Musculoskeletal system disorder

This study tests a new treatment called AZD0120 for people with AL amyloidosis, a rare disease where abnormal proteins build up in organs. The therapy uses a patient's own immune cells, modified to target and destroy harmful cells. The study aims to see if it is safe and effectiv…

This phase 3 trial tests whether adding pelabresib to the standard drug ruxolitinib works better than ruxolitinib alone for people with myelofibrosis, a type of bone marrow cancer. About 460 adults who have not taken JAK inhibitors before will receive either the combination or a …

This study tests whether platelet-rich fibrin (PRF) — a concentrate made from a patient's own blood — can improve gum healing after standard deep cleaning for periodontitis. Twenty adults with moderate to severe gum disease will receive deep cleaning on both sides of the mouth, w…

This study tests two different drug combinations for younger adults with a specific type of acute myeloid leukemia (CBF-AML). One group gets standard chemotherapy plus a targeted antibody, while the other gets the same chemotherapy plus a newer targeted pill. The goal is to see w…

This early-phase trial tests a personalized treatment for people with blood cancers like leukemia. Doctors take a patient's own T cells, modify them in the lab to recognize unique cancer mutations, and infuse them back after a short course of chemotherapy. The goal is to see if t…

This Phase 2 trial tests a new way to give radiation for sinus cancer after endoscopic surgery. Instead of radiating the whole sinus area, doctors will use a 'dose painting' technique that targets only the areas where cancer was found. The goal is to see if this reduces side effe…

This study tests whether omega-3 fatty acid supplements from fish oil, combined with a healthy diet, can reduce disease activity in adults with dermatomyositis, a rare autoimmune disease causing muscle weakness and skin rashes. About 300 participants will take either fish oil cap…

This study follows about 300 people with Duchenne muscular dystrophy who are taking the drug givinostat as part of their normal care. Researchers will track safety issues like low platelet counts and bleeding, and see how patients' muscle function changes over up to 5 years. The …

This Phase 1 trial tests surovatamig, a bispecific T-cell engager, in 48 adults with rheumatoid arthritis or systemic lupus erythematosus. The study gives the drug as injections in increasing doses to check safety, side effects, and how the body processes it. It is too early to k…

This study tests whether an investigational drug called PLG0206 can prevent infections from coming back after knee replacement surgery. About 240 adults who need a special cleaning surgery (DAIR) for an infected knee joint will receive either PLG0206 or a placebo during the proce…

This early study tests whether a second infusion of a patient's own modified immune cells (CAR-DC) is safe and can improve heart function in 5 adults with end-stage dilated cardiomyopathy. Participants had already received one dose but saw their heart function worsen again. The g…

This study tests whether curing (hardening) the bonding agent before placing dental sealants helps them stay on children's molars longer. Sealants are a standard way to prevent cavities, but they can wear off over time. Researchers will compare sealants placed with cured bond ver…

This early-stage trial tests a single intravenous dose of AFTX-201, a gene therapy designed to deliver a working copy of the BAG3 gene to heart cells. It enrolls 22 adults aged 18–55 with dilated cardiomyopathy and a BAG3 mutation. The study primarily checks safety and tolerabili…

This Phase 3 trial compares a low-dose combination of prednisone and methotrexate to standard high-dose prednisone for people with active cardiac sarcoidosis. Researchers hope the combo works just as well but causes fewer side effects and improves quality of life. The study plans…

This study looks at whether placing a small drain near the surgical site after one- or two-level lumbar spine surgery reduces complications like infection or the need for another operation. About 975 adults having open back surgery for spinal stenosis or spondylolisthesis are ran…

This study tests an oral drug called pacritinib in people aged 12 and older with myelodysplastic syndromes (MDS) or related blood cancers (MDS/MPN). The goal is to find the best dose and see if it can shrink or control the disease. Participants take capsules twice daily for up to…

This early-stage study tests a new drug called casdatifan (AB521) alone or combined with other cancer drugs in people with advanced clear cell kidney cancer or other solid tumors. The main goals are to check safety and find the right dose. About 362 participants will take part.

This phase II trial tests whether adding gilteritinib to the usual two-drug therapy (azacitidine and venetoclax) can help older or frail adults with a specific type of acute myeloid leukemia (FLT3-mutated) achieve deeper remission. About 147 participants will be randomly assigned…

This early-stage trial tests imatinib, a drug already used for certain cancers, in adults with a harmful RUNX1 gene mutation. The mutation causes easy bleeding and a high risk of blood cancers. The study aims to find the best dose and see if imatinib can improve platelet function…

This phase II trial tests several experimental drug combinations against the standard treatment for high-risk acute myeloid leukemia (AML) in patients aged 59 or younger. The goal is to see if newer regimens, including venetoclax and liposome formulations, can better shrink cance…

This phase II trial is testing whether adding the drug venetoclax to standard chemotherapy can improve remission rates in younger patients with intermediate-risk acute myeloid leukemia (AML). About 153 participants will receive either standard chemo or a combination with venetocl…

This study looks at whether giving the osteoporosis drug romosozumab in two separate 6-month blocks, with breaks for another drug called zoledronate, can build more bone than the standard 12-month course. It involves 270 postmenopausal women with osteoporosis and a recent fractur…

This early-stage trial tests a new cell therapy for people with heart failure caused by blocked arteries. The treatment uses the patient's own immune cells, engineered to target scar tissue in the heart. The study will check safety and whether it can improve heart function in 15 …

This study tests a new exercise program for people with spinal cord injury. It combines arm cycling with electrical stimulation to the legs, plus high-intensity interval training, after a muscle-strengthening prep phase. The goal is to see if this program improves heart fitness, …

This phase 2 trial tests whether giving olutasidenib with azacitidine, followed by olutasidenib alone as maintenance, can keep acute myeloid leukemia (AML) with an IDH1 mutation from returning. The study enrolls 28 adults who have already achieved remission after initial treatmen…

This early-stage trial tests an experimental cell therapy called IBR733 for adults with acute myeloid leukemia (AML) that has returned or not responded to standard treatment. The therapy involves giving immune cells by vein in repeated cycles. The main goals are to check safety, …

This trial compares two approaches for people with rotator cuff arthropathy, a condition where the shoulder joint wears down due to a torn rotator cuff. One group receives reverse total shoulder replacement surgery followed by standard rehab, while the other group completes a 12-…

This study tests if tranexamic acid (TXA), a drug that reduces bleeding, is safe and effective for children aged 10-18 having surgery for idiopathic scoliosis. Participants are randomly assigned to one of two TXA dosing regimens or a placebo. The main goal is to measure total blo…

This early-phase trial is testing whether adding the drug emapalumab to standard medications can safely prevent graft-versus-host disease (GVHD) in 15 adults with leukemia or myelodysplastic syndrome receiving a reduced-intensity stem cell transplant. Emapalumab blocks a protein …

This study follows adults who have received a Tipmed shoulder replacement to see how well the implant works and if any problems arise over the first year. Participants have conditions like severe arthritis, rotator cuff damage, or a broken shoulder bone. Researchers track shoulde…

This study tests a new type of CAR T-cell therapy that targets two proteins, CD19 and CD22, on cancer cells. It is for children and young adults aged 3 to 39 with B-cell cancers like leukemia or lymphoma that have not been cured by standard treatments. Participants receive their …

This Phase III trial tests whether adding the immunotherapy drug pembrolizumab to standard chemotherapy (doxorubicin) helps people with advanced dedifferentiated liposarcoma or undifferentiated pleomorphic sarcoma live longer without their cancer worsening. About 365 adults whose…

This study follows about 665 people with myelodysplastic syndromes, beta-thalassemia, or myelofibrosis who have already taken luspatercept in earlier trials. Researchers want to see how safe the drug is over many years by tracking side effects, disease progression, and survival. …

This early-stage study tests a new drug called KK2845 for adults whose acute myeloid leukemia (AML) has returned or not improved after standard treatments. The goal is to find a safe dose and see how well the body tolerates it. About 72 participants will take part in two phases: …

This study tests a medicine called Xolatryp in adults who have had a severe heart attack (STEMI) and are getting a procedure to open blocked arteries. Participants receive either a single 6-hour infusion of Xolatryp or a placebo, and their heart health is monitored for 30 days. T…

This early-stage study tests a single dose of ABBV-519 in 30 adults with moderate lupus or rheumatoid arthritis. Researchers will check how the drug moves through the body, how it affects immune cells, and whether it is safe. Participants will be followed for about a year to moni…

This study tests a new tool called OPTIBIO that uses blood markers and patient data to help doctors decide if it's safe to reduce biological therapy in rheumatoid arthritis patients who are in remission. About 184 adults with RA in stable remission will be randomly assigned to ha…

This study compares two types of partial knee replacements for people with arthritis on the inner side of the knee. One implant has a fixed bearing (the plastic piece stays still), while the other has a mobile bearing (the plastic piece can move slightly). Researchers will track …

This study tests a combination of four drugs, called CLAG-GO, in adults whose acute myeloid leukemia (AML) has not responded to standard treatment or has come back after remission. Participants receive the drugs during a hospital stay, and if the cancer goes into remission, they …

This study tests a new type of stem cell transplant for children with severe blood disorders like sickle cell disease or aplastic anemia. The transplant uses stem cells from a parent or other half-matched family donor, which are specially processed to remove certain immune cells.…

This early-stage trial is testing a new combination of chemotherapy drugs (thiotepa, busulfan, and fludarabine) followed by a stem cell transplant for people with certain blood cancers like leukemia and myelodysplastic syndrome. The goal is to see if this approach can reduce the …

This study tests a new way to prepare donor stem cells (called Orca-Q) for people with blood cancers like leukemia or MDS who need a transplant. The goal is to see if this engineered graft is safe and helps the body accept the new cells with fewer complications. About 300 partici…

This Phase 3 trial tests whether DYNE-101 can improve muscle function and daily life in 150 adults with myotonic dystrophy type 1 (DM1). Participants receive either the drug or a placebo by IV every few weeks for 48 weeks. The study measures how quickly people can stand from a ch…

This study tests a drug called risankizumab in children with juvenile psoriatic arthritis, a condition causing joint pain and swelling. About 40 kids will receive either risankizumab or the standard drug adalimumab for 24 weeks, with responders continuing for up to 2 years. The g…

This phase 3 trial tests whether adding the drug sapablursen to standard treatment helps people with polycythemia vera, a blood disorder causing too many red blood cells. About 250 participants who currently need regular blood removal (phlebotomy) will receive either sapablursen …

This trial compares two treatments for white spot lesions—early cavities that appear as milky-white marks on front teeth after braces. One treatment uses a special paste (MI Paste Plus) combined with etching, while the other uses a resin infiltration technique (Icon). The study i…

This study tests a one-time gene therapy called RGX-202 in boys with Duchenne muscular dystrophy (DMD). The therapy delivers a mini version of the missing dystrophin protein to muscle cells. Researchers will check safety and whether it improves muscle function, like standing and …

This early-phase study tests the drug TURALIO (pexidartinib) in people aged 3 to 35 whose cancer has not responded to standard treatments. The goal is to find a safe dose and see if it can shrink tumors or control leukemia. Participants take a daily capsule for up to 2 years, wit…

This early-stage trial tests a one-time gene therapy called RP-A701 in 8 adults with dilated cardiomyopathy caused by a faulty BAG3 gene. The therapy uses a harmless virus to deliver a working copy of the gene, aiming to improve heart function. The main goal is to check safety, b…

