Can a donor stem cell transplant fix broken immune systems?

NCT ID NCT02579967

Recruiting now Disease control Sponsor: National Cancer Institute (NCI) Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 07, 2026 · Updated 3 times

Summary

This study tests whether a stem cell transplant from a healthy donor can help people with severe primary immunodeficiencies. Participants aged 4 to 75 receive chemotherapy before the transplant to prepare their body. The goal is to see if the procedure is safe and can improve immune function, though risks like graft-versus-host disease and infection remain.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: allogeneic blood or marrow transplant (stem cells from a healthy donor)
What this could lead to: If successful, this could offer a way to control or improve severe immune system disorders by replacing faulty immune cells with healthy donor cells.
What could go wrong: This is an early-phase trial with risks like graft-versus-host disease, graft failure, and serious infections. Results may not apply to all patients.

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Conditions

The condition(s) this trial relates to.

autoimmune disease autoimmune lymphoproliferative syndrome common variable immunodeficiency immune system disorder inborn error of immunity lymphoproliferative syndrome Opportunistic Infections T cell immunodeficiency primary T-cell immunodeficiency

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

AUTOIMMUNE LYMPHOPROLIFERATIVE COMMON VARIABLE IMMUNODEFICIENCY IMMUNE SYSTEM DISEASES LYMPHOPROLIFERATIVE DISORDERS PRIMARY T-CELL IMMUNODEFICIENCY DISORDERS

Contacts and locations

Locations

National Institutes of Health Clinical Center
RECRUITING

Bethesda, Maryland, 20892, United States
National Marrow Donor Program
RECRUITING

Minneapolis, Minnesota, 55413-1753, United States

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