialysis—a treatment that filters waste from the blood when kidneys fail—changes how the body processes a combination drug called balcinrenone/dapagliflozin. The study will give a single dose of the drug to about 10 people with kidney failure who are on regular dialysis, then measure drug levels in the blood and dialysis fluid. The goal is to see if dialysis removes the drug and whether it is safe and well-tolerated in this group.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- balcinrenone/dapagliflozin (a combination capsule of two drugs)
- What this could lead to
- If successful, this could help doctors understand how to dose this drug combination for people with kidney failure on dialysis, potentially improving treatment options for this population.
- What could go wrong
- This is a small, early-phase study focused on drug levels and safety, not on clinical outcomes. Results may not reflect real-world use, and the drug may still have side effects or fail to show benefit in larger trials.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Research Site
Orlando, Florida, 32809, United States
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Other studies related to the condition(s) this trial covers.
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