GRAVES' DISEASE

This study is testing whether an investigational drug called IMVT-1402 can help adults with Graves' disease achieve normal thyroid levels without needing to continue their current thyroid medication. Researchers will compare IMVT-1402 against a placebo in 210 participants whose t…

This is the first human study testing a new drug called MER511 for Graves' disease, an autoimmune condition affecting the thyroid. Researchers will give the drug to 100 adults with Graves' disease to check for side effects and see how their bodies process it. The study will test …

This early-stage study is testing the safety of a new medication called GenSci098 for people with Graves' disease, an autoimmune condition that causes overactive thyroid. Researchers will give 24 participants increasing doses of the drug to check for side effects and see how the …

This study is testing a new mathematical model called OptiThyDose. It aims to help doctors calculate more accurate starting doses of thyroid medication for children with congenital hypothyroidism or Graves' disease. The goal is to get hormone levels into the right range faster, w…

This study is testing an investigational drug called rilzabrutinib to see if it can help control Graves' disease, an autoimmune condition that causes an overactive thyroid. About 30 adult participants with Graves' disease, some with and some without related eye problems, will tak…

This early study is testing a new type of treatment called HN2301 for people with Graves' disease that hasn't responded well to standard medications. The treatment aims to use the patient's own immune cells, modified inside the body, to target and control the disease. A small gro…

This study is testing a new, minimally invasive procedure called thyroid artery embolization (TAE) for people with large, non-cancerous thyroid lumps that cause neck pressure, cosmetic concerns, or overactive thyroid. The procedure blocks tiny arteries feeding the thyroid using p…

This study is testing whether an investigational drug called IMVT-1402 can help adults with Graves' disease achieve normal thyroid levels and stop their current thyroid medication. Researchers will compare the drug to a placebo in 240 participants over 26 weeks. The main goal is …

This early-stage study is testing a new type of treatment called CAR-T cell therapy for people with Graves' disease that hasn't responded well to standard medications. The therapy, which is borrowed from cancer treatments, aims to reset the patient's immune system to stop it from…

This is a small pilot study to see if it's practical to run a larger trial testing high-dose vitamin D in children with Graves' disease. It will enroll 30 children and teens (ages 9-17) who are newly diagnosed. The main goal is to check if families are willing to join, if kids ca…

This early study is testing whether a new drug called BHV-1300 is safe for people with Graves' disease, an autoimmune condition affecting the thyroid. Researchers will enroll 15 participants to monitor for side effects and check if the treatment affects specific markers of the di…

This study is testing if a personalized support program can help people with Graves' disease who struggle with long-term mental fatigue. It will enroll 220 adults to compare standard care alone against standard care plus a phone and online support system. The main goal is to see …

This study is testing if a special course about mental fatigue can help people with Graves' disease who struggle with persistent brain fog, poor concentration, and low energy. Researchers will enroll 96 patients and randomly assign them to either take the course along with their …

This study aims to understand why some people continue to experience mental fatigue and 'brain fog' even after their Graves' disease thyroid levels are successfully treated. Researchers will compare blood and spinal fluid from 180 people—including Graves' patients with and withou…

This study is testing a special wearable collar device that continuously measures radiation around the neck. The goal is to see if it can provide more detailed information than current methods about how patients with thyroid cancer or Graves' disease absorb radioactive iodine tre…

This study aims to understand the connection between body-wide inflammation, thyroid antibodies, and potential changes to the back of the eye in people with Graves' disease. Researchers will review the medical records of 100 people, including healthy individuals and those with Gr…

This study aims to understand how changes in thyroid hormone levels affect the body's metabolism. It will observe 60 people with Graves' disease or thyroid cancer as their hormone levels are intentionally adjusted with medication. Researchers will perform sugar tolerance tests to…