New shot could help tame stubborn Graves' disease

NCT ID NCT07570316

Recruiting now Disease control Sponsor: argenx Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 13, 2026 · Updated 4 times

Summary

This study tests a drug called efgartigimod, given as a shot under the skin, for adults with Graves' disease whose thyroid levels are still too high despite taking standard antithyroid drugs. About 230 people will take part, and some will get the drug while others get a placebo. The goal is to see if efgartigimod can help bring thyroid hormone levels back to normal without needing other medications.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: efgartigimod
What this could lead to: If it works, this could offer a new treatment option for people with Graves' disease whose thyroid levels are not well controlled with standard antithyroid drugs.
What could go wrong: This is an early Phase 3 trial, so results are not yet known. The drug may not work better than placebo, and side effects are possible. It is not a cure, and patients may still need ongoing medication.

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Conditions

The condition(s) this trial relates to.

Graves disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

GRAVES DISEASE

Contacts and locations

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Study contacts

Contact

Email: •••••@•••••

Locations

Biopharma Informatic, LLC
RECRUITING

McAllen, Texas, 78503, United States
Clinic of Endocrinology
RECRUITING

Houston, Texas, 77089, United States
Consano Clinical Research
RECRUITING

Shavano Park, Texas, 78231, United States
Diabetes Associates Medical Group
RECRUITING

Orange, California, 92868, United States
Endocrine Associates of West Village PC
RECRUITING

New York, New York, 10016, United States
Havana Research Institute LLC.
RECRUITING

Pasadena, California, 91105, United States
Ilumina Medical Research LLC
RECRUITING

Kissimmee, Florida, 34744, United States
In Vitro Fertilization Center LLC
RECRUITING

Tbilisi, 0159, Georgia
Johnson County Clin-Trials, Inc.
RECRUITING

Lenexa, Kansas, 66219, United States
Juno Research
RECRUITING

Houston, Texas, 77040, United States
LLC American Hospital Network
RECRUITING

Tbilisi, 0102, Georgia
LLC Todua Clinic
RECRUITING

Tbilisi, 0119, Georgia
LTD Israeli-Georgian Medical Research Clinic Healthycore
RECRUITING

Tbilisi, 0112, Georgia
Metro Detroit Endocrinology Center
RECRUITING

Dearborn, Michigan, 48126, United States
New Hospitals
RECRUITING

Tbilisi, 0114, Georgia
Northeast Florida Endocrine & Diabetes Associates (NEFEDA) - Orange Park Location
RECRUITING

Fleming Island, Florida, 32003, United States
Profound Research
RECRUITING

Farmington Hills, Michigan, 48334, United States
Research Institute of Dallas
RECRUITING

Dallas, Texas, 75231, United States
Southern Endocrinology Associates PA
RECRUITING

Mesquite, Texas, 75149, United States
Tekton Research - McKinney
RECRUITING

McKinney, Texas, 75069, United States
Tekton Research Irving
RECRUITING

Irving, Texas, 75039, United States
The Center for Diabetes and Endocrine Care
RECRUITING

Fort Lauderdale, Florida, 33312, United States

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