This study tests whether ozone therapy, followed by a remineralizing gel, can reverse the earliest stage of cavities in children aged 6-14. Half of the 80 participants will get ozone plus gel, the other half just gel. Researchers will check the teeth over 8 weeks using special li…

This Phase 3 trial tests whether adding the drug venetoclax to standard chemotherapy helps adults with newly diagnosed acute myeloid leukemia (AML) or a related high-risk condition. About 650 participants aged 18 to 75 will receive either venetoclax or a placebo alongside chemo. …

This early-phase trial is testing a new drug called MTS109, made with mRNA technology, for people with moderate to severe autoimmune diseases like lupus and scleroderma. Fifteen participants will receive several injections over a month to see if it is safe and tolerable. The goal…

This study tests a special stem cell transplant for children, teens, and young adults (ages 6 months to 25 years) with solid tumors that have come back or not responded to treatment. The transplant uses cells from a donor, with certain immune cells removed to reduce side effects,…

This Phase 3 trial tests the drug benralizumab (Fasenra) in children aged 6 to 17 with two rare eosinophilic diseases: EGPA and HES. The study aims to see if the drug is safe, how it works in the body, and whether it can help control the disease. Fourteen children will receive in…

This phase I trial tests whether adding the experimental drug iadademstat to two standard leukemia medications (azacitidine and venetoclax) is safe and tolerable for adults with newly diagnosed acute myeloid leukemia (AML) who cannot undergo intensive chemotherapy. Iadademstat bl…

This study tests a daily oral drug called TYRA-300 in 92 children aged 3–10 with achondroplasia (a common form of dwarfism). The goal is to see if it safely increases their growth rate. Researchers will try different doses to find the best one. It's a Phase 2 trial, so it's still…

This study is testing an oral medication called asciminib in children aged 1 to 18 with Philadelphia chromosome-positive chronic myeloid leukemia (Ph+ CML-CP) who have already tried other treatments. The goal is to find the right dose that works as well as it does in adults and t…

This early-stage trial tests an experimental treatment called QEL-005 for people with two serious autoimmune conditions: diffuse cutaneous systemic sclerosis and difficult-to-treat rheumatoid arthritis. QEL-005 is made from a patient's own white blood cells, which are genetically…

This study tests a new medicine called SBT777101 in 24 people with moderate-to-severe rheumatoid arthritis (RA). It is the first time this drug is given to humans, so the main goal is to check safety and side effects. Participants receive a single dose, and the dose is increased …

This study is testing a device called ExAblate 4000 that uses focused ultrasound waves to treat non-cancerous brain tumors in children and young adults. The goal is to see if the treatment is safe and can shrink tumors without open surgery. About 20 participants will be enrolled,…

This program provides access to an experimental drug, AOC 1044, for people with Duchenne muscular dystrophy (DMD) whose genetic mutation can be treated by skipping exon 44. The goal is to help control the disease and improve muscle function. Participants must be at least 2 years …

This study tests whether switching from tafamidis to acoramidis can raise blood levels of transthyretin (TTR) in adults with transthyretin amyloid cardiomyopathy (ATTR-CM). The drug acoramidis stabilizes TTR to prevent harmful amyloid clumps that stiffen the heart. Researchers wi…

This study tests whether injecting a person's own bone marrow stem cells into or near the eye can help treat various retinal and optic nerve diseases, including age-related macular degeneration, retinitis pigmentosa, and glaucoma. Participants receive stem cell injections via dif…

This study tests an oral drug called KT-621 in 264 adults with moderate to severe eosinophilic asthma that is not well controlled by current treatments. Participants will take either KT-621 or a placebo daily for several weeks. Researchers will measure changes in lung function an…

This study tests an experimental drug called Afimkibart (RO7790121) in 160 people with moderate to severe rheumatoid arthritis who did not get better with or could not tolerate standard treatments like TNF or JAK inhibitors. Participants will receive either the drug or a placebo …

This study tests whether taking omega-3 fatty acids (fish oil) plus low-dose aspirin can improve gum disease treatment in smokers with advanced periodontitis. Participants receive these supplements or a placebo alongside standard deep-cleaning procedures. The trial measures chang…

This study tests a single intravenous dose of a gene therapy called GNR-097 in boys aged 4 to 9 with Duchenne muscular dystrophy (DMD). The therapy uses a harmless virus to deliver a shortened version of the dystrophin gene, which is missing or faulty in DMD. The trial aims to se…

This phase 2 trial tests whether adding vedolizumab to standard drugs (cyclophosphamide and tacrolimus) can prevent graft-versus-host disease (GVHD) in people receiving stem cell transplants for blood cancers like leukemia and myelodysplastic syndrome. GVHD occurs when donor immu…

This study tests whether taking a once-daily JAK inhibitor for rheumatoid arthritis in the evening works better than taking it in the morning. About 90 adults with RA who qualify for this medication will be randomly assigned to morning or evening dosing. Researchers will compare …

This early-phase trial tests a new treatment called CD64 CAR T cells for adults with acute myeloid leukemia (AML) that has come back or not responded to standard therapy. The treatment uses a patient's own immune cells, modified in a lab to target and attack leukemia cells. The m…

This large Phase 3 trial is testing whether adding the experimental drug ziftomenib to standard chemotherapy helps people with untreated acute myeloid leukemia (AML) who have specific genetic mutations. About 1,300 participants will be randomly assigned to receive either ziftomen…

This trial investigates whether sulforaphane, a nutrient found in broccoli, can reduce heart damage caused by the chemotherapy drug doxorubicin in breast cancer patients. About 70 participants will receive either sulforaphane or a placebo alongside their chemotherapy. The study m…

This program provides expanded access to the experimental drug ziftomenib for adults with acute myeloid leukemia (AML) or acute lymphoblastic leukemia (ALL) that has specific genetic changes (KMT2A rearrangements or NPM1 mutations). It is for patients who have exhausted standard …

This early-stage trial is testing a new drug called DNL952 in 32 adults with late-onset Pompe disease. The main goal is to check if the drug is safe and how the body processes it. Participants will receive the drug through an IV infusion at different doses.

This Phase 3 study tests whether the oral drug zasocitinib (TAK-279) can improve symptoms of active psoriatic arthritis in people who have never used biologic treatments. About 1,088 adults will receive either zasocitinib, an active comparator, or a placebo for up to 60 weeks. Th…

This study tests a new medicine called tulisokibart for people with active psoriatic arthritis, a condition causing joint pain and skin plaques. Researchers will compare different doses of the drug to a placebo in 140 adults to see if it improves symptoms like joint tenderness an…

This study tests two different medicines placed inside root canals to kill bacteria in teeth with chronic infection. 24 adults with infected molars will receive either a bioceramic or a calcium hydroxide paste. Researchers measure bacterial levels before and after treatment to se…

This study compares a new flexible white dental crown (BioFLX) to the standard stainless steel crown for treating cavities in baby molars. Researchers want to see if the white crown works just as well as the metal one in terms of gum health, plaque buildup, wear, and staying in p…

This study tests a fetal surgery called FETO for severe congenital diaphragmatic hernia (CDH), a condition where a hole in the diaphragm allows organs to crowd the lungs. Researchers will place a tiny balloon in the fetal windpipe to encourage lung growth, then remove it before b…

This study tests a new drug, asciminib, as the first treatment for adults newly diagnosed with chronic myeloid leukemia (CML). If the drug alone does not achieve a deep response within 2 to 3 years, a low dose of another targeted therapy is added. The goal is to see if this appro…

This study tests whether tulisokibart can improve symptoms of radiographic axial spondyloarthritis, a type of arthritis that causes pain and swelling in the spine and pelvis. About 315 adults with active disease will receive either the drug or a placebo for 16 weeks. Researchers …

This early-stage trial tests a new treatment called AZD0120 for adults with three autoimmune diseases: systemic sclerosis, idiopathic inflammatory myopathies, or difficult-to-treat rheumatoid arthritis. AZD0120 is made from a patient's own immune cells, which are modified in a la…

This study tests a procedure called FETO, done during pregnancy, for babies with a severe congenital diaphragmatic hernia (CDH). The goal is to see if FETO helps more babies survive after birth and have fewer long-term health issues compared to standard care. The study will enrol…

This Phase 3 trial tests whether the experimental drug zasocitinib (TAK-279) can reduce joint swelling and pain in people with active psoriatic arthritis. About 600 adults will receive either the drug or a placebo for up to 60 weeks. The main goal is to see if more people on the …

This Phase 2 study tests atacicept, a drug that may reduce immune system attacks on the kidneys. About 250 adults with various autoimmune kidney diseases (like IgA nephropathy or membranous nephropathy) will receive weekly injections. Researchers will check safety and measure cha…

This study is testing the long-term safety and effectiveness of a drug called afimkibart in people with moderate to severe rheumatoid arthritis. Participants have already taken afimkibart in a previous study and will continue taking it. The goal is to see if the drug remains safe…

This study looks at whether placing a permanent crown on a dental implant right away (immediate loading) works as well as waiting 4 weeks (early loading) for lower first molars. About 100 adults who need a tooth removed and replaced will get an implant 12-16 weeks after extractio…

This early-stage trial tests whether infusions of stem cells from donated newborn tissue are safe for young people aged 4 to 39 with dilated cardiomyopathy, a condition where the heart becomes enlarged and weak. Up to 36 participants will receive three intravenous doses over 30 d…

This phase 2 trial tests whether dapagliflozin, a diabetes drug, is safe and can lower high urine protein levels in people with renal AL amyloidosis—a rare condition where abnormal proteins damage the kidneys. About 20 participants will take the drug daily for 6 months and be mon…

This study is for adults with a certain type of acute myeloid leukemia (AML) who are in remission and planning a stem cell transplant. It compares a combination of two drugs, venetoclax and azacitidine, against standard high-dose chemotherapy as a 'consolidation' step before the …

This study tests a drug called deucravacitinib in children aged 5 to 17 with active juvenile psoriatic arthritis, a condition causing joint pain and swelling. The trial aims to see if the drug can control the disease and prevent flare-ups. About 60 participants will receive eithe…

This study compares a new plastic (PEEK) knee implant to a standard metal one in 200 people with severe knee osteoarthritis who need total knee replacement. The goal is to see if the plastic implant works just as well as metal in terms of pain relief, movement, and safety. Partic…

This early-stage trial tests a combination of two drugs—peposertib and a low-dose form of the chemotherapy doxorubicin—in people with advanced sarcomas that have spread or can't be removed by surgery. The goal is to find the safest dose and see if the combo can shrink tumors or s…

This pilot study tests the drug olutasidenib, with or without azacitidine, in 25 adults with a specific type of acute myeloid leukemia (IDH1-mutated) that has returned or not responded after venetoclax treatment. The goal is to see if the cancer can be brought into remission. Par…

This study tests whether giving iron supplements to teens with iron deficiency before scoliosis surgery can reduce the need for blood transfusions and improve thinking and physical recovery afterward. About 275 participants aged 10-26 will receive either iron pills or a placebo f…

This study tests an experimental oral drug called GRWD0715 for axial spondyloarthritis, a chronic inflammatory condition affecting the spine and pelvis. The trial starts with healthy volunteers to check safety, then moves to patients to see if the drug reduces inflammation and im…

This phase 3 trial compares bomedemstat, an experimental oral drug, to hydroxyurea (standard therapy) in 300 people with essential thrombocythemia who have not yet received cytoreductive treatment. The goal is to see if bomedemstat better controls platelet counts and prevents com…

