Can a steroid shot make thyroid surgery safer?

NCT ID NCT05435547

Recruiting now Symptom relief Sponsor: Indiana University Source: ClinicalTrials.gov ↗

First seen Aug 05, 2026 · Last updated Aug 06, 2026 · Updated 1 time

Summary

This trial tests whether taking a short course of dexamethasone before surgery can reduce inflammation in the thyroid gland, making the operation easier for the surgeon. It includes adults with Graves' disease or Hashimoto's disease who are scheduled for a total thyroidectomy. Participants are randomly assigned to receive either the steroid or a placebo before surgery, and surgeons rate the difficulty of the operation using a standard scale.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Dexamethasone (a corticosteroid) taken before surgery
What this could lead to: If it works, a simple pre-surgery steroid course could make thyroid operations less difficult and potentially reduce complications.
What could go wrong: This is a small, early-stage trial, and the benefit may be modest. Steroids carry risks like increased blood sugar or infection, and not all patients may be eligible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Graves disease Hashimoto thyroiditis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

GRAVES DISEASE HASHIMOTO DISEASE

Contacts and locations

Locations

IU Health Methodist Hospital
RECRUITING

Indianapolis, Indiana, 46202, United States
IU Health North Hospital
RECRUITING

Indianapolis, Indiana, 46032, United States
IU Health University Hospital
RECRUITING

Indianapolis, Indiana, 46202, United States

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