AUTOIMMUNE DISEASES

This early-stage study is testing a new cell therapy for children with severe autoimmune diseases that haven't responded to standard treatments. Researchers are modifying a patient's own natural killer (NK) immune cells to target and remove harmful B cells that drive the disease.…

This early-stage study is testing a new type of cell therapy called anti-CD19/BCMA universal CAR-T cells in people with severe autoimmune diseases that have not improved with standard treatments. The main goals are to check if the treatment is safe and to see if it can help contr…

This early-stage study is testing whether a personalized cell therapy, similar to those used for some blood cancers, can help people with severe autoimmune diseases that haven't responded to standard treatments. Doctors will collect a patient's own immune cells, modify them to ta…

This early-stage study is testing the safety and initial effectiveness of an experimental drug called STR-P004 in adults with autoimmune diseases that have returned or haven't responded to standard treatments. The trial will enroll 39 participants with conditions like lupus and i…

This early-stage study is testing the safety and initial effects of a new type of cell therapy for people with severe autoimmune diseases that haven't responded well to standard treatments. The therapy, called 'universal' CAR-T, uses donated immune cells engineered to target and …

This early-stage study is testing a new injection called AFN50 for people with autoimmune diseases, focusing on lupus that has returned or hasn't responded to standard treatments. Researchers want to see if AFN50 is safe and if it can help control lupus symptoms by measuring dise…

This is the first time a new drug called BGB-45035 is being tested in people. The main goal is to check if it is safe and how the body processes it. The study will first give the drug to healthy volunteers at different doses. Later, a small group of adults with itchy skin conditi…

This study aims to find the better treatment strategy to control IgG4-related disease (IgG4-RD), a rare autoimmune condition, and prevent it from flaring up. It will compare two different combinations of a steroid pill (prednisone) with another immune-modifying drug over 12 month…

This study is testing a new therapy called CD19 CAR T cells for people with severe autoimmune diseases that have not improved with standard treatments. The therapy involves modifying a patient's own immune cells to target and remove the cells causing the disease. The main goals a…

This early-stage study is testing the safety of an experimental cell therapy called GT719 injection in people with moderate to severe autoimmune diseases that haven't responded to standard treatments. The study will enroll 10 participants with conditions like lupus, scleroderma, …

This is a very early study testing a new type of cell therapy for children with severe autoimmune diseases like lupus and scleroderma that haven't improved with standard treatments. Doctors will collect a patient's own immune cells, modify them in a lab to better target the disea…

This study provides access to cord blood units that are not yet FDA-approved for patients who need a transplant for blood cancers or other serious blood/immune disorders. It aims to see how well patients' immune systems recover after receiving these transplants and to monitor for…

This study aims to preserve fertility for girls and women under 40 who face cancer treatments or other conditions that could cause permanent infertility. Participants have one ovary surgically removed and frozen for potential future use when they wish to have children. The resear…

This is the first human study testing a new treatment called OPF-310, which involves transplanting specially encapsulated insulin-producing cells from pigs into people with unstable type 1 diabetes. The goal is to see if these transplanted cells can safely help control blood suga…

This study is testing whether an online training and peer support platform can help teenagers with type 1 diabetes better manage their health as they prepare to move from pediatric to adult healthcare. Researchers will compare the online platform plus usual care against usual car…

This is an early-stage safety study testing a new type of treatment called anito-cel for adults with generalized myasthenia gravis, a chronic autoimmune disease that causes severe muscle weakness. The therapy involves collecting a patient's own immune cells, genetically modifying…

This study is testing a personalized approach for people with severe, hard-to-classify inflammatory diseases that affect multiple organs and have not responded to standard treatments. Researchers will analyze each patient's unique molecular pathways to select a targeted therapy f…

This study is testing whether an online training and peer support platform called 'Support' helps adults with type 1 diabetes manage their daily care. Researchers are comparing two groups: one where doctors recommend the platform as part of regular care, and another where people …

This early-stage study is testing a new mRNA-based therapy called ABO2203 in people with autoimmune diseases that haven't responded well to standard treatments. The main goal is to check if the treatment is safe and tolerable, while also looking for early signs that it might help…