This early-phase trial tests a drug called DR-18 in 40 adults with acute myeloid leukemia or myelodysplastic syndrome whose cancer returned or persisted after a stem cell transplant. DR-18 is a modified immune protein designed to boost the body's natural defenses against cancer c…

This study is a registry that will follow 300 people who receive the Freedom Total Knee System, a new artificial knee implant. The goal is to see how well the device holds up over time and how safe it is. Participants are adults with severe knee arthritis who have not gotten reli…

This study looks at whether bone grafting right after a molar extraction is necessary or if it can be delayed until the dental implant is placed. Forty adults needing a molar implant will be randomly assigned to get either immediate grafting or delayed grafting. The goal is to se…

This phase II trial tests whether adding targeted total marrow irradiation to standard chemotherapy before a stem cell transplant can improve outcomes for people with high-risk acute myeloid leukemia, chronic myeloid leukemia, or myelodysplastic syndromes. The study will enroll 3…

This study is testing a drug called mavacamten in adults with a type of heart disease called obstructive hypertrophic cardiomyopathy (HOCM) in Japan. The goal is to see if mavacamten can improve heart function and symptoms when added to their current treatment. About 36 participa…

This study is following over 5,200 people who have had or will have spine surgery using Stryker devices, such as spinal fusion or deformity correction. The goal is to see how well these devices improve pain and function, and to track any side effects or complications. Participant…

This study tests two ways to treat a slow heart rate caused by overactive nerves, without using a permanent pacemaker. One method uses freezing (cryoablation) and the other uses burning (radiofrequency) to calm the nerves. Sixty adults aged 18 to 60 with symptoms like fainting or…

This study tests a new, gentler way to clean deep gum pockets in people with advanced periodontitis. It compares a standard deep-cleaning method using larger tools to a minimally invasive approach using thinner, more delicate instruments. The goal is to see if the gentler method …

This study tests two different bone graft materials (GTO® and GenOs®) used with a new, less invasive surgical method called NIPSA to repair bone damage from advanced gum disease. Researchers will compare how well each material helps reattach gums and fill in bone defects over 6 m…

This study tests a new type of immunotherapy called CAR-T cells that are designed to recognize and attack cancer cells carrying a protein called CD7. It includes people with several blood cancers, such as T-cell acute lymphoblastic leukemia and acute myeloid leukemia. The goal is…

This Phase 3 trial tests whether a gel made from donated umbilical cord stem cells (CARTISTEM) can reduce pain and improve knee function better than a simple surgical cleanup (debridement) in people with knee cartilage damage and osteoarthritis. About 300 adults aged 18-75 with m…

This trial is testing whether adding the targeted drug cabozantinib to standard chemotherapy (methotrexate, doxorubicin, and cisplatin) helps people with newly diagnosed osteosarcoma, a type of bone cancer. The study includes over 1,100 participants and aims to see if the combina…

This study compares two surgical techniques—ridge splitting and the sausage technique—to widen a narrow lower jawbone and place dental implants at the same time. Thirty adults with mild to moderate bone loss will be treated and followed for at least three months. The goal is to s…

This early-phase trial is testing a new drug called HC-7366 in 18 adults with acute myeloid leukemia (AML) that has come back or not responded to other treatments. The main goal is to find a safe dose and check for side effects. Researchers hope this drug may offer a new option f…

This study compares two mouthwashes used alongside standard gum disease treatment. One contains a higher dose of chlorhexidine (0.2%), while the other combines a lower dose of chlorhexidine (0.12%) with cetylpyridinium chloride. The goal is to see if the lower-dose combination wo…

This study tests a technique called acute normovolemic hemodilution (ANH) in 150 adults undergoing bone tumor surgery. Before surgery, some blood is removed and replaced with fluid, so that if bleeding occurs, the patient loses less red blood cells. The goal is to see if this red…

This early-stage trial tests a new treatment called CD4CAR T cells for people with chronic myelomonocytic leukemia (CMML) that has come back or not responded to standard care. The treatment uses a patient's own immune cells, modified in a lab to recognize and attack cancer cells.…

This phase 3 trial tests whether adding the drug revumenib to standard intensive chemotherapy helps people with newly diagnosed acute myeloid leukemia (AML) that has a specific genetic change (NPM1 mutation). About 468 participants will receive either revumenib or a placebo along…

This study tests whether a self-assembling peptide called P11-4 can help remineralize white spot lesions—early signs of tooth decay—on smooth tooth surfaces. Seventy-five participants aged 10 to 17 will be split into three groups: one gets a single peptide application, another ge…

This trial tests a gene therapy for Fanconi anemia, a rare genetic disorder that causes bone marrow failure and increases cancer risk. Participants receive their own stem cells that have been genetically corrected with a lentiviral vector to fix the faulty FANCA gene. The study e…

This phase II trial is for older adults with a specific type of acute myeloid leukemia (AML) that has IDH gene mutations. Researchers want to find out whether starting treatment with an IDH-targeted drug (ivosidenib or enasidenib) followed by standard therapy (azacitidine plus ve…

This Phase 2 trial is testing a stem cell transplant from a donor for people with various blood cancers and bone marrow disorders. The transplant uses strong chemotherapy or radiation to wipe out the diseased marrow, then replaces it with healthy donor cells. A new combination of…

This early-phase trial tests a new type of cell therapy for people with relapsed or refractory acute myeloid leukemia (AML). The treatment uses a patient's own immune cells, engineered to recognize six different targets on leukemia cells. The study aims to see if this approach is…

This study tests a new gene therapy for children with a severe inherited bone disease called osteopetrosis. The therapy uses the child's own blood stem cells, modified to fix the genetic defect, and then returned to the body. The goal is to improve blood cell production and survi…

This study tests an experimental drug called NNC6019-0001 in people with transthyretin amyloid cardiomyopathy (ATTR-CM), a condition where abnormal proteins build up in the heart. About 1,280 adults will receive either the drug or a placebo by IV, alongside their usual heart trea…

This Phase 1 trial tests the safety and tolerability of a new drug called AZD5492 in 72 adults with lupus, myositis, or rheumatoid arthritis. Participants receive one or two doses under the skin and are monitored for side effects and how the drug moves through the body. The study…

This study compares two surgical treatments for thumb base osteoarthritis: total joint replacement with the TOUCH prosthesis and trapeziectomy (removing a bone at the thumb base). Researchers want to see if joint replacement provides better grip strength and fewer complications. …

This early-stage trial tests a new type of immune cell therapy (called universal CAR T cells) for people with certain blood cancers, including T-cell leukemia and lymphoma. The therapy targets a protein called CD7 found on cancer cells. The study will check if the treatment is sa…

This phase 3 trial tests an experimental drug called sepofarsen in 32 people with Leber congenital amaurosis (LCA), a rare genetic condition that causes severe vision loss from birth. The drug is injected into one eye, while the other eye gets a placebo, to see if it safely impro…

This study tests whether a lab-grown cartilage implant (MACI) works better than a standard surgery (microfracture) for teens aged 10-17 with knee cartilage damage. About 45 participants will receive either treatment and be followed for improvements in pain and sports function. Th…

This phase 2 trial tests whether a combination of pentoxifylline and vitamin E can help heal jaw bone damage caused by certain osteoporosis or cancer drugs. The study will enroll 17 adults with stage 2 medication-related osteonecrosis of the jaw. Researchers will measure how many…

This study tests an experimental drug called AZD1163 in 320 people with moderate-to-severe rheumatoid arthritis who haven't gotten enough relief from standard treatments. Participants receive either AZD1163 or a placebo as an injection, along with their usual care. The main goal …

This early-phase trial is testing whether combining two oral drugs, eltanexor and venetoclax, is safe and effective for people with myelodysplastic syndrome (MDS) or acute myeloid leukemia (AML) that has returned or not responded to prior treatment. The study will enroll 60 adult…

This early-phase trial is testing a combination of two drugs—Hyper-CVAD chemotherapy and venetoclax—in 22 children and young adults whose leukemia has returned or not responded to treatment. The main goal is to find a safe dose and monitor side effects. If the combination proves …

This phase 3 trial compares a once-weekly growth hormone injection (lonapegsomatropin) to a daily one (somatropin) in 186 prepubertal children with growth failure due to Turner syndrome, SHOX deficiency, being small for gestational age, or idiopathic short stature. The goal is to…

This study tests whether baricitinib, a daily pill, is safe and works for children aged 1 to under 18 with systemic juvenile idiopathic arthritis (sJIA), a chronic inflammatory disease. About 58 children will receive either baricitinib or a standard injected drug (tocilizumab) to…

This study tests whether a new pill (gecacitinib) plus a weekly injection (pegylated interferon) can help people with polycythemia vera, a condition where the body makes too many red blood cells. The goal is to bring blood counts back to normal and ease symptoms. Thirty adults wi…

This study compares two methods for disinfecting root canals in teeth with apical periodontitis (an infection at the tooth root). Fifty adults with infected molars will receive either a laser-based disinfection or a standard protocol. The goal is to see which method reduces bacte…

This early-phase trial tests a cell therapy called Orca-T combined with standard drugs to prevent graft-versus-host disease (GVHD) in 24 adults with advanced blood cancers (like leukemia or MDS) receiving stem cell transplants from partially matched donors. The main goal is to se…

This early-stage study tests a new drug called LY4213663 in healthy volunteers and people with rheumatoid arthritis (RA). The main goal is to see if the drug is safe and what side effects it may cause. Researchers will also measure how the body processes the drug. The study lasts…

This early-phase trial is testing a new type of CAR T-cell therapy, called CD4CAR, in people with acute myeloid leukemia (AML) that has come back or not responded to standard treatment. The therapy targets a protein called CD4 on leukemia cells. The goal is to safely eliminate as…

This study tests a new drug called CCS1477 (inobrodib) in people with advanced blood cancers like leukemia, lymphoma, and myeloma that have not responded to standard treatments. The drug is given as an oral capsule, either alone or combined with other cancer medicines. The goal i…

This phase 2 trial tests a daily oral drug called zanzalintinib in 70 adults with advanced or metastatic bone sarcomas that cannot be removed by surgery. The study includes four groups based on sarcoma type. Researchers will check if the drug is safe and helps control the cancer.

