Can a Three-Drug combo quiet lupus kidney flares?
NCT ID NCT07760480
First seen Aug 12, 2026 · Last updated Aug 13, 2026 · Updated 1 time
Summary
This trial tests whether adding voclosporin to standard lupus nephritis treatment (mycophenolate mofetil and prednisolone) reduces kidney inflammation faster and more completely than standard treatment alone. Adults with active lupus nephritis will be randomly assigned to either triple or dual therapy, and will undergo kidney biopsies before and after 3 months of treatment to see how immune cells in the kidney respond. The study also looks for blood or urine markers that could monitor disease without repeated biopsies, and follows participants for up to 2 years.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- voclosporin added to standard treatment with mycophenolate mofetil and prednisolone
- What this could lead to
- If adding voclosporin works, it could lead to faster and more complete remission of kidney inflammation in lupus nephritis, potentially preserving kidney function and reducing long-term damage.
- What could go wrong
- This is a relatively small, early-phase trial, so results may not apply broadly. Adding voclosporin may increase side effects without improving outcomes, and the study's focus on early tissue changes may not predict long-term benefits.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Amsterdam University Medical Center
RECRUITINGAmsterdam, Netherlands
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