IMMUNE SYSTEM DISEASES

This study is testing whether a bone marrow or blood stem cell transplant from a healthy donor can cure people with severe primary immune deficiencies. The goal is to replace the patient's faulty immune system with a healthy one from a donor. Researchers are enrolling 354 patient…

This study is testing whether a stem cell transplant can cure people with serious inherited immune system disorders. Doctors will give patients healthy stem cells from a donor to try to rebuild their immune system. The goal is to see if this procedure can successfully replace the…

This study aims to see if two different drug treatments can help people with rare, hard-to-treat immune disorders get ready for a stem cell transplant. Researchers want to know if the treatments can calm the body's harmful inflammation, making it easier for the new donor cells to…

This is the first human study testing a new treatment called OPF-310, which involves transplanting specially encapsulated insulin-producing cells from pigs into people with unstable type 1 diabetes. The goal is to see if these transplanted cells can safely help control blood suga…

This study is testing a stem cell transplant to try to cure or control a rare and aggressive type of blood cancer called peripheral T-cell lymphoma. It is for patients aged 12 and older whose cancer has not responded to standard treatments. Researchers are also testing different …

This study is testing whether an online training and peer support platform can help teenagers with type 1 diabetes better manage their health as they prepare to move from pediatric to adult healthcare. Researchers will compare the online platform plus usual care against usual car…

This study is testing whether an online training and peer support platform called 'Support' helps adults with type 1 diabetes manage their daily care. Researchers are comparing two groups: one where doctors recommend the platform as part of regular care, and another where people …

This study aims to understand why and how a specific type of white blood cell, called an eosinophil, becomes active in the body. Researchers will observe people with high levels of these cells, which can occur due to allergies, asthma, or parasitic worm infections. The goal is to…

This study aims to observe how patients with moderate-to-severe atopic dermatitis (eczema) respond to the medication abrocitinib in real-world, everyday clinical practice. It will follow 200 patients aged 12 and older who are newly prescribed this medication by their doctor. Rese…

This study aims to learn more about Hyper IgE Syndrome, a rare immune disorder that causes severe eczema and frequent infections. Researchers will observe 300 patients and 300 of their relatives over time to understand how the disease develops, identify its genetic causes, and im…