GRAVES DISEASE

This early-phase study tests a new treatment called HN2301 for people with refractory Graves' disease, a thyroid condition that doesn't get better with standard medication. HN2301 uses a special injection to turn the body's own immune cells into cancer-fighting-like cells that ta…

This study is testing a computer model called OptiThyDose to help doctors find the right dose of thyroid medication for children with congenital hypothyroidism or Graves' disease. About 150 children will take part, and their thyroid hormone levels will be checked to see if the mo…

This early-stage study tests a new drug called MER511 in 100 adults with Graves' disease. The main goal is to see if the drug is safe and what side effects it may cause. Participants will receive the drug either through a vein or under the skin, and blood tests will check how the…

This study tests a new drug called rilzabrutinib in 30 adults with Graves' disease, a condition where the thyroid makes too much hormone. The goal is to see if the drug can safely lower thyroid hormone levels and improve symptoms. Participants will take one of two doses for 16 we…

This early-stage study tests a single injection of a new drug called GenSci098 in 24 adults with Graves' disease, a condition where the thyroid is overactive. The main goal is to see if the drug is safe and what side effects it might cause. Participants must have stopped other th…

This study tests a new drug called IMVT-1402 for adults with Graves' disease whose thyroid levels are still high despite current treatment. About 240 participants will receive either the drug or a placebo to see if it can bring thyroid hormones back to normal and allow patients t…

This pilot study tests whether adding high-dose vitamin D to standard methimazole therapy can help control thyroid function and antibody levels in children aged 9-17 newly diagnosed with Graves' disease. The main goal is to see if a larger trial is possible by measuring recruitme…

This study tests a new medicine called IMVT-1402 for adults with Graves' disease whose thyroid is still overactive despite current treatments. About 210 participants will receive either the drug or a placebo to see if it can bring thyroid levels back to normal and allow them to s…

This early-stage study tests whether BHV-1300 is safe for people with Graves' disease, a condition where the immune system attacks the thyroid. Researchers will also look at how the drug affects certain markers of the disease. About 15 adults with confirmed Graves' disease will t…

This early-stage study tests a new treatment called RD06-05, made from donor immune cells, for people with Graves' disease that hasn't improved with standard care. The goal is to see if it can safely stop the immune system from attacking the thyroid, allowing patients to stop thy…

This study tests whether a person-centred care (PCC) program, delivered by phone and online, can reduce mental fatigue and sick leave in adults with Graves' disease. About 220 people who have had their first episode of Graves' will either receive usual care or usual care plus the…

This study tests the safety of a new, less invasive procedure called thyroid artery embolization (TAE) for people with large, non-cancerous thyroid lumps or an overactive thyroid. Instead of surgery or other treatments, doctors block the blood supply to the thyroid using tiny par…

This study tests whether a special course on managing mental fatigue can improve brain fog, exhaustion, and quality of life in people with Graves' disease. About 96 adults with persistent mental fatigue will either take the course plus standard care or receive standard care alone…

This study aims to understand why some people with Graves' disease continue to experience mental fatigue even after their thyroid levels return to normal. Researchers will compare blood and spinal fluid samples from 180 participants—60 with mental fatigue, 60 without, and 60 heal…

This study examines how inflammation and thyroid antibodies relate to changes in the retina and optic nerve in people with Graves disease. Researchers will review medical records of 100 adults, comparing those with Graves disease (with or without eye involvement) to healthy contr…

This study looks at how changing thyroid hormone levels affects the way the body uses sugar and fat for energy. Researchers will study 60 people with Graves' disease (whose thyroid levels are lowered with medication) and thyroid cancer (whose levels are raised with medication). P…

This study is testing a special collar worn around the neck that measures how the body processes radioactive iodine used to treat thyroid cancer and Graves disease. The goal is to see if this device can give doctors better information to personalize the dose for each patient, pot…