Spondyloarthropathy

This study tests whether the Butantan-Dengue vaccine is safe and works well in people aged 12–59 with autoimmune rheumatic diseases (like rheumatoid arthritis or lupus) who are stable on low or no immune-suppressing drugs. Participants receive one vaccine dose and are monitored f…

This study tests whether tulisokibart can improve symptoms of radiographic axial spondyloarthritis, a type of arthritis that causes pain and swelling in the spine and pelvis. About 315 adults with active disease will receive either the drug or a placebo for 16 weeks. Researchers …

This study tests an experimental oral drug called GRWD0715 for axial spondyloarthritis, a chronic inflammatory condition affecting the spine and pelvis. The trial starts with healthy volunteers to check safety, then moves to patients to see if the drug reduces inflammation and im…

This study compares two ways of giving the drug bimekizumab to people with active psoriatic arthritis or axial spondyloarthritis: as an IV infusion or as a shot under the skin. The goal is to see if the IV method works just as well as the shot. About 392 adults who are suitable f…

This study tests a drug called bimekizumab in children aged 2 to 17 with specific types of juvenile arthritis (enthesitis-related arthritis and juvenile psoriatic arthritis). The goal is to see how the drug moves through the body and if it is safe. About 40 children will take par…

This study tests a bone marrow transplant from a family donor for children under 21 with severe non-cancer blood disorders like sickle cell disease, bone marrow failure, or immune problems. The goal is to see if the transplant can replace the diseased cells with healthy donor cel…

This study is testing whether adding traditional Chinese medicine (like herbs or acupuncture) to standard Western treatment helps people with ankylosing spondylitis, a type of arthritis that affects the spine. Researchers will follow 790 patients for 6 months to see if their abil…

This study looks at whether combining traditional Chinese medicine with standard Western treatments can better control spine inflammation and slow damage in people with ankylosing spondylitis. About 210 adults aged 18-75 will be followed for up to two years. The goal is to see if…

This study tests whether upadacitinib (Rinvoq), a daily pill, can reduce inflammation in the spine and joints of people with active psoriatic arthritis. About 100 adults who have not responded well to other treatments will receive either the drug or a placebo for 12 weeks. Resear…

This study tracks the safety and effectiveness of the arthritis drug Xeljanz XR in about 200 adults with moderate to severe rheumatoid arthritis, psoriatic arthritis, or ankylosing spondylitis. Participants take the drug as prescribed by their doctor, and researchers record any s…

This study follows 70 Korean adults with ankylosing spondylitis who have never taken biologic drugs. They will receive secukinumab as part of routine care. Researchers will measure changes in disease activity and inflammation over time to see how effective the treatment is in rea…

This study is testing whether a higher dose (300 mg) of the drug secukinumab (Cosentyx) can safely and effectively reduce symptoms in Chinese adults with active ankylosing spondylitis who have not gotten relief from at least two NSAIDs. One hundred participants will receive eithe…

This phase 3 trial tests whether VC005 tablets can reduce symptoms of active ankylosing spondylitis, a type of arthritis that mainly affects the spine. About 420 adults aged 18 to 70 will receive either VC005 or a placebo for 48 weeks. The main goal is to see how many achieve a 2…

This Phase 3 trial tests an experimental drug called 608 in 500 adults with active ankylosing spondylitis (AS), a type of arthritis that causes back pain and stiffness. Participants receive either 608 injections or a placebo. The main goal is to see if 608 improves symptoms like …

This study tests whether fecal microbiota transplants (FMT) given as capsules can safely improve symptoms in people newly diagnosed with rheumatoid arthritis, ankylosing spondylitis, psoriatic arthritis, Crohn's disease, or ulcerative colitis. Two hundred participants will receiv…

This study compares two types of hip replacement materials in 100 adults aged 18 to 65 who need a total hip replacement. One group gets a ceramic-on-polyethylene implant where the polyethylene is infused with vitamin E to reduce wear. The other group gets a standard ceramic-on-ce…

