AUTOIMMUNE DISEASES

This study was designed to test an experimental drug called HMPL-523 in adults with immune thrombocytopenia (ITP), a condition where the immune system destroys platelets, causing bleeding problems. The goal was to see if the drug is safe and can raise platelet counts. However, th…

This early-stage study is testing a new treatment called RD06-04, which uses a patient's own immune cells modified to target and attack faulty B cells. The goal is to see if it is safe and tolerable for people with active autoimmune diseases like lupus, scleroderma, and Sjögren's…

This study planned to test a combination of four drugs (ATG, low-dose IL-2, adalimumab, and exenatide) in people aged 18-35 newly diagnosed with type 1 diabetes. The goal was to see if the treatment could help the body keep making its own insulin and improve immune regulation. Ho…

This study tests a non-invasive device that uses low-frequency electromagnetic waves to help immune cells communicate better. The goal is to reduce flare-ups in people with lupus, rheumatoid arthritis, or multiple sclerosis. 120 adults will receive either real or placebo sessions…

This early-phase study tests a new treatment called Prula-cel for people with certain autoimmune diseases like lupus and scleroderma. Prula-cel uses specially engineered immune cells from a healthy donor to target and attack faulty immune cells that cause disease. The main goals …

This study tests an experimental drug called ifetroban in people with a severe form of scleroderma (diffuse cutaneous systemic sclerosis) or scleroderma-related high blood pressure in the lungs. The goal is to see if the drug is safe and can improve lung function. About 34 adults…

This study tests a treatment called Diamyd® in children aged 8 to 17 who are at high risk for type 1 diabetes. The goal is to see if giving the drug directly into lymph nodes is safe and can delay or prevent the disease from developing. Only 5 children with a specific genetic mar…

This study looks at whether giving children with a genetic risk for celiac disease a low-gluten diet (less than 3 grams per day) during their first three years can lower their chance of developing the condition by age 7. Over 1,100 children are taking part. Researchers will check…

This study is a registry that collects information from people with rheumatic or autoimmune diseases who are pregnant or planning pregnancy. Participants fill out surveys and allow researchers to use their medical records to track health, medications, and pregnancy outcomes. The …

This study collects medical information and biological samples from 32 cancer patients starting or restarting immunotherapy. The goal is to better understand why some patients develop immune-related side effects and how to manage them. Researchers hope this knowledge will improve…

This study looks at immune cells (B cells) from people with autoimmune diseases like lupus, people with infections, and healthy volunteers. Researchers want to understand how these cells differ between groups. The goal is to learn more about the immune system, not to test a new t…

This study looks at how memory and thinking skills change after hip or knee replacement surgery. Researchers will test 505 adults aged 50 and older before and after surgery to see how many experience cognitive decline. The goal is to identify risk factors and better understand ho…

This study tests whether offering doctors one-on-one educational meetings about biosimilar medications leads them to prescribe more biosimilars instead of the original brand-name drugs. About 1,325 clinicians who prescribe adalimumab will be randomly offered either an in-person o…