AUTOIMMUNE DISEASES

This early-stage study tests a personalized cell therapy (CD19 CAR-T) in 15 people with severe autoimmune diseases like lupus that haven't responded to standard treatments. The therapy uses a patient's own immune cells, modified to target and destroy faulty B cells that drive the…

This study tests whether analyzing a person's DNA and RNA can help doctors choose the right targeted therapy for hard-to-classify inflammatory diseases affecting at least two organs (including skin). Researchers will enroll 32 adults and check if the treatment improves symptoms a…

This early-stage study is testing a new treatment for autoimmune diseases like lupus, kidney disease, and scleroderma. It uses specially engineered immune cells (CAR T-cells) from a healthy donor to target and calm the overactive immune system. The main goal is to check safety an…

This early-stage study tests a new drug called BGB-45035 for safety and how the body processes it. First, healthy volunteers receive single or multiple doses. Then, people with autoimmune skin diseases like atopic dermatitis (eczema) or prurigo nodularis receive the drug to check…

This study tests a new treatment using specially engineered immune cells (CAR-T) to target and calm overactive immune cells in people with autoimmune diseases like lupus, scleroderma, and Sjogren's syndrome. About 20 adults aged 18 to 70 with active disease will receive either CD…

This study is testing a new treatment that combines two types of special cells—mesenchymal stem cells and CAR-T cells—to help people with autoimmune diseases. The goal is to see if this combination is safe and can reduce or stabilize symptoms. The study will enroll 30 adults with…

This early-stage study tests a new treatment called anito-cel for people with generalized myasthenia gravis, a condition causing muscle weakness. Anito-cel is a type of CAR-T cell therapy that targets specific immune cells to reduce disease activity. The study will enroll about 3…

This early-stage study tests an injection called GT719 in 10 adults with moderate to severe autoimmune diseases that haven't responded to other treatments. The main goal is to check safety and find the right dose. Researchers will also look for signs that the treatment helps cont…

This early-phase study tests a new treatment called OPF-310, which uses pig islet cells enclosed in a protective capsule, for people with unstable type 1 diabetes who still experience dangerous low blood sugar episodes despite using an automated insulin pump and continuous glucos…

This study tests a new treatment using CD19-CAR T cells for people with severe autoimmune diseases that haven't improved with standard therapies. About 18 participants will receive the cells to see if they can safely control the disease. The goal is to reduce symptoms and manage …

This early-phase study tests a new mRNA-based treatment (ABO2203) for people with autoimmune diseases that haven't improved with standard care. The therapy uses mRNA to produce a protein that helps the immune system attack harmful cells. The main goal is to check safety and toler…

This early-phase study tests a new treatment using specially engineered natural killer (NK) cells to target and calm overactive B cells in children with autoimmune diseases like lupus and IgA nephropathy. The goal is to see if this therapy is safe and can help control the disease…

This early study is testing a new treatment called CD19 CAR-T therapy for people with severe autoimmune diseases like lupus or scleroderma that haven't improved with standard treatments. The therapy uses a patient's own immune cells, modified in a lab to target and attack faulty …

This early-stage study is testing a new treatment called anti-CD19/BCMA universal CAR-T cells for people with severe autoimmune diseases like lupus, scleroderma, and rheumatoid arthritis that haven't responded to standard therapies. The treatment uses specially engineered immune …

This study compares two treatment strategies for people with IgG4-related disease affecting superficial organs like glands or lymph nodes. About 60 adults will receive either prednisone plus iguratimod or prednisone plus leflunomide for 12 months. The goal is to see which combina…

This study is testing a new treatment called STR-P004 for people with autoimmune diseases that have come back or not responded to other treatments. The main goal is to see if it is safe and to find the best dose. About 39 adults will take part, and researchers will watch for side…

This study gives people with blood cancers, immune disorders, and other serious diseases access to unlicensed cord blood units for transplant. It includes both children and adults of any age. The main goal is to see how well the body recovers its white blood cells after the trans…

This study tests whether an online training and peer support platform (Support-t) helps teenagers with type 1 diabetes prepare for moving from pediatric to adult healthcare. About 200 teens aged 14-16 from four Quebec hospitals will either receive usual care or also get access to…

This early-stage study tests a new treatment using specially engineered immune cells (CAR-NK cells) in 12 children with B cell-related autoimmune diseases like lupus or kidney disease. The goal is to see if it is safe and can control the disease by targeting faulty immune cells. …

