Brain fatigue after thyroid disease: immune system may be to blame
NCT ID NCT05678374
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study investigates why some people with Graves' disease continue to feel mentally fatigued even after their thyroid levels return to normal. Researchers will compare blood and spinal fluid from 180 participants—60 with mental fatigue, 60 without, and 60 healthy controls—to find antibodies that may attack brain proteins. The goal is to uncover whether an autoimmune reaction is causing the fatigue, which could lead to better diagnosis or treatments in the future.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
What this could lead to
If successful, this could identify specific immune markers that cause mental fatigue in Graves' disease, pointing toward future treatments.
What could go wrong
This is an early observational study, not a treatment trial. It may not find clear markers, and any findings will need validation in larger studies.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Department of Endocrinology, Sahlgrenska University Hospital
RECRUITINGGothenburg, 41346, Sweden
Contact Phone: •••-•••-•••• Email: •••••@•••••