Brain fatigue after thyroid disease: immune system may be to blame

This study investigates why some people with Graves' disease continue to feel mentally fatigued even after their thyroid levels return to normal. Researchers will compare blood and spinal fluid from 180 participants—60 with mental fatigue, 60 without, and 60 healthy controls—to find antibodies that may attack brain proteins. The goal is to uncover whether an autoimmune reaction is causing the fatigue, which could lead to better diagnosis or treatments in the future.