500-Patient study aims to unravel mysteries of rare immune diseases

NCT ID NCT07040774

Recruiting now Knowledge-focused Sponsor: Imagine Institute Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study follows 500 children and adults with rare genetic disorders called type I interferonopathies, which cause severe inflammation and neurological problems. Researchers will track how the disease progresses over time and look for biological markers to improve diagnosis and guide future treatments. The goal is to better understand these conditions and prepare for more effective clinical trials.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If successful, this study could identify biomarkers and patient subgroups, paving the way for tailored treatments and better-designed future clinical trials.
What could go wrong: This is an observational study, not a treatment trial. It will not directly test any therapy, and results may take years to impact patient care.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

autoimmune disease hereditary disease immune system disorder nervous system disorder type 1 interferonopathy

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

AUTOIMMUNE DISEASES GENETIC DISEASE IMMUNE DYSFUNCTION NEUROLOGICAL DISEASES OR CONDITIONS

Contacts and locations

Locations

APHM Hôpitaux de Marseille
RECRUITING

Marseille, France
Antwerp University Hospital
NOT_YET_RECRUITING

Antwerp, Belgium
CH Agen-Nérac
RECRUITING

Nérac, 47600, France
CHRU Nancy
RECRUITING

Nancy, France
CHU Morvan
RECRUITING

Brest, 29200, France
CHU d'Angers
RECRUITING

Angers, 49000, France
CHU de Besançon
RECRUITING

Besançon, 25030, France
CHU de Bordeaux
NOT_YET_RECRUITING

Bordeaux, France
CHU de Dijon
NOT_YET_RECRUITING

Dijon, 21231, France
CHU de Montpellier
RECRUITING

Montpellier, 34295, France
CHU de Nantes
RECRUITING

Nantes, 44000, France
Children's Hospital Zagreb
NOT_YET_RECRUITING

Zagreb, Croatia
Hacettepe İhsan Doğramacı Children's Hospital
RECRUITING

Ankara, Turkey (Türkiye)
Hospital Universitari Vall d'Hebron
NOT_YET_RECRUITING

Barcelona, Spain
Hospital Universitario Son Espases
NOT_YET_RECRUITING

Palma de Mallorca, Spain
Hôpital Armand Trousseau
NOT_YET_RECRUITING

Paris, 75012, France
Hôpital Bichat
NOT_YET_RECRUITING

Paris, 75018, France
Hôpital Bicêtre
NOT_YET_RECRUITING

Le Kremlin-Bicêtre, 94270, France
Hôpital Claude Huriez, CHU de Lille
NOT_YET_RECRUITING

Lille, 59000, France
Hôpital Femme Mère Enfant - HCL
RECRUITING

Bron, 69500, France
Hôpital Necker Enfants Malades
RECRUITING

Paris, Île-de-France Region, 75015, France
Hôpital Robert Debré
NOT_YET_RECRUITING

Paris, 75019, France
Hôpital de Mercy - CHR Metz Thionville
RECRUITING

Ars-Laquenexy, 57530, France
Hôpital de l'Archet
RECRUITING

Nice, 06200, France
Hôpital des Enfants - CHU de Toulouse
RECRUITING

Toulouse, 31300, France
Hôpitaux Nord Ouest Villefranche
RECRUITING

Gleizé, 69400, France
Karolinska University Hospital
NOT_YET_RECRUITING

Stockholm, Sweden
Leeds Teaching Hospitals NHS Trust
NOT_YET_RECRUITING

Leeds, United Kingdom
Medical University Innsbruck
NOT_YET_RECRUITING

Innsbruck, Austria
Meyer Children's Hospital IRCCS
NOT_YET_RECRUITING

Florence, Italy
Motol University Hospital
NOT_YET_RECRUITING

Prague, Czechia
University of Tübingen
NOT_YET_RECRUITING

Tübingen, Germany

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