This study tests whether the experimental drug LNK01001 can reduce pain and stiffness in adults with active ankylosing spondylitis, a type of arthritis that mainly affects the spine. About 352 participants will receive either LNK01001 or a placebo twice daily for 16 weeks, then e…

This study looks at whether people with rheumatoid arthritis, psoriatic arthritis, or axial spondyloarthritis who are doing well on a JAK inhibitor can safely reduce their dose. About 200 participants will either lower their dose or stay on the same dose, guided by disease activi…

This study compares muscle thickness around the shoulder blade in people with early ankylosing spondylitis (an inflammatory condition) versus those with mechanical shoulder blade movement problems. Researchers use ultrasound and electromyography (EMG) to see if they can tell the …

This study is testing a new radioactive tracer called [18F]AlF-FAPI-74 for PET/CT scans to see if it can find inflammation better than the current standard tracer. The trial will involve 140 people with fever of unknown origin, IgG4-related disease, or axial spondylarthritis. Res…

This study is testing a new blood-based test that aims to predict which medication will work best for each person with rheumatic diseases like rheumatoid arthritis or lupus. Researchers will take a blood sample and analyze immune cells to create a personalized treatment profile. …

This study tests whether using a carotid ultrasound (a neck scan) to find hidden plaque in arteries can help prevent heart attacks and strokes in people with inflammatory rheumatic diseases like rheumatoid arthritis or lupus. About 1,944 participants aged 50 and older will be spl…

This study tests whether a mobile app called ExerciseRx can help people with axial spondyloarthritis (a type of arthritis affecting the spine and joints) exercise more and improve their symptoms. Forty adults who are not very active will either use the app for guided exercises an…

This study tests whether a single nerve block injection (erector spinae plane block) can reduce persistent back pain in people with ankylosing spondylitis whose disease activity is already controlled by medication. Fifteen adults aged 18–65 will receive the injection and be monit…

This study looks at whether doing breathing exercises before orthopedic surgery (like knee, hip, or fracture repair) can help your lungs work better after the operation. It involves 36 adults who have used tobacco and are at risk for breathing problems after surgery. Participants…

This study tests a new, ultrasound-guided acupotomy technique to improve symptoms in people with ankylosing spondylitis, a type of arthritis that causes back pain and stiffness. About 60 adults with active disease will receive the treatment to see if it reduces pain and improves …

This study tests whether live or pre-recorded video exercise programs help people with ankylosing spondylitis (a chronic spine condition) feel better and move easier. About 66 adults will do exercises three times a week for 8 weeks, either via live video, recorded video, or a sim…

This study tests two ways to manage pain after hip replacement surgery. One group gets a nerve block plus a second nerve block; the other gets a nerve block plus wound numbing. The goal is to see which method reduces pain and the need for opioid painkillers. About 102 adults havi…

This study tests whether adding deep breathing exercises to core stability exercises can improve lung function and physical ability in people with ankylosing spondylitis (AS). AS is a type of arthritis that mainly affects the spine, causing pain, stiffness, and sometimes trouble …

This study tests whether a program of exercise and ergonomics training can reduce muscle and joint pain in teachers. About 80 teachers who have had pain for at least three months will be randomly assigned to receive the training or not. Researchers will measure changes in pain, d…

This study tests a self-management program for people recently diagnosed with inflammatory arthritis. The program includes nurse sessions to help patients learn skills to manage their condition. Researchers will compare the program plus usual care to usual care alone in 130 adult…

This study tests a web-based app called IAMABLE that provides evidence-based rehabilitation strategies for people with chronic conditions like heart disease, arthritis, or neurological disorders. Fifty adults aged 45 to 75 will use the app for 4 months to set goals and learn abou…

This study tests whether extra support for case managers helps veterans leaving the military better manage pain and reduce risky substance use. About 1800 veterans will take part. The program focuses on non-drug pain treatments and counseling.

