New drug combo aims to tame inflammation before stem cell transplant

NCT ID NCT05787574

Recruiting now Disease control Sponsor: Joseph Oved Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This phase 2 study tests whether giving emapalumab or a combination of fludarabine and dexamethasone before a stem cell transplant can reduce inflammation and help the donated cells take hold better. The trial involves 39 people with primary immune regulatory disorders or autoinflammatory conditions. Researchers will measure how well the stem cells engraft and track overall survival and event-free survival after the transplant.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Emapalumab (also called Gamifant), fludarabine, and dexamethasone
What this could lead to: If it works, this could point toward a safer way to prepare patients with immune disorders for a stem cell transplant, reducing inflammation and improving the chance of a successful transplant.
What could go wrong: This is a small, early-phase trial with only 39 participants, so results may not apply to everyone. The treatments also carry risks like infection or side effects from the drugs and transplant procedure.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

autoimmune lymphoproliferative syndrome autoinflammatory syndrome immune system disorder inborn error of immunity

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

AUTOIMMUNE LYMPHOPROLIFERATIVE IMMUNE SYSTEM DISEASES PRIMARY IMMUNE REGULATORY DISORDER

Contacts and locations

Locations

Children's Healthcare of Atlanta
RECRUITING

Atlanta, Georgia, 30322, United States
Children's Hospital of Philadelphia
RECRUITING

Philadelphia, Pennsylvania, 19104, United States
Children's Hospital of Wisconsin
RECRUITING

Milwaukee, Wisconsin, 53226, United States
Columbia University Irving Medical Center
RECRUITING

New York, New York, 10032, United States
Memorial Sloan Kettering Basking Ridge
ACTIVE_NOT_RECRUITING

Basking Ridge, New Jersey, 07920, United States
Memorial Sloan Kettering Bergen
ACTIVE_NOT_RECRUITING

Montvale, New Jersey, 07645, United States
Memorial Sloan Kettering Cancer Center
ACTIVE_NOT_RECRUITING

New York, New York, 10065, United States
Memorial Sloan Kettering Monmouth
ACTIVE_NOT_RECRUITING

Middletown, New Jersey, 07748, United States
Memorial Sloan Kettering Nassau
ACTIVE_NOT_RECRUITING

Rockville Centre, New York, 11553, United States
Memorial Sloan Kettering Suffolk - Commack
ACTIVE_NOT_RECRUITING

Commack, New York, 11725, United States
Memorial Sloan Kettering Westchester
ACTIVE_NOT_RECRUITING

Harrison, New York, 10604, United States
Texas Children's Hospital
RECRUITING

Houston, Texas, 77030, United States
University of California, San Francisco
RECRUITING

San Francisco, California, 94143, United States

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