Immune booster shot aims to speed recovery after cord blood transplant

NCT ID NCT04707300

Recruiting now Disease control Sponsor: Assistance Publique - Hôpitaux de Paris Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Aug 13, 2026 · Updated 3 times

Summary

This early-phase trial tests whether injecting special immune progenitor cells (HTLPs) can help the immune system recover faster after a cord blood transplant in adults with blood cancers. Ten participants will receive the injection alongside their transplant. The goal is to see if it is safe and if it speeds up T-cell recovery, which could lower infection risk and improve outcomes.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Human T Lymphoid Progenitor (HTLP) cells
What this could lead to: If successful, this could lead to faster immune recovery after cord blood transplants, reducing infection risk and improving outcomes for blood cancer patients.
What could go wrong: This is a very small, early-phase trial (only 10 participants) testing safety and feasibility. The approach may not work or could cause severe graft-versus-host disease.

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Conditions

The condition(s) this trial relates to.

acute myeloid leukemia hematopoietic and lymphoid cell neoplasm hematopoietic and lymphoid system neoplasm Neoplasm, Residual

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HEMATOLOGIC MALIGNANCY

Contacts and locations

Locations

Hematology department / Necker Children's Hospital
RECRUITING

Paris, Île-de-France Region, 75015, France
Hôpital Saint Louis
RECRUITING

Paris, France
IUCT Oncopole Toulouse
RECRUITING

Toulouse, France
Institut Gustave Roussy
NOT_YET_RECRUITING

Villejuif, France
Service d'Hématologie et thérapie cellulaire / CHU of Bordeaux
RECRUITING

Pessac, 33604, France

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