This study looks at the long-term safety and effectiveness of the drug baricitinib for children aged 1 to 17 with juvenile idiopathic arthritis (JIA). It includes 190 participants who have already taken baricitinib in a previous study. Researchers will monitor side effects and ho…

This study is testing whether teaching people with periodontitis (gum disease) to follow an anti-inflammatory diet can improve the results of standard non-surgical gum treatment. One hundred adults with a pro-inflammatory diet will be split into groups; some will get diet educati…

This early-stage study tests a new gene-editing medicine called PBGENE-DMD in 18 boys aged 2 to 7 with Duchenne muscular dystrophy. The treatment aims to correct the genetic mistake that causes the disease, potentially restoring muscle strength. Researchers are first checking if …

This early-phase study is testing a new drug called rebecsinib in 28 people whose secondary acute myeloid leukemia or high-risk myelofibrosis has come back or not responded to treatment. The drug is given by IV infusion four times per 28-day cycle for up to six cycles. The main g…

This study is testing a device called the Integrity Implant System to see if it helps people with torn rotator cuffs heal better after surgery. The implant is used to support the repair and reduce the chance of the tear coming back. About 150 adults will take part, and their prog…

This early-stage study tests an experimental drug called LY4298445 in healthy volunteers and people with lupus or rheumatoid arthritis. The main goal is to check safety and how the body handles the drug. Participants will receive either the drug or a placebo, and the study lasts …

This phase 2 trial is testing a new treatment called Orca-T for people with acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS). Orca-T is a personalized cell therapy made from a donor's blood that includes stem cells and immune cells. The goal is to see if it can impr…

This study tests whether a 6-week gait retraining program using real-time feedback can improve walking patterns and reduce early signs of knee osteoarthritis in people who have had ACL reconstruction. Seventy participants will be randomly assigned to receive either real-time biof…

This study tests a device called Vessel-X® that uses a special container to deliver bone cement into fractured vertebrae caused by osteoporosis. The goal is to reduce cement leakage and improve safety compared to standard procedures. About 146 adults aged 40 to 95 with spinal fra…

This study tests a one-time gene therapy called delandistrogene moxeparvovec in 83 people with Duchenne muscular dystrophy. The goal is to see if it is safe and helps the body make dystrophin, a protein missing in Duchenne. The trial is now enrolling non-ambulatory participants (…

This early-stage study tests a new drug (GSK5926371) in people with lupus and similar autoimmune diseases. The drug is designed to target and calm specific immune cells that attack the body. The main goal is to check if the drug is safe and how the body handles it, with 54 adults…

This study compares two treatment schedules for postmenopausal women with severe osteoporosis. One group gets romosozumab for 12 months then denosumab for 12 months. The other group cycles between the two drugs every 6 months for 2 years. Researchers will measure bone density and…

This phase 2 study tests two experimental drugs, lutikizumab and ravagalimab, alone or together, in about 180 adults with moderate-to-severe rheumatoid arthritis who have not improved with other treatments. The goal is to see if these drugs can reduce joint pain and swelling bett…

This early-stage trial is testing a combination of specially engineered immune cells (CAR T cells) and a vaccine for people with sarcoma that has come back or spread. The goal is to see if the treatment is safe and can help shrink tumors. About 20 participants will receive the th…

This study follows 300 adults with severe eosinophilic asthma who are prescribed benralizumab as part of their normal care in Germany. Researchers will track changes in asthma control, lung function, and medication use over one year. The goal is to see how the drug performs outsi…

This phase 3 trial tests a new long-acting version of the drug octreotide (Debio 4126) for people with acromegaly, a condition caused by too much growth hormone. The drug is given as a shot every 12 weeks, instead of the usual monthly injections. The study will compare it to a pl…

This trial investigates whether luspatercept can treat anemia caused by chemotherapy in adults with low-risk acute myeloid leukemia (AML). Participants receive luspatercept injections after chemotherapy, and researchers monitor hemoglobin levels and safety. The study aims to find…

This study tests whether a combination of venetoclax and azacitidine works better than standard chemotherapy to keep high-risk acute myeloid leukemia (AML) from coming back before a stem cell transplant. About 216 adults who have already achieved remission after initial treatment…

This early-phase trial is testing a new drug called BL-M11D1 in 120 adults with acute myeloid leukemia that has come back or not responded to standard treatments. The drug is designed to target and deliver a toxin directly to leukemia cells. The main goals are to check safety, fi…

This Phase 3 trial tests a gene therapy called FLT201 for adults with Gaucher disease type 1. The goal is to see if a single dose can keep blood counts stable so patients can stop their regular enzyme replacement or substrate reduction therapy. The study will enroll 45 people who…

This study tests an experimental oral drug called S-606001 in 45 adults with late-onset Pompe disease. Participants take the drug or a placebo on top of their standard enzyme replacement therapy. The main goal is to see if the drug improves lung function and walking ability over …

This early-phase trial is testing whether adding the drug daratumumab to standard chemotherapy can help adults aged 60 and older with a high-risk form of acute myeloid leukemia (AML). The main goal is to find the safest dose of daratumumab when given alongside chemotherapy. The s…

This early-phase trial tests a combination of CAR T cells that target three different markers (CLL-1, CD33, and CD123) on leukemia cells in patients with relapsed or refractory acute myeloid leukemia. The study aims to see if this approach is safe and can shrink tumors. Only 10 p…

This study compares two types of wrist fusion surgery for people with post-traumatic wrist arthritis. One surgery fuses four wrist bones and removes the scaphoid. The other fuses three or two bones and also removes the triquetrum. The goal is to see which approach gives better gr…

This early study tests a new medicine, MK-1045, in about 21 people with lupus or rheumatoid arthritis. The main goal is to see if it is safe and tolerable at different dose levels. Participants receive the drug through an IV infusion, and researchers monitor for side effects.

This early-stage trial is testing whether adding roginolisib to the standard drug ruxolitinib is safe and tolerable for adults with myelofibrosis whose disease no longer responds to JAK inhibitors. The study will enroll 26 participants and monitor side effects, heart changes, and…

This study tests a new medicine called MAS825 for people with Still's disease, a rare inflammatory condition causing fever, rash, and joint pain. About 20 children and adults with active disease will receive the drug to see if it safely controls symptoms. The goal is to improve d…

This phase 1 trial tests a new type of immunotherapy called universal CAR T cells in people with acute myeloid leukemia (AML) that has come back or not responded to treatment. The cells are engineered to recognize and attack leukemia cells by targeting four different proteins (CL…

This study tests whether a less invasive surgery called sentinel lymph node biopsy can replace standard neck dissection for early-stage oral cavity cancer. About 686 patients will be randomly assigned to one of the two procedures. The goal is to see if the gentler approach mainta…

This Phase 3 trial tests whether a single injection of IDCT (rebonuputemcel), a cell therapy, can safely reduce pain and disability in people with mild to moderate lumbar disc degeneration. About 162 adults with chronic low back pain will receive either the cell injection or a sh…

This trial tests a 4th-generation safety-engineered CAR T cell therapy for people with relapsed or late-stage sarcomas, including osteosarcoma and Ewing sarcoma. Participants receive a single infusion of these immune cells designed to target and attack sarcoma cells. The study ai…

This early-stage trial tests a brain-computer interface called BrainGate for people with paralysis from conditions like ALS or spinal cord injury. A small sensor is placed in the brain to interpret movement-related signals, allowing users to control a tablet computer just by thin…

This early-stage trial tests a new treatment called ICG415 CAR-T cells for adults with acute myeloid leukemia that has come back or not responded to standard therapy. The treatment involves taking a patient's own immune cells, engineering them to recognize and attack leukemia cel…

This study tests whether a balloon coated with the drug paclitaxel, used during standard sinus surgery, can reduce the need for additional procedures or medications in adults with chronic sinusitis. About 300 participants will receive either the drug-coated balloon or a plain bal…

This early-stage trial tests whether combining the drugs gilteritinib with ivosidenib or enasidenib is safe for people with acute myeloid leukemia (AML) that has returned or not responded to treatment. Participants must have specific gene mutations (FLT3 and IDH1 or FLT3 and IDH2…

This study tests a radioactive antibody (211At-BC8-B10) that seeks out and attacks cancer cells, followed by a donor stem cell transplant for people with high-risk leukemia or myelodysplastic syndrome (MDS) that has returned or not responded to treatment. The goal is to find the …

This study tests a new experimental drug called EP0042 in adults with advanced acute myeloid leukemia (AML) or related blood cancers. The goal is to find a safe dose that might work against the cancer, either alone or with other treatments. About 70 participants will take part to…

This study compares two ways of giving the drug bimekizumab to people with active psoriatic arthritis or axial spondyloarthritis: as an IV infusion or as a shot under the skin. The goal is to see if the IV method works just as well as the shot. About 392 adults who are suitable f…

This phase 3 trial tests whether a new drug called ABP 938 works as well as the approved treatment Eylea HD for wet age-related macular degeneration, a leading cause of vision loss. About 304 people aged 50 and older with untreated wet AMD will receive injections of either drug i…

This early-stage trial tests a new treatment called CD371-YSNVZ-IL18 CAR T cells for people with acute myeloid leukemia (AML) that has come back or not responded to standard therapy. The main goal is to find the safest dose and see what side effects occur. About 15 participants w…

This phase 2 trial tests a drug called AGA2115 in 48 Chinese adults and adolescents with osteogenesis imperfecta (types I, III, IV), a condition that makes bones brittle. Participants receive one of three dose schedules by injection under the skin. The study checks for side effec…

This study follows children and teens with osteogenesis imperfecta (brittle bone disease) who previously received romosozumab in an earlier trial. Researchers will monitor 71 participants for side effects over time. The goal is to see if the drug is safe for long-term use in this…

This phase 2 trial tests the drug pacritinib in 30 people with myelofibrosis, a rare bone marrow cancer, who also have low platelet counts. The goal is to see if pacritinib can reduce scarring (fibrosis) in the bone marrow and improve symptoms. Participants take pacritinib pills …

This study tests two different doses of the drug quizartinib as a maintenance therapy for adults with a specific type of acute myeloid leukemia (FLT3-ITD positive) who are in their first complete remission after initial treatment and have not had a stem cell transplant. The goal …

This trial investigates whether adding the antibiotic rifampicin to standard treatment improves outcomes for people with prosthetic joint infections caused by Cutibacterium acnes bacteria. These infections are hard to treat because the bacteria form a protective biofilm. The stud…

This study tests a drug called bimekizumab in children aged 2 to 17 with specific types of juvenile arthritis (enthesitis-related arthritis and juvenile psoriatic arthritis). The goal is to see how the drug moves through the body and if it is safe. About 40 children will take par…

This phase 3 trial tests whether the drug bimekizumab can clear or nearly clear the pustules and skin lesions of palmoplantar pustulosis (PPP) on the hands and feet. About 320 adults with moderate to severe PPP will receive either bimekizumab or a placebo for 16 weeks, with an op…

This study tests whether combining two drugs, revumenib and mezigdomide, is safe for people with specific types of acute leukemia that have returned or not responded to prior therapy. About 52 participants aged 12 and older will take part. The goal is to find the best dose and se…

This study tests whether a 20-day fasting schedule before hip replacement surgery can reduce complications like infections. 130 adults will either follow the fasting plan or receive standard care. Researchers will measure changes in gut bacteria and immune markers to see if fasti…

This phase 3 trial tests whether adding the targeted drug inotuzumab ozogamicin to standard chemotherapy and immunotherapy improves outcomes for children and young adults with high-risk B-cell acute lymphoblastic leukemia (B-ALL). The study will enroll about 6,000 participants an…

This early-phase trial tests a drug called CRD3874-SI, which activates the STING pathway to boost the immune system's ability to fight cancer cells. It is for people with acute myeloid leukemia (AML) that has returned or not responded to previous treatments. The main goal is to f…

This study tests a single dose of SGT-003, a gene therapy that delivers a working version of the dystrophin gene to muscle cells. About 60 boys with Duchenne muscular dystrophy, aged from infancy to under 18, will receive the treatment and be followed for 5 years. The goal is to …

This Phase 3 trial tests whether mocravimod, taken as a pill, can prevent acute myeloid leukemia (AML) from returning after a stem cell transplant. About 366 adults with high-risk AML will receive either mocravimod or a placebo for up to two years. The main goal is to see if the …

This study tests an experimental drug called linvoseltamab in 220 people with AL amyloidosis that has returned or not improved after prior therapy. The drug aims to reduce abnormal proteins that damage organs like the heart and kidneys. The trial first finds the safest dose, then…

