New pill could tame overactive thyroid in Graves' disease
NCT ID NCT06984627
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This phase 2 trial tests two doses of rilzabrutinib, an oral drug, in 30 adults with Graves' disease (with or without eye problems). The main goal is to see if the drug lowers high thyroid hormone levels over 16 weeks. Researchers will also monitor safety and side effects.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
rilzabrutinib
What this could lead to
If successful, this could point toward a new oral treatment option for Graves' disease that helps control thyroid hormone levels without lifelong medication.
What could go wrong
This is a small, early-phase trial with only 30 participants, so results may not apply broadly. The drug may not effectively lower thyroid hormones or could cause side effects.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Investigational Site Number : 1240001
RECRUITINGSherbrooke, Quebec, J1H 5N4, Canada
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Investigational Site Number : 1240002
RECRUITINGSurrey, British Columbia, V3T 4G8, Canada
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Investigational Site Number : 1240003
RECRUITINGCalgary, Alberta, T2N 4L7, Canada
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Investigational Site Number : 2760001
RECRUITINGFrankfurt, 60590, Germany
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Investigational Site Number : 2760002
RECRUITINGEssen, 45147, Germany
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Investigational Site Number : 3800001
RECRUITINGMilan, Milano, 20122, Italy
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Investigational Site Number : 3800002
RECRUITINGPisa, 56126, Italy
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Investigational Site Number : 3800003
RECRUITINGPalermo, 90127, Italy
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Investigational Site Number : 7240001
RECRUITINGPamplona, Navarre, 31008, Spain
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Investigational Site Number : 7240002
RECRUITINGBarcelona, Catalunya [Cataluña], 08036, Spain
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Investigational Site Number : 7240004
RECRUITINGSeville, Sevilla, 41009, Spain
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Investigational Site Number : 8260001
RECRUITINGNewcastle upon Tyne, England, NE2 4HH, United Kingdom
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Investigational Site Number : 8260003
RECRUITINGMilton Keynes, Buckinghamshire, MK6 5LD, United Kingdom