Math model aims to perfect thyroid drug doses for kids

NCT ID NCT06864351

Recruiting now Disease control Sponsor: University Children's Hospital Basel Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 26, 2026 · Updated 2 times

Summary

This study tests a computer model called OptiThyDose that helps doctors find the best dose of thyroid medication for children with congenital hypothyroidism or Graves' disease. The model uses past lab results to keep thyroid hormone levels in a healthy range. About 150 children will take part, and half will get doses guided by the model to see if it improves control compared to standard care.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Levothyroxine (LT4) or carbimazole/methimazole (CMZ/MMZ)
What this could lead to: If it works, this could help doctors give children with thyroid disease a more precise drug dose, improving symptom control and reducing the need for frequent blood tests.
What could go wrong: This is an early-stage study with only 150 children, so the model may not work for everyone. It also relies on existing drugs, not a new treatment, so the benefit may be modest.

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Conditions

The condition(s) this trial relates to.

congenital hypothyroidism Graves disease thyroid gland disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CONGENITAL HYPOTHYROIDISM GRAVES DISEASE THYROID DISEASES

Contacts and locations

Locations

Department of Paediatric Endocrinology, Diabetology and Gynaecology, Hôpital Necker-Enfants Malades, Assistance Publique-Hôpitaux de Paris
NOT_YET_RECRUITING

Paris, 75015, France
Paediatric Endocrinology and Diabetology, University Children's Hospital Basel (UKBB)
RECRUITING

Basel, Canton of Basel-City, 4031, Switzerland

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