Engineered immune cells aim to tame childhood autoimmune diseases

NCT ID NCT06792799

Recruiting now Disease control Sponsor: The Children's Hospital of Zhejiang University School of Medicine Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This early-phase trial is testing a new type of cell therapy (CAR-NK cells) in 36 children with B-cell-related autoimmune diseases like lupus and certain kidney diseases. The therapy uses specially designed immune cells to target and potentially control the overactive immune system. The main goals are to check if the treatment is safe and if it can reduce disease activity.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: anti-CD19/BCMA CAR NK cells (KN5601)
What this could lead to: If successful, this could point toward a new treatment option for children with severe autoimmune diseases like lupus or kidney disease that don't respond to standard therapies.
What could go wrong: This is a very early (Phase 1) trial with only 36 participants, so safety and effectiveness are not yet proven. There are risks from the chemotherapy given before the cell infusion and from the cells themselves, including serious side effects.

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Conditions

The condition(s) this trial relates to.

autoimmune disease idiopathic multidrug-resistant nephrotic syndrome IgA glomerulonephritis nephrotic syndrome systemic lupus erythematosus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

AUTOIMMUNE DISEASES IGAN - IGA NEPHROPATHY MULTI-DRUG RESISTANT NEPHROTIC SYNDROME SYSTEMIC LUPUS ERTHEMATOSUS

Contacts and locations

Locations

Children's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310000
RECRUITING

Hangzhou, Zhejiang, 310052, China

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