LYMPHOPROLIFERATIVE DISORDERS

This study is testing whether a bone marrow or blood stem cell transplant from a healthy donor can cure people with severe primary immune deficiencies. The goal is to replace the patient's faulty immune system with a healthy one from a donor. Researchers are enrolling 354 patient…

This study is testing whether a stem cell transplant can cure people with serious inherited immune system disorders. Doctors will give patients healthy stem cells from a donor to try to rebuild their immune system. The goal is to see if this procedure can successfully replace the…

This study is testing an experimental cell therapy called tabelecleucel for transplant patients who develop a rare cancer caused by Epstein-Barr virus. The treatment uses specially prepared immune cells to target and fight the virus-related cancer in patients who haven't responde…

This trial is testing if a drug called alectinib, already approved for a type of lung cancer, can help treat other rare cancers that share the same genetic change (ALK mutation). It will involve about 30 adults and children with various rare or hard-to-treat cancers. The goal is …

This trial is testing if an existing immunotherapy drug called atezolizumab can help control rare cancers or common cancers with rare genetic features. It will involve about 30 adults and children whose cancers have specific genetic markers. The goal is to see if this approved dr…

This trial is testing if a drug called entrectinib, already approved for some lung cancers, can help control other rare cancers that share the same genetic change (called ROS1-positive). It aims to enroll about 30 adults and children with these rare cancers to see if the drug shr…

This study is testing a stem cell transplant to try to cure or control a rare and aggressive type of blood cancer called peripheral T-cell lymphoma. It is for patients aged 12 and older whose cancer has not responded to standard treatments. Researchers are also testing different …

This early-stage trial is testing the safety of a new gene therapy called KLN-1010 for people with multiple myeloma that has returned after multiple treatments. The therapy aims to reprogram the patient's own immune cells inside their body to attack cancer cells. Researchers will…

This study is testing whether an experimental cell therapy called tabelecleucel can help control diseases caused by the Epstein-Barr virus in people with weakened immune systems. The trial includes 190 participants who have developed serious conditions like lymphomas or sarcomas …

This study is testing an oral drug called pacritinib for people with specific types of T-cell lymphomas that have come back or stopped responding to other treatments. The main goal is to see how well the drug shrinks the cancer and controls the disease. About 100 participants wil…

This study is testing an 8-week online rehabilitation program designed to help cancer survivors manage long-term side effects and improve their daily function. Researchers will compare the virtual program to usual care for 388 adults who have finished primary cancer treatment but…

This study aims to better understand various blood cancers by analyzing patient samples using multiple advanced laboratory techniques. Researchers will examine bone marrow, blood, and tissue samples from 1,040 patients across Italy, both from past collections and new participants…

This study aims to find new treatments for blood cancers like leukemia. Researchers will test hundreds of approved and experimental drugs on cancer cells taken from 250 patients. The goal is to see which drugs work best on different types of cancer cells and to learn why, which c…