This study compares yoga therapy to standard physiotherapy for people with moderate axial spondyloarthritis, a type of inflammatory arthritis affecting the spine and pelvis. Seventy-two participants will attend group sessions twice a week for ten weeks. The goal is to see if yoga…

This study looks at whether an 8-week gluten-free diet can reduce gut inflammation and improve symptoms in people with ankylosing spondylitis. Researchers will measure changes in intestinal permeability, disease activity, and quality of life in 60 adults. Participants are randoml…

This study aims to uncover genetic changes that cause autoimmune diseases in people native to Peru. Researchers will collect blood, urine, and stool samples from 300 participants, including patients with conditions like lupus and rheumatoid arthritis, their family members, and he…

This study aims to learn more about how diseases related to blood clots, the immune system, and blood vessels start and change over time. Researchers will enroll up to 1,000 people aged 5 and older, including those with these conditions, their healthy relatives, and healthy volun…

This study follows up to 2,000 people with spondyloarthritis (a group of inflammatory joint and spine conditions) and their healthy relatives. Researchers aim to identify symptoms, genetic factors, and medical tests that predict who will develop more severe forms of the disease. …

This study aims to learn more about rare skeletal disorders by collecting medical records, blood samples, and genetic data from 100 participants. People with known or suspected bone conditions, as well as their healthy family members, can join either remotely or in person. The go…

This study looks at whether sulfasalazine, a drug for inflammatory arthritis, makes the standard diabetes blood test (HbA1c) falsely low. That could mean diabetes goes undiagnosed or is undertreated in these patients. Researchers will use continuous glucose monitors and fasting b…

This study looks for better ways to detect lung inflammation and infections early in people who have received a stem cell transplant from a donor. About 40 participants aged 5 to 70 will get regular lung scans, breathing tests, blood draws, and a procedure where a tube collects f…

This study compares the gut microbiome—bacteria, fungi, and viruses—in people with Crohn's disease, with or without arthritis, and healthy controls. Researchers aim to find microbial biomarkers linked to arthritis in Crohn's patients. No treatment is given; it is purely observati…

This study looks at how heavy smartphone use impacts neck posture, muscle strength, balance, and tongue pressure in people with rheumatoid arthritis or ankylosing spondylitis. Researchers will compare these patients to healthy individuals to separate the effects of the disease fr…

This study translates and tests several health questionnaires—covering pain, arm and leg function, mood, and daily activities—for use with Albanian-speaking people. Researchers will check if the translated versions are reliable and accurate by giving them to about 300 participant…

This study tests a new tool called the PRISM Dashboard, which gives physiotherapists feedback on how their decisions compare to their peers. The goal is to see if this feedback helps reduce differences in care for people with muscle and joint pain. About 60 physiotherapists and t…

This study aims to learn how well heart scans (MRI, ultrasound, PET) can detect and predict outcomes in people with suspected or known inflammatory heart diseases. Researchers will follow 5,000 adults for one year to see how often heart involvement is confirmed and how it affects…

This study is testing an educational tool designed for people with melanoma who also have an autoimmune disease and are considering treatment with immune checkpoint inhibitors. Researchers want to see if the tool is easy to use and helpful for both patients and healthcare provide…

This study looks at whether a doctor's computer tool (MedSafer) and patient brochures (EMPOWER) can help reduce the use of potentially harmful medications in adults aged 60 and older with rheumatic diseases who take five or more regular drugs. Researchers will follow 100 particip…

This study looks at how to make it easier for people with axial spondyloarthritis to start using the Axia app. Two groups of 200 participants will get different onboarding brochures: one with standard instructions and one with a 14-day free trial. Researchers will track how many …

This study looks at how much of the drug bimekizumab passes into breast milk. Researchers will collect milk samples from 20 breastfeeding mothers with conditions like psoriasis or arthritis over several weeks. The goal is to understand potential exposure for nursing infants, not …

