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Can a donor stem cell transplant fix broken immune systems?

NCT ID NCT02579967

Recruiting now Disease control Sponsor: National Cancer Institute (NCI) Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 01, 2026 · Updated 2 times

Summary

This study tests whether a stem cell transplant from a healthy donor can help people with severe primary immunodeficiencies. Participants aged 4 to 75 receive chemotherapy before the transplant to prepare their body. The goal is to see if the procedure is safe and can improve immune function, though risks like graft-versus-host disease and infection remain.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

allogeneic blood or marrow transplant (stem cells from a healthy donor)

What this could lead to

If successful, this could offer a way to control or improve severe immune system disorders by replacing faulty immune cells with healthy donor cells.

What could go wrong

This is an early-phase trial with risks like graft-versus-host disease, graft failure, and serious infections. Results may not apply to all patients.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

autoimmune disease autoimmune lymphoproliferative syndrome common variable immunodeficiency immune system disorder inborn error of immunity lymphoproliferative syndrome Opportunistic Infections T cell immunodeficiency primary T-cell immunodeficiency

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

AUTOIMMUNE LYMPHOPROLIFERATIVE COMMON VARIABLE IMMUNODEFICIENCY IMMUNE SYSTEM DISEASES LYMPHOPROLIFERATIVE DISORDERS PRIMARY T-CELL IMMUNODEFICIENCY DISORDERS

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • National Institutes of Health Clinical Center

    RECRUITING

    Bethesda, Maryland, 20892, United States

    Contact Phone: •••-•••-••••

  • National Marrow Donor Program

    RECRUITING

    Minneapolis, Minnesota, 55413-1753, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••