This early-stage study tests a new oral drug called onvansertib for people with chronic myelomonocytic leukemia (CMML) or related blood cancers that have returned or stopped responding to standard treatments. The drug works by blocking a protein that helps cancer cells grow. The …

This study is testing a new approach for people with high-risk acute leukemias or myelodysplastic syndrome. Before a donor stem cell transplant, patients receive a radioactive antibody (211At-BC8-B10) designed to target and kill cancer cells while sparing healthy tissue. The goal…

This study tests a new two-drug treatment for people with advanced soft tissue sarcomas (cancers of the muscles, fat, or other connective tissues). The drugs, abemaciclib and gemcitabine, work together to stop cancer cells from growing. The trial will compare this new combo to th…

This trial compares two types of full-arch dental implant frameworks—one made from a single piece of zirconia and the other from titanium with a zirconia top—in people who have lost all teeth in one or both jaws. The goal is to see which material leads to fewer mechanical problem…

This trial investigates whether adding up to three corticosteroid injections to standard exercise therapy improves pain and function in adults with chronic midportion Achilles tendinopathy. Participants receive either the steroid injection or a placebo (lidocaine only), alongside…

This study tests whether a non-invasive device that gently stimulates a nerve in the ear can help people with psoriatic arthritis. The device, called taVNS, is used for 20 minutes daily over 10 days. Researchers will measure changes in disease activity, pain, quality of life, and…

This trial tests a procedure called FETO, where a small balloon is placed in the windpipe of a fetus with severe left congenital diaphragmatic hernia (CDH). The balloon blocks the airway temporarily, which may help the lungs grow larger before birth. The study includes pregnant w…

This study tests a daily pill called vibegron to see if it safely improves bladder control in children aged 2 to 18 with neurogenic detrusor overactivity (NDO), a condition where the bladder contracts too often due to nerve damage. Participants must already use a catheter to empt…

This trial investigates whether using a device that sends mild electrical pulses to the thigh muscles (neuromuscular electrical stimulation, or NMES) can prevent muscle loss and weakness after abdominal surgery for colorectal or gastric cancer. Some participants will also receive…

This study tests a special sealant called Immiseal that is applied during brain or spine surgery to prevent leaks of cerebrospinal fluid. It is used along with standard repair methods to create a watertight seal. The study follows adults aged 18 to 75 who need dural repair after …

This study is testing a small, leadless pacemaker placed in the heart's upper chamber (atrium) for people with sinus node dysfunction, a condition where the heart's natural pacemaker doesn't work properly. Participants receive the Aveir AR pacemaker and a loop recorder to track h…

This trial investigates whether montelukast, a common asthma medication, can reduce inflammation and prevent cartilage breakdown after anterior cruciate ligament (ACL) reconstruction. The study enrolls adults aged 25 to 50 who also have a meniscus tear, a group at high risk for r…

This study compares muscle thickness around the shoulder blade in people with early ankylosing spondylitis (an inflammatory condition) versus those with mechanical shoulder blade movement problems. Researchers use ultrasound and electromyography (EMG) to see if they can tell the …

This study explores whether MRI scans can safely and accurately detect cancerous or precancerous mouth lesions in people with Fanconi Anemia, a rare genetic condition that raises cancer risk. Researchers will compare MRI results to standard biopsies in 80 adult participants. If s…

This study looks at a new genetic test called Caris Chromoseq for people with certain blood cancers (acute myeloid leukemia, myelodysplastic syndrome, or myeloproliferative neoplasms). The test scans the entire genome to help classify the cancer and guide risk assessment. Researc…

This phase 2 study tests a new radioactive imaging agent, 18F-mFBG, to measure nerve damage in the hearts of 20 people with stable heart failure and implantable defibrillators (ICDs). The goal is to see if the agent can reveal differences in nerve function between those who have …

This early-stage trial tests a fluorescent dye called panitumumab-IRDye800 that attaches to cancer cells. Before surgery, 30 adults with brain tumors will receive a single infusion of the dye. During their operation, a special camera will detect the dye's glow, helping surgeons d…

This study enrolls about 4,000 adults aged 60 and older with heart failure who are at high risk for ATTR amyloidosis, a rare disease that stiffens the heart. Doctors receive special training on how to spot and diagnose the condition using standard tests. The goal is to see if thi…

This study tests a portable ultrasound system to measure the position of the shoulder blade (scapula) in patients with shoulder arthritis while they stand. The goal is to see if this non-radiation method can give results similar to CT scans taken when lying down. Thirty adults sc…

This study is testing a new radioactive tracer called 68Ga-EV203 for PET/CT scans in people with blood cancers like multiple myeloma, lymphoma, and leukemia. The goal is to see how the tracer spreads in the body, how much radiation it gives off, and whether it can find tumors bet…

This study is testing whether a special bone scan (SPECT/CT) can predict which patients with chronic back pain will have good results from lumbar fusion surgery. Researchers will measure how much the scan lights up in the spine and compare it to pain and disability scores one yea…

This study is testing a cloud-based AI platform called Willem that analyzes electrocardiogram (ECG) data to detect Transthyretin cardiac amyloidosis (ATTR-CA), a rare and serious heart condition. Researchers will compare ECGs from 2000 adults—some with confirmed ATTR-CA and some …

This study tests whether a special PET scan (FET PET/CT) can better locate small pituitary tumors that cause Cushing disease. About 50 adults with confirmed Cushing disease who are scheduled for pituitary surgery will receive the scan before their operation. The goal is to see if…

This early-phase trial tests a vaccine (CMV-MVA Triplex) given to both stem cell donors and recipients to boost immunity against cytomegalovirus (CMV) and prevent active infection after a half-matched stem cell transplant. About 46 people with various blood cancers will take part…

This study investigates whether eating prunes and taking calcium and vitamin D supplements can prevent bone loss in postmenopausal women. Researchers will measure bone density and bone health markers over two years. The goal is to find a simple, natural way to maintain bone stren…

This study tests a laser treatment called OSC/SS to prevent retinal detachment in people with Stickler Syndrome, a genetic condition that raises the risk of vision loss. About 500 children and adults will receive the procedure in one or both eyes and be followed for 5 years. Rese…

This phase 3 trial tests whether acoramidis can prevent or delay transthyretin amyloidosis (ATTR) in 587 adults who carry a faulty gene but have no symptoms yet. ATTR causes sticky plaques to build up in the heart and nerves, leading to heart failure and nerve damage. Acoramidis …

This study is testing a gel called OSTENIL TENDON to see if it safely reduces pain and improves movement in people with tendon problems. Researchers will enroll 84 adults with one of four types of tendinopathy. The main goal is to measure pain changes three months after treatment…

This study is testing whether applying a special mud (peloid) to the jaw and chewing muscles can reduce pain and improve jaw function in adults with temporomandibular joint (TMJ) disorders. Forty participants will receive 20-minute mud treatments five days a week for two weeks. R…

This study tests different dry needling and electroacupuncture methods on healthy adults with hidden muscle knots in the forearm. 150 participants will be split into five groups to see which technique causes the least soreness and best improves grip strength and movement. Results…

This study tests whether giving dexamethasone through a vein can improve pain control after total hip replacement. About 198 adults having hip surgery will receive either no dexamethasone, 4 mg, or 8 mg, along with standard anesthesia and a nerve block. The main goal is to see ho…

This study tests whether injecting ozone gas into the knee joint, combined with exercise, can reduce pain and improve function in people aged 40-75 with moderate knee osteoarthritis. Participants receive three weekly ozone injections at different concentrations (10, 15, or 20 µg/…

This study will compare three pain management methods after hip surgery in 108 adults aged 65 and older. The methods are a nerve block (PENG block), a local anesthetic injection around the joint (periarticular injection), or both combined. The goal is to see which approach reduce…

This study tests three approaches—oxygen therapy, the drug trazodone, and brief low-oxygen episodes—to see if they can improve sleep apnea in people with chronic cervical spinal cord injury. Researchers will measure changes in breathing and sleep quality in 100 participants. The …

This study tests whether a numbing injection called a PENG block can reduce inflammation and pain in older adults having hip replacement surgery. Sixty patients will receive either the numbing drug ropivacaine or a placebo (salt water) after spinal anesthesia. The goal is to see …

This study compares two manual therapy techniques—myofascial release and instrument-assisted soft tissue mobilization—for treating plantar fasciitis in pregnant women. Forty-four women in their second or third trimester will receive one of the two treatments over four weeks, alon…

This study compares two methods of pulsed radiofrequency treatment for the suprascapular nerve in people with chronic shoulder pain from rotator cuff problems. Thirty-two adults aged 40 to 80 will be randomly assigned to receive the treatment at either the suprascapular notch or …

This trial tests a new anti-fog suction device that keeps the camera lens clear during nose-to-pituitary tumor surgery. Twenty adults with pituitary or craniopharyngioma tumors will either get the device or the usual water-squirt method. The goal is to see if the device reduces f…

This pilot study tests a wearable device called MedRhythms that uses shoe sensors and headphones to deliver real-time rhythmic cues (like a musical beat) to help people with incomplete spinal cord injury improve their walking. Fifteen participants will use the device during super…

This study compares two physical therapy techniques—Mulligan mobilization and proprioceptive neuromuscular facilitation (PNF)—added to standard care for people with subacromial impingement syndrome, a common cause of shoulder pain. Participants, aged 20 to 40, will receive one of…

This study tests whether injecting the steroid dexamethasone near the tooth ligament or under the gum helps numb the tooth better and reduces pain during root canal treatment. It includes 84 adults with severe, irreversible pulpitis in a lower molar. Participants receive one of t…

This study tests whether a 2-week gratitude journaling activity is feasible and acceptable for people with temporomandibular disorder (TMD) and other chronic pain conditions. Sixty participants will either write down things they are grateful for or reflect on daily activities. Re…

This study tests whether the drug sonlicromanol can reduce fatigue and improve physical abilities like balance and leg strength in adults with a specific genetic form of mitochondrial disease. About 220 participants will take either the drug or a placebo twice daily for 52 weeks.…

This study tests whether high-intensity walking therapy helps people with incomplete spinal cord injury walk better than standard rehab. About 25 adults who had a spinal injury within the past year will take part. Their walking speed, endurance, and daily activity will be measure…

This study tests a modular, powered leg brace (exoskeleton) designed to assist knee movement and reduce pain in people with knee osteoarthritis. The brace provides a small amount of torque to help the joint, potentially lowering muscle effort and painful loads on the knee. Resear…

This study compares two minimally invasive procedures—cryoneurolysis (freezing nerves) and radiofrequency (using electric pulses)—to relieve knee pain in adults with osteoarthritis who haven't responded to standard treatments like painkillers or physical therapy. Sixty participan…

This study tests whether a team of pharmacists and physiotherapists can help people with early knee osteoarthritis manage their condition. Participants will get one-on-one pharmacist care, including medication review and education, plus individual or group physiotherapy sessions.…

This study tests whether starting an accelerated shoulder rehabilitation program immediately after reverse total shoulder replacement leads to better pain relief and function than the standard rehab approach. About 74 people with shoulder osteoarthritis will be randomly assigned …

This study tests the Point Mini, a mechanical finger prosthetic, in 14 children aged 3-17 with partial hand differences from amputation or birth. Each child uses their current device for one month, then the Point Mini for two months, to compare hand function, ease of use, and how…

This Phase 2 trial tests whether KL1333 can reduce fatigue and improve leg strength in adults with primary mitochondrial disease, a genetic condition that affects energy production. About 180 participants will receive either KL1333 or a placebo twice daily for 48 weeks. The study…