This study looks at 200 adults with rheumatoid arthritis, psoriatic arthritis, or ankylosing spondylitis to see if certain blood markers (related to oxidative stress) can help doctors monitor how the disease changes over a year. Participants give blood samples at the start, 6 mon…

This study follows 2250 Chinese adults with axial spondyloarthritis (a type of inflammatory arthritis affecting the spine) to see how their condition changes over time. Researchers will measure physical function, spinal damage on X-rays, and episodes of eye inflammation. The goal…

This study aims to better understand why people with inflammatory arthritis experience chronic pain. Researchers will look at how the brain processes pain and how it affects daily life. 350 adults starting or switching arthritis medications will be followed over time. The goal is…

This study aims to improve how doctors diagnose and treat chronic muscle and joint pain by using simple questionnaires and pain sensitivity tests. Researchers will study 250 adults with conditions like osteoarthritis, fibromyalgia, chronic low back pain, or inflammatory arthritis…

This study aims to better understand rare forms of inflammatory arthritis, including those linked to other autoimmune diseases or cancer immunotherapy. Researchers will analyze joint tissue samples from 100 adults to compare the immune cells and molecules involved. The goal is to…

This study looks at different types of low back pain in people with ankylosing spondylitis, a type of arthritis that mainly affects the spine. Researchers want to see how these pain types relate to daily function and quality of life. The study will involve 200 adults with ankylos…

This study is testing a tool called B-COMPASS that uses a 22-question survey to predict whether people will follow their prescribed treatments. Researchers will enroll 3100 adults with cardiovascular, endocrine, immune, nerve, cancer, or rare diseases across Europe. The goal is t…

This study follows 252 adults with muscle, bone, or joint problems (like arthritis, back pain, or after surgery) to see how well they do their prescribed home exercises. Researchers will track who sticks with the program and why, looking at factors like pain, mood, and support. T…

This study looks at whether palliative and supportive care, usually given to people near the end of life, could also help those with long-term inflammatory arthritis like rheumatoid arthritis. Researchers will interview patients and survey healthcare professionals to understand u…

This study is creating a biobank of blood and tissue samples from 2,000 people with rheumatoid arthritis, psoriatic arthritis, spondyloarthritis, or osteoporosis. Researchers will analyze these samples to find biomarkers that predict how well a patient responds to treatment. The …

This study looks at why people with axial spondyloarthritis often feel very tired and how that relates to muscle function. Researchers will measure exercise capacity in 122 adults starting a new targeted therapy. The goal is to better understand the connection between fatigue and…

This study tests whether using a virtual reality (VR) headset during shoulder exercises helps patients feel more engaged and motivated. Fifty adults with shoulder problems will do rehab exercises in a VR environment and then answer questionnaires about how easy and immersive the …

This study uses two special scanners (HR-pQCT and pQCT) to take detailed pictures of bone and muscle in 1,000 people with conditions that raise the risk of bone loss, like osteoporosis, arthritis, or kidney disease. The goal is to see if these scanners can spot tiny changes in bo…

This study is creating a large registry of 800 people receiving biologic medications for immune conditions like autoimmune diseases and primary immune deficiencies. Researchers will collect blood samples and health data to better understand how these treatments work and who respo…

This study is building a large registry and biorepository of 5,000 adults with various rheumatic diseases like rheumatoid arthritis, lupus, and scleroderma. Researchers at Yale University will collect medical data and biological samples over time to better understand these condit…

This study will follow 300 people with knee osteoarthritis or chronic inflammatory arthritis for up to 10 years. Researchers will collect blood, joint fluid, and platelet-rich plasma samples to look for biomarkers linked to pain, joint damage, and the need for knee replacement. T…

This study aims to create a secure national database for muscle and joint (musculoskeletal) conditions by collecting routine data from community clinics and GP practices. About 22,000 adults will have their information anonymously gathered to help develop a dashboard that tracks …

