Scientists hunt for hidden triggers of autoimmune diseases

NCT ID NCT06587828

Recruiting now Knowledge-focused Sponsor: TScan Therapeutics, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study collects tissue and blood samples from 300 people with autoimmune diseases like Crohn's, multiple sclerosis, and celiac disease. Researchers aim to identify the specific targets of immune cells (T cells) that cause inflammation. The goal is to discover new targets for future therapies that could calm the immune system without shutting it down completely.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If successful, this could identify new targets for therapies that calm the immune system in autoimmune diseases like Crohn's or multiple sclerosis.
What could go wrong: This is an early-stage sample collection study, not a treatment trial. It may not lead to any new therapies, and results may not apply to all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

ankylosing spondylitis autoimmune disease birdshot chorioretinopathy celiac disease Crohn disease diffuse scleroderma inflammatory bowel disease multiple sclerosis Non-Radiographic Axial Spondyloarthritis pulmonary systemic sclerosis scleroderma spondyloarthropathy systemic sclerosis ulcerative colitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ANKYLOSING SPONDYLITIS AUTOIMMUNE DISEASES BIRDSHOT CHORIORETINITIS CELIAC DISEASE CROHN&AMP;#39;S DISEASE MULTIPLE SCLEROSIS NON-RADIOGRAPHIC AXIAL SPONDYLOARTHRITIS (NR-AXSPA) SCLERODERMA ULCERATIVE COLITIS

Contacts and locations

Locations

Arnold Arthritis & Rheumatology
RECRUITING

Skokie, Illinois, 60076, United States
Cura Clinical Research
RECRUITING

Sherman Oaks, California, 91403, United States
Knowledge Research Center
RECRUITING

Orange, California, 92868, United States
Massachusetts Eye Research and Surgery Institution (MERSI)
RECRUITING

Waltham, Massachusetts, 02451, United States
Medical College of Wisconsin
COMPLETED

Milwaukee, Wisconsin, 53226, United States
Nexus Research
RECRUITING

Cranston, Rhode Island, 02920, United States
Nexus Research
RECRUITING

Cranston, Rhode Island, 02920, United States
Novel Research
RECRUITING

Bellaire, Texas, 77401, United States
Palmetto Gastroenterology Clinical Research, LLC
RECRUITING

Summerville, South Carolina, 29486, United States
RI Rheumatology
RECRUITING

Cranston, Rhode Island, 02920, United States
Susquehanna Research Group
RECRUITING

Harrisburg, Pennsylvania, 17110, United States
University of Kentucky Research Foundation
RECRUITING

Lexington, Kentucky, 40536, United States

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