Engineered immune cells take aim at childhood autoimmune diseases

NCT ID NCT07674147

Not yet recruiting Disease control Sponsor: The Children's Hospital of Zhejiang University School of Medicine Source: ClinicalTrials.gov ↗

First seen Jun 29, 2026 · Last updated Jun 30, 2026 · Updated 1 time

Summary

This early-phase trial tests a single infusion of universal CAR-T cells (RD06-05) in 30 children and adolescents with severe autoimmune diseases, including lupus, scleroderma, and kidney inflammation. The cells are designed to target and calm overactive immune cells. The main goal is to check safety, but researchers will also look for signs of disease improvement.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: RD06-05 (universal CD19/BCMA-targeted CAR-T cell injection)
What this could lead to: If successful, this could offer a new treatment option for children with hard-to-treat autoimmune diseases, potentially reducing disease activity and need for ongoing medications.
What could go wrong: This is a very early, small study (30 participants) focused on safety. CAR-T therapy carries serious risks like cytokine release syndrome, neurotoxicity, and infections. It may not work for all patients or diseases tested.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

acquired idiopathic inflammatory myopathy autoimmune disease idiopathic inflammatory myopathy idiopathic multidrug-resistant nephrotic syndrome IgA glomerulonephritis lupus nephritis nephrotic syndrome systemic lupus erythematosus systemic sclerosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

AUTOIMMUNE DISEASES IGAN - IGA NEPHROPATHY IIM- IDIOPATHIC INFLAMMATORY MYOPATHIES MULTI-DRUG RESISTANT NEPHROTIC SYNDROME SLE - SYSTEMIC LUPUS ERYTHEMATOSUS SSC-SYSTEMIC SCLEROSIS

Contacts and locations

Locations

Children's Hospital, Zhejiang University School of Medicine

Hangzhou, Zhejiang, 310052, China
Nanjing Children's Hospital

Nanjing, Jiangsu, 210000, China

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