This study compares Kinesio taping and McConnell taping in people aged 18–50 with patellofemoral pain syndrome (front knee pain). Participants will receive one of the taping methods plus a 6-week exercise program, or just exercise alone. Researchers will measure muscle activation…

This study compares two exercise methods that use a cuff to partly restrict blood flow to the leg: resistance training with light weights versus stationary cycling. Both aim to reduce pain and improve strength in athletes with patellofemoral pain syndrome. Forty-eight athletes ag…

This study looks at whether adding kinesio taping or local vibration therapy to a standard 6-week physiotherapy program can help people with chronic shoulder pain (subacromial pain syndrome). Sixty-three adults will be split into three groups: one gets standard rehab alone, one a…

This study tests whether a non-invasive brain stimulation technique called rTMS can reduce nerve pain, depression, and sleep problems in people with spinal cord injury. Researchers will compare two different rTMS protocols against a placebo in 63 adults. Participants continue the…

This study tests whether cannabidiol (CBD) can safely improve behavior, mood, sleep, and daily function in people with Sanfilippo syndrome, a rare genetic disorder. Thirty-five participants will receive either CBD or a placebo, then switch after a break. Caregivers will report on…

This trial compares two standard anesthesia methods—inhaled sevoflurane versus intravenous propofol—during arthroscopic rotator cuff repair. The goal is to see which one gives surgeons a clearer view inside the shoulder joint, which is important for safety and success. About 110 …

This Stanford study tests whether people with knee osteoarthritis can learn to change how they activate their calf muscles while walking, using a vibrating feedback device. The goal is to reduce the force on the knee joint. Thirty-one participants will train on a treadmill or ove…

This study tests whether shining low-level laser light on muscles can reduce fatigue and improve quality of life in 40 adults with chronic fatigue syndrome. Participants will receive either real laser therapy or a sham treatment three times a week for eight weeks. Researchers wil…

This study looks at whether a high-dose capsaicin patch (made from chili pepper extract) can relieve long-lasting tailbone pain that hasn't responded to other treatments. Researchers will review medical records from 106 patients treated over six years to see how well the patch wo…

This study compares two types of nerve blocks to see which provides better pain relief after total hip replacement. Fifty adults having hip surgery will receive one of the two blocks. Researchers will measure pain scores and how much extra morphine is needed. The goal is to impro…

This study tests whether taking vitamin C around the time of knee replacement surgery can reduce long-term pain. About 400 adults having knee replacement will be randomly assigned to receive vitamin C or a placebo for 8 weeks. The main goal is to see if a larger study is possible…

This study tests whether injecting Botox or hyaluronic acid into the knee joint can reduce pain in people with knee osteoarthritis. Fifty adults aged 50 and older with moderate to severe knee arthritis will receive three weekly injections of one of the two treatments. The main go…

This study compares two exercise programs for people with knee osteoarthritis: supervised cycling on a stationary bike and a land-based therapeutic exercise program with strengthening and balance training. The goal is to see which approach better reduces pain sensitivity during a…

This study tests whether a combination of special joint mobilizations, pain education, and core exercises can reduce pain and improve shoulder function in people with frozen shoulder. Thirty-six adults with the condition will be randomly assigned to either this new program or sta…

This study tests whether a personalized mix of endurance and strength exercises, done at home with video check-ins, can improve mobility and muscle strength in people with mitochondrial myopathy. Fifteen adults with confirmed genetic mutations will follow the program for up to 12…

This Phase 3 study tests a once-weekly injection called eloralintide in 900 adults with osteoarthritis of the knee who are also overweight or obese. The goal is to see if it reduces knee pain and helps with weight loss compared to a placebo. Participants will be in the study for …

This study tests whether a gentle brain stimulation technique called tDCS, applied before eccentric knee exercises, can improve pain and function more than exercise alone in people with patellar tendinopathy (jumper's knee). Forty-two adults with chronic knee pain will be randoml…

This study tests a single injection called SL1002 to see if it safely reduces knee pain in people with osteoarthritis. About 150 adults aged 40 and older with mild to moderate knee arthritis will receive either the study drug or a placebo. The main goal is to measure pain relief …

This study tests a hydrogel wound dressing (Emanate Perio PODS) to see if it helps gums heal better after scaling and root planing, a deep cleaning for stage 3 periodontitis. 72 adults will use the gel at home twice a day for 30 minutes, or receive no extra treatment. The main go…

This study tests whether a sensory projector called Tovertafel Pixie can reduce anxiety in patients with special needs during dental care. About 100 adults will be observed in a real-life setting at Nantes University Hospital. The projector displays calming images on ceilings or …

This Phase 2 trial is testing four experimental drugs (taken orally or by IV) against placebo in 10,000 people with chronic pain from knee osteoarthritis, diabetic nerve damage, or low-back pain. The goal is to see if any of these drugs can safely reduce pain. The study uses a fl…

This study tests a smartwatch-based system that gives real-time tips and reminders to help people with spinal cord injury increase their physical activity. About 196 adults who use wheelchairs will be split into two groups: one gets a standard web-based exercise program, and the …

This trial tests a wearable robot called ENMS-BSF that combines soft muscles, electrical stimulation, and balance feedback to correct foot drop and foot inversion after a stroke. Sixty people who had a stroke at least six months ago and have mild-to-moderate walking problems will…

This study tests whether a testosterone drug (Depo-Testosterone) can reduce fatigue and improve sexual function, mood, and body composition in young men (ages 18-54) who have survived cancer and now have low testosterone. Participants must be in remission for at least one year an…

This study tests whether adding hyaluronic acid to a standard corticosteroid injection works better for shoulder tendonitis pain than the steroid alone. About 132 adults with confirmed supraspinatus tendinopathy will receive either the combo or a placebo injection. Pain levels ar…

This study is testing whether giving one dose of methadone just before total knee replacement surgery can help control pain afterward and reduce the amount of other painkillers needed. About 192 adults aged 21-75 having a knee replacement will be randomly assigned to receive meth…

This study tests whether a spinal cord stimulator, combined with physical therapy, can help people who have had a stroke regain arm and hand movement. Twenty adults with long-term arm weakness will first do therapy alone, then get a spinal implant and repeat therapy with stimulat…

This study looks at whether a special version of clamshell exercises can help people with moderate hip osteoarthritis feel less pain and move better. Researchers will compare three exercise programs in 54 adults aged 45 to 60. The goal is to find the best way to improve hip funct…

This study looks at whether using a special stationary bike while lying in bed, the day after spine surgery, helps people get moving sooner. About 88 adults having elective spine surgery will either get standard care or add a 30-minute in-bed cycling session. Researchers will tra…

This study tests whether a numbing injection called Twin Block can reduce jaw muscle pain and the need for opioid painkillers after wisdom tooth removal. About 48 healthy adults who have jaw pain the day after surgery will receive either the Twin Block or a placebo. Researchers w…

This study tests a medical device called VCFix to treat broken vertebrae (spinal bones) from compression fractures. The goal is to reduce pain and improve movement in 103 adults aged 21-85 with a single recent fracture. The device is placed into the bone to restore height and sta…

This study tests whether daily cannabis extracts (CBD or THC) can reduce pain interference in people with hip or knee osteoarthritis. One hundred adults aged 40-80 will take either CBD, THC, or a placebo capsule daily for 8 weeks and track their symptoms remotely. The goal is to …

This trial compares using tiny titanium tacks versus traditional stitches to hold a gum graft in place after surgery. The goal is to see if the tacks cause less pain and make recovery easier. Adults needing a gum graft around natural teeth will be randomly assigned to one of the …

This trial compares two injection treatments for knee osteoarthritis: a combination of platelet-rich plasma (PRP) and hyaluronic acid versus hyaluronic acid alone. Researchers want to see if the combined approach provides better pain relief and function after one year. The study …

This study tests whether joining a virtual support group can help reduce anxiety in people who have had Takotsubo syndrome, also known as 'broken heart syndrome.' Participants meet online every other week for group therapy and education. The goal is to see if this support lowers …

This study tests whether a newer multi-tined electrode provides longer pain relief than a standard single-tip electrode during radiofrequency ablation for lumbar spondylosis, a common cause of lower back pain. About 25 adults with chronic lower back pain from worn facet joints wi…

This study investigates knee osteoarthritis and cartilage degeneration by combining MRI scans with gait analysis. Researchers aim to better understand how the disease affects both the structure and function of the knee joint. The study involves 25 participants with knee pain or c…

This study aims to understand how and why eosinophils (a type of white blood cell) become active in conditions like allergies, asthma, and parasitic infections. Researchers will observe up to 800 people aged 1 to 100 with high eosinophil levels. No experimental treatments are giv…

This study collects blood and tissue samples from 2000 people—some with cancer and some without—to create a blinded reference set. Researchers will use these samples to evaluate how well new blood tests can detect many types of cancer early. The goal is to improve the accuracy of…

This study looks at how common and severe gum disease is in people with obesity. Researchers will check dental health, analyze saliva for signs of inflammation, and look at genes linked to obesity. They will also study the bacteria in dental plaque to understand the connection be…

This study provides ongoing check-ups for people who received a donor stem cell transplant at the NIH at least three years ago. Researchers will monitor for late side effects, disease return, and overall health. Participants will have yearly visits that may include blood tests, b…

This study tests a virtual reality program called SurviVRSE that teaches breast cancer survivors about heart health. Thirty women currently receiving certain cancer treatments will use the VR headset during one infusion session. Researchers will measure how much they learn, how e…

This study aims to learn more about rare inherited disorders that affect the brain, spinal cord, muscles, and nerves. Researchers will collect medical history, perform exams, and run genetic tests on up to 3,500 participants. No new treatments are tested; the goal is to better un…

This study aims to understand the causes and progression of systemic juvenile idiopathic arthritis (sJIA) and adult-onset Still's disease (AOSD) by observing up to 2,000 participants over time. Researchers will collect medical history, blood samples, and genetic data to identify …

This study collects blood, bone marrow, skin, saliva, and stool samples from up to 1,000 healthy volunteers aged 18 and older. The samples will be stored in a database for researchers to compare with samples from people who have myelodysplastic syndromes (MDS), a group of blood d…

This study looks at whether a blood test for tumor DNA (ctDNA) and detailed scans can help predict how well chemotherapy works in people with a rare soft tissue cancer called leiomyosarcoma. About 40 participants will give blood samples and have scans before, during, and after tr…

This study aims to uncover genetic changes that cause autoimmune diseases in people native to Peru. Researchers will collect blood, urine, and stool samples from 300 participants, including patients with conditions like lupus and rheumatoid arthritis, their family members, and he…

This study looks at whether people with a curved spine (sagittal imbalance) from lumbar spinal stenosis can have their spine naturally straighten after a simple decompression surgery, without needing a more complex fusion procedure. Researchers will measure spine alignment change…

This registry study follows about 100 people with FOP, a rare disease where soft tissue turns to bone. Some participants take palovarotene (an approved treatment), while others do not. Researchers will track side effects, flare-ups, and daily function over time to see how well th…

This study aims to uncover the genetic causes of hereditary leiomyomatosis renal cell cancer (HLRCC), a condition that can lead to painful skin bumps, uterine fibroids, and kidney tumors. Researchers will study people with known or suspected HLRCC and their family members to iden…

This study looks at people with smell loss caused by chronic rhinosinusitis. Participants will undergo a 3-month smell training program. Researchers will measure changes in smell function, mental health, and immune markers in blood and tissue samples. The goal is to understand th…