This early-stage study is testing whether a type of cell therapy called CAR-T, which is used to treat some cancers, can help people with serious autoimmune diseases like lupus, scleroderma, and vasculitis. The therapy involves collecting a patient's own immune cells, modifying th…

This study is testing a new clinic-based program designed to help more Black and Latinx adults with autoimmune rheumatic diseases get the updated COVID-19 vaccine. Researchers want to see if providing better information and addressing access issues can increase vaccination rates …

This study is testing whether an experimental drug called Diamyd, injected directly into a lymph node, is safe and can prevent or delay the onset of type 1 diabetes. It involves 16 children and teenagers (ages 8-18) who have specific genetic and immune markers putting them at hig…

This study aims to better understand what causes migraine by investigating the immune system. Researchers will compare levels of specific immune cells and inflammatory signals in women with and without migraine, some of whom also have other autoimmune conditions. The goal is to g…

This study aims to understand how the immune systems of children with celiac disease react to very small, controlled amounts of gluten. About 45 children, who are already on a strict gluten-free diet, will take either a placebo or one of two small gluten doses for three days. Res…

This study aims to build a collection of blood and tissue samples from children with rare autoimmune and autoinflammatory diseases like lupus. Researchers will analyze these samples to identify genetic changes and immune system problems that cause these conditions. The goal is to…

This study aims to understand why some people continue to experience mental fatigue and 'brain fog' even after their Graves' disease thyroid levels are successfully treated. Researchers will compare blood and spinal fluid from 180 people—including Graves' patients with and withou…

This study aims to understand how rare genetic immune disorders called type 1 interferonopathies progress over time in both children and adults. Researchers will follow 500 European patients to track their symptoms, identify patterns, and find biological markers that could help w…

This study aims to discover new targets for future autoimmune disease treatments by analyzing tissue and blood samples. Researchers will collect samples from 300 adults with conditions like Crohn's disease, multiple sclerosis, or ulcerative colitis during periods of active inflam…

This study is creating a registry to learn more about how autoimmune diseases affect pregnancy. It will follow 1,000 pregnant women with conditions like lupus or rheumatoid arthritis to identify risk factors for complications. The goal is to gather information that can help impro…

This study aims to understand the long-term health of people who have survived a rare and life-threatening blood clotting disorder called immune thrombotic thrombocytopenic purpura (iTTP). Researchers will look back at the medical records of over 1,200 patients in France to learn…

This study aims to understand why some cancer patients develop serious, sometimes life-threatening, side effects from a powerful type of treatment called immune checkpoint inhibitors. Researchers will collect blood, tissue, and stool samples from 1,000 patients to look for biolog…

This study aims to collect and analyze white blood cells from healthy volunteers and patients to support the development of new engineered cell therapies. Researchers will examine the number, type, and function of these cells to better understand how they might be used to treat a…

This is a long-term research project gathering health information from 10,000 people in the U.S. to build a detailed picture of brain inflammation and related conditions like Long COVID, ME/CFS, and autoimmune diseases. Participants, including both affected and healthy individual…

This study aims to better understand a group of rare, severe genetic diseases that disrupt the immune system and brain, often leading to poor quality of life and high mortality. Researchers will study 1000 participants, including patients, their family members, and healthy contro…

This study aims to understand if newer automated insulin delivery systems affect eating behaviors and food-related stress in people with type 1 diabetes. Researchers will observe 106 youth and adults in Canada to see if these technologies allow for more flexibility with carb coun…

This study aims to create better tools for diagnosing and treating children with rare, inherited immune system disorders that cause severe autoimmune diseases. Researchers will analyze blood and tissue samples from 500 children to find molecular patterns that predict how their di…

This study aims to understand why autoimmune diseases like lupus and rheumatoid arthritis often appear earlier and are more severe in people of Peruvian ancestry compared to European populations. Researchers will collect blood, urine, and stool samples from 300 participants with …

This study is creating a large registry of patients with immune system diseases who are receiving biologic medications as part of their standard care. Researchers will collect health information and samples from about 800 participants to better understand how these treatments wor…