AUTOIMMUNE DISEASES

This study tests a new drug called ATH-063 in people with moderate to severe ulcerative colitis who have not improved with other advanced treatments. The goal is to see if the drug can reduce symptoms like diarrhea and bleeding and help the gut heal. About 120 adults will receive…

This early-phase study tests a new mRNA drug that targets and clears faulty immune cells (B cells and plasma cells) in people with relapsed autoimmune diseases. The goal is to reset the immune system and reduce symptoms. About 27 adults aged 18-70 will receive the treatment to ch…

This study tests a new treatment using a patient's own immune cells, modified to target and attack faulty immune cells that cause autoimmune diseases. It is for people with severe lupus or other autoimmune conditions that have not responded to standard therapies. The goal is to c…

This early-phase study tests a new drug called WGb-0301 for people with autoimmune diseases (like lupus or autoimmune hepatitis) that have not responded to standard treatments. The drug uses mRNA technology to target and clear certain immune cells (B cells) that are causing the d…

This early-phase study tests an experimental drug called S-4321 in 24 adults with autoimmune diseases like rheumatoid arthritis, psoriasis, lupus, or eczema. The main goal is to check safety and how the body processes the drug. Researchers will also look at early signs of effecti…

This early-phase study tests a new mRNA therapy for people with severe autoimmune diseases like lupus or immune anemia. The treatment uses lipid nanoparticles to deliver mRNA that targets and clears harmful B cells. The goal is to control the disease and reduce symptoms, but ongo…

This early study tests a new drug called STR-P004 in 9 adults with immune-mediated kidney diseases. The goal is to see if the drug is safe and how the body processes it. Participants will receive up to 8 infusions over 1-2 months, with possible dose increases to find the best lev…

This study tests a new drug called inectolizumab combined with steroids in people newly diagnosed with neuromyelitis optica spectrum disorder (NMOSD), a rare autoimmune disease that attacks the nerves. The goal is to see if the drug can help control the disease while allowing pat…

This study tests a new treatment called CD19/BCMA CAR-T for people with severe autoimmune diseases like lupus and Sjögren's syndrome that haven't improved with standard care. The therapy uses a patient's own immune cells, modified in a lab to target and attack faulty immune cells…

This study looks at a new way to offer vaccines to adults with chronic illnesses or weakened immune systems while they are in the hospital. The goal is to see if offering vaccines during hospital visits helps more people get vaccinated. Researchers will track how many patients ar…

This study will follow 5,000 adults with immune system issues to see how often they also have clonal hematopoiesis (a type of blood cell change) or related blood diseases like VEXAS syndrome. Researchers will track new cases over time to better understand these conditions. No tre…