This early-stage study tests a new injection called AFN50 in 18 adults with active lupus despite standard treatment. The goal is to see if it is safe and can help control the disease by targeting immune cells. Participants will be monitored for side effects and changes in their c…

This early-stage study tests a new treatment called QT-219C, which uses specially engineered immune cells (CAR-T cells) to target and destroy faulty B cells that cause autoimmune diseases like lupus and kidney disease. The treatment involves a one-time infusion after a short chem…

This study tests a simple program to help Black and Latinx adults with rheumatic diseases get the updated COVID-19 vaccine. Participants will receive guidance and support during their regular rheumatology visits. The goal is to see if this approach increases vaccination rates in …

This study tests an online training and support platform designed to help adults with type 1 diabetes better manage their condition. About 322 participants will use the platform for 12 months, either through their usual clinic care or on their own. Researchers will measure change…

This study aims to create a large registry of 800 patients receiving biologic medications for immune diseases like autoimmune conditions and primary immune deficiencies. Researchers will collect medical records, blood samples, and other data to better understand how these treatme…

This study aims to understand why some people with Graves' disease continue to experience mental fatigue even after their thyroid levels return to normal. Researchers will compare blood and spinal fluid samples from 180 participants—60 with mental fatigue, 60 without, and 60 heal…

This study aims to learn more about a group of rare genetic diseases called type 1 interferonopathies, which cause the immune system to be overactive and can affect the brain, joints, and blood. Researchers will follow 500 children and adults with these conditions over time to tr…

This study looks at how newer insulin delivery systems, like automated insulin pumps, affect eating behaviors in people with type 1 diabetes. Researchers want to see if these technologies reduce the burden of carbohydrate counting and lower the risk of disordered eating. About 10…

This study looks at how the immune system of children with celiac disease responds to very small amounts of gluten, like what might happen with accidental exposure. About 51 kids on a strict gluten-free diet will take either a placebo or a low or high dose of gluten for three day…

This study is creating a registry of 1,000 pregnant women with autoimmune diseases like lupus and rheumatoid arthritis. Researchers will track their health and pregnancy outcomes to identify risk factors and ways to improve care for both mothers and babies. The study does not tes…

This study reviews medical records from over 1,200 people with immune thrombotic thrombocytopenic purpura (iTTP), a rare and life-threatening blood disorder. The goal is to understand long-term health issues like heart disease and how new treatments affect survival. No new treatm…

This study aims to understand how genetic changes contribute to autoimmune diseases in people native to Peru. Researchers will recruit 300 participants, including patients with conditions like lupus or rheumatoid arthritis, their family members, and healthy volunteers. Participan…

This study aims to better understand rare genetic diseases that affect both the immune system and the nervous system. Researchers will collect medical information and samples from 1,000 participants, including patients, their relatives, and healthy controls. The goal is to descri…

This study looks at why migraine is more common in people with autoimmune diseases like multiple sclerosis or rheumatoid arthritis. Researchers will measure immune cells and inflammatory markers in 396 women with and without migraine, including those with autoimmune conditions. T…

This study is creating a new tool to help doctors diagnose and choose treatments for autoimmune diseases. Researchers will analyze blood samples from 500 children with autoimmune conditions and healthy children to find patterns in genes and other molecules. The goal is to make di…

This study looks at white blood cells from healthy volunteers and people with autoimmune diseases, inflammation, or liver transplant rejection. The goal is to understand these cells better so scientists can create new engineered regulatory T cell (Treg) therapies. The study invol…

This study aims to help preserve fertility in females under 40 who face infertility due to treatments like chemotherapy or radiation. Participants will have an ovary surgically removed and frozen for future use. Researchers will also study how to improve the freezing and maturati…

This study is collecting blood and other biological samples from 400 children and their relatives who have rare autoimmune or autoinflammatory diseases like lupus. The goal is to find genetic mutations that cause these conditions. No treatments are tested; this is purely a resear…

This study collects tissue and blood samples from 300 people with autoimmune diseases like Crohn's, multiple sclerosis, and celiac disease. Researchers will look for T cells that are active in inflamed tissues to find their targets. The goal is to discover new targets for future …

This study collects medical information and biological samples (blood, tissue, stool) from 1,000 cancer patients receiving immune checkpoint inhibitors. The goal is to understand why some patients develop inflammatory side effects (immune-related adverse events) and find ways to …

This study is collecting health information from up to 10,000 people with conditions like Long COVID, ME/CFS, and autoimmune diseases. Participants use a smartphone app to share symptoms, health history, and wearable data. The goal is to better understand these illnesses and help…