This pilot study investigates how a gel made from hyaluronic acid and polynucleotides affects early healing of gum defects after surgery. Researchers will measure molecular markers in gum fluid and use laser imaging to track blood flow changes. The study includes 24 adults with a…

This study aims to understand the genetic and biological causes of Proteus syndrome, a rare condition causing abnormal growth of bones, skin, and other tissues. Researchers will follow up to 1,500 participants over time, using medical exams, imaging, and blood tests to track how …

This study looks at whether a tailored exercise program can help older blood cancer survivors slow down the aging process. Researchers will enroll 180 people aged 50 and older who have had blood cancer. The goal is to see if participants can stick with the exercise plan and if it…

This registry tracks 2,000 adults with congenital heart disease who are on the waiting list for a heart or heart-lung transplant. The goal is to understand why some patients get worse or die while waiting, while others improve enough to be removed from the list. By collecting dat…

This study aims to learn more about heart and blood vessel diseases by observing people who have them or are at risk. Researchers will collect samples and perform tests like imaging and stress tests on up to 5,000 participants, including healthy volunteers and relatives of affect…

This pilot study aims to see if a new method can safely measure how tired patients get during a special type of exercise after total knee replacement. Twenty adults recovering from knee surgery will try cycling while blood flow to their legs is partially restricted. The results w…

This study looks at whether measuring the amount of venetoclax in the blood can help doctors give the right dose to people with newly diagnosed acute myeloid leukemia (AML). Currently, everyone gets the same dose, but drug levels vary a lot between patients. The goal is to find a…

This study follows people with rare genetic disorders that cause harmful substances to build up in the body, leading to brain damage. Researchers will monitor up to 200 participants over time using exams, surveys, and lab tests. The goal is to better understand how these diseases…

This study will test how the heart drug empagliflozin is absorbed and processed in 10 children with Duchenne muscular dystrophy, ages 8 to 18. The goal is to find the best dose for protecting the heart in this rare disease. Participants will take the drug by mouth and have blood …

This study looks at how the types of bacteria in the mouth change in people with severe gum disease as they go from having some teeth left to having no teeth, and then after getting dental implants. Researchers will collect microbial samples and analyze DNA to see if different im…

This study looks at how blood pressure changes in the first year after a spinal cord injury and whether a device that stimulates the spine through the skin can help. Five people with recent injuries will be followed for a year, testing the stimulation during sessions to see if it…

This study investigates whether a protein called lumican, found in the blood, can identify postmenopausal women who have fragile bones but normal bone density scans. About 100 women will have their bone density, muscle strength, and blood lumican levels measured. The goal is to s…

This study observes about 170 children and adults with achondroplasia in the United States over roughly 5 years. Researchers will collect health records and questionnaires to track growth, medical issues, surgeries, and quality of life. The goal is to better understand the condit…

This study screens males with Duchenne muscular dystrophy (ages 0 to under 25) for antibodies against AAV8, a virus used in some gene therapies. The goal is to find out how many have these antibodies and to identify who might be eligible for future gene therapy trials. No treatme…

This study looks at a new tool called the Functional Muscle-Bone Incongruity Index (FKUI) that combines handgrip strength and bone density measurements. Researchers want to see if this combined approach gives a fuller picture of muscle and bone health than looking at each measure…

This registry collects detailed information from cancer patients treated with proton radiation therapy. Researchers will track treatment plans, side effects, and quality of life over 15 years. The goal is to learn which patients benefit most from this precise form of radiation an…

This study is creating a large collection of medical data and blood samples from 450 adults with autoimmune diseases (rheumatoid arthritis, lupus, or scleroderma) and 50 healthy volunteers. Researchers will use advanced lab techniques to find unique biological markers that could …

This study collects bone marrow and blood samples from up to 600 people with mastocytosis, a condition where too many mast cells cause symptoms like itching and bone pain. Researchers will study what makes these cells grow and survive. The goal is to learn more about the disease,…

This study will follow 1,000 people receiving Medtronic spinal or cranial devices during routine surgery. Researchers will track outcomes like fusion success, pain relief, and device safety for up to two years. The goal is to gather real-world data on how these already-approved p…

This study uses MRI and ultrasound to watch how muscles, tendons, and bones work together when you move. Researchers hope to learn what normal and injured movement looks like, which could lead to better ways to diagnose and treat problems like knee pain. Healthy volunteers and pe…

This study collects wisdom teeth and surrounding tissue that are normally thrown away after oral surgery. Researchers will use these samples to learn more about oral health and disease. Up to 3,000 people aged 16 to 50 who need their wisdom teeth removed can join. The study also …

This study investigates clonal hematopoiesis (CH) — small mutations in blood cells that can arise naturally or after cancer treatment — in adults receiving chemotherapy or radiation for solid tumors like breast, lung, or colorectal cancer. Researchers will collect blood, saliva, …

This study aims to learn more about myositis, a group of diseases that cause muscle inflammation and damage. Researchers will observe up to 1,200 children and adults with myositis, along with healthy volunteers, to track changes in the immune system and other health problems over…

This study looks at how genetic immune system problems might lead to gum disease and other mouth issues. Researchers will collect samples like saliva, plaque, and blood from 700 people, including those with immune defects, healthy adults with gum disease, and healthy adults witho…

This study follows up to 500 people with polyostotic fibrous dysplasia or McCune-Albright syndrome to learn how these conditions change over time. Researchers will collect medical data and tissue samples to better understand the disease. The goal is to improve future diagnosis an…

This study aims to understand how heart problems develop in people with Duchenne and Becker muscular dystrophy, as well as in carriers. Researchers will collect cardiac MRI scans and clinical data from 1,000 participants to build a registry. Using advanced image analysis and deep…

This study follows up to 2,000 people with spondyloarthritis (a group of inflammatory joint and spine conditions) and their healthy relatives. Researchers aim to identify symptoms, genetic factors, and medical tests that predict who will develop more severe forms of the disease. …

This early-stage study will check if two different tablet forms of the drug HRS-1893 are processed the same way in the body. Thirty-six healthy adults will take both versions and have blood tests to measure drug levels. The goal is to see if the two formulations are equivalent, n…

This study explores whether a substance called thromboxane A2, which is involved in blood clotting and fat metabolism, also plays a role in osteoarthritis. Researchers will measure thromboxane levels in blood and joint fluid from 20 people with knee osteoarthritis and look for a …

This study looks at how a simple monitor called the Pleth Variability Index (PVI) changes during laparoscopic-assisted vaginal hysterectomy. Researchers will track PVI at six key moments when the patient's body position changes, such as tilting the head down or raising the legs. …

This study looks at two types of fat tissue in people with knee osteoarthritis: one inside the knee joint (Hoffa's fat pad) and one inside the thigh muscle. Researchers want to see if these fat deposits are different in size, fat content, and scar tissue. The goal is to better un…

This study follows 100 adults with healthy gums or various stages of gum disease over two years. Researchers will collect saliva and plaque samples at yearly visits to measure specific biomarkers. The goal is to see if these markers can predict who will develop or worsen gum dise…

This study will check if a protein called periostin in the blood is related to how much back pain limits daily activities and quality of life. Researchers will measure periostin in 38 adults with lumbar disc problems and compare it to their scores on disability and health questio…

This study is building a huge registry of information and biological samples from adults with or at risk for many types of cancer, as well as healthy volunteers. Researchers will use this resource to study what causes cancer and how to better prevent, detect, and treat it. The re…

This study is testing a new leg exoskeleton designed by the NIH to help children and young adults with muscle weakness from conditions like cerebral palsy or spinal cord injury. Researchers want to see how well the device works in different real-world settings, like walking on a …

This research study creates a registry of older adults with cancer to collect information about their health, treatments, and outcomes. Participants complete a geriatric assessment and allow researchers to follow their medical records. The goal is to better understand how cancer …

This study looks at whether taking NSAIDs (like ibuprofen) changes the level of a protein called periostin in the blood of people with degenerative disc disease. Researchers will compare three groups: patients using NSAIDs, patients not using NSAIDs, and healthy people without ba…

This study follows about 50 boys under 18 with X-linked myotubular myopathy (XLMTM), a rare genetic muscle condition, to see how often they develop liver problems like cholestasis. No drugs are given—researchers simply collect health data, including liver scans, over one year. Th…

This study aims to better understand disorders that cause hearing to fluctuate, such as Meniere's disease. Researchers will use advanced MRI scans and blood tests to look for biomarkers linked to hearing changes. The goal is to identify different types of these disorders and pave…

This study at Hashemite University looks at how people with and without tennis elbow feel pressure pain and how their bodies briefly turn down pain after a cold stimulus. Participants answer short questionnaires and have their pressure-pain threshold tested with a handheld device…

This study looks at anxiety related to cancer screenings in adults with Fanconi anemia, a rare condition that raises cancer risk. Researchers will observe 20 participants during their regular screening visits, noting body language, worries, and the clinic environment. No treatmen…

This study looks at gum disease in people with rare kidney disorders like Alport syndrome, Fabry disease, and tuberous sclerosis, as well as lupus. Researchers will compare 100 participants to those with chronic kidney disease and healthy controls. They aim to understand how comm…

This pilot study uses a special MRI scan to measure water movement in the spinal discs of children aged 8 to 16, both with and without scoliosis. The goal is to learn more about how the discs behave in scoliosis, which may help explain why the condition develops. The study involv…

This study uses computer models to compare four types of hip socket surgery in children aged 2 to 18 with hip dysplasia. Researchers will create 3D models from MRI scans and simulate each surgery to see how they change socket shape and volume. The goal is to understand which tech…

This study is looking for early signs of heart amyloidosis in Black adults who carry a specific gene change (V122I TTR) that raises their risk. Researchers will use heart MRI scans and blood tests to detect protein buildup before symptoms appear. The goal is to find ways to diagn…

This study aims to collect medical information and tissue samples from 500 people with suspected or confirmed inflammatory muscle diseases, as well as healthy volunteers. Researchers will use blood, muscle, and skin samples to study what causes these diseases and how they progres…

This study tests a new PET scan technique to better track heart damage in people with a condition called ATTR-CM, a progressive heart muscle disease. Researchers will scan 140 participants to see if the imaging can show how well treatments are working. The goal is to improve moni…

This study looks at whether high uric acid levels (hyperuricemia) are linked to more severe gum disease and bone loss. Researchers will measure inflammation and oxidative stress markers in gum fluid and blood from 80 adults. Participants are grouped by gum health and uric acid st…

This study gathers blood and bone marrow samples from 150 adults with myelodysplastic syndrome (MDS), a blood disorder that can turn into acute leukemia. Researchers want to find biological markers that help predict which patients are likely to progress to leukemia. The goal is t…

This study is testing a new device called BloodTrackR that lets people with rheumatoid arthritis collect a small blood sample at home using a finger prick and a smartphone app. Twenty participants will try the device and answer questions about how easy it is to use. The goal is t…

This study tests a new way to screen patients with acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS) by analyzing their bone marrow and blood for specific biomarkers. The goal is to quickly match patients with a treatment trial that targets their cancer's unique mark…

This study aims to learn more about rare skeletal disorders by collecting medical records, blood samples, and genetic data from 100 participants. People with known or suspected bone conditions, as well as their healthy family members, can join either remotely or in person. The go…

This study aims to learn more about the causes of rheumatic diseases—conditions that cause joint pain, stiffness, and swelling—and why they often affect minority groups more severely. Researchers will observe up to 7,500 adults with known or suspected rheumatic disease, providing…