This study watches 2000 people having hip or knee replacement surgery to see how long spinal anaesthesia lasts. The goal is to learn how the amount of anaesthetic affects timing, helping doctors decide if patients can safely go home the same day. No new treatments are tested—just…

This research study collects health information from 10,000 people with brain inflammation conditions like Long COVID, ME/CFS, and autoimmune diseases. Participants use a smartphone app to share symptoms, health history, and wearable data. The goal is to find disease subtypes and…

This study looks at how often people can return to sports at least three years after total knee replacement. It compares three different types of knee prostheses to see if one type leads to better sports participation. The study will include 660 adults who had their first knee re…

This registry enrolls pregnant women or those planning pregnancy who have autoimmune diseases like lupus or rheumatoid arthritis. Researchers at Duke University will track health data to find ways to improve outcomes for mothers and babies. The goal is to better understand risk f…

This study looks at how changing the heel cushion on an ankle-foot brace (AFO) affects walking in people who use one daily. Forty adults with leg injuries or nerve problems will try four different heel wedges—tall or short, soft or firm—while walking at controlled speeds. Researc…

This study looks at how natural cannabis compounds (phytocannabinoids) affect immune cells from 100 people with chronic inflammatory diseases like rheumatoid arthritis, lupus, and Crohn's disease. Researchers will take a blood sample and expose the cells to different cannabis ext…

This study looks at how 3D computer simulation and printing can help surgeons better plan and perform bone correction surgeries. Researchers will compare the planned corrections to the actual results in 100 children and young adults with rare bone deformities. The goal is to make…

This study is tracking 20,000 people who have had or will have shoulder replacement surgery to see how well the implants work over at least 10 years. Researchers will measure pain, daily function, and strength using standard shoulder scores. The goal is to better understand the l…

This study collects tissue and blood samples from 300 people with autoimmune diseases like Crohn's, multiple sclerosis, and celiac disease. Researchers aim to identify the specific targets of immune cells (T cells) that cause inflammation. The goal is to discover new targets for …

This study follows 4,000 children who receive orthopedic implants (like rods or screws) during standard care for bone fractures, deformities, or hip problems. Researchers will track how long the implants last, any complications, and how well they work over time. The goal is to ga…

This study is building a registry of people with rare bone diseases (skeletal dysplasias) in Italy. Researchers will collect medical history, genetic data, and treatment details over time to better understand how these conditions progress. No experimental treatments are given; th…

This study follows 144 adults with muscle or bone problems who are already scheduled to receive treatment with Chattanooga Intelect devices (like TENS or ultrasound). Researchers will measure pain, muscle strength, and movement range to confirm the devices are safe and work as ex…

This study is looking at how the gut bacteria (microbiome) change in children with juvenile spondyloarthritis as they receive different treatments. Researchers will collect stool and blood samples from 25 children over several months to see if certain bacteria affect how well the…

This study aims to improve how doctors measure disease activity in people with axial spondyloarthritis (axSpA), a type of inflammatory arthritis affecting the spine and joints. Researchers will use whole-body MRI scans and machine learning to create a new assessment model. The st…

This study follows 700 people with chronic diseases like arthritis, diabetes, or heart disease for 4 years. Participants wear a small movement sensor for 5 days, three times a year, to track their physical activity and sedentary time. Researchers want to see if a person's unique …

This study looks at whether the types of bacteria in your gut can predict how well you will respond to biologic drugs for spondyloarthritis, a group of inflammatory conditions affecting the spine and joints. Researchers will compare the gut bacteria of 80 people starting biothera…

This study will follow 700 adults with axial spondyloarthritis or psoriatic arthritis who have recently started one of several newer treatments (bimekizumab, upadacitinib, risankizumab, guselkumab, or a TNF inhibitor). Researchers will collect medical records and patient surveys …