Immune system reset: CAR T-Cells take on autoimmune diseases
NCT ID NCT07161193
First seen Jun 26, 2026 · Last updated Jun 26, 2026
Summary
This study tests a new treatment using CD19 CAR T-cells for people with severe autoimmune diseases that haven't improved with standard therapies. About 30 participants will receive a single dose of these engineered immune cells after chemotherapy. The goal is to see if it's safe and can control the disease by targeting and destroying faulty immune cells.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- CD19 CAR T-cells (a type of immune cell therapy)
- What this could lead to
- If successful, this could offer a new way to control severe autoimmune diseases that haven't responded to other treatments, potentially reducing symptoms and need for ongoing medications.
- What could go wrong
- This is an early-phase trial with only 30 participants, so results may not apply to everyone. There are serious risks like cytokine release syndrome and nerve toxicity, and it's unclear if the effects will last without continued treatment.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Henan Province Engineering Technology Research Center of Immunological Precision Medicine and Artificial Intelligence Application, The Second Affiliated Hospital of Henan University of Science and Technology, Luoyang, China
Luoyang, Henan, 471003, China
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