Could a metabolic modulator help people with type 1 diabetes use insulin better?
NCT ID NCT07699380
First seen Jul 13, 2026 · Last updated Jul 14, 2026 · Updated 1 time
Summary
This study tests whether a drug called AMX0035 can improve how the body responds to insulin in adults with type 1 diabetes. Participants take either AMX0035 or a placebo daily for 24 weeks. Researchers measure insulin sensitivity using a glucose clamp test and track blood sugar control with continuous monitors.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- AMX0035 (sodium phenylbutyrate + taurursodiol)
- What this could lead to
- If it works, this could point toward a new way to improve insulin sensitivity and metabolic control in people with type 1 diabetes, potentially reducing insulin needs.
- What could go wrong
- This is a mid-stage trial with only 60 participants, so results may not apply broadly. The drug may not improve insulin sensitivity or could cause side effects.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Amsterdam UMC
NOT_YET_RECRUITINGAmsterdam, Netherlands
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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University of Washington Medicine Diabetes Institute (UWMDI)
RECRUITINGSeattle, Washington, 98109, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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