This study looks at whether severe gum disease (periodontitis) is linked to stiffer arteries, which is a sign of heart risk. Researchers will compare 206 adults aged 40-69—half with advanced gum disease and half with healthy gums—using a simple test that measures artery stiffness…

This study is building a library of information and samples from 60 adults with suspected autoimmune myopathy, a rare muscle disease. Researchers will collect blood, urine, stool, and muscle tissue, along with medical data, to better understand the condition. The goal is to impro…

This study collects blood, bone marrow, urine, and tissue samples from up to 6,000 people with solid tumors, blood cancers, or non-cancerous blood disorders, as well as from their healthy family members who are stem cell donors. The samples are stored and used in research to bett…

This study looks at whether testing lung cancer cells in a lab can predict which drugs will work best for each patient. Researchers will collect fluid from around the lungs of 400 people with lung cancer who need drainage for shortness of breath. They will grow the cancer cells i…

This study follows 300 adults with systemic lupus erythematosus (SLE) who are seen by a team of specialists at a hospital in Brest, France. Researchers will collect data on disease patterns, symptoms, and test results over time. The goal is to better understand lupus and improve …

This study will follow 78 people aged 50 to 85 who need a total knee replacement to see how well a newer all-polyethylene (plastic) knee implant holds up over 5 years. Researchers want to know if this design, which may be cheaper and have fewer mechanical problems, works as well …

This study will follow about 1,850 people with ATTR amyloidosis, a rare disease that affects the heart and nerves. Researchers will collect information on patients' health, treatments, and outcomes over time to better understand the disease and how current therapies work in every…

This study looks at joint tissue from people with early osteoarthritis to find different patterns of inflammation. Researchers will take small samples using a needle under local anesthetic, along with blood tests. The goal is to better understand how the disease starts and progre…

This study looks at how people who have lost an arm or were born without one experience phantom limb sensations—like feeling their missing hand move. Researchers will interview participants and map these sensations to help design prosthetics that are easier to control and feel mo…

This study is looking at how problems with the jaw, neck, and head position relate to the severity of temporomandibular disorder (TMD), a condition that causes jaw pain and dysfunction. Researchers will assess 60 adults using questionnaires and physical measurements. The goal is …

This study looks at whether certain genes make some people more likely to develop eye damage from the drug Plaquenil, which is used for autoimmune diseases like lupus and rheumatoid arthritis. Researchers will compare people who have had eye damage from Plaquenil with those who h…

This study is tracking 1,500 people with cardiac sarcoidosis—a condition where inflammation affects the heart—to learn how doctors currently diagnose and treat it. Researchers will also test whether corticosteroid therapy improves outcomes. The goal is to create better guidelines…

This study investigates whether fragments of tumor DNA circulating in the blood can be used to detect and monitor soft tissue sarcoma. Researchers will collect blood and tumor tissue samples from 40 adults with high-risk sarcomas to see if this DNA can serve as a biomarker for ca…

This study enrolls up to 15,000 children with known or suspected endocrine or metabolic disorders, along with their family members. Researchers will collect medical records, blood, saliva, and other samples to identify genetic changes linked to these conditions. The goal is to be…

This study aims to create a smartphone system that sends personalized pain management tips to adults with multiple sclerosis or spinal cord injury who have chronic pain. Researchers will interview participants to understand their preferences for the content and timing of these no…

This study investigates whether tightness in the pectoralis minor, a small chest muscle, is linked to partial rotator cuff tears in the shoulder. Researchers will compare 45 patients with tears to 45 without, matching them by age, sex, body size, and dominant side. Using simple m…

This study aims to find how common the KIT D816V mutation is in people with suspected clonal mast cell disease. Researchers will collect blood samples from 450 participants and test them using two sensitive methods. The results may improve understanding and diagnosis of these rar…

This study looks for proteins and other factors that might predict whether a teenager's scoliosis curve will get worse. Researchers will compare blood samples and health information from 500 teens with and without scoliosis over 6–12 months. The goal is to better understand what …

This study is collecting blood and tumor samples from 200 people with metastatic leiomyosarcoma who are starting chemotherapy. Researchers will analyze circulating tumor DNA (ctDNA) and genetic changes to see if they can predict how well the chemotherapy works. Participants also …

This study looks at whether sulfasalazine, a drug for inflammatory arthritis, makes the standard diabetes blood test (HbA1c) falsely low. That could mean diabetes goes undiagnosed or is undertreated in these patients. Researchers will use continuous glucose monitors and fasting b…

This study looks at adults with two types of scoliosis (idiopathic and degenerative) to understand what physical problems they have that physical therapy might help. Researchers will compare them to healthy adults using surveys and physical exams. The goal is to gather informatio…

This study aims to collect information and bone samples from up to 1,000 people with bone or mineral disorders, such as tumor-induced osteomalacia or familial tumoral calcinosis. Participants receive standard medical evaluations and may provide bone tissue from surgery or a biops…

This study follows people of all ages who have or may have a RUNX1 gene variant, which can cause bleeding problems and increase the risk of blood cancers. Researchers will collect medical history, blood samples, and bone marrow over many years to understand how the condition deve…

This pilot study looks at how different types and intensities of exercise affect muscle recovery in people taking statins compared to those not on statins. Researchers will test cycling and resistance training at various levels, measuring muscle damage markers and pain sensitivit…

This study follows people with acquired or inherited bone marrow failure for up to 20 years to learn how the diseases and treatments affect the body over time. Participants, aged 2 and older, will have regular check-ups and tests every 1 to 3 years. The goal is to better understa…

This study is testing whether a special ultrafast ultrasound can better measure muscle changes in boys and men with Duchenne or Becker muscular dystrophy. Researchers will compare muscle stiffness, fat content, and blood flow in 60 participants (patients and healthy volunteers) o…

This study will follow 8,000 Medicare patients with lumbar spinal stenosis who receive either the MILD procedure or interspinous process decompression. Researchers will track complications and whether patients need additional surgery within two years. The goal is to see which app…

This study is collecting joint fluid and tissue samples from 50 adults with inflammatory or non-inflammatory bone and joint diseases. Researchers will use both standard and advanced lab techniques to find new biomarkers that could help diagnose rheumatic diseases more accurately …

This global registry enrolls people with Pompe disease to track how the condition changes over time, whether they receive treatment or not. By collecting data from up to 2,000 participants, researchers hope to better understand the disease's progression and improve patient care. …

This study aims to uncover the genetic causes of pituitary and hypothalamic tumors in children. Researchers will collect blood and tumor samples from up to 2,000 participants to analyze DNA and look for inherited patterns. The study also trains doctors and tests new MRI technique…

This study follows children and adults worldwide who have a rare genetic muscle disease called TNNT1 myopathy. Researchers aim to document how the disease progresses over time, including survival and motor milestones. The goal is to identify reliable measures that can be used in …

This study aims to better understand how Pompe disease affects the nerves and muscles involved in breathing. Researchers will analyze nerve conduction and diaphragm activity in 20 adults with Pompe disease or unexplained respiratory failure. The goal is to identify patterns that …

This registry will follow 1,000 adults with chronic-phase CML who are taking approved TKIs (like Gleevec or Tasigna) as their first or second treatment. Over 5 years, researchers will track side effects, treatment changes, and patient-reported experiences to understand how these …

This study aims to learn more about alkaptonuria, a rare genetic disease that causes a pigment to build up in bones and tissues, leading to arthritis and other problems. Researchers will evaluate 300 patients over several years using advanced medical tests. The goal is to better …

This study looks at whether patients who feel more stressed before shoulder surgery for rotator cuff problems have a harder recovery. Researchers will measure stress levels in 100 adults using a questionnaire before their operation. The goal is to see if high stress is linked to …

This study looks at how wearing a shoulder sling changes the way people move and keep their balance during everyday activities like walking or climbing stairs. Researchers will track 30 people—some with shoulder injuries and some healthy—using motion-capture cameras. The goal is …

This study looks at whether certain proteins in saliva can signal the start of gum disease. Researchers will collect saliva from 240 adults with healthy gums, gingivitis, or periodontitis and measure specific biomarkers linked to bone loss. The goal is to find a simple, non-invas…

This study reviews medical records of 200 children under 18 who had scoliosis surgery. Researchers want to find out which factors increase the chance of needing a blood transfusion from a donor and whether using a cell saver device—which recycles the patient's own blood—can lower…

This study aims to uncover the genetic causes of cardiomyopathy in children by analyzing DNA from affected individuals and their families. Researchers hope to identify mutations that lead to different types of cardiomyopathy, which could improve genetic counseling and deepen unde…

This observational study examines a specific group of patients with a type of acute myeloid leukemia (AML) that has an NPM1 mutation. Researchers want to see if a particular subset, called APL-like, is linked to early blood vessel problems like bleeding or clots. The study will l…

This study is a registry that collects information from children and teens up to age 21 who are having spine surgery with robotic and navigation tools. The goal is to track how accurately screws are placed and how much radiation patients and surgeons receive. No new treatment is …

This study looks at whether a common yeast infection in babies' mouths, called oral thrush, is linked to severe cavities in early childhood. Researchers will follow 70 children, half with a history of thrush and half without, for two years. They will regularly check teeth and tak…

This study follows people with myelodysplastic syndromes (MDS) for up to 20 years to understand how the disease changes over time. Researchers will collect blood, bone marrow, and other samples from 1,100 participants, including healthy donors. The goal is to learn more about MDS…

This study is looking for clues to predict how well different rheumatoid arthritis (RA) drugs will work in individual patients. Researchers will give 400 adults with RA one or more standard medications and track their response over 16 weeks. The goal is to find genetic or other f…

This study follows people with a rare and advanced cancer of the nasal cavity and sinuses called T4 sinonasal adenoid cystic carcinoma. All participants receive the standard treatment: surgery followed by radiation therapy. The goal is to measure how long people live without the …

This study uses a special real-time MRI technique to watch how the jaw joint moves in healthy people and in those with temporomandibular joint (TMJ) disorders. By comparing the motion patterns, researchers hope to better understand what goes wrong in TMJ disorders. The study invo…

This study looks at whether a simple, non-invasive fingertip sensor (called pleth variability index, or PVI) can help doctors track blood pressure and fluid needs during skull surgery in children aged 0 to 6 years with craniosynostosis. The researchers will compare PVI readings w…

This study looks at blood cells from people with chronic myelomonocytic leukemia (CMML) to learn more about how the disease works. Researchers will study specific immune cells, including monocytes and immature granulocytes, to understand why they don't develop normally. The goal …

This study investigates why some children still have speech problems (velopharyngeal insufficiency) after cleft palate surgery. Researchers will use real-time MRI to look at how the soft palate moves and its muscle structure in children aged 7 to 12. By comparing children with di…

This study follows about 100 adults who received a Tipmed hip replacement during routine care. Researchers track complications and hip function over two years to see how well the device performs in real life. The goal is to gather practical evidence on safety and effectiveness, n…

This study looks at how using unstable loads (like a wobbly barbell) during shoulder presses affects shoulder movement and muscle activity in overhead athletes (e.g., volleyball, tennis, baseball players) who have subacromial pain syndrome. Researchers compare stable vs unstable …

This registry follows 5000 people who have received Dezawa MuseCells as part of their routine care for conditions like osteoarthritis, pain, and wound healing. Participants report their symptoms and any side effects through online surveys over five years. The goal is to understan…